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Michael Tri Hoang Do, Ph.D.


Harvard Medical School, Boston, MAPhD2004Neurobiology
Johns Hopkins University School of Medicine, Baltimore, MDPostdoc2011Neuroscience

Our lab asks how light drives functions that are as diverse as visual perception and setting of the internal body clock. We pose this question for different species to learn how visual mechanisms are tailored to distinct needs. Our research spans organizational levels and time scales, from molecules to circuits and from milliseconds to hours. We focus on the retina and brain, relying primarily on electrophysiological and optical techniques applied in vitro and in vivo.

Visual performance is remarkable. Perception can be elicited by a small number of photons, yet continues when light has intensified by many orders of magnitude. How is this dynamic range established? In cases of severe blindness where visual awareness is lost, light can still synchronize the body clock with the solar day. What are the origins of this robustness?

Such questions of system function apply throughout biology. Posing them in the visual system is advantageous because the input, light, is precisely controllable and the outputs, such as the patterns of impulses sent from the eye to the brain, are often given to quantification. Thus, the intervening operations and their suitability to the organism can be made especially clear.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY036071 (DO, MICHAEL TRI HOANG) May 1, 2024 - Apr 30, 2029
    Signal Generation and Processing in the Retinohypothalamic Pathway
    Role: Principal Investigator
  2. R01EY034089 (DO, MICHAEL TRI HOANG) Sep 1, 2022 - Jun 30, 2027
    Downstream Actions of Biophysical Mechanisms in the Visual System
    Role: Principal Investigator
  3. R21EY032731 (DO, MICHAEL TRI HOANG) May 1, 2021 - Mar 31, 2023
    Origins and Transformations of Signals for Circadian Regulation
    Role: Principal Investigator
  4. R01EY030628 (DO, MICHAEL TRI HOANG) Sep 1, 2019 - Aug 31, 2023
    Neurophysiology of the Fovea
    Role: Principal Investigator
  5. R21EY028633 (SANES, JOSHUA R) Feb 1, 2018 - Jan 31, 2020
    Defining cell types of foveal and peripheral retina by high-throughput, single-celltranscriptional profiling
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.