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Lyn Howard Jones, Ph.D.

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Biography
The Scripps Research Institute, CAPD12/2000Chemical Biology
University of Nottingham, Nottingham, UKPhD12/1998Synthetic Chemistry
University of Bath, Bath, UKBSc06/1995Chemistry
2020 - pres
Fellow of the AAAS
2014 - pres
Fellow of the Royal Society of Biology
2014 - pres
Fellow of the Linnean Society
2014
Capps Green Zomayer Award (Royal Society of Chemistry)
2010 - pres
Fellow of the Royal Society of Chemistry
2009
Young Industrialist of the Year Award (Royal Society of Chemistry)

Overview
Chief Scientist of the Center for Protein Degradation at the Dana-Farber Cancer Institute. 20 years drug discovery experience and leader in medicinal chemical biology. Interests: protein homeostasis; chemoproteomics and chemogenomics; therapeutic target identification and validation; molecular pharmacology; protein labeling chemical biology and covalent drug discovery. >100 publications in chemistry and chemical biology.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gopalsamy A, Aulabaugh AE, Barakat A, Beaumont KC, Cabral S, Canterbury DP, Casimiro-Garcia A, Chang JS, Chen MZ, Choi C, Dow RL, Fadeyi OO, Feng X, France SP, Howard RM, Janz JM, Jasti J, Jasuja R, Jones LH, King-Ahmad A, Knee KM, Kohrt JT, Limberakis C, Liras S, Martinez CA, McClure KF, Narayanan A, Narula J, Novak JJ, O'Connell TN, Parikh MD, Piotrowski DW, Plotnikova O, Robinson RP, Sahasrabudhe PV, Sharma R, Thuma BA, Vasa D, Wei L, Wenzel AZ, Withka JM, Xiao J, Yayla HG. PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease. J Med Chem. 2020 Dec 24. PMID: 33356244.
    Citations:    
  2. Nowak RP, Jones LH. Target Validation Using PROTACs: Applying the Four Pillars Framework. SLAS Discov. 2020 Dec 17; 2472555220979584. PMID: 33334221.
    Citations:    
  3. Kostic M, Jones LH. Critical Assessment of Targeted Protein Degradation as a Research Tool and Pharmacological Modality. Trends Pharmacol Sci. 2020 05; 41(5):305-317. PMID: 32222318.
    Citations:    Fields:    
  4. Jones LH. Pharmacological Correction of Proteinopathies via Lysosomal Degradation. Biochemistry. 2020 02 18; 59(6):727-728. PMID: 31999102.
    Citations:    Fields:    Translation:Cells
  5. Jones LH. Precision Retargeting: A Selective Covalent Inhibitor Illuminates CDK7 Biology. Cell Chem Biol. 2019 06 20; 26(6):779-780. PMID: 31226310.
    Citations:    Fields:    
  6. Jones LH. Expanding chemogenomic space using chemoproteomics. Bioorg Med Chem. 2019 08 01; 27(15):3451-3453. PMID: 31221609.
    Citations:    Fields:    Translation:HumansCells
  7. Jones LH, Xu H, Fadeyi OO. Quantifying drug-target engagement in live cells using sulfonyl fluoride chemical probes. Methods Enzymol. 2019; 622:201-220. PMID: 31155053.
    Citations:    Fields:    Translation:HumansCells
  8. Jones LH. Emerging Utility of Fluorosulfate Chemical Probes. ACS Med Chem Lett. 2018 Jul 12; 9(7):584-586. PMID: 30034581.
    Citations: 3     
  9. Jones LH. Reactive Chemical Probes: Beyond the Kinase Cysteinome. Angew Chem Int Ed Engl. 2018 07 20; 57(30):9220-9223. PMID: 29644769.
    Citations: 3     Fields:    Translation:HumansCells
  10. Jones LH. Small-Molecule Kinase Downregulators. Cell Chem Biol. 2018 01 18; 25(1):30-35. PMID: 29174540.
    Citations: 6     Fields:    Translation:HumansCells
  11. Li J, Wang B, Juba BM, Vazquez M, Kortum SW, Pierce BS, Pacheco M, Roberts L, Strohbach JW, Jones LH, Hett E, Thorarensen A, Telliez JB, Sharei A, Bunnage M, Gilbert JB. Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells. ACS Chem Biol. 2017 12 15; 12(12):2970-2974. PMID: 29088528.
    Citations: 2     Fields:    Translation:HumansCells
  12. Storer RI, Pike A, Swain NA, Alexandrou AJ, Bechle BM, Blakemore DC, Brown AD, Castle NA, Corbett MS, Flanagan NJ, Fengas D, Johnson MS, Jones LH, Marron BE, Payne CE, Printzenhoff D, Rawson DJ, Rose CR, Ryckmans T, Sun J, Theile JW, Torella R, Tseng E, Warmus JS. Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes. Bioorg Med Chem Lett. 2017 11 01; 27(21):4805-4811. PMID: 29029933.
    Citations:    
  13. Cherry JJ, DiDonato CJ, Androphy EJ, Calo A, Potter K, Custer SK, Du S, Foley TL, Gopalsamy A, Reedich EJ, Gordo SM, Gordon W, Hosea N, Jones LH, Krizay DK, LaRosa G, Li H, Mathur S, Menard CA, Patel P, Ramos-Zayas R, Rietz A, Rong H, Zhang B, Tones MA. In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. PLoS One. 2017; 12(9):e0185079. PMID: 28945765.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017; 12(9):e0184843. PMID: 28934246.
    Citations:    
  15. Zhang F, Bodycombe NE, Haskell KM, Sun YL, Wang ET, Morris CA, Jones LH, Wood LD, Pletcher MT. A flow cytometry-based screen identifies MBNL1 modulators that rescue splicing defects in myotonic dystrophy type I. Hum Mol Genet. 2017 08 15; 26(16):3056-3068. PMID: 28535287.
    Citations:    
  16. Fadeyi OO, Hoth LR, Choi C, Feng X, Gopalsamy A, Hett EC, Kyne RE, Robinson RP, Jones LH. Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue. ACS Chem Biol. 2017 08 18; 12(8):2015-2020. PMID: 28718624.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  17. Denny RA, Flick AC, Coe J, Langille J, Basak A, Liu S, Stock I, Sahasrabudhe P, Bonin P, Hay DA, Brennan PE, Pletcher M, Jones LH, Chekler ELP. Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain. J Med Chem. 2017 07 13; 60(13):5349-5363. PMID: 28375629.
    Citations: 3     Fields:    Translation:HumansCells
  18. Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EW. Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 04; 53(37):5182-5185. PMID: 28439590.
    Citations:    
  19. Jones LH, Neubert H. Clinical chemoproteomics-Opportunities and obstacles. Sci Transl Med. 2017 04 19; 9(386). PMID: 28424333.
    Citations: 3     Fields:    
  20. Field SD, Arkin J, Li J, Jones LH. Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor. ACS Chem Biol. 2017 05 19; 12(5):1183-1187. PMID: 28318222.
    Citations: 4     Fields:    Translation:HumansCells
  21. Gopalsamy A, Narayanan A, Liu S, Parikh MD, Kyne RE, Fadeyi O, Tones MA, Cherry JJ, Nabhan JF, LaRosa G, Petersen DN, Menard C, Foley TL, Noell S, Ren Y, Loria PM, Maglich-Goodwin J, Rong H, Jones LH. Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem. 2017 04 13; 60(7):3094-3108. PMID: 28257199.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Jones LH, Bunnage ME. Applications of chemogenomic library screening in drug discovery. Nat Rev Drug Discov. 2017 Apr; 16(4):285-296. PMID: 28104905.
    Citations: 24     Fields:    Translation:HumansAnimals
  23. Xu H, Roberts LR, Chou S, Pierce B, Narayanan A, Jones LH. Quantitative measurement of intracellular HDAC1/2 drug occupancy using a trans-cyclooctene largazole thiol probe. Medchemcomm. 2017 Apr 01; 8(4):767-770. PMID: 30108795.
    Citations: 1     
  24. Zhao Q, Ouyang X, Wan X, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J. Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes. J Am Chem Soc. 2017 01 18; 139(2):680-685. PMID: 28051857.
    Citations: 24     Fields:    Translation:Cells
  25. Telliez JB, Dowty ME, Wang L, Jussif J, Lin T, Li L, Moy E, Balbo P, Li W, Zhao Y, Crouse K, Dickinson C, Symanowicz P, Hegen M, Banker ME, Vincent F, Unwalla R, Liang S, Gilbert AM, Brown MF, Hayward M, Montgomery J, Yang X, Bauman J, Trujillo JI, Casimiro-Garcia A, Vajdos FF, Leung L, Geoghegan KF, Quazi A, Xuan D, Jones L, Hett E, Wright K, Clark JD, Thorarensen A. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol. 2016 12 16; 11(12):3442-3451. PMID: 27791347.
    Citations:    
  26. Fadeyi O, Parikh MD, Chen MZ, Kyne RE, Taylor AP, O'Doherty I, Kaiser SE, Barbas S, Niessen S, Shi M, Weinrich SL, Kath JC, Jones LH, Robinson RP. Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis. Chembiochem. 2016 10 17; 17(20):1925-1930. PMID: 27504718.
    Citations: 3     Fields:    Translation:Cells
  27. Hett EC, Kyne RE, Gopalsamy A, Tones MA, Xu H, Thio GL, Nolan E, Jones LH. Selectivity Determination of a Small Molecule Chemical Probe Using Protein Microarray and Affinity Capture Techniques. ACS Comb Sci. 2016 10 10; 18(10):611-615. PMID: 27494431.
    Citations: 1     Fields:    Translation:HumansCells
  28. Liu S, Dakin LA, Xing L, Withka JM, Sahasrabudhe PV, Li W, Banker ME, Balbo P, Shanker S, Chrunyk BA, Guo Z, Chen JM, Young JA, Bai G, Starr JT, Wright SW, Bussenius J, Tan S, Gopalsamy A, Lefker BA, Vincent F, Jones LH, Xu H, Hoth LR, Geoghegan KF, Qiu X, Bunnage ME, Thorarensen A. Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. Sci Rep. 2016 08 16; 6:30859. PMID: 27527709.
    Citations: 5     Fields:    Translation:HumansCells
  29. Porter JD, Watson J, Roberts LR, Gill SK, Groves H, Dhariwal J, Almond MH, Wong E, Walton RP, Jones LH, Tregoning J, Kilty I, Johnston SL, Edwards MR. Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium. J Antimicrob Chemother. 2016 10; 71(10):2767-81. PMID: 27494903.
    Citations: 8     Fields:    Translation:HumansCells
  30. Taylor AP, Robinson RP, Fobian YM, Blakemore DC, Jones LH, Fadeyi O. Modern advances in heterocyclic chemistry in drug discovery. Org Biomol Chem. 2016 Jul 12; 14(28):6611-37. PMID: 27282396.
    Citations: 24     Fields:    Translation:HumansCells
  31. Rana P, Will Y, Nadanaciva S, Jones LH. Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorg Med Chem Lett. 2016 08 15; 26(16):4003-6. PMID: 27397500.
    Citations:    
  32. Jones LH, Weerapana E. Protein labelling. Mol Biosyst. 2016 05 24; 12(6):1725-7. PMID: 27215194.
    Citations:    Fields:    Translation:HumansAnimalsCells
  33. Albrow VE, Grimley RL, Clulow J, Rose CR, Sun J, Warmus JS, Tate EW, Jones LH, Storer RI. Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling. Mol Biosyst. 2016 05 24; 12(6):1781-9. PMID: 27021930.
    Citations: 3     Fields:    Translation:HumansCells
  34. Jones LH. Understanding the chemically-reactive proteome. Mol Biosyst. 2016 05 24; 12(6):1728-30. PMID: 26726011.
    Citations: 2     Fields:    Translation:HumansCells
  35. Xu H, Gopalsamy A, Hett EC, Salter S, Aulabaugh A, Kyne RE, Pierce B, Jones LH. Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells. Org Biomol Chem. 2016 Jul 14; 14(26):6179-83. PMID: 27216142.
    Citations: 4     Fields:    Translation:HumansCells
  36. Jones LH. An industry perspective on drug target validation. Expert Opin Drug Discov. 2016 07; 11(7):623-5. PMID: 27111834.
    Citations: 3     Fields:    Translation:Humans
  37. Chekler EL, Pellegrino JA, Lanz TA, Denny RA, Flick AC, Coe J, Langille J, Basak A, Liu S, Stock IA, Sahasrabudhe P, Bonin PD, Lee K, Pletcher MT, Jones LH. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec 17; 22(12):1588-96. PMID: 26670081.
    Citations: 10     Fields:    Translation:HumansCells
  38. Jones LH. Recent advances in the molecular design of synthetic vaccines. Nat Chem. 2015 Dec; 7(12):952-60. PMID: 26587710.
    Citations: 12     Fields:    
  39. Jones LH. Cell permeable affinity- and activity-based probes. Future Med Chem. 2015; 7(16):2131-41. PMID: 26511518.
    Citations: 3     Fields:    Translation:HumansCells
  40. Jones LH, Burrows J, Feeder N, Glossop P, James K, Jones RM, Kenyon AS, Patel S, Roberts DF, Selby MD, Strang RS, Stuart EF, Trevethick MA, Watson J, Wright KN, Clarke N. Molecular hybridization yields triazole bronchodilators for the treatment of COPD. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5121-6. PMID: 26471092.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  41. Xu H, Hett EC, Gopalsamy A, Parikh MD, Geoghegan KF, Kyne RE, Menard CA, Narayanan A, Robinson RP, Johnson DS, Tones MA, Jones LH. A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS. Mol Biosyst. 2015 Oct; 11(10):2709-12. PMID: 25959423.
    Citations:    Fields:    Translation:HumansCells
  42. Bunnage ME, Gilbert AM, Jones LH, Hett EC. Know your target, know your molecule. Nat Chem Biol. 2015 Jun; 11(6):368-72. PMID: 25978985.
    Citations: 18     Fields:    Translation:HumansAnimals
  43. Narayanan A, Jones LH. Sulfonyl fluorides as privileged warheads in chemical biology. Chem Sci. 2015 May 01; 6(5):2650-2659. PMID: 28706662.
    Citations: 32     
  44. Hett EC, Xu H, Geoghegan KF, Gopalsamy A, Kyne RE, Menard CA, Narayanan A, Parikh MD, Liu S, Roberts L, Robinson RP, Tones MA, Jones LH. Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes. ACS Chem Biol. 2015 Apr 17; 10(4):1094-8. PMID: 25571984.
    Citations: 20     Fields:    Translation:HumansCells
  45. Kilty I, Jones LH. TAK1 selective inhibition: state of the art and future opportunities. Future Med Chem. 2015; 7(1):23-33. PMID: 25582331.
    Citations: 13     Fields:    Translation:HumansCells
  46. Xu H, Jones LH. Click chemistry patents and their impact on drug discovery and chemical biology. Pharm Pat Anal. 2015; 4(2):109-19. PMID: 25853470.
    Citations: 1     Fields:    
  47. Jones LH, Heinis C. Chemical biology & drug discovery. Eur J Med Chem. 2014 Dec 17; 88:1-2. PMID: 25307206.
    Citations:    
  48. Marculescu C, Kossen H, Morgan RE, Mayer P, Fletcher SA, Tolner B, Chester KA, Jones LH, Baker JR. Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds. Chem Commun (Camb). 2014 Jul 11; 50(54):7139-42. PMID: 24853662.
    Citations:    
  49. Jones LH. Rare diseases. Foreword. Future Med Chem. 2014 Jun; 6(9):969-70. PMID: 25068979.
    Citations:    
  50. Jones LH, Narayanan A, Hett EC. Understanding and applying tyrosine biochemical diversity. Mol Biosyst. 2014 May; 10(5):952-69. PMID: 24623162.
    Citations:    
  51. Chooi KP, Galan SR, Raj R, McCullagh J, Mohammed S, Jones LH, Davis BG. Synthetic phosphorylation of p38a recapitulates protein kinase activity. J Am Chem Soc. 2014 Feb 05; 136(5):1698-701. PMID: 24393126.
    Citations: 9     Fields:    Translation:Cells
  52. Kilty I, Green MP, Bell AS, Brown DG, Dodd PG, Hewson C, Hughes SJ, Phillips C, Ryckmans T, Smith RT, van Hoorn WP, Cohen P, Jones LH. TAK1 inhibition in the DFG-out conformation. Chem Biol Drug Des. 2013 Nov; 82(5):500-5. PMID: 23745990.
    Citations:    
  53. Pryde DC, Jones LH, Gervais DP, Stead DR, Blakemore DC, Selby MD, Brown AD, Coe JW, Badland M, Beal DM, Glen R, Wharton Y, Miller GJ, White P, Zhang N, Benoit M, Robertson K, Merson JR, Davis HL, McCluskie MJ. Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice. PLoS One. 2013; 8(10):e76557. PMID: 24098532.
    Citations:    
  54. Castañeda L, Wright ZV, Marculescu C, Tran TM, Chudasama V, Maruani A, Hull EA, Nunes JP, Fitzmaurice RJ, Smith ME, Jones LH, Caddick S, Baker JR. A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones. Tetrahedron Lett. 2013 Jul 03; 54(27):3493-3495. PMID: 24058217.
    Citations:    
  55. Bunnage ME, Chekler EL, Jones LH. Target validation using chemical probes. Nat Chem Biol. 2013 Apr; 9(4):195-9. PMID: 23508172.
    Citations: 90     Fields:    Translation:Humans
  56. Liu Q, Sabnis Y, Zhao Z, Zhang T, Buhrlage SJ, Jones LH, Gray NS. Developing irreversible inhibitors of the protein kinase cysteinome. Chem Biol. 2013 Feb 21; 20(2):146-59. PMID: 23438744.
    Citations: 114     Fields:    Translation:HumansCells
  57. Jones LH, Price DA. Medicinal chemistry of glucagon-like peptide receptor agonists. Prog Med Chem. 2013; 52:45-96. PMID: 23384666.
    Citations:    
  58. Jones LH. Chemistry and biology of biomolecule nitration. Chem Biol. 2012 Sep 21; 19(9):1086-92. PMID: 22999877.
    Citations: 8     Fields:    Translation:HumansAnimals
  59. Beal DM, Jones LH. Molecular scaffolds using multiple orthogonal conjugations: applications in chemical biology and drug discovery. Angew Chem Int Ed Engl. 2012 Jun 25; 51(26):6320-6. PMID: 22517597.
    Citations: 8     Fields:    
  60. Jones LH, Rotella DP, D'Oca G. Welcome to Pharmaceutical Patent Analyst. Foreword. Pharm Pat Anal. 2012 Mar; 1(1):1-2. PMID: 24236703.
    Citations:    
  61. Beal DM, Albrow VE, Burslem G, Hitchen L, Fernandes C, Lapthorn C, Roberts LR, Selby MD, Jones LH. Click-enabled heterotrifunctional template for sequential bioconjugations. Org Biomol Chem. 2012 Jan 21; 10(3):548-54. PMID: 22101938.
    Citations:    
  62. Moschos SA, Frick M, Taylor B, Turnpenny P, Graves H, Spink KG, Brady K, Lamb D, Collins D, Rockel TD, Weber M, Lazari O, Perez-Tosar L, Fancy SA, Lapthorn C, Green MX, Evans S, Selby M, Jones G, Jones L, Kearney S, Mechiche H, Gikunju D, Subramanian R, Uhlmann E, Jurk M, Vollmer J, Ciaramella G, Yeadon M. Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense. Mol Ther. 2011 Dec; 19(12):2163-8. PMID: 21971426.
    Citations:    
  63. Hughes AD, Jones LH. Dual-pharmacology muscarinic antagonist and ß2 agonist molecules for the treatment of chronic obstructive pulmonary disease. Future Med Chem. 2011 Oct; 3(13):1585-605. PMID: 21942250.
    Citations:    
  64. Jones LH, Hughes AD. Inhalation by design. Future Med Chem. 2011 Oct; 3(13):1563-5. PMID: 21942245.
    Citations:    
  65. Osborne R, Clarke N, Glossop P, Kenyon A, Liu H, Patel S, Summerhill S, Jones LH. Efficient conversion of a nonselective norepinephrin reuptake inhibitor into a dual muscarinic antagonist-ß2-agonist for the treatment of chronic obstructive pulmonary disease. J Med Chem. 2011 Oct 13; 54(19):6998-7002. PMID: 21863888.
    Citations:    
  66. Targett-Adams P, Graham EJ, Middleton J, Palmer A, Shaw SM, Lavender H, Brain P, Tran TD, Jones LH, Wakenhut F, Stammen B, Pryde D, Pickford C, Westby M. Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action. J Virol. 2011 Jul; 85(13):6353-68. PMID: 21507963.
    Citations:    
  67. Jones LH, Allan G, Corbau R, Middleton DS, Mowbray CE, Newman SD, Phillips C, Webster R, Westby M. Comparison of the non-nucleoside reverse transcriptase inhibitor lersivirine with its pyrazole and imidazole isomers. Chem Biol Drug Des. 2011 May; 77(5):393-7. PMID: 21352504.
    Citations:    
  68. Storer RI, Aciro C, Jones LH. Squaramides: physical properties, synthesis and applications. Chem Soc Rev. 2011 May; 40(5):2330-46. PMID: 21399835.
    Citations:    
  69. Jones LH, Beal D, Selby MD, Everson O, Burslem GM, Dodd P, Millbank J, Tran TD, Wakenhut F, Graham EJ, Targett-Adams P. In-cell click labelling of small molecules to determine subcellular localisation. J Chem Biol. 2011 Apr; 4(2):49-53. PMID: 22096474.
    Citations:    
  70. Jones LH, Baldock H, Bunnage ME, Burrows J, Clarke N, Coghlan M, Entwistle D, Fairman D, Feeder N, Fulton C, Hilton L, James K, Jones RM, Kenyon AS, Marshall S, Newman SD, Osborne R, Patel S, Selby MD, Stuart EF, Trevethick MA, Wright KN, Price DA. Inhalation by design: dual pharmacology ß-2 agonists/M3 antagonists for the treatment of COPD. Bioorg Med Chem Lett. 2011 May 01; 21(9):2759-63. PMID: 21075627.
    Citations:    Fields:    Translation:AnimalsCells
  71. Scott AD, Phillips C, Alex A, Flocco M, Bent A, Randall A, O'Brien R, Damian L, Jones LH. Thermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitors. ChemMedChem. 2009 Dec; 4(12):1985-9. PMID: 19882701.
    Citations:    
  72. Mowbray CE, Corbau R, Hawes M, Jones LH, Mills JE, Perros M, Selby MD, Stupple PA, Webster R, Wood A. Pyrazole NNRTIs 3: optimisation of physicochemical properties. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5603-6. PMID: 19717303.
    Citations:    
  73. Price DA, Blagg J, Jones L, Greene N, Wager T. Physicochemical drug properties associated with in vivo toxicological outcomes: a review. Expert Opin Drug Metab Toxicol. 2009 Aug; 5(8):921-31. PMID: 19519283.
    Citations:    
  74. Jones LH, Allan G, Barba O, Burt C, Corbau R, Dupont T, Knöchel T, Irving S, Middleton DS, Mowbray CE, Perros M, Ringrose H, Swain NA, Webster R, Westby M, Phillips C. Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays. J Med Chem. 2009 Feb 26; 52(4):1219-23. PMID: 19175319.
    Citations:    
  75. Clayden J, Pickworth M, Jones LH. Relaying stereochemistry through aromatic ureas: 1,9 and 1,15 remote stereocontrol. Chem Commun (Camb). 2009 Feb 07; (5):547-9. PMID: 19283286.
    Citations:    
  76. Clayden J, Lemiègre L, Morris GA, Pickworth M, Snape TJ, Jones LH. Helix persistence and breakdown in oligoureas of metaphenylenediamine: apparent diastereotopicity as a spectroscopic marker of helix length in solution. J Am Chem Soc. 2008 Nov 12; 130(45):15193-202. PMID: 18844355.
    Citations: 2     Fields:    Translation:Cells
  77. Jones LH, Allan G, Corbau R, Hay D, Middleton DS, Mowbray CE, Newman SD, Perros M, Randall A, Vuong H, Webster R, Westby M, Williams D. Optimization of 5-aryloxyimidazole non-nucleoside reverse transcriptase inhibitors. ChemMedChem. 2008 Nov; 3(11):1756-62. PMID: 18855969.
    Citations:    
  78. Clayden J, Lemiègre L, Pickworth M, Jones L. Conformation and stereodynamics of 2,2'-disubstituted N,N'-diaryl ureas. Org Biomol Chem. 2008 Aug 21; 6(16):2908-13. PMID: 18688483.
    Citations:    
  79. Jones LH, Randall A, Napier C, Trevethick M, Sreckovic S, Watson J. Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):825-7. PMID: 18042383.
    Citations:    
  80. Jones LH, Randall A, Barba O, Selby MD. Synthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor. Org Biomol Chem. 2007 Nov 07; 5(21):3431-3. PMID: 17943200.
    Citations:    
  81. Pryde DC, Cook AS, Burring DJ, Jones LH, Foll S, Platts MY, Sanderson V, Corless M, Stobie A, Middleton DS, Foster L, Barker L, Van Der Graaf P, Stacey P, Kohl C, Coggon S, Beaumont K. Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Bioorg Med Chem. 2007 Jan 01; 15(1):142-59. PMID: 17070062.
    Citations:    
  82. Jones LH, Dupont T, Mowbray CE, Newman SD. A concise and selective synthesis of novel 5-aryloxyimidazole NNRTIs. Org Lett. 2006 Apr 13; 8(8):1725-7. PMID: 16597151.
    Citations:    
  83. Armstrong A, Jones LH, Knight JD, Kelsey RD. Oxaziridine-mediated amination of primary amines: scope and application to a one-pot pyrazole synthesis. Org Lett. 2005 Feb 17; 7(4):713-6. PMID: 15704932.
    Citations:    
  84. Jones LH, Altobell LJ, MacDonald MT, Boyle NA, Wentworth P, Lerner RA, Janda KD. Active immunization with a glycolipid transition state analogue protects against endotoxic shock. Angew Chem Int Ed Engl. 2002 Nov 15; 41(22):4241-4. PMID: 12434351.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.