Harvard Catalyst Profiles

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Shuichi Mizuno, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03AR045793 (MIZUNO, SHUICHI) Sep 30, 1998 - Aug 31, 2002
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kusanagi A, Blahut EB, Ogura T, Tsuchiya A, Mizuno S. Repairing Cartilage with Processed Chondrocyte Constructs: A 6-Month Study Using a Porcine Model. Cartilage. 2021 12; 13(2_suppl):1088S-1101S. PMID: 34763541.
    Citations:    Fields:    
  2. Takeoka Y, Paladugu P, Kang JD, Mizuno S. Augmented Chondroitin Sulfate Proteoglycan Has Therapeutic Potential for Intervertebral Disc Degeneration by Stimulating Anabolic Turnover in Bovine Nucleus Pulposus Cells under Changes in Hydrostatic Pressure. Int J Mol Sci. 2021 Jun 02; 22(11). PMID: 34199496.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Takeoka Y, Kang JD, Mizuno S. In vitro nucleus pulposus tissue model with physicochemical stresses. JOR Spine. 2020 Sep; 3(3):e1105. PMID: 33015578.
    Citations: 1     
  4. Ogura T, Minas T, Tsuchiya A, Mizuno S. Effects of hydrostatic pressure and deviatoric stress on human articular chondrocytes for designing neo-cartilage construct. J Tissue Eng Regen Med. 2019 07; 13(7):1143-1152. PMID: 30964967.
    Citations: 3     Fields:    Translation:HumansCells
  5. Mizuno S, Kashiwa K, Kang JD. Molecular and histological characteristics of bovine caudal nucleus pulposus by combined changes in hydrostatic and osmotic pressures in vitro. J Orthop Res. 2019 02; 37(2):466-476. PMID: 30480329.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Takada E, Mizuno S. Reproduction of Characteristics of Extracellular Matrices in Specific Longitudinal Depth Zone Cartilage within Spherical Organoids in Response to Changes in Osmotic Pressure. Int J Mol Sci. 2018 May 18; 19(5). PMID: 29783650.
    Citations: 3     Fields:    Translation:AnimalsCells
  7. Rider SM, Mizuno S, Kang JD. Molecular Mechanisms of Intervertebral Disc Degeneration. Spine Surg Relat Res. 2019 Jan 25; 3(1):1-11. PMID: 31435545.
    Citations: 18     
  8. Ogura T, Tsuchiya A, Minas T, Mizuno S. Optimization of Extracellular Matrix Synthesis and Accumulation by Human Articular Chondrocytes in 3-Dimensional Construct with Repetitive Hydrostatic Pressure. Cartilage. 2018 04; 9(2):192-201. PMID: 29262701.
    Citations: 1     Fields:    Translation:HumansCells
  9. Mizuno S, Takada E, Fukai N. Spheroidal Organoids Reproduce Characteristics of Longitudinal Depth Zones in Bovine Articular Cartilage. Cells Tissues Organs. 2016; 202(5-6):382-392. PMID: 27654347.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Ogura T, Tsuchiya A, Minas T, Mizuno S. Methods of high integrity RNA extraction from cell/agarose construct. BMC Res Notes. 2015 Nov 04; 8:644. PMID: 26537242.
    Citations: 2     Fields:    Translation:AnimalsCells
  11. Ogawa R, Orgill DP, Murphy GF, Mizuno S. Hydrostatic pressure-driven three-dimensional cartilage induction using human adipose-derived stem cells and collagen gels. Tissue Eng Part A. 2015 Jan; 21(1-2):257-66. PMID: 25060524.
    Citations: 13     Fields:    Translation:HumansCells
  12. Tatsumura M, Sakane M, Ochiai N, Mizuno S. Off-loading of cyclic hydrostatic pressure promotes production of extracellular matrix by chondrocytes. Cells Tissues Organs. 2013; 198(6):405-13. PMID: 24777062.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Glowacki J, Mizuno S, Kung J, Goff J, Epperly M, Dixon T, Wang H, Greenberger JS. Effects of mouse genotype on bone wound healing and irradiation-induced delay of healing. In Vivo. 2014 Mar-Apr; 28(2):189-96. PMID: 24632972.
    Citations: 4     Fields:    Translation:Animals
  14. Zhou S, Mizuno S, Glowacki J. Wnt pathway regulation by demineralized bone is approximated by both BMP-2 and TGF-ß1 signaling. J Orthop Res. 2013 Apr; 31(4):554-60. PMID: 23239467.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. Mizuno S, Ogawa R. Using changes in hydrostatic and osmotic pressure to manipulate metabolic function in chondrocytes. Am J Physiol Cell Physiol. 2011 Jun; 300(6):C1234-45. PMID: 21270297.
    Citations: 14     Fields:    Translation:AnimalsCells
  16. Mizuno S. Novel cell culture model using pure hydrostatic pressure and a semipermeable membrane pouch. Cell Transplant. 2011; 20(5):767-74. PMID: 21054931.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Ogawa R, Mizuno S. Cartilage regeneration using adipose-derived stem cells. Curr Stem Cell Res Ther. 2010 Jun; 5(2):129-32. PMID: 19941456.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  18. Manome Y, Mizuno S, Akiyama N, Fujioka K, Saito H, Hataba Y, Kobayashi T, Watanabe M. Three-dimensional cell culture of glioma and morphological comparison of four different human cell lines. Anticancer Res. 2010 Feb; 30(2):383-9. PMID: 20332443.
    Citations: 1     Fields:    Translation:HumansCells
  19. Ogawa R, Mizuno S, Murphy GF, Orgill DP. The effect of hydrostatic pressure on three-dimensional chondroinduction of human adipose-derived stem cells. Tissue Eng Part A. 2009 Oct; 15(10):2937-45. PMID: 19290804.
    Citations: 25     Fields:    Translation:HumansCells
  20. Glowacki J, Zhou S, Mizuno S. Mechanisms of osteoinduction/chondroinduction by demineralized bone. J Craniofac Surg. 2009 Mar; 20 Suppl 1:634-8. PMID: 19169155.
    Citations: 4     Fields:    Translation:HumansCells
  21. Glowacki J, Mizuno S. Collagen scaffolds for tissue engineering. Biopolymers. 2008 May; 89(5):338-44. PMID: 17941007.
    Citations: 171     Fields:    Translation:HumansAnimals
  22. Mizuno S. [Bioengineering for cartilage and intervertebral disc regeneration]. Clin Calcium. 2006 Dec; 16(12):2059-64. PMID: 17142938.
    Citations:    Fields:    Translation:Humans
  23. Kim HT, Zaffagnini S, Mizuno S, Abelow S, Safran MR. A peek into the possible future of management of articular cartilage injuries: gene therapy and scaffolds for cartilage repair. J Orthop Sports Phys Ther. 2006 Oct; 36(10):765-73. PMID: 17063838.
    Citations: 5     Fields:    Translation:HumansCells
  24. Watanabe S, Inagaki S, Kinouchi I, Takai H, Masuda Y, Mizuno S. Hydrostatic pressure/perfusion culture system designed and validated for engineering tissue. J Biosci Bioeng. 2005 Jul; 100(1):105-11. PMID: 16233859.
    Citations: 3     Fields:    
  25. Mizuno S. A novel method for assessing effects of hydrostatic fluid pressure on intracellular calcium: a study with bovine articular chondrocytes. Am J Physiol Cell Physiol. 2005 Feb; 288(2):C329-37. PMID: 15643052.
    Citations: 22     Fields:    Translation:AnimalsCells
  26. Mizuno S, Glowacki J. Low oxygen tension enhances chondroinduction by demineralized bone matrix in human dermal fibroblasts in vitro. Cells Tissues Organs. 2005; 180(3):151-8. PMID: 16260861.
    Citations: 7     Fields:    Translation:HumansCells
  27. Manome Y, Saeki N, Yoshinaga H, Watanabe M, Mizuno S. A culture device demonstrates that hydrostatic pressure increases mRNA of RGS5 in neuroblastoma and CHC1-L in lymphocytic cells. Cells Tissues Organs. 2003; 174(4):155-61. PMID: 14504426.
    Citations:    Fields:    Translation:HumansCells
  28. Mizuno S, Tateishi T, Ushida T, Glowacki J. Hydrostatic fluid pressure enhances matrix synthesis and accumulation by bovine chondrocytes in three-dimensional culture. J Cell Physiol. 2002 Dec; 193(3):319-27. PMID: 12384984.
    Citations: 22     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.