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Ke Yuan, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Klouda T, Condon D, Hao Y, Tian W, Lvova M, Chakraborty A, Nicolls MR, Zhou X, Raby BA, Yuan K. From 2D to 3D: Promising Advances in Imaging Lung Structure. Front Med (Lausanne). 2020; 7:343. PMID: 32766264.
    Citations:    
  2. Yuan K, Liu Y, Zhang Y, Nathan A, Tian W, Yu J, Sweatt AJ, Shamshou EA, Condon D, Chakraborty A, Agarwal S, Auer N, Zhang S, Wu JC, Zamanian RT, Nicolls MR, de Jesus Perez VA. Mural Cell SDF1 Signaling Is Associated with the Pathogenesis of Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 2020 Jun; 62(6):747-759. PMID: 32084325.
    Citations:    
  3. Zhang J, Yen YC, Qin L, Chang CL, Yuan KS, Wu ATH, Wu SY. Outcomes of Adjuvant Oral versus Intravenous Fluoropyrimidines for High-Risk Stage II or Stage III Colon Adenocarcinoma: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study. J Cancer. 2020; 11(14):4157-4165. PMID: 32368298.
    Citations:    
  4. Lin KC, Chen TM, Yuan KS, Wu ATH, Wu SY. Assessment of Predictive Scoring System for 90-Day Mortality Among Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Completed Concurrent Chemoradiotherapy. JAMA Netw Open. 2020 Mar 02; 3(3):e1920671. PMID: 32215631.
    Citations:    
  5. Chang CL, Yuan KS, Wu ATH, Wu SY. Adjuvant Therapy for High-Risk Stage II or III Colon Adenocarcinoma: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study. Cancers (Basel). 2019 Dec 12; 11(12). PMID: 31842371.
    Citations:    
  6. Xu L, Wang P, Feng X, Tang J, Li L, Zheng X, Zhang J, Hu Y, Lan T, Yuan K, Zhang Y, Ren S, Hao X, Zhang M, Xu M. SETD3 is regulated by a couple of microRNAs and plays opposing roles in proliferation and metastasis of hepatocellular carcinoma. Clin Sci (Lond). 2019 10 30; 133(20):2085-2105. PMID: 31654063.
    Citations:    
  7. Chang CL, Yuan KS, Wu ATH, Wu SY. Toxicity Profiles of Fractionated Radiotherapy, Contemporary Stereotactic Radiosurgery, and Transsphenoidal Surgery in Nonfunctioning Pituitary Macroadenomas. Cancers (Basel). 2019 Oct 26; 11(11). PMID: 31717774.
    Citations:    
  8. Lin WC, Chang CL, Hsu HL, Yuan KS, Wu ATH, Wu SY. Three-Dimensional Conformal Radiotherapy-Based or Intensity-Modulated Radiotherapy-Based Concurrent Chemoradiotherapy in Patients with Thoracic Esophageal Squamous Cell Carcinoma. Cancers (Basel). 2019 Oct 10; 11(10). PMID: 31658709.
    Citations:    
  9. Hsiao PK, Chang CL, Yuan KS, Wu ATH, Wu SY. Results of Treatment with Modern Fractionated Radiotherapy, Contemporary Stereotactic Radiosurgery, and Transsphenoidal Surgery in Nonfunctioning Pituitary Macroadenoma. J Clin Med. 2019 Apr 16; 8(4). PMID: 30995734.
    Citations:    
  10. Yuan K, Shamskhou EA, Orcholski ME, Nathan A, Reddy S, Honda H, Mani V, Zeng Y, Ozen MO, Wang L, Demirci U, Tian W, Nicolls MR, de Jesus Perez VA. Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension. Circulation. 2019 04 02; 139(14):1710-1724. PMID: 30586764.
    Citations:    
  11. Shamskhou EA, Verghese L, Yuan K, de Jesus Perez VA. EMAPII: A Key Player in HIV-Nef-induced Pulmonary Vasculopathy. Am J Respir Cell Mol Biol. 2019 Mar; 60(3):257-258. PMID: 30376353.
    Citations:    
  12. Shamskhou EA, Kratochvil MJ, Orcholski ME, Nagy N, Kaber G, Steen E, Balaji S, Yuan K, Keswani S, Danielson B, Gao M, Medina C, Nathan A, Chakraborty A, Bollyky PL, De Jesus Perez VA. Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice. Biomaterials. 2019 05; 203:52-62. PMID: 30852423.
    Citations:    
  13. Lee CH, Zhang JF, Yuan KS, Wu ATH, Wu SY. Risk of cardiotoxicity induced by adjuvant anthracycline-based chemotherapy and radiotherapy in young and old Asian women with breast cancer. Strahlenther Onkol. 2019 Jul; 195(7):629-639. PMID: 30690687.
    Citations:    
  14. Yuan KH, Zhang Z, Deng L. Fit indices for mean structures with growth curve models. Psychol Methods. 2019 Feb; 24(1):36-53. PMID: 30372100.
    Citations:    
  15. Qin L, Chen TM, Kao YW, Lin KC, Yuan KS, Wu ATH, Shia BC, Wu SY. Predicting 90-Day Mortality in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma after Curative Surgery. Cancers (Basel). 2018 Oct 22; 10(10). PMID: 30360381.
    Citations:    
  16. Yu HH, Chengchuan Ko E, Chang CL, Yuan KS, Wu ATH, Shan YS, Wu SY. Fucoidan Inhibits Radiation-Induced Pneumonitis and Lung Fibrosis by Reducing Inflammatory Cytokine Expression in Lung Tissues. Mar Drugs. 2018 Oct 19; 16(10). PMID: 30347679.
    Citations:    
  17. Qin L, Kao YW, Lin YL, Peng BY, Deng WP, Chen TM, Lin KC, Yuan KS, Wu AT, Shia BC, Wu SY. Combination of recurrent oral aphthae and dry eye syndrome may constitute an independent risk factor for oral cavity cancer in elderly women. Cancer Manag Res. 2018; 10:3273-3281. PMID: 30233243.
    Citations:    
  18. Lin YK, Hsieh MC, Chang CL, Chow JM, Yuan KS, Wu ATH, Wu SY. Intensity-modulated radiotherapy with systemic chemotherapy improves survival in patients with nonmetastatic unresectable pancreatic adenocarcinoma: A propensity score-matched, nationwide, population-based cohort study. Radiother Oncol. 2018 11; 129(2):326-332. PMID: 30082144.
    Citations:    
  19. Qin L, Kao YW, Lin YL, Peng BY, Deng WP, Chen TM, Lin KC, Yuan KS, Wu ATH, Shia BC, Wu SY. Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study. Cancer Med. 2018 08; 7(8):4104-4114. PMID: 30009475.
    Citations:    
  20. Yen YC, Hsu HL, Chang JH, Lin WC, Chang YC, Chang CL, Chow JM, Yuan KS, Wu ATH, Wu SY. Efficacy of thoracic radiotherapy in patients with stage IIIB-IV epidermal growth factor receptor-mutant lung adenocarcinomas who received and responded to tyrosine kinase inhibitor treatment. Radiother Oncol. 2018 10; 129(1):52-60. PMID: 29703499.
    Citations:    
  21. Orcholski ME, Yuan K, Rajasingh C, Tsai H, Shamskhou EA, Dhillon NK, Voelkel NF, Zamanian RT, de Jesus Perez VA. Drug-induced pulmonary arterial hypertension: a primer for clinicians and scientists. Am J Physiol Lung Cell Mol Physiol. 2018 06 01; 314(6):L967-L983. PMID: 29417823.
    Citations:    
  22. Chen TM, Lin KC, Yuan KS, Chang CL, Chow JM, Wu SY. Treatment of advanced nasopharyngeal cancer using low- or high-dose concurrent chemoradiotherapy with intensity-modulated radiotherapy: A propensity score-matched, nationwide, population-based cohort study. Radiother Oncol. 2018 10; 129(1):23-29. PMID: 29277447.
    Citations:    
  23. Cain MK, Zhang Z, Yuan KH. Univariate and multivariate skewness and kurtosis for measuring nonnormality: Prevalence, influence and estimation. Behav Res Methods. 2017 10; 49(5):1716-1735. PMID: 27752968.
    Citations:    
  24. Chang CL, Tsai HC, Lin WC, Chang JH, Hsu HL, Chow JM, Yuan KS, Wu ATH, Wu SY. Dose escalation intensity-modulated radiotherapy-based concurrent chemoradiotherapy is effective for advanced-stage thoracic esophageal squamous cell carcinoma. Radiother Oncol. 2017 10; 125(1):73-79. PMID: 28923576.
    Citations:    
  25. Lin WC, Ding YF, Hsu HL, Chang JH, Yuan KS, Wu ATH, Chow JM, Chang CL, Chen SU, Wu SY. Value and application of trimodality therapy or definitive concurrent chemoradiotherapy in thoracic esophageal squamous cell carcinoma. Cancer. 2017 Oct 15; 123(20):3904-3915. PMID: 28608916.
    Citations:    
  26. Lin YK, Hsu HL, Lin WC, Chang JH, Chang YC, Chang CL, Yuan KS, Wu ATH, Wu SY. Efficacy of postoperative radiotherapy in patients with pathological stage N2 epidermal growth factor receptor wild type adenocarcinoma and squamous cell carcinoma lung cancer. Oncotarget. 2017 May 23; 8(21):35280-35288. PMID: 27835914.
    Citations:    
  27. Orcholski ME, Khurshudyan A, Shamskhou EA, Yuan K, Chen IY, Kodani SD, Morisseau C, Hammock BD, Hong EM, Alexandrova L, Alastalo TP, Berry G, Zamanian RT, de Jesus Perez VA. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2017 08 01; 313(2):L252-L266. PMID: 28473326.
    Citations: 3     Fields:    Translation:HumansCells
  28. Chang CL, Yuan KS, Wu SY. High-dose or low-dose cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer. Head Neck. 2017 07; 39(7):1364-1370. PMID: 28370614.
    Citations:    
  29. Chang JH, Wu CC, Yuan KS, Wu ATH, Wu SY. Locoregionally recurrent head and neck squamous cell carcinoma: incidence, survival, prognostic factors, and treatment outcomes. Oncotarget. 2017 Aug 15; 8(33):55600-55612. PMID: 28903447.
    Citations:    
  30. Hsieh MC, Lee WH, Wu AT, Chow JM, Chang CL, Yuan KS, Wu SY. Cyproheptadine use in hepatocellular carcinoma. Am J Cancer Res. 2017; 7(3):584-602. PMID: 28401014.
    Citations:    
  31. Yen YC, Chang JH, Lin WC, Chiou JF, Chang YC, Chang CL, Hsu HL, Chow JM, Yuan KS, Wu ATH, Wu SY. Effectiveness of esophagectomy in patients with thoracic esophageal squamous cell carcinoma receiving definitive radiotherapy or concurrent chemoradiotherapy through intensity-modulated radiation therapy techniques. Cancer. 2017 06 01; 123(11):2043-2053. PMID: 28152166.
    Citations:    
  32. Yuan K, Orcholski ME, Huang NF, de Jesus Perez VA. In Vivo Study of Human Endothelial-Pericyte Interaction Using the Matrix Gel Plug Assay in Mouse. J Vis Exp. 2016 12 19; (118). PMID: 28060266.
    Citations:    
  33. Chen JH, Yen YC, Chen TM, Yuan KS, Lee FP, Lin KC, Lai MT, Wu CC, Chang CL, Wu SY. Survival prognostic factors for metachronous second primary head and neck squamous cell carcinoma. Cancer Med. 2017 01; 6(1):142-153. PMID: 27987269.
    Citations:    
  34. Wu SY, Wu AT, Yuan KS, Liu SH. Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells. J Cancer. 2016; 7(15):2408-2419. PMID: 27994679.
    Citations:    
  35. Liu JC, Hao WR, Hsu YP, Sung LC, Kao PF, Lin CF, Wu AT, Yuan KS, Wu SY. Statins dose-dependently exert a significant chemopreventive effect on colon cancer in patients with chronic obstructive pulmonary disease: A population-based cohort study. Oncotarget. 2016 Oct 04; 7(40):65270-65283. PMID: 27542242.
    Citations:    
  36. Yuan K, Shao NY, Hennigs JK, Discipulo M, Orcholski ME, Shamskhou E, Richter A, Hu X, Wu JC, de Jesus Perez VA. Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension. Am J Pathol. 2016 09; 186(9):2500-14. PMID: 27456128.
    Citations:    
  37. Yuan K, Cai L, Ngok SP, Ma L, Botham CM. Ten Simple Rules for Writing a Postdoctoral Fellowship. PLoS Comput Biol. 2016 07; 12(7):e1004934. PMID: 27415752.
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  38. Sung YK, Yuan K, de Jesus Perez VA. Novel approaches to pulmonary arterial hypertension drug discovery. Expert Opin Drug Discov. 2016; 11(4):407-14. PMID: 26901465.
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  39. Takahashi J, Orcholski M, Yuan K, de Jesus Perez V. PDGF-dependent ß-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension. FEBS Lett. 2016 Jan; 590(1):101-9. PMID: 26787464.
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  40. Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H, Koskenvuo JW, Alvira C, Rabinovitch M, Alastalo TP. Loss of PPAR? in endothelial cells leads to impaired angiogenesis. J Cell Sci. 2016 Feb 15; 129(4):693-705. PMID: 26743080.
    Citations:    
  41. Zhang Z, Yuan KH. Robust Coefficients Alpha and Omega and Confidence Intervals With Outlying Observations and Missing Data: Methods and Software. Educ Psychol Meas. 2016 Jun; 76(3):387-411. PMID: 29795870.
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  42. Brunner NW, Zamanian RT, Ikeno F, Mitsutake Y, Connolly AJ, Shuffle E, Yuan K, Orcholski M, Lyons J, de Jesus Perez VA. Optical Coherence Tomography of Pulmonary Arterial Walls in Humans and Pigs (Sus scrofa domesticus). Comp Med. 2015 Jun; 65(3):217-24. PMID: 26141446.
    Citations:    
  43. Chang YT, Tseng CN, Tannenberg P, Eriksson L, Yuan K, de Jesus Perez VA, Lundberg J, Lengquist M, Botusan IR, Catrina SB, Tran PK, Hedin U, Tran-Lundmark K. Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension. Cardiovasc Res. 2015 Jul 01; 107(1):20-31. PMID: 25952902.
    Citations:    
  44. Jiang X, Nguyen TT, Tian W, Sung YK, Yuan K, Qian J, Rajadas J, Sallenave JM, Nickel NP, de Jesus Perez V, Rabinovitch M, Nicolls MR. Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection. Am J Transplant. 2015 Jul; 15(7):1768-81. PMID: 25727073.
    Citations:    
  45. Yuan K, Liu Y, Chen HN, Zhang L, Lan J, Gao W, Dou Q, Nice EC, Huang C. Thiol-based redox proteomics in cancer research. Proteomics. 2015 Jan; 15(2-3):287-99. PMID: 25251260.
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  46. Ali ZA, de Jesus Perez V, Yuan K, Orcholski M, Pan S, Qi W, Chopra G, Adams C, Kojima Y, Leeper NJ, Qu X, Zaleta-Rivera K, Kato K, Yamada Y, Oguri M, Kuchinsky A, Hazen SL, Jukema JW, Ganesh SK, Nabel EG, Channon K, Leon MB, Charest A, Quertermous T, Ashley EA. Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. J Clin Invest. 2014 Dec; 124(12):5159-74. PMID: 25401476.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  47. Yuan K, Orcholski ME, Panaroni C, Shuffle EM, Huang NF, Jiang X, Tian W, Vladar EK, Wang L, Nicolls MR, Wu JY, de Jesus Perez VA. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. Am J Pathol. 2015 Jan; 185(1):69-84. PMID: 25447046.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  48. de Jesus Perez V, Yuan K, Alastalo TP, Spiekerkoetter E, Rabinovitch M. Targeting the Wnt signaling pathways in pulmonary arterial hypertension. Drug Discov Today. 2014 Aug; 19(8):1270-6. PMID: 24955837.
    Citations:    
  49. Li M, Vattulainen S, Aho J, Orcholski M, Rojas V, Yuan K, Helenius M, Taimen P, Myllykangas S, De Jesus Perez V, Koskenvuo JW, Alastalo TP. Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1118-28. PMID: 24433082.
    Citations:    
  50. de Jesus Perez VA, Yuan K, Lyuksyutova MA, Dewey F, Orcholski ME, Shuffle EM, Mathur M, Yancy L, Rojas V, Li CG, Cao A, Alastalo TP, Khazeni N, Cimprich KA, Butte AJ, Ashley E, Zamanian RT. Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 May 15; 189(10):1260-72. PMID: 24702692.
    Citations:    
  51. Tian W, Jiang X, Sung YK, Qian J, Yuan K, Nicolls MR. Leukotrienes in pulmonary arterial hypertension. Immunol Res. 2014 May; 58(2-3):387-93. PMID: 24570092.
    Citations:    
  52. Brunner N, de Jesus Perez VA, Richter A, Haddad F, Denault A, Rojas V, Yuan K, Orcholski M, Liao X. Perioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgery. Pulm Circ. 2014 Mar; 4(1):10-24. PMID: 25006417.
    Citations:    
  53. Chen HM, Hu ZK, Zheng XL, Yuan ZS, Xu ZB, Yuan LQ, Perez VA, Yuan K, Orcholski M, Liao XB. Effectiveness of YouTube as a Source of Medical Information on Heart Transplantation. Interact J Med Res. 2013 Nov 21; 2(2):e28. PMID: 24263225.
    Citations:    
  54. Jiang X, Hsu JL, Tian W, Yuan K, Olcholski M, Perez Vde J, Semenza GL, Nicolls MR. Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus. J Mol Med (Berl). 2013 Sep; 91(9):1081-93. PMID: 23797537.
    Citations:    
  55. Liao XB, Zhang ZY, Yuan K, Liu Y, Feng X, Cui RR, Hu YR, Yuan ZS, Gu L, Li SJ, Mao DA, Lu Q, Zhou XM, de Jesus Perez VA, Yuan LQ. MiR-133a modulates osteogenic differentiation of vascular smooth muscle cells. Endocrinology. 2013 Sep; 154(9):3344-52. PMID: 23798596.
    Citations:    
  56. Yuan K, Orcholski M, Tian X, Liao X, de Jesus Perez VA. MicroRNAs: promising therapeutic targets for the treatment of pulmonary arterial hypertension. Expert Opin Ther Targets. 2013 May; 17(5):557-64. PMID: 23379818.
    Citations:    
  57. de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Li CG, Tojais NF, Nickel N, Rajagopalan V, Spiekerkoetter E, Wang L, Dutta R, Bernstein D, Rabinovitch M. Loss of adenomatous poliposis coli-a3 integrin interaction promotes endothelial apoptosis in mice and humans. Circ Res. 2012 Dec 07; 111(12):1551-64. PMID: 23011394.
    Citations:    
  58. Yuan K, Lian Z, Sun B, Clayton MM, Ng IO, Feitelson MA. Role of miR-148a in hepatitis B associated hepatocellular carcinoma. PLoS One. 2012; 7(4):e35331. PMID: 22496917.
    Citations:    
  59. Tong X, Zhang Z, Yuan KH. Abstract: Evaluation of Test Statistics for Robust Structural Equation Modeling With Nonnormal Missing Data. Multivariate Behav Res. 2011 Nov 30; 46(6):1016. PMID: 26736130.
    Citations:    
  60. McDunn JE, Muenzer JT, Dunne B, Zhou A, Yuan K, Hoekzema A, Hilliard C, Chang KC, Davis CG, McDonough J, Hunt C, Grigsby P, Piwnica-Worms D, Hotchkiss RS. An anti-apoptotic peptide improves survival in lethal total body irradiation. Biochem Biophys Res Commun. 2009 May 15; 382(4):657-62. PMID: 19303399.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.