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Shashi Kant, Ph.D.

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Biography
2020
Alan Lerner Award

Overview
Dr. Kant is an assistant professor of medicine at Harvard Medical School and an associate scientist at the Division of Cardiovascular Medicine in the Department of Medicine at Brigham and Womens Hospital.
Dr. Kant received his Ph.D. degree from Hannover Medical School, Hannover, Germany. Dr. Kant did his postdoctoral training at Howard Hughes Medical Institute under Dr. Roger Davis at the University of Massachusetts Medical School. Dr. Kant was an assistant professor of the Division of Cardiovascular Medicine in the Department of Medicine at the University of Massachusetts Medical School before joining the Division of Cardiovascular Medicine in the Department of Medicine at Brigham and Womens Hospital.
Dr. Kant has authored several publications in high impact journals of Cell Reports, Journal of Clinical Investigation, Genes and Developments, and Nature Communications. Dr. Kant is a recognized expert in the stress signaling and its role in metabolism and cardiovascular biology. Dr. Kant has been an ad-hoc committee member on NIH and AHA grant review committees.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Specht KS, Kant S, Addington AK, McMillan R, Hulver MW, Learnard H, Campbell M, Donnelly S, Caliz AD, Pei Y, Reif M, Bond J, DeMarco A, Craige B, Keaney JF, Craige SM. Nox4 mediates skeletal muscle metabolic responses to exercise. Mol Metab. 2021 Jan 02; 101160. PMID: 33400973.
    Citations:    
  2. Kant S, Craige SM, Chen K, Reif MM, Learnard H, Kelly M, Caliz AD, Tran KV, Ramo K, Peters OM, Freeman M, Davis RJ, Keaney JF. Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis. Nat Commun. 2019 09 17; 10(1):4223. PMID: 31530804.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Craige SM, Chen K, Blanton RM, Keaney JF, Kant S. JNK and cardiometabolic dysfunction. Biosci Rep. 2019 07 31; 39(7). PMID: 31270248.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Min SY, Learnard H, Kant S, Gealikman O, Rojas-Rodriguez R, DeSouza T, Desai A, Keaney JF, Corvera S, Craige SM. Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue. Int J Mol Sci. 2019 Apr 25; 20(8). PMID: 31027261.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Kant S, Standen CL, Morel C, Jung DY, Kim JK, Swat W, Flavell RA, Davis RJ. A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. Cell Rep. 2017 Sep 19; 20(12):2775-2783. PMID: 28930674.
    Citations: 9     Fields:    Translation:AnimalsCells
  6. Nam M, Akie TE, Sanosaka M, Craige SM, Kant S, Keaney JF, Cooper MP. Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression. Sci Rep. 2017 05 17; 7(1):2013. PMID: 28515438.
    Citations: 2     Fields:    Translation:AnimalsCells
  7. Craige SM, Kröller-Schön S, Li C, Kant S, Cai S, Chen K, Contractor MM, Pei Y, Schulz E, Keaney JF. PGC-1a dictates endothelial function through regulation of eNOS expression. Sci Rep. 2016 12 02; 6:38210. PMID: 27910955.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  8. Craige SM, Reif MM, Kant S. Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states. Biochim Biophys Acta. 2016 09; 1862(9):1581-6. PMID: 27259981.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Vertii A, Ivshina M, Zimmerman W, Hehnly H, Kant S, Doxsey S. The Centrosome Undergoes Plk1-Independent Interphase Maturation during Inflammation and Mediates Cytokine Release. Dev Cell. 2016 05 23; 37(4):377-386. PMID: 27219065.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  10. Li C, Reif MM, Craige SM, Kant S, Keaney JF. Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling. Nitric Oxide. 2016 05 01; 55-56:45-53. PMID: 26989010.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Craige SM, Kant S, Reif M, Chen K, Pei Y, Angoff R, Sugamura K, Fitzgibbons T, Keaney JF. Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions. Free Radic Biol Med. 2015 Dec; 89:1-7. PMID: 26169727.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  12. Craige SM, Kant S, Keaney JF. Reactive oxygen species in endothelial function - from disease to adaptation - . Circ J. 2015; 79(6):1145-55. PMID: 25986771.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  13. Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ. Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity. Cell Rep. 2013 Aug 29; 4(4):681-8. PMID: 23954791.
    Citations: 12     Fields:    Translation:Animals
  14. Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A. The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Mol Cell Biol. 2012 Jul; 32(13):2467-78. PMID: 22508986.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  15. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 May; 32(10):2010-9. PMID: 22431523.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  16. Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov; 121(11):4383-92. PMID: 21965325.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  17. Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev. 2011 Oct 01; 25(19):2069-78. PMID: 21979919.
    Citations: 44     Fields:    Translation:AnimalsCells
  18. Schumacher S, Laass K, Kant S, Shi Y, Visel A, Gruber AD, Kotlyarov A, Gaestel M. Scaffolding by ERK3 regulates MK5 in development. EMBO J. 2004 Dec 08; 23(24):4770-9. PMID: 15538386.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.