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Michael Tri Hoang Do, Ph.D.

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Biography
Harvard Medical School, Boston, MAPhD2004Neurobiology
Johns Hopkins University School of Medicine, Baltimore, MDPostdoc2011Neuroscience

Overview
Our lab asks how light drives functions that are as diverse as visual perception and setting of the internal body clock. We pose this question for different species to learn how visual mechanisms are tailored to distinct needs. Our research spans organizational levels and time scales, from molecules to circuits and from milliseconds to hours. We focus on the retina and brain, relying primarily on electrophysiological and optical techniques applied in vitro and in vivo.

Visual performance is remarkable. Perception can be elicited by a small number of photons, yet continues when light has intensified by many orders of magnitude. How is this dynamic range established? In cases of severe blindness where visual awareness is lost, light can still synchronize the body clock with the solar day. What are the origins of this robustness?

Such questions of system function apply throughout biology. Posing them in the visual system is advantageous because the input, light, is precisely controllable and the outputs, such as the patterns of impulses sent from the eye to the brain, are often given to quantification. Thus, the intervening operations and their suitability to the organism can be made especially clear.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21EY032731 (DO, MICHAEL TRI HOANG) May 1, 2021 - Mar 31, 2023
    NIH
    Origins and Transformations of Signals for Circadian Regulation
    Role: Principal Investigator
  2. R01EY030628 (DO, MICHAEL TRI HOANG) Sep 1, 2019 - Aug 31, 2023
    NIH
    Neurophysiology of the Fovea
    Role: Principal Investigator
  3. R21EY028633 (SANES, JOSHUA R) Feb 1, 2018 - Jan 31, 2020
    NIH
    Defining cell types of foveal and peripheral retina by high-throughput, single-celltranscriptional profiling
    Role: Co-Principal Investigator
  4. R21EY025840 (DO, MICHAEL TRI HOANG) Mar 1, 2016 - Feb 28, 2019
    NIH
    Cellular Mechanisms of High-Acuity Vision
    Role: Principal Investigator
  5. R01EY025555 (GAMLIN, PAUL DOUGLAS) Dec 1, 2015 - Nov 30, 2021
    NIH
    Intrinsically photosensitive retinal ganglion cells and their central projections
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Do MTH. Light links neonatal neurons for learning. Cell. 2022 08 18; 185(17):3081-3083. PMID: 35985285.
    Citations:    Fields:    Translation:AnimalsCells
  2. Do MTH. Individual variations of visual information. Neuron. 2022 02 16; 110(4):564-565. PMID: 35176239.
    Citations:    Fields:    Translation:AnimalsCells
  3. Baldicano AK, Nasir-Ahmad S, Novelli M, Lee SCS, Do MTH, Martin PR, Grünert U. Retinal ganglion cells expressing CaM kinase II in human and nonhuman primates. J Comp Neurol. 2022 06; 530(9):1470-1493. PMID: 35029299; PMCID: PMC9010361.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Nasir-Ahmad S, Vanstone KA, Novelli M, Lee SCS, Do MTH, Martin PR, Grünert U. Satb1 expression in retinal ganglion cells of marmosets, macaques, and humans. J Comp Neurol. 2022 04; 530(6):923-940. PMID: 34622958; PMCID: PMC8831458.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Bryman GS, Liu A, Do MTH. Optimized Signal Flow through Photoreceptors Supports the High-Acuity Vision of Primates. Neuron. 2020 10 28; 108(2):335-348.e7. PMID: 32846139.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Do MTH. Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior. Neuron. 2019 10 23; 104(2):205-226. PMID: 31647894.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  7. Peng YR, Shekhar K, Yan W, Herrmann D, Sappington A, Bryman GS, van Zyl T, Do MTH, Regev A, Sanes JR. Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina. Cell. 2019 02 21; 176(5):1222-1237.e22. PMID: 30712875; PMCID: PMC6424338.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  8. Do MTH. Mixed Palettes of Melanopsin Phototransduction. Cell. 2018 10 18; 175(3):637-639. PMID: 30340036; PMCID: PMC6584953.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Emanuel AJ, Kapur K, Do MTH. Biophysical Variation within the M1 Type of Ganglion Cell Photoreceptor. Cell Rep. 2017 Oct 24; 21(4):1048-1062. PMID: 29069587.
    Citations: 22     Fields:    Translation:AnimalsCells
  10. Milner ES, Do MTH. A Population Representation of Absolute Light Intensity in the Mammalian Retina. Cell. 2017 Nov 02; 171(4):865-876.e16. PMID: 28965762; PMCID: PMC6647834.
    Citations: 30     Fields:    Translation:AnimalsCells
  11. Do MTH. The outer and inner halves of photoreceptor adaptation. J Physiol. 2017 06 01; 595(11):3247-3248. PMID: 28261801; PMCID: PMC5451729.
    Citations:    Fields:    Translation:Cells
  12. Emanuel AJ, Do MT. Melanopsin tristability for sustained and broadband phototransduction. Neuron. 2015 Mar 04; 85(5):1043-55. PMID: 25741728.
    Citations: 56     Fields:    Translation:AnimalsCells
  13. Do MT, Yau KW. Adaptation to steady light by intrinsically photosensitive retinal ganglion cells. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7470-5. PMID: 23589882.
    Citations: 30     Fields:    Translation:AnimalsCells
  14. Schmidt TM, Do MT, Dacey D, Lucas R, Hattar S, Matynia A. Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function. J Neurosci. 2011 Nov 09; 31(45):16094-101. PMID: 22072661; PMCID: PMC3267581.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  15. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. Melanopsin signalling in mammalian iris and retina. Nature. 2011 Nov 02; 479(7371):67-73. PMID: 22051675.
    Citations: 123     Fields:    Translation:AnimalsCells
  16. Müller LP, Do MT, Yau KW, He S, Baldridge WH. Tracer coupling of intrinsically photosensitive retinal ganglion cells to amacrine cells in the mouse retina. J Comp Neurol. 2010 Dec 01; 518(23):4813-24. PMID: 20963830.
    Citations: 47     Fields:    Translation:AnimalsCells
  17. Do MT, Yau KW. Intrinsically photosensitive retinal ganglion cells. Physiol Rev. 2010 Oct; 90(4):1547-81. PMID: 20959623.
    Citations: 149     Fields:    Translation:HumansAnimalsCells
  18. Do MT, Kang SH, Xue T, Zhong H, Liao HW, Bergles DE, Yau KW. Photon capture and signalling by melanopsin retinal ganglion cells. Nature. 2009 Jan 15; 457(7227):281-7. PMID: 19118382.
    Citations: 122     Fields:    Translation:AnimalsCells
  19. Fu Y, Liao HW, Do MT, Yau KW. Non-image-forming ocular photoreception in vertebrates. Curr Opin Neurobiol. 2005 Aug; 15(4):415-22. PMID: 16023851; PMCID: PMC2885887.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  20. Do MT, Bean BP. Sodium currents in subthalamic nucleus neurons from Nav1.6-null mice. J Neurophysiol. 2004 Aug; 92(2):726-33. PMID: 15056687.
    Citations: 49     Fields:    Translation:AnimalsCells
  21. Do MT, Bean BP. Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron. 2003 Jul 03; 39(1):109-20. PMID: 12848936.
    Citations: 128     Fields:    Translation:AnimalsCells
  22. Coopman PJ, Do MT, Barth M, Bowden ET, Hayes AJ, Basyuk E, Blancato JK, Vezza PR, McLeskey SW, Mangeat PH, Mueller SC. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature. 2000 Aug 17; 406(6797):742-7. PMID: 10963601.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  23. Coopman PJ, Do MT, Thompson EW, Mueller SC. Phagocytosis of cross-linked gelatin matrix by human breast carcinoma cells correlates with their invasive capacity. Clin Cancer Res. 1998 Feb; 4(2):507-15. PMID: 9516943.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.