Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Julian Hecker, Ph.D.

Title
Institution
Department
Address

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hecker J, Prokopenko D, Moll M, Lee S, Kim W, Qiao D, Voorhies K, Kim W, Vansteelandt S, Hobbs BD, Cho MH, Silverman EK, Lutz SM, DeMeo DL, Weiss ST, Lange C. A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables. PLoS Genet. 2022 Nov; 18(11):e1010464. PMID: 36383614; PMCID: PMC9668174.
    Citations:    Fields:    Translation:Humans
  2. Kim W, Hecker J, Barr RG, Boerwinkle E, Cade B, Correa A, Dupuis J, Gharib SA, Lange L, London SJ, Morrison AC, O'Connor GT, Oelsner EC, Psaty BM, Vasan RS, Redline S, Rich SS, Rotter JI, Yu B, Lange C, Manichaikul A, Zhou JJ, Sofer T, Silverman EK, Qiao D, Cho MH. Assessing the contribution of rare genetic variants to phenotypes of chronic obstructive pulmonary disease using whole-genome sequence data. Hum Mol Genet. 2022 11 10; 31(22):3873-3885. PMID: 35766891; PMCID: PMC9652112.
    Citations:    Fields:    
  3. Hecker J, Chun S, Samiei A, Liu C, Laurie C, Kachroo P, Lutz SM, Lee S, Smith AV, Lasky-Su J, Cho MH, Sharma S, Quirós MES, Avila L, Celedón JC, Raby B, Zhou X, Silverman EK, DeMeo DL, Lange C, Weiss ST. FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies. Hum Mol Genet. 2022 Oct 18. PMID: 36255742.
    Citations:    Fields:    
  4. Tang J, Novak T, Hecker J, Grubbs G, Zahra FT, Bellusci L, Pourhashemi S, Chou J, Moffitt K, Halasa NB, Schwartz SP, Walker TC, Tarquinio KM, Zinter MS, Staat MA, Gertz SJ, Cvijanovich NZ, Schuster JE, Loftis LL, Coates BM, Mack EH, Irby K, Fitzgerald JC, Rowan CM, Kong M, Flori HR, Maddux AB, Shein SL, Crandall H, Hume JR, Hobbs CV, Tremoulet AH, Shimizu C, Burns JC, Chen SR, Moon HK, Lange C, Randolph AG, Khurana S. Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Nat Commun. 2022 Aug 12; 13(1):4732. PMID: 35961980.
    Citations:    Fields:    
  5. Tang J, Novak T, Hecker J, Grubbs G, Zahra FT, Bellusci L, Pourhashemi S, Chou J, Moffitt K, Halasa NB, Schwartz SP, Walker TC, Tarquinio KM, Zinter MS, Staat MA, Gertz SJ, Cvijanovich NZ, Schuster JE, Loftis LL, Coates BM, Mack EH, Irby K, Fitzgerald JC, Rowan CM, Kong M, Flori HR, Maddux AB, Shein SL, Crandall H, Hume JR, Hobbs CV, Tremoulet AH, Shimizu C, Burns JC, Chen SR, Moon HK, Lange C, Randolph AG, Khurana S. Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Nat Commun. 2022 05 27; 13(1):2979. PMID: 35624101; PMCID: PMC9142524.
    Citations:    Fields:    Translation:HumansCells
  6. Voorhies K, Bie R, Hokanson JE, Weiss ST, Chen Wu A, Hecker J, Hahn G, Demeo DL, Silverman E, Cho MH, Lange C, Lutz SM. Covariate adjustment of spirometric and smoking phenotypes: The potential of neural network models. PLoS One. 2022; 17(5):e0266752. PMID: 35544468; PMCID: PMC9094505.
    Citations:    Fields:    
  7. Prokopenko D, Lee S, Hecker J, Mullin K, Morgan S, Katsumata Y, Weiner MW, Fardo DW, Laird N, Bertram L, Hide W, Lange C, Tanzi RE. Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2. Mol Psychiatry. 2022 04; 27(4):1963-1969. PMID: 35246634; PMCID: PMC9126808.
    Citations: 1     Fields:    Translation:Humans
  8. Hahn G, Wu CM, Lee S, Lutz SM, Khurana S, Baden LR, Haneuse S, Qiao D, Hecker J, DeMeo DL, Tanzi RE, Choudhary MC, Etemad B, Mohammadi A, Esmaeilzadeh E, Cho MH, Li JZ, Randolph AG, Laird NM, Weiss ST, Silverman EK, Ribbeck K, Lange C. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 10; 45(7):685-693. PMID: 34159627; PMCID: PMC8426743.
    Citations: 4     Fields:    Translation:HumansCells
  9. Lee S, Lasky-Su J, Won S, Laurie C, Celedón JC, Lange C, Weiss S, Hecker J. Novel recessive locus for body mass index in childhood asthma. Thorax. 2021 12; 76(12):1227-1230. PMID: 33888571; PMCID: PMC8531156.
    Citations:    Fields:    Translation:Humans
  10. Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Vaz Fragoso CA, Laurie C, Raby BA, Celedón JC, Cho MH, Won S, Weiss ST, Hecker J. A novel locus for exertional dyspnoea in childhood asthma. Eur Respir J. 2021 02; 57(2). PMID: 32855217; PMCID: PMC8185954.
    Citations: 1     Fields:    Translation:Humans
  11. Hecker J, William Townes F, Kachroo P, Laurie C, Lasky-Su J, Ziniti J, Cho MH, Weiss ST, Laird NM, Lange C. A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests. Bioinformatics. 2020 Dec 26. PMID: 33367522; PMCID: PMC8016468.
    Citations: 2     Fields:    
  12. Lee S, Lasky-Su J, Kim W, Won S, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J. An interaction of the 17q12-21 locus with mold exposure in childhood asthma. Pediatr Allergy Immunol. 2021 02; 32(2):373-376. PMID: 32946604; PMCID: PMC8277824.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  13. Hahn G, Lutz SM, Hecker J, Prokopenko D, Cho MH, Silverman EK, Weiss ST, Lange C. locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies. Genet Epidemiol. 2021 02; 45(1):82-98. PMID: 32929743.
    Citations: 2     Fields:    Translation:Humans
  14. Prokopenko D, Hecker J, Kirchner R, Chapman BA, Hoffman O, Mullin K, Hide W, Bertram L, Laird N, DeMeo DL, Lange C, Tanzi RE. Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data. Sci Rep. 2020 03 19; 10(1):5029. PMID: 32193444.
    Citations: 14     Fields:    Translation:HumansCells
  15. Böhmer AC, Hecker J, Schröder J, Gharahkhani P, May A, Gerges C, Anders M, Becker J, Hess T, Kreuser N, Thieme R, Noder T, Venerito M, Veits L, Schmidt T, Fuchs C, Izbicki JR, Hölscher AH, Dietrich A, Moulla Y, Lyros O, Lang H, Lorenz D, Schumacher B, Mayershofer R, Vashist Y, Ott K, Vieth M, Weismüller J, Moebus S, Knapp M, Neuhaus H, Rösch T, Ell C, Nöthen MM, Whiteman DC, Tomlinson I, Jankowski J, Fitzgerald RC, Palles C, Vaughan TL, Gockel I, Thrift AP, Fier H, Schumacher J. Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies. Cancer Epidemiol Biomarkers Prev. 2020 02; 29(2):427-433. PMID: 31748258.
    Citations: 4     Fields:    Translation:Humans
  16. Hecker J, Ruczinski I, Cho MH, Silverman EK, Coull B, Lange C. A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP. Genet Epidemiol. 2020 03; 44(2):139-147. PMID: 31713269.
    Citations: 3     Fields:    Translation:Humans
  17. Forstner AJ, Awasthi S, Wolf C, Maron E, Erhardt A, Czamara D, Eriksson E, Lavebratt C, Allgulander C, Friedrich N, Becker J, Hecker J, Rambau S, Conrad R, Geiser F, McMahon FJ, Moebus S, Hess T, Buerfent BC, Hoffmann P, Herms S, Heilmann-Heimbach S, Kockum I, Olsson T, Alfredsson L, Weber H, Alpers GW, Arolt V, Fehm L, Fydrich T, Gerlach AL, Hamm A, Kircher T, Pané-Farré CA, Pauli P, Rief W, Ströhle A, Plag J, Lang T, Wittchen HU, Mattheisen M, Meier S, Metspalu A, Domschke K, Reif A, Hovatta I, Lindefors N, Andersson E, Schalling M, Mbarek H, Milaneschi Y, de Geus EJC, Boomsma DI, Penninx BWJH, Thorgeirsson TE, Steinberg S, Stefansson K, Stefansson H, Müller-Myhsok B, Hansen TF, Børglum AD, Werge T, Mortensen PB, Nordentoft M, Hougaard DM, Hultman CM, Sullivan PF, Nöthen MM, Woldbye DPD, Mors O, Binder EB, Rück C, Ripke S, Deckert J, Schumacher J. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression. Mol Psychiatry. 2021 08; 26(8):4179-4190. PMID: 31712720.
    Citations: 7     Fields:    Translation:Humans
  18. Kachroo P, Hecker J, Chawes BL, Ahluwalia TS, Cho MH, Qiao D, Kelly RS, Chu SH, Virkud YV, Huang M, Barnes KC, Burchard EG, Eng C, Hu D, Celedón JC, Daya M, Levin AM, Gui H, Williams LK, Forno E, Mak ACY, Avila L, Soto-Quiros ME, Cloutier MM, Acosta-Pérez E, Canino G, Bønnelykke K, Bisgaard H, Raby BA, Lange C, Weiss ST, Lasky-Su JA. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. Chest. 2019 12; 156(6):1068-1079. PMID: 31557467; PMCID: PMC6904857.
    Citations: 4     Fields:    Translation:Humans
  19. Ragland MF, Benway CJ, Lutz SM, Bowler RP, Hecker J, Hokanson JE, Crapo JD, Castaldi PJ, DeMeo DL, Hersh CP, Hobbs BD, Lange C, Beaty TH, Cho MH, Silverman EK. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690. PMID: 30908940; PMCID: PMC6775891.
    Citations: 23     Fields:    Translation:Humans
  20. An J, Won S, Lutz SM, Hecker J, Lange C. Effect of population stratification on SNP-by-environment interaction. Genet Epidemiol. 2019 12; 43(8):1046-1055. PMID: 31429121.
    Citations: 2     Fields:    Translation:Humans
  21. Hecker J, Laird N, Lange C. A comparison of popular TDT-generalizations for family-based association analysis. Genet Epidemiol. 2019 04; 43(3):300-317. PMID: 30609057; PMCID: PMC6599182.
    Citations: 2     Fields:    Translation:Humans
  22. Maaser A, Forstner AJ, Strohmaier J, Hecker J, Ludwig KU, Sivalingam S, Streit F, Degenhardt F, Witt SH, Reinbold CS, Koller AC, Raff R, Heilmann-Heimbach S, Fischer SB, Herms S, Hoffmann P, Thiele H, Nürnberg P, Löhlein Fier H, Orozco-Díaz G, Carmenate-Naranjo D, Proenza-Barzaga N, Auburger GWJ, Andlauer TFM, Cichon S, Marcheco-Teruel B, Mors O, Rietschel M, Nöthen MM. Exome sequencing in large, multiplex bipolar disorder families from Cuba. PLoS One. 2018; 13(10):e0205895. PMID: 30379966.
    Citations: 9     Fields:    Translation:Humans
  23. Hecker J, Prokopenko D, Lange C, Fier HL. PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies. Biostatistics. 2018 07 01; 19(3):295-306. PMID: 28968646.
    Citations: 2     Fields:    Translation:Humans
  24. Xiao X, Wang L, Wang C, Yuan TF, Zhou D, Zheng F, Li L, Grigoroiu-Serbanescu M, Ikeda M, Iwata N, Takahashi A, Kamatani Y, Kubo M, Preisig M, Kutalik Z, Castelao E, Pistis G, Amin N, van Duijn CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, Nöthen MM, Chang H, Luo XJ, Fang Y, Yao YG, Zhang C, Rietschel M, Li M. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders. Transl Psychiatry. 2017 12 11; 7(12):1273. PMID: 29225345; PMCID: PMC5802692.
    Citations: 3     Fields:    Translation:Humans
  25. Hecker J, Xu X, Townes FW, Loehlein Fier H, Corcoran C, Laird N, Lange C. Family-based tests for associating haplotypes with general phenotype data: Improving the FBAT-haplotype algorithm. Genet Epidemiol. 2018 02; 42(1):123-126. PMID: 29159827; PMCID: PMC5774664.
    Citations: 3     Fields:    Translation:Humans
  26. Hecker J, Maaser A, Prokopenko D, Fier HL, Lange C. Reporting Correct p Values in VEGAS Analyses. Twin Res Hum Genet. 2017 06; 20(3):257-259. PMID: 28345502.
    Citations: 2     Fields:    Translation:Humans
  27. Loehlein Fier H, Prokopenko D, Hecker J, Cho MH, Silverman EK, Weiss ST, Tanzi RE, Lange C. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol. 2017 05; 41(4):332-340. PMID: 28318110; PMCID: PMC5525021.
    Citations: 6     Fields:    Translation:Humans
  28. Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nöthen MM. Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nat Commun. 2017 03 08; 8:14694. PMID: 28272467; PMCID: PMC5344973.
    Citations: 14     Fields:    Translation:HumansCells
  29. Forstner AJ, Hecker J, Hofmann A, Maaser A, Reinbold CS, Mühleisen TW, Leber M, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Schumacher J, Streit F, Meier S, Herms S, Hoffmann P, Lacour A, Witt SH, Reif A, Müller-Myhsok B, Lucae S, Maier W, Schwarz M, Vedder H, Kammerer-Ciernioch J, Pfennig A, Bauer M, Hautzinger M, Moebus S, Schenk LM, Fischer SB, Sivalingam S, Czerski PM, Hauser J, Lissowska J, Szeszenia-Dabrowska N, Brennan P, McKay JD, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Krasnov V, Chuchalin A, Babadjanova G, Pantelejeva G, Abramova LI, Tiganov AS, Polonikov A, Khusnutdinova E, Alda M, Cruceanu C, Rouleau GA, Turecki G, Laprise C, Rivas F, Mayoral F, Kogevinas M, Grigoroiu-Serbanescu M, Becker T, Schulze TG, Rietschel M, Cichon S, Fier H, Nöthen MM. Identification of shared risk loci and pathways for bipolar disorder and schizophrenia. PLoS One. 2017; 12(2):e0171595. PMID: 28166306.
    Citations: 32     Fields:    Translation:HumansCells
  30. Chang H, Li L, Peng T, Grigoroiu-Serbanescu M, Bergen SE, Landén M, Hultman CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Cichon S, Nöthen MM, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Rietschel M, Xiao X, Li M. Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1. Mol Neurobiol. 2017 09; 54(7):5166-5176. PMID: 27562178.
    Citations: 1     Fields:    Translation:HumansCells
  31. Prokopenko D, Hecker J, Silverman EK, Pagano M, Nöthen MM, Dina C, Lange C, Fier HL. Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project. Bioinformatics. 2016 05 01; 32(9):1366-72. PMID: 26722118.
    Citations: 17     Fields:    Translation:HumansAnimals
  32. Hecker J, Prokopenko D, Lange C, Fier HL. On the Recombination Rate Estimation in the Presence of Population Substructure. PLoS One. 2015; 10(12):e0145152. PMID: 26716445.
    Citations:    Fields:    Translation:Humans
  33. Li M, Huang L, Grigoroiu-Serbanescu M, Bergen SE, Landén M, Hultman CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Cichon S, Nöthen MM, Alkelai A, Lerer B, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Rietschel M. Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis. Mol Neurobiol. 2016 12; 53(10):6608-6619. PMID: 26637325.
    Citations: 11     Fields:    Translation:HumansCells
  34. Prokopenko D, Hecker J, Silverman E, Nöthen MM, Schmid M, Lange C, Loehlein Fier H. Using Network Methodology to Infer Population Substructure. PLoS One. 2015; 10(6):e0130708. PMID: 26098940.
    Citations:    Fields:    Translation:Humans
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Hecker's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (133)
Explore
_
Co-Authors (35)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.