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Emre Bektik, Ph.D.

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Biography
Case Western Reserve University, Cleveland, OHIOPostdoctoral Research06/2019Heart Regeneration, Cardiac Physiology
Tsukuba University, JAPANPh.D.03/2018Human Biology

Overview
I received my PhD degree at University of Tsukuba, Japan. My graduate study was focused on understanding mechanisms of direct cardiac reprogramming. My research work found that immature induced cardiomyocytes (iCMs) had active cell cycle status during early reprogramming stage of iCMs and suppression of cell cycle at S-phase effectively improved reprogramming quality and quantity. In another study in human cells, my work showed that additional reprogramming factors, HAND2 and miR-1, beside previously identified 7-factor reprogramming cocktail, improved maturity of human iCMs. More recently, we found that inhibition of cAMP/PKA/CREB signaling axis improves fibroblast plasticity for cardiac reprogramming.

As a postdoctoral fellow, I focused more on the roles on non-coding RNAs in heart development and disease. During my early postdoc career, I worked on understanding non-canonical functions of microRNAs, particularly of miR-1, in cardiac physiology. My essential work found that miR-1 could directly bind with Kir2.1 ion channel at protein level and regulate the action potential in cardiomyocytes. Our later findings showed that miR-1 binds to Kir2.1 through a sequence of nucleotides outside its seed sequence and modulates channel gating. As miR-1 deficiency is directly linked with ventricular cardiac arrhythmias, our findings elucidating a non-canonical microRNA function may improve molecular understanding of arrhythmias that result from miR-1 deficiency and help generating effective strategies to treat ventricular arrhythmias. Interestingly, this interaction seems not to be restricted to miR-1 and Kir2.1 as my work showed several other potential binding partners of miR-1 and it is likely that other ion channels might also be non-canonically regulated by different miRs. Currently, I am working on novel functions of long non-coding RNAs in atrial cell specification and cardiac hypertrophy in Prof. Da-zhi Wang's lab at Boston Children's Hospital.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bektik E, Sun Y, Dennis AT, Sakon P, Yang D, Deschênes I, Fu JD. Inhibition of CREB-CBP Signaling Improves Fibroblast Plasticity for Direct Cardiac Reprogramming. Cells. 2021 06 22; 10(7). PMID: 34206684; PMCID: PMC8307124.
    Citations: 1     Fields:    Translation:AnimalsCells
  2. Yang D, Wan X, Dennis AT, Bektik E, Wang Z, Costa MGS, Fagnen C, Vénien-Bryan C, Xu X, Gratz DH, Hund TJ, Mohler PJ, Laurita KR, Deschênes I, Fu JD. MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel. Circulation. 2021 04 20; 143(16):1597-1613. PMID: 33590773; PMCID: PMC8132313.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  3. Bektik E, Fu JD. Production of Cardiomyocyte-Like Cells by Fibroblast Reprogramming with Defined Factors. Methods Mol Biol. 2021; 2239:33-46. PMID: 33226611.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Bektik E, Cowan DB, Wang DZ. Long Non-Coding RNAs in Atrial Fibrillation: Pluripotent Stem Cell-Derived Cardiomyocytes as a Model System. Int J Mol Sci. 2020 Jul 30; 21(15). PMID: 32751460.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Sattayaprasert P, Vasireddi SK, Bektik E, Jeon O, Hajjiri M, Mackall JA, Moravec CS, Alsberg E, Fu J, Laurita KR. Human Cardiac Mesenchymal Stem Cells Remodel in Disease and Can Regulate Arrhythmia Substrates. Circ Arrhythm Electrophysiol. 2020 10; 13(10):e008740. PMID: 32755466.
    Citations: 3     Fields:    Translation:HumansCells
  6. Bektik E, Fu JD. Ameliorating the Fibrotic Remodeling of the Heart through Direct Cardiac Reprogramming. Cells. 2019 07 04; 8(7). PMID: 31277520; PMCID: PMC6679082.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  7. Bektik E, Dennis A, Pawlowski G, Zhou C, Maleski D, Takahashi S, Laurita KR, Deschênes I, Fu JD. S-phase Synchronization Facilitates the Early Progression of Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit. Int J Mol Sci. 2018 May 04; 19(5). PMID: 29734659.
    Citations: 12     Fields:    Translation:AnimalsCells
  8. Sun Y, Timofeyev V, Dennis A, Bektik E, Wan X, Laurita KR, Deschênes I, Li RA, Fu JD. A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1 -Induced Activation of Pacemaker Current. Stem Cell Rev Rep. 2017 Oct; 13(5):631-643. PMID: 28623610; PMCID: PMC5784831.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Bektik E, Dennis A, Prasanna P, Madabhushi A, Fu JD. Single cell qPCR reveals that additional HAND2 and microRNA-1 facilitate the early reprogramming progress of seven-factor-induced human myocytes. PLoS One. 2017; 12(8):e0183000. PMID: 28796841.
    Citations: 9     Fields:    Translation:HumansCells
  10. Sakalar E, Abasiyanik MF, Bektik E, Tayyrov A. Effect of heat processing on DNA quantification of meat species. J Food Sci. 2012 Sep; 77(9):N40-4. PMID: 22900921.
    Citations: 9     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.