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Lyn Howard Jones, Ph.D.

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Biography
The Scripps Research Institute, CAPD12/2000Chemical Biology
University of Nottingham, Nottingham, UKPhD12/1998Synthetic Chemistry
University of Bath, Bath, UKBSc06/1995Chemistry
2014 - pres
Fellow of the Royal Society of Biology
2014 - pres
Fellow of the Linnean Society
2014
Capps Green Zomayer Award (Royal Society of Chemistry)
2010 - pres
Fellow of the Royal Society of Chemistry
2009
Young Industrialist of the Year Award (Royal Society of Chemistry)

Overview
Chief Scientist of the Center for Protein Degradation at the Dana-Farber Cancer Institute. 20 years drug discovery experience and leader in medicinal chemical biology. Interests: protein homeostasis; chemoproteomics and chemogenomics; therapeutic target identification and validation; molecular pharmacology; protein labeling chemical biology and covalent drug discovery. >100 publications in chemistry and chemical biology.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kostic M, Jones LH. Critical Assessment of Targeted Protein Degradation as a Research Tool and Pharmacological Modality. Trends Pharmacol Sci. 2020 May; 41(5):305-317. PMID: 32222318.
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  2. Jones LH. Pharmacological Correction of Proteinopathies via Lysosomal Degradation. Biochemistry. 2020 Feb 18; 59(6):727-728. PMID: 31999102.
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  3. Jones LH. Precision Retargeting: A Selective Covalent Inhibitor Illuminates CDK7 Biology. Cell Chem Biol. 2019 06 20; 26(6):779-780. PMID: 31226310.
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  4. Jones LH. Expanding chemogenomic space using chemoproteomics. Bioorg Med Chem. 2019 08 01; 27(15):3451-3453. PMID: 31221609.
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  5. Jones LH, Xu H, Fadeyi OO. Quantifying drug-target engagement in live cells using sulfonyl fluoride chemical probes. Methods Enzymol. 2019; 622:201-220. PMID: 31155053.
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  6. Jones LH. Emerging Utility of Fluorosulfate Chemical Probes. ACS Med Chem Lett. 2018 Jul 12; 9(7):584-586. PMID: 30034581.
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  7. Jones LH. Reactive Chemical Probes: Beyond the Kinase Cysteinome. Angew Chem Int Ed Engl. 2018 07 20; 57(30):9220-9223. PMID: 29644769.
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  8. Jones LH. Small-Molecule Kinase Downregulators. Cell Chem Biol. 2018 01 18; 25(1):30-35. PMID: 29174540.
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  9. Li J, Wang B, Juba BM, Vazquez M, Kortum SW, Pierce BS, Pacheco M, Roberts L, Strohbach JW, Jones LH, Hett E, Thorarensen A, Telliez JB, Sharei A, Bunnage M, Gilbert JB. Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells. ACS Chem Biol. 2017 12 15; 12(12):2970-2974. PMID: 29088528.
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  10. Cherry JJ, DiDonato CJ, Androphy EJ, Calo A, Potter K, Custer SK, Du S, Foley TL, Gopalsamy A, Reedich EJ, Gordo SM, Gordon W, Hosea N, Jones LH, Krizay DK, LaRosa G, Li H, Mathur S, Menard CA, Patel P, Ramos-Zayas R, Rietz A, Rong H, Zhang B, Tones MA. In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. PLoS One. 2017; 12(9):e0185079. PMID: 28945765.
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  11. Fadeyi OO, Hoth LR, Choi C, Feng X, Gopalsamy A, Hett EC, Kyne RE, Robinson RP, Jones LH. Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue. ACS Chem Biol. 2017 08 18; 12(8):2015-2020. PMID: 28718624.
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  12. Denny RA, Flick AC, Coe J, Langille J, Basak A, Liu S, Stock I, Sahasrabudhe P, Bonin P, Hay DA, Brennan PE, Pletcher M, Jones LH, Chekler ELP. Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain. J Med Chem. 2017 07 13; 60(13):5349-5363. PMID: 28375629.
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  13. Jones LH, Neubert H. Clinical chemoproteomics-Opportunities and obstacles. Sci Transl Med. 2017 04 19; 9(386). PMID: 28424333.
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  14. Field SD, Arkin J, Li J, Jones LH. Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor. ACS Chem Biol. 2017 05 19; 12(5):1183-1187. PMID: 28318222.
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  15. Gopalsamy A, Narayanan A, Liu S, Parikh MD, Kyne RE, Fadeyi O, Tones MA, Cherry JJ, Nabhan JF, LaRosa G, Petersen DN, Menard C, Foley TL, Noell S, Ren Y, Loria PM, Maglich-Goodwin J, Rong H, Jones LH. Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem. 2017 04 13; 60(7):3094-3108. PMID: 28257199.
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  16. Jones LH, Bunnage ME. Applications of chemogenomic library screening in drug discovery. Nat Rev Drug Discov. 2017 Apr; 16(4):285-296. PMID: 28104905.
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  17. Xu H, Roberts LR, Chou S, Pierce B, Narayanan A, Jones LH. Quantitative measurement of intracellular HDAC1/2 drug occupancy using a trans-cyclooctene largazole thiol probe. Medchemcomm. 2017 Apr 01; 8(4):767-770. PMID: 30108795.
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  18. Zhao Q, Ouyang X, Wan X, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J. Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes. J Am Chem Soc. 2017 01 18; 139(2):680-685. PMID: 28051857.
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  19. Fadeyi O, Parikh MD, Chen MZ, Kyne RE, Taylor AP, O'Doherty I, Kaiser SE, Barbas S, Niessen S, Shi M, Weinrich SL, Kath JC, Jones LH, Robinson RP. Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis. Chembiochem. 2016 10 17; 17(20):1925-1930. PMID: 27504718.
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  20. Hett EC, Kyne RE, Gopalsamy A, Tones MA, Xu H, Thio GL, Nolan E, Jones LH. Selectivity Determination of a Small Molecule Chemical Probe Using Protein Microarray and Affinity Capture Techniques. ACS Comb Sci. 2016 10 10; 18(10):611-615. PMID: 27494431.
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  21. Liu S, Dakin LA, Xing L, Withka JM, Sahasrabudhe PV, Li W, Banker ME, Balbo P, Shanker S, Chrunyk BA, Guo Z, Chen JM, Young JA, Bai G, Starr JT, Wright SW, Bussenius J, Tan S, Gopalsamy A, Lefker BA, Vincent F, Jones LH, Xu H, Hoth LR, Geoghegan KF, Qiu X, Bunnage ME, Thorarensen A. Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. Sci Rep. 2016 08 16; 6:30859. PMID: 27527709.
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  22. Porter JD, Watson J, Roberts LR, Gill SK, Groves H, Dhariwal J, Almond MH, Wong E, Walton RP, Jones LH, Tregoning J, Kilty I, Johnston SL, Edwards MR. Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium. J Antimicrob Chemother. 2016 10; 71(10):2767-81. PMID: 27494903.
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  23. Taylor AP, Robinson RP, Fobian YM, Blakemore DC, Jones LH, Fadeyi O. Modern advances in heterocyclic chemistry in drug discovery. Org Biomol Chem. 2016 Jul 12; 14(28):6611-37. PMID: 27282396.
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  24. Albrow VE, Grimley RL, Clulow J, Rose CR, Sun J, Warmus JS, Tate EW, Jones LH, Storer RI. Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling. Mol Biosyst. 2016 05 24; 12(6):1781-9. PMID: 27021930.
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  25. Jones LH. Understanding the chemically-reactive proteome. Mol Biosyst. 2016 05 24; 12(6):1728-30. PMID: 26726011.
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  26. Xu H, Gopalsamy A, Hett EC, Salter S, Aulabaugh A, Kyne RE, Pierce B, Jones LH. Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells. Org Biomol Chem. 2016 Jul 14; 14(26):6179-83. PMID: 27216142.
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  27. Jones LH, Weerapana E. Protein labelling. Mol Biosyst. 2016 05 24; 12(6):1725-7. PMID: 27215194.
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  28. Jones LH. An industry perspective on drug target validation. Expert Opin Drug Discov. 2016 07; 11(7):623-5. PMID: 27111834.
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  29. Chekler EL, Pellegrino JA, Lanz TA, Denny RA, Flick AC, Coe J, Langille J, Basak A, Liu S, Stock IA, Sahasrabudhe P, Bonin PD, Lee K, Pletcher MT, Jones LH. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec 17; 22(12):1588-96. PMID: 26670081.
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  30. Jones LH. Recent advances in the molecular design of synthetic vaccines. Nat Chem. 2015 Dec; 7(12):952-60. PMID: 26587710.
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  31. Jones LH. Cell permeable affinity- and activity-based probes. Future Med Chem. 2015; 7(16):2131-41. PMID: 26511518.
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  32. Jones LH, Burrows J, Feeder N, Glossop P, James K, Jones RM, Kenyon AS, Patel S, Roberts DF, Selby MD, Strang RS, Stuart EF, Trevethick MA, Watson J, Wright KN, Clarke N. Molecular hybridization yields triazole bronchodilators for the treatment of COPD. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5121-6. PMID: 26471092.
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  33. Xu H, Hett EC, Gopalsamy A, Parikh MD, Geoghegan KF, Kyne RE, Menard CA, Narayanan A, Robinson RP, Johnson DS, Tones MA, Jones LH. A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS. Mol Biosyst. 2015 Oct; 11(10):2709-12. PMID: 25959423.
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  34. Bunnage ME, Gilbert AM, Jones LH, Hett EC. Know your target, know your molecule. Nat Chem Biol. 2015 Jun; 11(6):368-72. PMID: 25978985.
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  35. Narayanan A, Jones LH. Sulfonyl fluorides as privileged warheads in chemical biology. Chem Sci. 2015 May 01; 6(5):2650-2659. PMID: 28706662.
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  36. Hett EC, Xu H, Geoghegan KF, Gopalsamy A, Kyne RE, Menard CA, Narayanan A, Parikh MD, Liu S, Roberts L, Robinson RP, Tones MA, Jones LH. Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes. ACS Chem Biol. 2015 Apr 17; 10(4):1094-8. PMID: 25571984.
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  37. Kilty I, Jones LH. TAK1 selective inhibition: state of the art and future opportunities. Future Med Chem. 2015; 7(1):23-33. PMID: 25582331.
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  38. Xu H, Jones LH. Click chemistry patents and their impact on drug discovery and chemical biology. Pharm Pat Anal. 2015; 4(2):109-19. PMID: 25853470.
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  39. Chooi KP, Galan SR, Raj R, McCullagh J, Mohammed S, Jones LH, Davis BG. Synthetic phosphorylation of p38a recapitulates protein kinase activity. J Am Chem Soc. 2014 Feb 05; 136(5):1698-701. PMID: 24393126.
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  40. Bunnage ME, Chekler EL, Jones LH. Target validation using chemical probes. Nat Chem Biol. 2013 Apr; 9(4):195-9. PMID: 23508172.
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  41. Liu Q, Sabnis Y, Zhao Z, Zhang T, Buhrlage SJ, Jones LH, Gray NS. Developing irreversible inhibitors of the protein kinase cysteinome. Chem Biol. 2013 Feb 21; 20(2):146-59. PMID: 23438744.
    Citations: 81     Fields:    Translation:HumansCells
  42. Beal DM, Jones LH. Molecular scaffolds using multiple orthogonal conjugations: applications in chemical biology and drug discovery. Angew Chem Int Ed Engl. 2012 Jun 25; 51(26):6320-6. PMID: 22517597.
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  43. Jones LH, Baldock H, Bunnage ME, Burrows J, Clarke N, Coghlan M, Entwistle D, Fairman D, Feeder N, Fulton C, Hilton L, James K, Jones RM, Kenyon AS, Marshall S, Newman SD, Osborne R, Patel S, Selby MD, Stuart EF, Trevethick MA, Wright KN, Price DA. Inhalation by design: dual pharmacology ß-2 agonists/M3 antagonists for the treatment of COPD. Bioorg Med Chem Lett. 2011 May 01; 21(9):2759-63. PMID: 21075627.
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  44. Clayden J, Lemiègre L, Morris GA, Pickworth M, Snape TJ, Jones LH. Helix persistence and breakdown in oligoureas of metaphenylenediamine: apparent diastereotopicity as a spectroscopic marker of helix length in solution. J Am Chem Soc. 2008 Nov 12; 130(45):15193-202. PMID: 18844355.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.