Harvard Catalyst Profiles

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Abhishek Niroula, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Slabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. J Exp Med. 2021 Dec 06; 218(12). PMID: 34698806.
    Citations:    Fields:    
  2. Niroula A, Sekar A, Murakami MA, Trinder M, Agrawal M, Wong WJ, Bick AG, Uddin MM, Gibson CJ, Griffin GK, Honigberg MC, Zekavat SM, Paruchuri K, Natarajan P, Ebert BL. Distinction of lymphoid and myeloid clonal hematopoiesis. Nat Med. 2021 Oct 18. PMID: 34663986.
    Citations:    Fields:    
  3. Bhattacharya R, Zekavat SM, Uddin MM, Pirruccello J, Niroula A, Gibson C, Griffin GK, Libby P, Ebert BL, Bick A, Natarajan P. Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events. JAMA Cardiol. 2021 Sep 01; 6(9):1069-1077. PMID: 34106216.
    Citations: 1     Fields:    
  4. Beauchamp EM, Leventhal M, Bernard E, Hoppe ER, Todisco G, Creignou M, Gallì A, Castellano CA, McConkey M, Tarun A, Wong W, Schenone M, Stanclift C, Tanenbaum B, Malolepsza E, Nilsson B, Bick AG, Weinstock JS, Miller M, Niroula A, Dunford A, Taylor-Weiner A, Wood T, Barbera A, Anand S, Psaty BM, Desai P, Cho MH, Johnson AD, Loos R, MacArthur DG, Lek M, Neuberg DS, Lage K, Carr SA, Hellstrom-Lindberg E, Malcovati L, Papaemmanuil E, Stewart C, Getz G, Bradley RK, Jaiswal S, Ebert BL. ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing. Blood Cancer Discov. 2021 Sep; 2(5):500-517. PMID: 34568833.
    Citations:    
  5. Yu B, Roberts MB, Raffield LM, Zekavat SM, Nguyen NQH, Biggs ML, Brown MR, Griffin G, Desai P, Correa A, Morrison AC, Shah AM, Niroula A, Uddin MM, Honigberg MC, Ebert BL, Psaty BM, Whitsel EA, Manson JE, Kooperberg C, Bick AG, Ballantyne CM, Reiner AP, Natarajan P, Eaton CB. Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure. J Am Coll Cardiol. 2021 07 06; 78(1):42-52. PMID: 34210413.
    Citations:    Fields:    Translation:Humans
  6. Shakur R, Ochoa JP, Robinson AJ, Niroula A, Chandran A, Rahman T, Vihinen M, Monserrat L. Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology. NPJ Genom Med. 2021 Jun 14; 6(1):47. PMID: 34127679.
    Citations:    
  7. Duran-Lozano L, Thorleifsson G, Lopez de Lapuente Portilla A, Niroula A, Went M, Thodberg M, Pertesi M, Ajore R, Cafaro C, Olason PI, Stefansdottir L, Bragi Walters G, Halldorsson GH, Turesson I, Kaiser MF, Weinhold N, Abildgaard N, Andersen NF, Mellqvist UH, Waage A, Juul-Vangsted A, Thorsteinsdottir U, Hansson M, Houlston R, Rafnar T, Stefansson K, Nilsson B. Germline variants at SOHLH2 influence multiple myeloma risk. Blood Cancer J. 2021 04 19; 11(4):76. PMID: 33875642.
    Citations:    Fields:    
  8. Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, Chang K, Laurie C, Burugula BB, Gibson CJ, Niroula A, Lin AE, Taub MA, Aguet F, Ardlie K, Mitchell BD, Barnes KC, Moscati A, Fornage M, Redline S, Psaty BM, Silverman EK, Weiss ST, Palmer ND, Vasan RS, Burchard EG, Kardia SLR, He J, Kaplan RC, Smith NL, Arnett DK, Schwartz DA, Correa A, de Andrade M, Guo X, Konkle BA, Custer B, Peralta JM, Gui H, Meyers DA, McGarvey ST, Chen IY, Shoemaker MB, Peyser PA, Broome JG, Gogarten SM, Wang FF, Wong Q, Montasser ME, Daya M, Kenny EE, North KE, Launer LJ, Cade BE, Bis JC, Cho MH, Lasky-Su J, Bowden DW, Cupples LA, Mak ACY, Becker LC, Smith JA, Kelly TN, Aslibekyan S, Heckbert SR, Tiwari HK, Yang IV, Heit JA, Lubitz SA, Johnsen JM, Curran JE, Wenzel SE, Weeks DE, Rao DC, Darbar D, Moon JY, Tracy RP, Buth EJ, Rafaels N, Loos RJF, Durda P, Liu Y, Hou L, Lee J, Kachroo P, Freedman BI, Levy D, Bielak LF, Hixson JE, Floyd JS, Whitsel EA, Ellinor PT, Irvin MR, Fingerlin TE, Raffield LM, Armasu SM, Wheeler MM, Sabino EC, Blangero J, Williams LK, Levy BD, Sheu WH, Roden DM, Boerwinkle E, Manson JE, Mathias RA, Desai P, Taylor KD, Johnson AD, Auer PL, Kooperberg C, Laurie CC, Blackwell TW, Smith AV, Zhao H, Lange E, Lange L, Rich SS, Rotter JI, Wilson JG, Scheet P, Kitzman JO, Lander ES, Engreitz JM, Ebert BL, Reiner AP, Jaiswal S, Abecasis G, Sankaran VG, Kathiresan S, Natarajan P. Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2021 Mar; 591(7851):E27. PMID: 33707633.
    Citations: 1     Fields:    
  9. Mattsson J, Ekdahl L, Junghus F, Ajore R, Erlandsson E, Niroula A, Pertesi M, Frendéus B, Teige I, Nilsson B. Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing. Nat Commun. 2021 02 24; 12(1):1277. PMID: 33627649.
    Citations:    Fields:    Translation:HumansCells
  10. Grahn THM, Niroula A, Végvári Á, Oburoglu L, Pertesi M, Warsi S, Safi F, Miharada N, Capellera-Garcia S, Siva K, Liu Y, Rörby E, Nilsson B, Zubarev RA, Karlsson S. Correction: S100A6 is a critical regulator of hematopoietic stem cells. Leukemia. 2020 Dec; 34(12):3439. PMID: 32665696.
    Citations:    Fields:    
  11. Honigberg MC, Zekavat SM, Niroula A, Griffin GK, Bick AG, Pirruccello JP, Nakao T, Whitsel EA, Farland LV, Laurie C, Kooperberg C, Manson JE, Gabriel S, Libby P, Reiner AP, Ebert BL, Natarajan P. Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women. Circulation. 2021 Feb 02; 143(5):410-423. PMID: 33161765.
    Citations: 9     Fields:    
  12. Grahn THM, Niroula A, Végvári Á, Oburoglu L, Pertesi M, Warsi S, Safi F, Miharada N, Garcia SC, Siva K, Liu Y, Rörby E, Nilsson B, Zubarev RA, Karlsson S. S100A6 is a critical regulator of hematopoietic stem cells. Leukemia. 2020 12; 34(12):3323-3337. PMID: 32555370.
    Citations: 2     Fields:    
  13. Miller PG, Niroula A, Ceremsak JJ, Gibson CJ, Taylor MS, Birndt S, Perner F, Arnason J, Sperling AS, Agrawal M, Schram AM, Nikiforow S, Pihan G, Hasserjian RP, Aster JC, La Rosée P, Morgan EA, Berliner N, Ebert BL. Identification of germline variants in adults with hemophagocytic lymphohistiocytosis. Blood Adv. 2020 03 10; 4(5):925-929. PMID: 32150605.
    Citations: 1     Fields:    Translation:HumansCells
  14. Niroula A, Ajore R, Nilsson B. MPRAscore: robust and non-parametric analysis of massively parallel reporter assays. Bioinformatics. 2019 12 15; 35(24):5351-5353. PMID: 31359027.
    Citations: 2     Fields:    
  15. Yang Y, Ding X, Zhu G, Niroula A, Lv Q, Vihinen M. ProTstab - predictor for cellular protein stability. BMC Genomics. 2019 Nov 04; 20(1):804. PMID: 31684883.
    Citations: 1     Fields:    Translation:HumansCells
  16. Niroula A, Vihinen M. How good are pathogenicity predictors in detecting benign variants? PLoS Comput Biol. 2019 02; 15(2):e1006481. PMID: 30742610.
    Citations: 15     Fields:    Translation:Humans
  17. Ali M, Ajore R, Wihlborg AK, Niroula A, Swaminathan B, Johnsson E, Stephens OW, Morgan G, Meissner T, Turesson I, Goldschmidt H, Mellqvist UH, Gullberg U, Hansson M, Hemminki K, Nahi H, Waage A, Weinhold N, Nilsson B. The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression. Nat Commun. 2018 04 25; 9(1):1649. PMID: 29695719.
    Citations: 7     Fields:    Translation:HumansCells
  18. Yang Y, Urolagin S, Niroula A, Ding X, Shen B, Vihinen M. PON-tstab: Protein Variant Stability Predictor. Importance of Training Data Quality. Int J Mol Sci. 2018 Mar 28; 19(4). PMID: 29597263.
    Citations: 12     Fields:    
  19. Daneshjou R, Wang Y, Bromberg Y, Bovo S, Martelli PL, Babbi G, Lena PD, Casadio R, Edwards M, Gifford D, Jones DT, Sundaram L, Bhat RR, Li X, Pal LR, Kundu K, Yin Y, Moult J, Jiang Y, Pejaver V, Pagel KA, Li B, Mooney SD, Radivojac P, Shah S, Carraro M, Gasparini A, Leonardi E, Giollo M, Ferrari C, Tosatto SCE, Bachar E, Azaria JR, Ofran Y, Unger R, Niroula A, Vihinen M, Chang B, Wang MH, Franke A, Petersen BS, Pirooznia M, Zandi P, McCombie R, Potash JB, Altman RB, Klein TE, Hoskins RA, Repo S, Brenner SE, Morgan AA. Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. Hum Mutat. 2017 09; 38(9):1182-1192. PMID: 28634997.
    Citations: 15     Fields:    Translation:Humans
  20. Carraro M, Minervini G, Giollo M, Bromberg Y, Capriotti E, Casadio R, Dunbrack R, Elefanti L, Fariselli P, Ferrari C, Gough J, Katsonis P, Leonardi E, Lichtarge O, Menin C, Martelli PL, Niroula A, Pal LR, Repo S, Scaini MC, Vihinen M, Wei Q, Xu Q, Yang Y, Yin Y, Zaucha J, Zhao H, Zhou Y, Brenner SE, Moult J, Tosatto SCE. Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI. Hum Mutat. 2017 09; 38(9):1042-1050. PMID: 28440912.
    Citations: 4     Fields:    Translation:HumansCells
  21. Niroula A, Vihinen M. PON-P and PON-P2 predictor performance in CAGI challenges: Lessons learned. Hum Mutat. 2017 09; 38(9):1085-1091. PMID: 28224672.
    Citations: 2     Fields:    Translation:Humans
  22. Halvarsson BM, Wihlborg AK, Ali M, Lemonakis K, Johnsson E, Niroula A, Cibulskis C, Weinhold N, Försti A, Alici E, Langer C, Pfreundschuh M, Goldschmidt H, Mellqvist UH, Turesson I, Waage A, Hemminki K, Golub T, Nahi H, Gullberg U, Hansson M, Nilsson B. Direct evidence for a polygenic etiology in familial multiple myeloma. Blood Adv. 2017 Apr 11; 1(10):619-623. PMID: 29296704.
    Citations: 9     Fields:    
  23. Niroula A, Vihinen M. Predicting Severity of Disease-Causing Variants. Hum Mutat. 2017 04; 38(4):357-364. PMID: 28070986.
    Citations: 13     Fields:    Translation:Humans
  24. Niroula A, Vihinen M. Variation Interpretation Predictors: Principles, Types, Performance, and Choice. Hum Mutat. 2016 06; 37(6):579-97. PMID: 26987456.
    Citations: 41     Fields:    Translation:Humans
  25. Yang Y, Niroula A, Shen B, Vihinen M. PON-Sol: prediction of effects of amino acid substitutions on protein solubility. Bioinformatics. 2016 07 01; 32(13):2032-4. PMID: 27153720.
    Citations: 12     Fields:    Translation:Humans
  26. Niroula A, Vihinen M. PON-mt-tRNA: a multifactorial probability-based method for classification of mitochondrial tRNA variations. Nucleic Acids Res. 2016 Mar 18; 44(5):2020-7. PMID: 26843426.
    Citations: 15     Fields:    Translation:HumansCells
  27. Niroula A, Vihinen M. Classification of Amino Acid Substitutions in Mismatch Repair Proteins Using PON-MMR2. Hum Mutat. 2015 Dec; 36(12):1128-34. PMID: 26333163.
    Citations: 9     Fields:    Translation:HumansCells
  28. Niroula A, Vihinen M. Harmful somatic amino acid substitutions affect key pathways in cancers. BMC Med Genomics. 2015 Aug 19; 8:53. PMID: 26282678.
    Citations: 7     Fields:    Translation:Humans
  29. Niroula A, Urolagin S, Vihinen M. PON-P2: prediction method for fast and reliable identification of harmful variants. PLoS One. 2015; 10(2):e0117380. PMID: 25647319.
    Citations: 61     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.