Harvard Catalyst Profiles

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Xin Gu, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nardone C, Palanski BA, Scott DC, Timms RT, Barber KW, Gu X, Mao A, Leng Y, Watson EV, Schulman BA, Cole PA, Elledge SJ. A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. Mol Cell. 2023 01 05; 83(1):57-73.e9. PMID: 36608670; PMCID: PMC9908011.
    Citations:    Fields:    Translation:AnimalsCells
  2. Gu X, Jouandin P, Lalgudi PV, Binari R, Valenstein ML, Reid MA, Allen AE, Kamitaki N, Locasale JW, Perrimon N, Sabatini DM. Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. Nature. 2022 Sep; 609(7929):E11. PMID: 36100671.
    Citations:    Fields:    
  3. Gu X, Jouandin P, Lalgudi PV, Binari R, Valenstein ML, Reid MA, Allen AE, Kamitaki N, Locasale JW, Perrimon N, Sabatini DM. Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. Nature. 2022 08; 608(7921):209-216. PMID: 35859173.
    Citations: 3     Fields:    Translation:AnimalsCells
  4. Valenstein ML, Rogala KB, Lalgudi PV, Brignole EJ, Gu X, Saxton RA, Chantranupong L, Kolibius J, Quast JP, Sabatini DM. Structure of the nutrient-sensing hub GATOR2. Nature. 2022 07; 607(7919):610-616. PMID: 35831510; PMCID: PMC9464592.
    Citations: 7     Fields:    Translation:HumansCells
  5. Rogala KB, Gu X, Kedir JF, Abu-Remaileh M, Bianchi LF, Bottino AMS, Dueholm R, Niehaus A, Overwijn D, Fils AP, Zhou SX, Leary D, Laqtom NN, Brignole EJ, Sabatini DM. Structural basis for the docking of mTORC1 on the lysosomal surface. Science. 2019 10 25; 366(6464):468-475. PMID: 31601708.
    Citations: 61     Fields:    Translation:HumansCells
  6. Shen K, Valenstein ML, Gu X, Sabatini DM. Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. J Biol Chem. 2019 02 22; 294(8):2970-2975. PMID: 30651352; PMCID: PMC6393612.
    Citations: 24     Fields:    Translation:HumansCells
  7. Gu X, Orozco JM, Saxton RA, Condon KJ, Liu GY, Krawczyk PA, Scaria SM, Harper JW, Gygi SP, Sabatini DM. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Science. 2017 11 10; 358(6364):813-818. PMID: 29123071; PMCID: PMC5747364.
    Citations: 199     Fields:    Translation:HumansCells
  8. Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 03 16; 543(7645):438-442. PMID: 28199306; PMCID: PMC5360989.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.