Michael Tri Hoang Do, Ph.D.
Title Associate Professor of Neurology Institution Boston Children's Hospital Address Center for Life Science 12061 Mailstop BCH3147 3 Blackfan Circle Boston MA 02115
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Biography
Harvard Medical School, Boston, MA | PhD | 2004 | Neurobiology |
Johns Hopkins University School of Medicine, Baltimore, MD | Postdoc | 2011 | Neuroscience |
Overview
Our lab asks how light drives functions that are as diverse as visual perception and setting of the internal body clock. We pose this question for different species to learn how visual mechanisms are tailored to distinct needs. Our research spans organizational levels and time scales, from molecules to circuits and from milliseconds to hours. We focus on the retina and brain, relying primarily on electrophysiological and optical techniques applied in vitro and in vivo.
Visual performance is remarkable. Perception can be elicited by a small number of photons, yet continues when light has intensified by many orders of magnitude. How is this dynamic range established? In cases of severe blindness where visual awareness is lost, light can still synchronize the body clock with the solar day. What are the origins of this robustness?
Such questions of system function apply throughout biology. Posing them in the visual system is advantageous because the input, light, is precisely controllable and the outputs, such as the patterns of impulses sent from the eye to the brain, are often given to quantification. Thus, the intervening operations and their suitability to the organism can be made especially clear.
Research
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R21EY032731
(DO, MICHAEL TRI HOANG)
May 1, 2021 - Mar 31, 2023
Origins and Transformations of Signals for Circadian Regulation
Role: Principal Investigator
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R01EY030628
(DO, MICHAEL TRI HOANG)
Sep 1, 2019 - Aug 31, 2023
Neurophysiology of the Fovea
Role: Principal Investigator
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R21EY028633
(SANES, JOSHUA R)
Feb 1, 2018 - Jan 31, 2020
Defining cell types of foveal and peripheral retina by high-throughput, single-celltranscriptional profiling
Role: Co-Principal Investigator
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R21EY025840
(DO, MICHAEL TRI HOANG)
Mar 1, 2016 - Feb 28, 2019
Cellular Mechanisms of High-Acuity Vision
Role: Principal Investigator
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R01EY025555
(GAMLIN, PAUL DOUGLAS)
Dec 1, 2015 - Nov 30, 2021
Intrinsically photosensitive retinal ganglion cells and their central projections
Role: Principal Investigator
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R01EY023648
(DO, MICHAEL TRI HOANG)
Sep 1, 2013 - Jul 31, 2023
Properties and Mechanisms of Melanopsin Photoreception
Role: Principal Investigator
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F32EY016959
(DO, MICHAEL TRI HOANG)
Sep 30, 2005 - Sep 29, 2008
Intrinsic photosensitivity of retinal ganglion cells
Role: Principal Investigator
Bibliographic
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