Harvard Catalyst Profiles

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Michael Scott Caplan, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD037581 (CAPLAN, MICHAEL S) Aug 1, 2000 - Sep 30, 2011
    The Role of PAF and TLR in NEC
    Role: Principal Investigator
  2. K08HD000999 (CAPLAN, MICHAEL S) Jan 1, 1993 - Dec 31, 1998
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Frost BL, Patel AL, Robinson DT, Berseth CL, Cooper T, Caplan M. Randomized Controlled Trial of Early Docosahexaenoic Acid and Arachidonic Acid Enteral Supplementation in Very Low Birth Weight Infants. J Pediatr. 2021 May; 232:23-30.e1. PMID: 33358843.
    Citations:    Fields:    
  2. Gephart SM, Underwood MA, Rosito S, Kim JH, Caplan MS. Grading the evidence to identify strategies to modify risk for necrotizing enterocolitis. Pediatr Res. 2020 08; 88(Suppl 1):41-47. PMID: 32855512.
    Citations: 2     Fields:    
  3. Patel RM, Ferguson J, McElroy SJ, Khashu M, Caplan MS. Defining necrotizing enterocolitis: current difficulties and future opportunities. Pediatr Res. 2020 08; 88(Suppl 1):10-15. PMID: 32855506.
    Citations:    Fields:    
  4. Chaaban H, Burge K, Eckert J, Keshari RS, Silasi R, Lupu C, Warner B, Escobedo M, Caplan M, Lupu F. Neutrophil extracellular trap inhibition increases inflammation, bacteraemia and mortality in murine necrotizing enterocolitis. J Cell Mol Med. 2020 Jun 08. PMID: 32515131.
    Citations:    Fields:    
  5. Caplan MS, Underwood MA, Modi N, Patel R, Gordon PV, Sylvester KG, McElroy S, Manzoni P, Gephart S, Chwals WJ, Turner MA, Davis JM. Necrotizing Enterocolitis: Using Regulatory Science and Drug Development to Improve Outcomes. J Pediatr. 2019 09; 212:208-215.e1. PMID: 31235383.
    Citations: 6     Fields:    Translation:Humans
  6. Caplan MS. Improving Outcomes Due to Neonatal Necrotizing Enterocolitis. Clin Perinatol. 2019 03; 46(1):xvii-xviii. PMID: 30771824.
    Citations:    Fields:    Translation:Humans
  7. Garofalo NA, Caplan MS. Oropharyngeal Mother's Milk: State of the Science and Influence on Necrotizing Enterocolitis. Clin Perinatol. 2019 03; 46(1):77-88. PMID: 30771821.
    Citations: 3     Fields:    Translation:Humans
  8. Frost BL, Caplan MS. Can Fish Oil Reduce the Incidence of Necrotizing Enterocolitis by Altering the Inflammatory Response? Clin Perinatol. 2019 03; 46(1):65-75. PMID: 30771820.
    Citations: 3     Fields:    Translation:Humans
  9. Lu J, Synowiec S, Lu L, Yu Y, Bretherick T, Takada S, Yarnykh V, Caplan J, Caplan M, Claud EC, Drobyshevsky A. Microbiota influence the development of the brain and behaviors in C57BL/6J mice. PLoS One. 2018; 13(8):e0201829. PMID: 30075011.
    Citations: 28     Fields:    Translation:AnimalsCells
  10. Neu J, Modi N, Caplan M. Necrotizing enterocolitis comes in different forms: Historical perspectives and defining the disease. Semin Fetal Neonatal Med. 2018 12; 23(6):370-373. PMID: 30100524.
    Citations: 4     Fields:    Translation:Humans
  11. Hackam D, Caplan M. Necrotizing enterocolitis: Pathophysiology from a historical context. Semin Pediatr Surg. 2018 Feb; 27(1):11-18. PMID: 29275810.
    Citations: 10     Fields:    Translation:Humans
  12. Caplan MS. Paediatrics: Are human milk oligosaccharides the magic bullet for necrotizing enterocolitis? Nat Rev Gastroenterol Hepatol. 2017 07; 14(7):394-395. PMID: 28513631.
    Citations: 3     Fields:    Translation:Humans
  13. Frost BL, Modi BP, Jaksic T, Caplan MS. New Medical and Surgical Insights Into Neonatal Necrotizing Enterocolitis: A Review. JAMA Pediatr. 2017 01 01; 171(1):83-88. PMID: 27893069.
    Citations: 29     Fields:    Translation:Humans
  14. Caplan MS. Introduction. Semin Perinatol. 2017 02; 41(1):1. PMID: 27836426.
    Citations:    Fields:    Translation:Humans
  15. Caplan MS, Fanaroff A. Necrotizing: A historical perspective. Semin Perinatol. 2017 02; 41(1):2-6. PMID: 27836425.
    Citations: 5     Fields:    Translation:Humans
  16. Robinson DT, Caplan M, Carlson SE, Yoder R, Murthy K, Frost B. Early docosahexaenoic and arachidonic acid supplementation in extremely-low-birth-weight infants. Pediatr Res. 2016 10; 80(4):505-10. PMID: 27356083.
    Citations: 2     Fields:    Translation:HumansCells
  17. Rodriguez NA, Vento M, Claud EC, Wang CE, Caplan MS. Oropharyngeal administration of mother's colostrum, health outcomes of premature infants: study protocol for a randomized controlled trial. Trials. 2015 Oct 12; 16:453. PMID: 26458907.
    Citations: 9     Fields:    Translation:Humans
  18. Rodriguez NA, Caplan MS. Oropharyngeal administration of mother's milk to prevent necrotizing enterocolitis in extremely low-birth-weight infants: theoretical perspectives. J Perinat Neonatal Nurs. 2015 Jan-Mar; 29(1):81-90. PMID: 25633403.
    Citations: 7     Fields:    Translation:Humans
  19. Robinson DT, Caplan MS. Linking fat intake, the intestinal microbiome, and necrotizing enterocolitis in premature infants. Pediatr Res. 2015 Jan; 77(1-2):121-6. PMID: 25303279.
    Citations: 7     Fields:    Translation:Humans
  20. Frost BL, Jilling T, Lapin B, Maheshwari A, Caplan MS. Maternal breast milk transforming growth factor-beta and feeding intolerance in preterm infants. Pediatr Res. 2014 Oct; 76(4):386-93. PMID: 24995914.
    Citations: 9     Fields:    Translation:Humans
  21. Wu SF, Chiu HY, Chen AC, Lin HY, Lin HC, Caplan M. Efficacy of different probiotic combinations on death and necrotizing enterocolitis in a premature rat model. J Pediatr Gastroenterol Nutr. 2013 Jul; 57(1):23-8. PMID: 23535766.
    Citations: 12     Fields:    Translation:AnimalsCells
  22. Frost BL, Caplan MS. Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. Semin Pediatr Surg. 2013 May; 22(2):88-93. PMID: 23611612.
    Citations: 11     Fields:    Translation:Humans
  23. Carlisle EM, Poroyko V, Caplan MS, Alverdy J, Morowitz MJ, Liu D. Murine gut microbiota and transcriptome are diet dependent. Ann Surg. 2013 Feb; 257(2):287-94. PMID: 23001074.
    Citations: 10     Fields:    Translation:AnimalsCells
  24. Robinson DT, Carlson SE, Murthy K, Frost B, Li S, Caplan M. Docosahexaenoic and arachidonic acid levels in extremely low birth weight infants with prolonged exposure to intravenous lipids. J Pediatr. 2013 Jan; 162(1):56-61. PMID: 22878111.
    Citations: 4     Fields:    Translation:Humans
  25. Wu SF, Caplan M, Lin HC. Necrotizing enterocolitis: old problem with new hope. Pediatr Neonatol. 2012 Jun; 53(3):158-63. PMID: 22770103.
    Citations: 14     Fields:    Translation:Humans
  26. Caplan M. Are probiotics ready for prime time? JPEN J Parenter Enteral Nutr. 2012 Jan; 36(1 Suppl):6S. PMID: 22237880.
    Citations: 1     Fields:    Translation:Humans
  27. Bian S, Bai JP, Chapin H, Le Moellic C, Dong H, Caplan M, Sigworth FJ, Navaratnam DS. Interactions between ß-catenin and the HSlo potassium channel regulates HSlo surface expression. PLoS One. 2011; 6(12):e28264. PMID: 22194818.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  28. Caplan M, Frost B. Myth: necrotizing enterocolitis: probiotics will end the disease, and surgical intervention improves the outcome. Semin Fetal Neonatal Med. 2011 Oct; 16(5):264-8. PMID: 21482212.
    Citations: 6     Fields:    Translation:Humans
  29. Frost BL, Caplan MS. Probiotics and prevention of neonatal necrotizing enterocolitis. Curr Opin Pediatr. 2011 Apr; 23(2):151-5. PMID: 21252675.
    Citations: 5     Fields:    Translation:Humans
  30. Carlisle EM, Poroyko V, Caplan MS, Alverdy JA, Liu D. Gram negative bacteria are associated with the early stages of necrotizing enterocolitis. PLoS One. 2011 Mar 22; 6(3):e18084. PMID: 21445365.
    Citations: 24     Fields:    Translation:AnimalsCells
  31. Soliman A, Michelsen KS, Karahashi H, Lu J, Meng FJ, Qu X, Crother TR, Rabizadeh S, Chen S, Caplan MS, Arditi M, Jilling T. Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. PLoS One. 2010 Oct 15; 5(10):e15044. PMID: 20976181.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  32. Alves DS, Farr GA, Seo-Mayer P, Caplan MJ. AS160 associates with the Na+,K+-ATPase and mediates the adenosine monophosphate-stimulated protein kinase-dependent regulation of sodium pump surface expression. Mol Biol Cell. 2010 Dec; 21(24):4400-8. PMID: 20943949.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  33. Lu J, Pierce M, Franklin A, Jilling T, Stafforini DM, Caplan M. Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. Pediatr Res. 2010 Sep; 68(3):225-30. PMID: 20531249.
    Citations: 20     Fields:    Translation:Animals
  34. Chaaban H, Shin M, Sirya E, Lim YP, Caplan M, Padbury JF. Inter-alpha inhibitor protein level in neonates predicts necrotizing enterocolitis. J Pediatr. 2010 Nov; 157(5):757-61. PMID: 20955849.
    Citations: 29     Fields:    Translation:Humans
  35. Morowitz MJ, Poroyko V, Caplan M, Alverdy J, Liu DC. Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis. Pediatrics. 2010 Apr; 125(4):777-85. PMID: 20308210.
    Citations: 72     Fields:    Translation:Humans
  36. Carmosino M, Valenti G, Caplan M, Svelto M. Polarized traffic towards the cell surface: how to find the route. Biol Cell. 2009 Nov 16; 102(2):75-91. PMID: 19909237.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  37. Farr GA, Hull M, Mellman I, Caplan MJ. Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. J Cell Biol. 2009 Jul 27; 186(2):269-82. PMID: 19620635.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  38. Caplan MS. Probiotic and prebiotic supplementation for the prevention of neonatal necrotizing enterocolitis. J Perinatol. 2009 May; 29 Suppl 2:S2-6. PMID: 19399005.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  39. Carmosino M, Giménez I, Caplan M, Forbush B. Exon loss accounts for differential sorting of Na-K-Cl cotransporters in polarized epithelial cells. Mol Biol Cell. 2008 Oct; 19(10):4341-51. PMID: 18667527.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  40. Caplan MS. Neonatal necrotizing enterocolitis. Introduction. Semin Perinatol. 2008 Apr; 32(2):69. PMID: 18346529.
    Citations: 8     Fields:    Translation:Humans
  41. Frost BL, Jilling T, Caplan MS. The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. Semin Perinatol. 2008 Apr; 32(2):100-6. PMID: 18346533.
    Citations: 42     Fields:    Translation:HumansCells
  42. Lu J, Caplan MS, Li D, Jilling T. Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1181-90. PMID: 18356536.
    Citations: 18     Fields:    Translation:AnimalsCells
  43. Lin D, Kamsteeg EJ, Zhang Y, Jin Y, Sterling H, Yue P, Roos M, Duffield A, Spencer J, Caplan M, Wang WH. Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels. J Biol Chem. 2008 Mar 21; 283(12):7674-81. PMID: 18211905.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  44. De Plaen IG, Liu SX, Tian R, Neequaye I, May MJ, Han XB, Hsueh W, Jilling T, Lu J, Caplan MS. Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis. Pediatr Res. 2007 Jun; 61(6):716-21. PMID: 17426653.
    Citations: 39     Fields:    Translation:Animals
  45. Lu J, Jilling T, Li D, Caplan MS. Polyunsaturated fatty acid supplementation alters proinflammatory gene expression and reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Pediatr Res. 2007 Apr; 61(4):427-32. PMID: 17515866.
    Citations: 36     Fields:    Translation:Animals
  46. Caplan M. Is EGF the Holy Grail for NEC? J Pediatr. 2007 Apr; 150(4):329-30. PMID: 17382103.
    Citations: 4     Fields:    Translation:HumansAnimals
  47. Jilling T, Simon D, Lu J, Meng FJ, Li D, Schy R, Thomson RB, Soliman A, Arditi M, Caplan MS. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol. 2006 Sep 01; 177(5):3273-82. PMID: 16920968.
    Citations: 157     Fields:    Translation:AnimalsCells
  48. MacKendrick W, Caplan M. Ensuring accurate knowledge of prematurity outcomes for prenatal counseling. Pediatrics. 2005 Oct; 116(4):1053-4; author reply 1054. PMID: 16199726.
    Citations:    Fields:    Translation:Humans
  49. Caplan MS, Simon D, Jilling T. The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. Semin Pediatr Surg. 2005 Aug; 14(3):145-51. PMID: 16084401.
    Citations: 46     Fields:    Translation:HumansCells
  50. Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, Hammerman C. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr. 2005 Aug; 147(2):192-6. PMID: 16126048.
    Citations: 124     Fields:    Translation:HumansCellsCTClinical Trials
  51. Qu XW, Thaete LG, Rozenfeld RA, Zhu Y, De Plaen IG, Caplan MS, Hsueh W. Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase. Crit Care Med. 2005 May; 33(5):1050-6. PMID: 15891335.
    Citations: 5     Fields:    Translation:Animals
  52. Jilling T, Lu J, Jackson M, Caplan MS. Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis. Pediatr Res. 2004 Apr; 55(4):622-9. PMID: 14764921.
    Citations: 66     Fields:    Translation:HumansAnimals
  53. Amer MD, Hedlund E, Rochester J, Caplan MS. Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis. Biol Neonate. 2004; 85(3):159-66. PMID: 14646336.
    Citations: 13     Fields:    Translation:Humans
  54. Lu J, Caplan MS, Saraf AP, Li D, Adler L, Liu X, Jilling T. Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G340-50. PMID: 14512286.
    Citations: 6     Fields:    Translation:AnimalsCells
  55. Thaete LG, Neerhof MG, Jilling T, Caplan MS. Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. J Soc Gynecol Investig. 2003 Apr; 10(3):145-50. PMID: 12699876.
    Citations: 5     Fields:    Translation:Animals
  56. Hsueh W, Caplan MS, Qu XW, Tan XD, De Plaen IG, Gonzalez-Crussi F. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. Pediatr Dev Pathol. 2003 Jan-Feb; 6(1):6-23. PMID: 12424605.
    Citations: 89     Fields:    Translation:HumansAnimals
  57. Hammerman C, Goldschmidt D, Caplan MS, Kaplan M, Bromiker R, Eidelman AI, Gartner LM, Hochman A. Protective effect of bilirubin in ischemia-reperfusion injury in the rat intestine. J Pediatr Gastroenterol Nutr. 2002 Sep; 35(3):344-9. PMID: 12352525.
    Citations: 19     Fields:    Translation:Animals
  58. Claud EC, Li D, Xiao Y, Caplan MS, Jilling T. Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. Pediatr Res. 2002 Aug; 52(2):155-62. PMID: 12149490.
    Citations: 6     Fields:    Translation:HumansCells
  59. Caplan MS, Amer M, Jilling T. The role of human milk in necrotizing enterocolitis. Adv Exp Med Biol. 2002; 503:83-90. PMID: 12026031.
    Citations: 6     Fields:    Translation:Humans
  60. Caplan MS, Jilling T. The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis. Lipids. 2001 Sep; 36(9):1053-7. PMID: 11724457.
    Citations: 12     Fields:    Translation:HumansAnimals
  61. Caplan MS, Russell T, Xiao Y, Amer M, Kaup S, Jilling T. Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model. Pediatr Res. 2001 May; 49(5):647-52. PMID: 11328947.
    Citations: 30     Fields:    Translation:AnimalsCells
  62. Caplan MS, Jilling T. New concepts in necrotizing enterocolitis. Curr Opin Pediatr. 2001 Apr; 13(2):111-5. PMID: 11317050.
    Citations: 38     Fields:    Translation:Humans
  63. Tan XD, Chang H, Qu XW, Caplan M, Gonzalez-Crussi F, Hsueh W. Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. Br J Pharmacol. 2000 Apr; 129(7):1522-9. PMID: 10742310.
    Citations: 7     Fields:    Translation:AnimalsCells
  64. Caplan MS, Jilling T. Neonatal necrotizing enterocolitis: possible role of probiotic supplementation. J Pediatr Gastroenterol Nutr. 2000; 30 Suppl 2:S18-22. PMID: 10749397.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  65. Caplan MS, Miller-Catchpole R, Kaup S, Russell T, Lickerman M, Amer M, Xiao Y, Thomson R. Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Gastroenterology. 1999 Sep; 117(3):577-83. PMID: 10464133.
    Citations: 62     Fields:    Translation:AnimalsCells
  66. Li D, Cheng SX, Fisone G, Caplan MJ, Ohtomo Y, Aperia A. Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPase. Am J Physiol. 1998 12; 275(6):F863-9. PMID: 9843902.
    Citations: 6     Fields:    Translation:AnimalsCells
  67. Hsueh W, Caplan MS, Tan X, MacKendrick W, Gonzalez-Crussi F. Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. Pediatr Dev Pathol. 1998 Jan-Feb; 1(1):2-16. PMID: 10463267.
    Citations: 19     Fields:    Translation:HumansAnimals
  68. Gu H, Caplan MJ, Rudnick G. Cloned catecholamine transporters expressed in polarized epithelial cells: sorting, drug sensitivity, and ion-coupling stoichiometry. Adv Pharmacol. 1998; 42:175-9. PMID: 9327872.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  69. Caplan MS, Lickerman M, Adler L, Dietsch GN, Yu A. The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis. Pediatr Res. 1997 Dec; 42(6):779-83. PMID: 9396557.
    Citations: 34     Fields:    Translation:HumansAnimals
  70. Neerhof MG, Silver RK, Caplan MS, Thaete LG. Endothelin-1-induced placental and fetal growth restriction in the rat. J Matern Fetal Med. 1997 May-Jun; 6(3):125-8. PMID: 9172051.
    Citations: 4     Fields:    Translation:Animals
  71. Caplan MS, Hedlund E, Adler L, Lickerman M, Hsueh W. The platelet-activating factor receptor antagonist WEB 2170 prevents neonatal necrotizing enterocolitis in rats. J Pediatr Gastroenterol Nutr. 1997 Mar; 24(3):296-301. PMID: 9138176.
    Citations: 25     Fields:    Translation:Animals
  72. Thaete LG, Neerhof MG, Caplan MS. Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat. Am J Obstet Gynecol. 1997 Jan; 176(1 Pt 1):73-6. PMID: 9024092.
    Citations: 13     Fields:    Translation:Animals
  73. Silver RK, Kupferminc MJ, Russell TL, Adler L, Mullen TA, Caplan MS. Evaluation of nitric oxide as a mediator of severe preeclampsia. Am J Obstet Gynecol. 1996 Oct; 175(4 Pt 1):1013-7. PMID: 8885767.
    Citations: 6     Fields:    Translation:HumansCells
  74. Gu HH, Ahn J, Caplan MJ, Blakely RD, Levey AI, Rudnick G. Cell-specific sorting of biogenic amine transporters expressed in epithelial cells. J Biol Chem. 1996 Jul 26; 271(30):18100-6. PMID: 8663573.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  75. Qu X, Huang L, Burthart T, Crawford SE, Caplan MS, Hsueh W. Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. Prostaglandins. 1996 Apr; 51(4):249-62. PMID: 8935185.
    Citations: 7     Fields:    Translation:AnimalsCells
  76. Caplan M, Millard D. Efficacy and cost analysis of treating low birth weight infants with erythropoietin. J Pediatr. 1995 Oct; 127(4):672-3. PMID: 7562305.
    Citations:    Fields:    Translation:Humans
  77. Silver RK, Mullen TA, Caplan MS, O'Connell PD, Ragin A. Inducible platelet adherence to human umbilical vein endothelium by anticardiolipin antibody-positive sera. Am J Obstet Gynecol. 1995 Sep; 173(3 Pt 1):702-7. PMID: 7573229.
    Citations: 1     Fields:    Translation:HumansCells
  78. Sun XM, MacKendrick W, Tien J, Huang W, Caplan MS, Hsueh W. Endogenous bacterial toxins are required for the injurious action of platelet-activating factor in rats. Gastroenterology. 1995 Jul; 109(1):83-8. PMID: 7797043.
    Citations: 6     Fields:    Translation:Animals
  79. Hageman JR, Caplan MS. An introduction to the structure and function of inflammatory mediators for clinicians. Clin Perinatol. 1995 Jun; 22(2):251-61. PMID: 7671538.
    Citations: 1     Fields:    Translation:Humans
  80. Sun X, Caplan MS, Liu Y, Hsueh W. Endotoxin-resistant mice are protected from PAF-induced bowel injury and death. Role of TNF, complement activation, and endogenous PAF production. Dig Dis Sci. 1995 Mar; 40(3):495-502. PMID: 7895533.
    Citations: 7     Fields:    Translation:Animals
  81. Quigley RL, Caplan MS, Perkins JA, Arentzon CE, Alexander JC, Kuehn BE, Hoff WJ, Wallock ME. Cardiopulmonary bypass with adequate flow and perfusion pressures prevents endotoxaemia and pathologic cytokine production. Perfusion. 1995; 10(1):27-31. PMID: 7795310.
    Citations:    Fields:    Translation:Humans
  82. Caplan MS, Hedlund E, Adler L, Hsueh W. Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis. Pediatr Pathol. 1994 Nov-Dec; 14(6):1017-28. PMID: 7855004.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  83. Caplan MS, MacKendrick W. Inflammatory mediators and intestinal injury. Clin Perinatol. 1994 Jun; 21(2):235-46. PMID: 8070224.
    Citations: 8     Fields:    Translation:HumansAnimals
  84. Simonson SG, Welty-Wolf K, Huang YT, Griebel JA, Caplan MS, Fracica PJ, Piantadosi CA. Altered mitochondrial redox responses in gram negative septic shock in primates. Circ Shock. 1994 May; 43(1):34-43. PMID: 7982271.
    Citations: 13     Fields:    Translation:AnimalsCells
  85. Lee MJ, Silver RK, O'Connell PD, Caplan MS. Endothelial cell 1-acyl-platelet-activating factor synthesis in response to anticardiolipin antibody-positive serum fractions. Prostaglandins. 1994 Mar; 47(3):221-31. PMID: 8016391.
    Citations:    Fields:    Translation:HumansCells
  86. Caplan MS, Hedlund E, Hill N, MacKendrick W. The role of endogenous nitric oxide and platelet-activating factor in hypoxia-induced intestinal injury in rats. Gastroenterology. 1994 Feb; 106(2):346-52. PMID: 8299901.
    Citations: 15     Fields:    Translation:Animals
  87. Sun X, Caplan MS, Hsueh W. Tumour necrosis factor and endotoxin synergistically activate intestinal phospholipase A2 in mice. Role of endogenous platelet activating factor and effect of exogenous platelet activating factor. Gut. 1994 Feb; 35(2):215-9. PMID: 8307472.
    Citations: 7     Fields:    Translation:AnimalsCells
  88. Hsueh W, Caplan MS, Sun X, Tan X, MacKendrick W, Gonzalez-Crussi F. Platelet-activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis. Acta Paediatr Suppl. 1994; 396:11-7. PMID: 8086673.
    Citations: 13     Fields:    Translation:HumansAnimals
  89. MacKendrick W, Caplan M. Necrotizing enterocolitis. New thoughts about pathogenesis and potential treatments. Pediatr Clin North Am. 1993 Oct; 40(5):1047-59. PMID: 8414709.
    Citations: 10     Fields:    Translation:Humans
  90. MacKendrick W, Caplan M, Hsueh W. Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat. Pediatr Res. 1993 Aug; 34(2):222-8. PMID: 8233729.
    Citations: 6     Fields:    Translation:AnimalsCells
  91. Caplan MS, MacKendrick W. Necrotizing enterocolitis: a review of pathogenetic mechanisms and implications for prevention. Pediatr Pathol. 1993 May-Jun; 13(3):357-69. PMID: 8516229.
    Citations: 20     Fields:    Translation:Humans
  92. Caplan MS. PAF and surfactant preparations. Lancet. 1993 Apr 03; 341(8849):865-6. PMID: 8096568.
    Citations:    Fields:    Translation:HumansAnimals
  93. Silver RK, O'Connell PD, Caplan MS. Acetylsalicylic acid inhibits anticardiolipin antibody-induced platelet-activating factor (PAF) synthesis. Prostaglandins. 1993 Feb; 45(2):143-51. PMID: 8430224.
    Citations: 1     Fields:    Translation:HumansCells
  94. MacKendrick W, Hill N, Hsueh W, Caplan M. Increase in plasma platelet-activating factor levels in enterally fed preterm infants. Biol Neonate. 1993; 64(2-3):89-95. PMID: 8260551.
    Citations: 10     Fields:    Translation:Humans
  95. Caplan MS, Adler L, Kelly A, Hsueh W. Hypoxia increases stimulus-induced PAF production and release from human umbilical vein endothelial cells. Biochim Biophys Acta. 1992 Oct 30; 1128(2-3):205-10. PMID: 1420292.
    Citations: 4     Fields:    Translation:Humans
  96. Caplan MS, Kelly A, Hsueh W. Endotoxin and hypoxia-induced intestinal necrosis in rats: the role of platelet activating factor. Pediatr Res. 1992 May; 31(5):428-34. PMID: 1603619.
    Citations: 19     Fields:    Translation:Animals
  97. Silver RK, Caplan MS, Kelly AM. Amniotic fluid platelet-activating factor (PAF) is elevated in patients with tocolytic failure and preterm delivery. Prostaglandins. 1992 Feb; 43(2):181-7. PMID: 1542743.
    Citations: 13     Fields:    Translation:Humans
  98. Caplan MS, Sun XM, Hsueh W. Hypoxia, PAF, and necrotizing enterocolitis. Lipids. 1991 Dec; 26(12):1340-3. PMID: 1819729.
    Citations: 2     Fields:    Translation:HumansAnimals
  99. Musemeche C, Caplan M, Hsueh W, Sun X, Kelly A. Experimental necrotizing enterocolitis: the role of polymorphonuclear neutrophils. J Pediatr Surg. 1991 Sep; 26(9):1047-9; discussion 1049-50. PMID: 1941482.
    Citations: 12     Fields:    Translation:AnimalsCells
  100. Zhang C, Hsueh W, Caplan MS, Kelly A. Platelet activating factor-induced shock and intestinal necrosis in the rat: role of endogenous platelet-activating factor and effect of saline infusion. Crit Care Med. 1991 Aug; 19(8):1067-72. PMID: 1650306.
    Citations: 4     Fields:    Translation:Animals
  101. Caplan MS, Hsueh W, Sun XM, Gidding SS, Hageman JR. Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn. Am Rev Respir Dis. 1990 Dec; 142(6 Pt 1):1258-62. PMID: 2252241.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  102. Caplan MS, Sun XM, Hsueh W. Hypoxia causes ischemic bowel necrosis in rats: the role of platelet-activating factor (PAF-acether). Gastroenterology. 1990 Oct; 99(4):979-86. PMID: 2394352.
    Citations: 15     Fields:    Translation:Animals
  103. Caplan MS, Hsueh W. Necrotizing enterocolitis: role of platelet activating factor, endotoxin, and tumor necrosis factor. J Pediatr. 1990 Jul; 117(1 Pt 2):S47-51. PMID: 2194011.
    Citations: 15     Fields:    Translation:Animals
  104. Arditi M, Manogue KR, Caplan M, Yogev R. Cerebrospinal fluid cachectin/tumor necrosis factor-alpha and platelet-activating factor concentrations and severity of bacterial meningitis in children. J Infect Dis. 1990 Jul; 162(1):139-47. PMID: 2355190.
    Citations: 22     Fields:    Translation:HumansCells
  105. Caplan M, Hsueh W, Kelly A, Donovan M. Serum PAF acetylhydrolase increases during neonatal maturation. Prostaglandins. 1990 Jun; 39(6):705-14. PMID: 2371412.
    Citations: 15     Fields:    Translation:Humans
  106. Caplan MS, Sun XM, Hseuh W, Hageman JR. Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis. J Pediatr. 1990 Jun; 116(6):960-4. PMID: 2348301.
    Citations: 59     Fields:    Translation:Humans
  107. Caplan MS, MacGregor SN. Perinatal management of congenital diaphragmatic hernia and anterior abdominal wall defects. Clin Perinatol. 1989 Dec; 16(4):917-38. PMID: 2531647.
    Citations: 1     Fields:    Translation:Humans
  108. Caplan MS, Cohn RA, Langman CB, Conway JA, Shkolnik A, Brouillette RT. Favorable outcome of neonatal aortic thrombosis and renovascular hypertension. J Pediatr. 1989 Aug; 115(2):291-5. PMID: 2666628.
    Citations: 5     Fields:    Translation:Humans
  109. Baron R, Neff L, Roy C, Boisvert A, Caplan M. Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast. Cell. 1986 Jul 18; 46(2):311-20. PMID: 2424614.
    Citations: 16     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.