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Kamela Charmaine Ng, M.Sc.

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Biography
University of Amsterdam & University of Barcelona, Netherlands, Spain, BelgiumPhD - Joint Doctorate in Transdisciplinary Global Health Solutions06/2020Rifampicin-resistant TB diagnostic challenges & statistical modeling of RR-TB data
University of the Philippines Diliman, PhilippinesMSc Microbiology06/2012Molecular characterization and drug resistance profiling of Salmonella enterica
2018
Fonds Wetenschappelijk Onderzoek Grant for participation in a conference abroad
2018
Union scholarship
2017
Fonds Wetenschappelijk Onderzoek Grant for participation in a conference abroad
2016
Erasmus Mundus Joint Doctorate Scholarship
2015
International Publication Award
2010
Academic Excellence in the Biological Sciences
2009
Philippine Association for the Advancement of Science Second place poster presentation
2009
Cum Laude

Overview
Kamela's research career has been focused on addressing antimicrobial resistance and engaging key stakeholders to potentially translate her research findings into programmatic reforms.

She is a research fellow in the Department of Global Health and Social Medicine at Harvard Medical School under the mentorship of Megan B. Murray. She is primarily tasked to undertake genome-wide association analyses to identify markers in the Mycobacterium tuberculosis genome that could predict for suboptimal clinical responses of patients to TB treatment and differential culturability of the pathogen. The identified markers may aid clinicians in adjusting the patient's regimen for better treatment response.

Prior to joining the Harvard Medical School, she pursued her PhD in Belgium, the Netherlands, and Spain under the Erasmus Mundus Trans Global Health program. She worked on improving the understanding of routine rapid diagnostic test data to address diagnostic challenges that affect interruption of rifampicin-resistant TB transmission. She also introduced a novel approach that utilizes routine diagnostic data as a public health surveillance tool for improved control of rifampicin-resistant TB. She has undergone high quality transdisciplinary research training during her PhD, benefiting from interactions with a diverse group of research scientists, national TB control program managers, and policy makers.

She was involved in a pioneering research that investigated for the first time, whole genomes of Philippine drug-resistant M. tuberculosis strains. Their study reported novel and known single nucleotide polymorphisms associated with multidrug- and pre-extensively- drug-resistant TB strains collected from various areas in the Philippines. The resistance-associated genotypes they documented may aid in better understanding of drug-resistant TB transmission in the country.

She holds a Bachelor of Science degree in Biology and a Master of Science degree in Microbiology from the University of the Philippines Diliman. Her M.Sc. research project "Multiplex PCR-based Serogrouping and Serotyping and Antimicrobial Susceptibility Testing of Salmonella enterica from Tonsil and Jejunum with Jejunal Lymph Nodes of Slaughtered Swine in Metro Manila" was scaled-up by the Philippine Agriculture and Fisheries Biotechnology Program of the Department of Agriculture. Kamela also served as a faculty member at the Institute of Biology in UP Diliman and De La Salle University Manila where she taught Microbiology, Fundamentals of Biology, Molecular Biology, Immunobiology and Phycology.

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Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ng KCS, Rigouts L, de Jong BC, Lynen L. False rifampicin resistance in Xpert Ultra applied to lymph node aspirate: a case report. Open Forum Infect Dis. 2020 Jun 2. 2020. View Publication.
  2. Ng KCS, Rigouts L, de Jong BC, Lynen L. False Rifampicin Resistance in Xpert Ultra Applied to Lymph Node Aspirate: A Case Report. Open Forum Infect Dis. 2020 Jun; 7(6):ofaa204. PMID: 32607388.
    Citations:    
  3. Ng KCS, Supply P, Cobelens FGJ, Gaudin C, Gonzalez-Martin J, de Jong BC, Rigouts L. How Well Do Routine Molecular Diagnostics Detect Rifampin Heteroresistance in Mycobacterium tuberculosis? J Clin Microbiol. 2019 11; 57(11). PMID: 31413081.
    Citations:    
  4. Ng KCS, Ngabonziza JCS, Lempens P, de Jong BC, van Leth F, Meehan CJ. Bridging the TB data gap: in silico extraction of rifampicin-resistant tuberculosis diagnostic test results from whole genome sequence data. PeerJ. 2019; 7:e7564. PMID: 31523514.
    Citations:    
  5. Torrea G, Ng KCS, Van Deun A, André E, Kaisergruber J, Ssengooba W, Desmaretz C, Gabriels S, Driesen M, Diels M, Asnong S, Fissette K, Gumusboga M, Rigouts L, Affolabi D, Joloba M, De Jong BC. Variable ability of rapid tests to detect Mycobacterium tuberculosis rpoB mutations conferring phenotypically occult rifampicin resistance. Sci Rep. 2019 08 14; 9(1):11826. PMID: 31413308.
    Citations:    
  6. Ng KCS, van Deun A, Meehan CJ, Torrea G, Driesen M, Gabriëls S, Rigouts L, André E, de Jong BC. Xpert Ultra Can Unambiguously Identify Specific Rifampin Resistance-Conferring Mutations. J Clin Microbiol. 2018 09; 56(9). PMID: 29925643.
    Citations:    
  7. Roa MB, Tablizo FA, Morado EKD, Cunanan LF, Uy IDC, Ng KCS, Manalastas-Cantos KG, Reyes JM, Ganchua SKC, Ang CF, Kato-Maeda M, Cattamanchi A, Karaoz U, Destura RV, Lluisma AO. Whole-genome sequencing and single nucleotide polymorphisms in multidrug-resistant clinical isolates of Mycobacterium tuberculosis from the Philippines. J Glob Antimicrob Resist. 2018 12; 15:239-245. PMID: 30130640.
    Citations:    
  8. Ng KC, Meehan CJ, Torrea G, Goeminne L, Diels M, Rigouts L, de Jong BC, André E. Potential Application of Digitally Linked Tuberculosis Diagnostics for Real-Time Surveillance of Drug-Resistant Tuberculosis Transmission: Validation and Analysis of Test Results. JMIR Med Inform. 2018 Feb 27; 6(1):e12. PMID: 29487047.
    Citations:    
  9. Ng KC, Rivera WL. Multiplex PCR-Based Serogrouping and Serotyping of Salmonella enterica from Tonsil and Jejunum with Jejunal Lymph Nodes of Slaughtered Swine in Metro Manila, Philippines. J Food Prot. 2015 May; 78(5):873-80. PMID: 25951380.
    Citations:    
  10. Ng KC, Rivera WL. Antimicrobial Resistance of Salmonella enterica Isolates from Tonsil and Jejunum with Lymph Node Tissues of Slaughtered Swine in Metro Manila, Philippines. ISRN Microbiol. 2014; 2014:364265. PMID: 24724034.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.