Harvard Catalyst Profiles

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Karl R Koehler, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR075018 (KOEHLER, KARL RUSSELL) Sep 17, 2019 - Aug 31, 2024
    NIH
    Generation of human skin organoids from pluripotency
    Role: Principal Investigator
  2. R01DC017461 (KOEHLER, KARL RUSSELL) Dec 1, 2018 - Nov 30, 2023
    NIH
    Engineering multi-lineage human inner ear organoids
    Role: Principal Investigator
  3. R03DC015624 (KOEHLER, KARL RUSSELL) Jul 1, 2016 - Jun 30, 2019
    NIH
    Modeling Otic Neurogenesis in Human Stem Cell-Derived Organoids
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ye MJ, Vadhul RB, Sharma D, Campiti VJ, Burgin SJ, Illing EA, Ting JY, Park JH, Koehler KR, Lee HB, Vernon DJ, Johnson JD, Nesemeier BR, Shipchandler TZ. Aerosol and droplet generation from orbital repair: Surgical risk in the pandemic era. Am J Otolaryngol. 2021 Feb 27; 42(4):102970. PMID: 33667797.
    Citations:    Fields:    
  2. Lee J, Koehler KR. Skin organoids: A new human model for developmental and translational research. Exp Dermatol. 2021 Apr; 30(4):613-620. PMID: 33507537.
    Citations:    Fields:    
  3. Nourbakhsh A, Colbert BM, Nisenbaum E, El-Amraoui A, Dykxhoorn DM, Koehler KR, Chen ZY, Liu XZ. Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art. J Assoc Res Otolaryngol. 2021 Apr; 22(2):95-105. PMID: 33507440.
    Citations:    Fields:    
  4. van der Valk WH, Steinhart MR, Zhang J, Koehler KR. Building inner ears: recent advances and future challenges for in vitro organoid systems. Cell Death Differ. 2021 Jan; 28(1):24-34. PMID: 33318601.
    Citations:    Fields:    
  5. Arkenberg MR, Dimmitt NH, Johnson HC, Koehler KR, Lin CC. Dynamic Click Hydrogels for Xeno-Free Culture of Induced Pluripotent Stem Cells. Adv Biosyst. 2020 11; 4(11):e2000129. PMID: 32924337.
    Citations: 1     
  6. Lee J, Rabbani CC, Gao H, Steinhart MR, Woodruff BM, Pflum ZE, Kim A, Heller S, Liu Y, Shipchandler TZ, Koehler KR. Hair-bearing human skin generated entirely from pluripotent stem cells. Nature. 2020 06; 582(7812):399-404. PMID: 32494013.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  7. Kao R, Rabbani CC, Patel JM, Parkhurst SM, Mantravadi AV, Ting JY, Sim MW, Koehler K, Shipchandler TZ. Management of Mandible Fracture in 150 Children Across 7 Years in a US Tertiary Care Hospital. JAMA Facial Plast Surg. 2019 Sep 01; 21(5):414-418. PMID: 31169865.
    Citations:    Fields:    Translation:Humans
  8. Tang PC, Alex AL, Nie J, Lee J, Roth AA, Booth KT, Koehler KR, Hashino E, Nelson RF. Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids. Stem Cell Reports. 2019 07 09; 13(1):147-162. PMID: 31204303.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  9. Lee J, B?scke R, Tang PC, Hartman BH, Heller S, Koehler KR. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids. Cell Rep. 2018 01 02; 22(1):242-254. PMID: 29298425.
    Citations: 24     Fields:    Translation:AnimalsCells
  10. Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E. Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. Nat Biotechnol. 2017 06; 35(6):583-589. PMID: 28459451.
    Citations: 57     Fields:    Translation:HumansCells
  11. Nie J, Koehler KR, Hashino E. Directed Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Sensory Epithelia in 3D Culture. Methods Mol Biol. 2017; 1597:67-83. PMID: 28361311.
    Citations: 4     Fields:    Translation:AnimalsCells
  12. DeJonge RE, Liu XP, Deig CR, Heller S, Koehler KR, Hashino E. Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture. PLoS One. 2016; 11(9):e0162508. PMID: 27607106.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  13. Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR. Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells. Nat Commun. 2016 05 24; 7:11508. PMID: 27215798.
    Citations: 26     Fields:    Translation:AnimalsCells
  14. Longworth-Mills E, Koehler KR, Hashino E. Generating Inner Ear Organoids from Mouse Embryonic Stem Cells. Methods Mol Biol. 2016; 1341:391-406. PMID: 25822723.
    Citations: 9     Fields:    Translation:AnimalsCells
  15. Shimomura A, Patel D, Wilson SM, Koehler KR, Khanna R, Hashino E. Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP. PLoS One. 2015; 10(8):e0135060. PMID: 26258652.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  16. Koehler KR, Hashino E. 3D mouse embryonic stem cell culture for generating inner ear organoids. Nat Protoc. 2014; 9(6):1229-44. PMID: 24784820.
    Citations: 42     Fields:    Translation:AnimalsCells
  17. Koehler KR, Mikosz AM, Molosh AI, Patel D, Hashino E. Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature. 2013 Aug 08; 500(7461):217-21. PMID: 23842490.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  18. Vemula S, Shi J, Mali RS, Ma P, Liu Y, Hanneman P, Koehler KR, Hashino E, Wei L, Kapur R. ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53. Blood. 2012 Oct 04; 120(14):2868-78. PMID: 22889758.
    Citations: 18     Fields:    Translation:AnimalsCells
  19. Krishnan S, Mali RS, Koehler KR, Vemula S, Chatterjee A, Ghosh J, Ramdas B, Ma P, Hashino E, Kapur R. Class I(A) PI3Kinase regulatory subunit, p85a, mediates mast cell development through regulation of growth and survival related genes. PLoS One. 2012; 7(1):e28979. PMID: 22238586.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Koehler KR, Tropel P, Theile JW, Kondo T, Cummins TR, Viville S, Hashino E. Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells. BMC Neurosci. 2011 Aug 10; 12:82. PMID: 21831300.
    Citations: 20     Fields:    Translation:AnimalsCells
  21. Kondo T, Matsuoka AJ, Shimomura A, Koehler KR, Chan RJ, Miller JM, Srour EF, Hashino E. Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3. Stem Cells. 2011 May; 29(5):836-46. PMID: 21374761.
    Citations: 35     Fields:    Translation:HumansCells
  22. Matsuoka AJ, Fritsch MH, Koehler KR, Hashino E. In-vivo assessment of migration and engraftment of stem cells in the cochlea using a high-resolution microscopic-endoscope. Laryngoscope. 2010; 120 Suppl 4:S212. PMID: 21225810.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.