Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jean Schaffer, M.D.

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Other Positions


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP1DK119141 (SCHAFFER, JEAN E.) Sep 1, 2018 - Aug 31, 2023
    Ribosome Heterogeneity as a Mechanism for Metabolic Regulation
    Role: Principal Investigator
  2. R01DK108357 (SCHAFFER, JEAN E.) Jan 15, 2016 - Dec 31, 2019
    Tissue Responses to Metabolic Stress
    Role: Principal Investigator
  3. P20HL113444 (SCHAFFER, JEAN E.) Apr 15, 2012 - Feb 28, 2018
    Lipid Biomarkers for Diabetic Heart Disease
    Role: Principal Investigator
  4. P30HL101263 (SCHAFFER, JEAN E) Sep 30, 2009 - Aug 31, 2012
    Faculty Recruit for Washington University Diabetic Cardiovascular Disease Center
    Role: Principal Investigator
  5. R01DK064989 (SCHAFFER, JEAN E.) Sep 1, 2003 - Mar 31, 2022
    Cellular Mechanisms that Promote or Prevent Lipotoxicity
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sletten AC, Davidson JW, Yagabasan B, Moores S, Schwaiger-Haber M, Fujiwara H, Gale S, Jiang X, Sidhu R, Gelman SJ, Zhao S, Patti GJ, Ory DS, Schaffer JE. Author Correction: Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis. Nat Commun. 2021 Nov 24; 12(1):6993. PMID: 34819504.
    Citations:    Fields:    
  2. Sletten AC, Davidson JW, Yagabasan B, Moores S, Schwaiger-Haber M, Fujiwara H, Gale S, Jiang X, Sidhu R, Gelman SJ, Zhao S, Patti GJ, Ory DS, Schaffer JE. Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis. Nat Commun. 2021 09 01; 12(1):5214. PMID: 34471131; PMCID: PMC8410784.
    Citations:    Fields:    Translation:AnimalsCells
  3. Krishnan K, Qian M, Feltes M, Chen ZW, Gale S, Wang L, Sugasawa Y, Reichert DE, Schaffer JE, Ory DS, Evers AS, Covey DF. Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents. ACS Chem Biol. 2021 08 20; 16(8):1493-1507. PMID: 34355883.
    Citations: 1     Fields:    Translation:Cells
  4. Sidhu R, Kell P, Dietzen DJ, Farhat NY, Do AND, Porter FD, Berry-Kravis E, Reunert J, Marquardt T, Giugliani R, Lourenço CM, Wang RY, Movsesyan N, Plummer E, Schaffer JE, Ory DS, Jiang X. Application of a glycinated bile acid biomarker for diagnosis and assessment of response to treatment in Niemann-pick disease type C1. Mol Genet Metab. 2020 12; 131(4):405-417. PMID: 33257258; PMCID: PMC8139135.
    Citations: 2     Fields:    Translation:Humans
  5. Peterson LR, Jiang X, Chen L, Goldberg AC, Farmer MS, Ory DS, Schaffer JE. Alterations in plasma triglycerides and ceramides: links with cardiac function in humans with type 2 diabetes. J Lipid Res. 2020 07; 61(7):1065-1074. PMID: 32393551.
    Citations: 7     Fields:    Translation:Humans
  6. Schaffer JE. Death by lipids: The role of small nucleolar RNAs in metabolic stress. J Biol Chem. 2020 06 19; 295(25):8628-8635. PMID: 32393576.
    Citations: 2     Fields:    Translation:HumansAnimals
  7. Feltes M, Gale SE, Moores S, Ory DS, Schaffer JE. Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick Type C1-deficient cells after cyclodextrin treatment. J Lipid Res. 2020 03; 61(3):403-412. PMID: 31988149; PMCID: PMC7053843.
    Citations: 7     Fields:    Translation:HumansCells
  8. Sidhu R, Kell P, Dietzen DJ, Farhat NY, Do AND, Porter FD, Berry-Kravis E, Vite CH, Reunert J, Marquardt T, Giugliani R, Lourenço CM, Bodamer O, Wang RY, Plummer E, Schaffer JE, Ory DS, Jiang X. Application of N-palmitoyl-O-phosphocholineserine for diagnosis and assessment of response to treatment in Niemann-Pick type C disease. Mol Genet Metab. 2020 04; 129(4):292-302. PMID: 32033912; PMCID: PMC7145728.
    Citations: 8     Fields:    Translation:HumansAnimals
  9. McGrath ER, Himali JJ, Xanthakis V, Duncan MS, Schaffer JE, Ory DS, Peterson LR, DeCarli C, Pase MP, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating ceramide ratios and risk of vascular brain aging and dementia. Ann Clin Transl Neurol. 2020 02; 7(2):160-168. PMID: 31950603; PMCID: PMC7034495.
    Citations: 9     Fields:    Translation:Humans
  10. Cresci S, Zhang R, Yang Q, Duncan MS, Xanthakis V, Jiang X, Vasan RS, Schaffer JE, Peterson LR. Genetic Architecture of Circulating Very-Long-Chain (C24:0 and C22:0) Ceramide Concentrations. J Lipid Atheroscler. 2020; 9(1):172-183. PMID: 32489964; PMCID: PMC7266332.
    Citations: 5     
  11. Sidhu R, Mondjinou Y, Qian M, Song H, Kumar AB, Hong X, Hsu FF, Dietzen DJ, Yanjanin NM, Porter FD, Berry-Kravis E, Vite CH, Gelb MH, Schaffer JE, Ory DS, Jiang X. N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease. J Lipid Res. 2019 08; 60(8):1410-1424. PMID: 31201291.
    Citations: 9     Fields:    Translation:HumansAnimals
  12. Davidson J, Molitor E, Moores S, Gale SE, Subramanian K, Jiang X, Sidhu R, Kell P, Zhang J, Fujiwara H, Davidson C, Helquist P, Melancon BJ, Grigalunas M, Liu G, Salahi F, Wiest O, Xu X, Porter FD, Pipalia NH, Cruz DL, Holson EB, Schaffer JE, Walkley SU, Maxfield FR, Ory DS. 2-Hydroxypropyl-ß-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 10; 1864(10):1545-1561. PMID: 31051283; PMCID: PMC6679735.
    Citations: 8     Fields:    Translation:AnimalsCells
  13. Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE. Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking. J Lipid Res. 2019 03; 60(3):707-716. PMID: 30617147.
    Citations: 5     Fields:    Translation:HumansCells
  14. Jiang X, Sidhu R, Orsini JJ, Farhat NY, Porter FD, Berry-Kravis E, Schaffer JE, Ory DS. Diagnosis of niemann-pick C1 by measurement of bile acid biomarkers in archived newborn dried blood spots. Mol Genet Metab. 2019 02; 126(2):183-187. PMID: 30172462; PMCID: PMC6365165.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  15. Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J. Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop. Circulation. 2018 07 17; 138(3):305-315. PMID: 30012703; PMCID: PMC6056021.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  16. Rimer JM, Lee J, Holley CL, Crowder RJ, Chen DL, Hanson PI, Ory DS, Schaffer JE. Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation. J Biol Chem. 2018 08 24; 293(34):13284-13296. PMID: 29980600.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  17. Peterson LR, Xanthakis V, Duncan MS, Gross S, Friedrich N, Völzke H, Felix SB, Jiang H, Sidhu R, Nauck M, Jiang X, Ory DS, Dörr M, Vasan RS, Schaffer JE. Ceramide Remodeling and Risk of Cardiovascular Events and Mortality. J Am Heart Assoc. 2018 05 03; 7(10). PMID: 29728014.
    Citations: 60     Fields:    Translation:Humans
  18. Sidhu R, Mikulka CR, Fujiwara H, Sands MS, Schaffer JE, Ory DS, Jiang X. A HILIC-MS/MS method for simultaneous quantification of the lysosomal disease markers galactosylsphingosine and glucosylsphingosine in mouse serum. Biomed Chromatogr. 2018 Jul; 32(7):e4235. PMID: 29516569; PMCID: PMC5992066.
    Citations: 9     Fields:    Translation:Animals
  19. Sletten AC, Peterson LR, Schaffer JE. Manifestations and mechanisms of myocardial lipotoxicity in obesity. J Intern Med. 2018 11; 284(5):478-491. PMID: 29331057; PMCID: PMC6045461.
    Citations: 37     Fields:    Translation:HumansAnimals
  20. Mikhalkova D, Holman SR, Jiang H, Saghir M, Novak E, Coggan AR, O'Connor R, Bashir A, Jamal A, Ory DS, Schaffer JE, Eagon JC, Peterson LR. Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction. Obesity (Silver Spring). 2018 02; 26(2):284-290. PMID: 29243396; PMCID: PMC5783730.
    Citations: 14     Fields:    Translation:Humans
  21. Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. Circ Res. 2018 01 05; 122(1):58-73. PMID: 29092894; PMCID: PMC5756120.
    Citations: 100     Fields:    Translation:AnimalsCells
  22. Li MW, Sletten AC, Lee J, Pyles KD, Matkovich SJ, Ory DS, Schaffer JE. Nuclear export factor 3 regulates localization of small nucleolar RNAs. J Biol Chem. 2017 12 08; 292(49):20228-20239. PMID: 29021253.
    Citations: 10     Fields:    Translation:AnimalsCells
  23. Jackson CE, Scruggs BS, Schaffer JE, Hanson PI. Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis. Biophys J. 2017 09 19; 113(6):1342-1352. PMID: 28629620; PMCID: PMC5607042.
    Citations: 34     Fields:    Translation:HumansCells
  24. McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, Finck BN. Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology. 2017 05; 65(5):1543-1556. PMID: 28027586.
    Citations: 47     Fields:    Translation:AnimalsCells
  25. Lee J, Harris AN, Holley CL, Mahadevan J, Pyles KD, Lavagnino Z, Scherrer DE, Fujiwara H, Sidhu R, Zhang J, Huang SC, Piston DW, Remedi MS, Urano F, Ory DS, Schaffer JE. Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest. 2016 12 01; 126(12):4616-4625. PMID: 27820699; PMCID: PMC5127695.
    Citations: 27     Fields:    Translation:AnimalsCells
  26. Caputa G, Schaffer JE. RNA Regulation of Lipotoxicity and Metabolic Stress. Diabetes. 2016 07; 65(7):1816-23. PMID: 27288006; PMCID: PMC4915576.
    Citations: 10     Fields:    Translation:Animals
  27. Schaffer JE. Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death: Introduction to a Thematic Review Series. J Lipid Res. 2016 08; 57(8):1327-8. PMID: 27260998.
    Citations: 20     Fields:    Translation:Cells
  28. Jiang X, Sidhu R, Mydock-McGrane L, Hsu FF, Covey DF, Scherrer DE, Earley B, Gale SE, Farhat NY, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Reunert J, Marquardt T, Runz H, Giugliani R, Schaffer JE, Ory DS. Development of a bile acid-based newborn screen for Niemann-Pick disease type C. Sci Transl Med. 2016 05 04; 8(337):337ra63. PMID: 27147587.
    Citations: 41     Fields:    Translation:Humans
  29. Airhart S, Cade WT, Jiang H, Coggan AR, Racette SB, Korenblat K, Spearie CA, Waller S, O'Connor R, Bashir A, Ory DS, Schaffer JE, Novak E, Farmer M, Waggoner AD, Dávila-Román VG, Javidan-Nejad C, Peterson LR. A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study. J Clin Endocrinol Metab. 2016 Feb; 101(2):504-12. PMID: 26652763; PMCID: PMC4880128.
    Citations: 17     Fields:    Translation:Humans
  30. Iaea DB, Gale SE, Bielska AA, Krishnan K, Fujiwara H, Jiang H, Maxfield FR, Schlesinger PH, Covey DF, Schaffer JE, Ory DS. A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. J Lipid Res. 2015 Dec; 56(12):2408-19. PMID: 26497473.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  31. Caputa G, Zhao S, Criado AE, Ory DS, Duncan JG, Schaffer JE. RNASET2 is required for ROS propagation during oxidative stress-mediated cell death. Cell Death Differ. 2016 Feb; 23(2):347-57. PMID: 26206090; PMCID: PMC4716297.
    Citations: 16     Fields:    Translation:AnimalsCells
  32. Praggastis M, Tortelli B, Zhang J, Fujiwara H, Sidhu R, Chacko A, Chen Z, Chung C, Lieberman AP, Sikora J, Davidson C, Walkley SU, Pipalia NH, Maxfield FR, Schaffer JE, Ory DS. A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele. J Neurosci. 2015 May 27; 35(21):8091-106. PMID: 26019327; PMCID: PMC4444535.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  33. Jinn S, Brandis KA, Ren A, Chacko A, Dudley-Rucker N, Gale SE, Sidhu R, Fujiwara H, Jiang H, Olsen BN, Schaffer JE, Ory DS. snoRNA U17 regulates cellular cholesterol trafficking. Cell Metab. 2015 Jun 02; 21(6):855-67. PMID: 25980348; PMCID: PMC4456254.
    Citations: 20     Fields:    Translation:AnimalsCells
  34. Sidhu R, Jiang H, Farhat NY, Carrillo-Carrasco N, Woolery M, Ottinger E, Porter FD, Schaffer JE, Ory DS, Jiang X. A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid. J Lipid Res. 2015 Jun; 56(6):1222-33. PMID: 25866316.
    Citations: 16     Fields:    Translation:Humans
  35. Holley CL, Li MW, Scruggs BS, Matkovich SJ, Ory DS, Schaffer JE. Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. J Biol Chem. 2015 May 01; 290(18):11741-8. PMID: 25792744.
    Citations: 31     Fields:    Translation:AnimalsCells
  36. Bowler RP, Jacobson S, Cruickshank C, Hughes GJ, Siska C, Ory DS, Petrache I, Schaffer JE, Reisdorph N, Kechris K. Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes. Am J Respir Crit Care Med. 2015 Feb 01; 191(3):275-84. PMID: 25494452; PMCID: PMC4351578.
    Citations: 60     Fields:    Translation:HumansCells
  37. Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Colucci WS, Miller EJ. Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol. 2015 Feb; 79:275-83. PMID: 25497302; PMCID: PMC4301992.
    Citations: 30     Fields:    Translation:AnimalsCells
  38. Tortelli B, Fujiwara H, Bagel JH, Zhang J, Sidhu R, Jiang X, Yanjanin NM, Shankar RK, Carillo-Carasco N, Heiss J, Ottinger E, Porter FD, Schaffer JE, Vite CH, Ory DS. Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1). Hum Mol Genet. 2014 Nov 15; 23(22):6022-33. PMID: 24964810.
    Citations: 24     Fields:    Translation:HumansAnimalsCTClinical Trials
  39. Brandis KA, Gale S, Jinn S, Langmade SJ, Dudley-Rucker N, Jiang H, Sidhu R, Ren A, Goldberg A, Schaffer JE, Ory DS. Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular cholesterol trafficking. J Biol Chem. 2013 Dec 13; 288(50):35703-13. PMID: 24174535.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  40. Fan M, Sidhu R, Fujiwara H, Tortelli B, Zhang J, Davidson C, Walkley SU, Bagel JH, Vite C, Yanjanin NM, Porter FD, Schaffer JE, Ory DS. Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling. J Lipid Res. 2013 Oct; 54(10):2800-14. PMID: 23881911.
    Citations: 57     Fields:    Translation:HumansAnimals
  41. Jiang H, Hsu FF, Farmer MS, Peterson LR, Schaffer JE, Ory DS, Jiang X. Development and validation of LC-MS/MS method for determination of very long acyl chain (C22:0 and C24:0) ceramides in human plasma. Anal Bioanal Chem. 2013 Sep; 405(23):7357-65. PMID: 23857140.
    Citations: 10     Fields:    Translation:Humans
  42. Schilling JD, Machkovech HM, He L, Diwan A, Schaffer JE. TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway. J Immunol. 2013 Feb 01; 190(3):1285-96. PMID: 23275600; PMCID: PMC3552058.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  43. Schilling JD, Machkovech HM, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, Schaffer JE. Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages. J Biol Chem. 2013 Feb 01; 288(5):2923-32. PMID: 23250746.
    Citations: 61     Fields:    Translation:AnimalsCells
  44. Li X, Gonzalez O, Shen X, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Tsuchiya K, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JE, Bornfeldt KE. Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):232-40. PMID: 23241406.
    Citations: 16     Fields:    Translation:AnimalsCells
  45. Schilling JD, Machkovech HM, Kim AH, Schwendener R, Schwedwener R, Schaffer JE. Macrophages modulate cardiac function in lipotoxic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2012 Dec 01; 303(11):H1366-73. PMID: 23042950.
    Citations: 19     Fields:    Translation:AnimalsCells
  46. Scruggs BS, Michel CI, Ory DS, Schaffer JE. SmD3 regulates intronic noncoding RNA biogenesis. Mol Cell Biol. 2012 Oct; 32(20):4092-103. PMID: 22869524.
    Citations: 11     Fields:    Translation:AnimalsCells
  47. Crawford PA, Schaffer JE. Metabolic stress in the myocardium: adaptations of gene expression. J Mol Cell Cardiol. 2013 Feb; 55:130-8. PMID: 22728216.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  48. Peterson LR, McKenzie CR, Schaffer JE. Diabetic cardiovascular disease: getting to the heart of the matter. J Cardiovasc Transl Res. 2012 Aug; 5(4):436-45. PMID: 22639341.
    Citations: 11     Fields:    Translation:Humans
  49. Michel CI, Holley CL, Scruggs BS, Sidhu R, Brookheart RT, Listenberger LL, Behlke MA, Ory DS, Schaffer JE. Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metab. 2011 Jul 06; 14(1):33-44. PMID: 21723502.
    Citations: 115     Fields:    Translation:AnimalsCells
  50. Jiang X, Sidhu R, Porter FD, Yanjanin NM, Speak AO, te Vruchte DT, Platt FM, Fujiwara H, Scherrer DE, Zhang J, Dietzen DJ, Schaffer JE, Ory DS. A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. J Lipid Res. 2011 07; 52(7):1435-45. PMID: 21518695.
    Citations: 100     Fields:    Translation:Humans
  51. Anderson CC, Gibson AA, Schaffer JE, Peterson LR, Holland MR, Miller JG. Bayesian parameter estimation for characterizing the cyclic variation of echocardiographic backscatter to assess the hearts of asymptomatic type 2 diabetes mellitus subjects. Ultrasound Med Biol. 2011 May; 37(5):805-12. PMID: 21439721.
    Citations: 1     Fields:    Translation:HumansAnimals
  52. Porter FD, Scherrer DE, Lanier MH, Langmade SJ, Molugu V, Gale SE, Olzeski D, Sidhu R, Dietzen DJ, Fu R, Wassif CA, Yanjanin NM, Marso SP, House J, Vite C, Schaffer JE, Ory DS. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Sci Transl Med. 2010 Nov 03; 2(56):56ra81. PMID: 21048217; PMCID: PMC3170139.
    Citations: 155     Fields:    Translation:HumansAnimalsCells
  53. Ory DS, Schaffer JE. ApoA-1 in diabetes: damaged goods. Diabetes. 2010 Oct; 59(10):2358-9. PMID: 20876728; PMCID: PMC3279547.
    Citations: 4     Fields:    Translation:Humans
  54. Holland MR, Gibson AA, Bauer AQ, Peterson LR, Schaffer JE, Bach RG, Cresci S, Miller JG. Echocardiographic tissue characterization demonstrates differences in the left and right sides of the ventricular septum. Ultrasound Med Biol. 2010 Oct; 36(10):1653-61. PMID: 20800946.
    Citations: 3     Fields:    Translation:Humans
  55. Jungheim ES, Schoeller EL, Marquard KL, Louden ED, Schaffer JE, Moley KH. Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology. 2010 Aug; 151(8):4039-46. PMID: 20573727; PMCID: PMC2940512.
    Citations: 125     Fields:    Translation:AnimalsCells
  56. Liu L, Shi X, Bharadwaj KG, Ikeda S, Yamashita H, Yagyu H, Schaffer JE, Yu YH, Goldberg IJ. DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity. J Biol Chem. 2009 Dec 25; 284(52):36312-36323. PMID: 19778901.
    Citations: 112     Fields:    Translation:AnimalsCells
  57. Gibson AA, Schaffer JE, Peterson LR, Bilhorn KR, Robert KM, Haider TA, Farmer MS, Holland MR, Miller JG. Quantitative analysis of the magnitude and time delay of cyclic variation of myocardial backscatter from asymptomatic type 2 diabetes mellitus subjects. Ultrasound Med Biol. 2009 Sep; 35(9):1458-67. PMID: 19616360.
    Citations: 6     Fields:    Translation:Humans
  58. Brookheart RT, Michel CI, Schaffer JE. As a matter of fat. Cell Metab. 2009 Jul; 10(1):9-12. PMID: 19583949; PMCID: PMC2751821.
    Citations: 113     Fields:    Translation:Cells
  59. Brookheart RT, Michel CI, Listenberger LL, Ory DS, Schaffer JE. The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress. J Biol Chem. 2009 Mar 20; 284(12):7446-54. PMID: 19150982.
    Citations: 42     Fields:    Translation:AnimalsCells
  60. Flagg TP, Cazorla O, Remedi MS, Haim TE, Tones MA, Bahinski A, Numann RE, Kovacs A, Schaffer JE, Nichols CG, Nerbonne JM. Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy. Circ Res. 2009 Jan 02; 104(1):95-103. PMID: 19023131.
    Citations: 27     Fields:    Translation:AnimalsCells
  61. Gale SE, Westover EJ, Dudley N, Krishnan K, Merlin S, Scherrer DE, Han X, Zhai X, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, Ory DS. Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. J Biol Chem. 2009 Jan 16; 284(3):1755-64. PMID: 18996837.
    Citations: 31     Fields:    Translation:AnimalsCells
  62. Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS. Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. J Clin Invest. 2008 Jun; 118(6):2281-90. PMID: 18483620; PMCID: PMC2381744.
    Citations: 56     Fields:    Translation:AnimalsCells
  63. Gelsthorpe ME, Baumann N, Millard E, Gale SE, Langmade SJ, Schaffer JE, Ory DS. Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding. J Biol Chem. 2008 Mar 28; 283(13):8229-36. PMID: 18216017; PMCID: PMC2276376.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  64. O'Connor RD, Gropler RJ, Peterson L, Schaffer J, Ackerman JJ. Limits of a localized magnetic resonance spectroscopy assay for ex vivo myocardial triacylglycerol. J Pharm Biomed Anal. 2007 Nov 05; 45(3):382-9. PMID: 17931816.
    Citations: 2     Fields:    Translation:Animals
  65. Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, Schaffer JE. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res. 2006 Dec; 47(12):2726-37. PMID: 16960261.
    Citations: 255     Fields:    Translation:AnimalsCells
  66. Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13807-12. PMID: 16940355; PMCID: PMC1564205.
    Citations: 81     Fields:    Translation:AnimalsCells
  67. Lee Y, Naseem RH, Park BH, Garry DJ, Richardson JA, Schaffer JE, Unger RH. Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice. Biochem Biophys Res Commun. 2006 May 26; 344(1):446-52. PMID: 16603124.
    Citations: 28     Fields:    Translation:Animals
  68. Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS. A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. J Biol Chem. 2006 Apr 21; 281(16):11082-9. PMID: 16495223.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  69. Holland MR, Gibson AA, Peterson LR, Areces M, Schaffer JE, Perez JE, Miller JG. Measurements of the cyclic variation of myocardial backscatter from two-dimensional echocardiographic images as an approach for characterizing diabetic cardiomyopathy. J Cardiometab Syndr. 2006; 1(2):149-52. PMID: 17694597.
    Citations: 11     Fields:    Translation:Humans
  70. Richards MR, Harp JD, Ory DS, Schaffer JE. Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes. J Lipid Res. 2006 Mar; 47(3):665-72. PMID: 16357361.
    Citations: 46     Fields:    Translation:AnimalsCells
  71. Borradaile NM, Schaffer JE. Lipotoxicity in the heart. Curr Hypertens Rep. 2005 Dec; 7(6):412-7. PMID: 16386196.
    Citations: 46     Fields:    Translation:HumansAnimals
  72. Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto ET, Ory DS, Schaffer JE. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Mol Biol Cell. 2006 Feb; 17(2):770-8. PMID: 16319173; PMCID: PMC1356587.
    Citations: 70     Fields:    Translation:AnimalsCells
  73. Millard EE, Gale SE, Dudley N, Zhang J, Schaffer JE, Ory DS. The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol. J Biol Chem. 2005 Aug 05; 280(31):28581-90. PMID: 15908696.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  74. Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res. 2005 Feb 04; 96(2):225-33. PMID: 15618539.
    Citations: 162     Fields:    Translation:AnimalsCells
  75. Lee Y, Naseem RH, Duplomb L, Park BH, Garry DJ, Richardson JA, Schaffer JE, Unger RH. Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13624-9. PMID: 15347805; PMCID: PMC518804.
    Citations: 50     Fields:    Translation:Animals
  76. Mashek DG, Bornfeldt KE, Coleman RA, Berger J, Bernlohr DA, Black P, DiRusso CC, Farber SA, Guo W, Hashimoto N, Khodiyar V, Kuypers FA, Maltais LJ, Nebert DW, Renieri A, Schaffer JE, Stahl A, Watkins PA, Vasiliou V, Yamamoto TT. Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. J Lipid Res. 2004 Oct; 45(10):1958-61. PMID: 15292367.
    Citations: 53     Fields:    Translation:HumansAnimals
  77. Kwon G, Pappan KL, Marshall CA, Schaffer JE, McDaniel ML. cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells. J Biol Chem. 2004 Mar 05; 279(10):8938-45. PMID: 14688288.
    Citations: 43     Fields:    Translation:AnimalsCells
  78. Zhang J, Dudley-Rucker N, Crowley JR, Lopez-Perez E, Issandou M, Schaffer JE, Ory DS. The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking. J Lipid Res. 2004 Feb; 45(2):223-31. PMID: 14617742.
    Citations: 6     Fields:    Translation:AnimalsCells
  79. Schaffer JE. Lipotoxicity: when tissues overeat. Curr Opin Lipidol. 2003 Jun; 14(3):281-7. PMID: 12840659.
    Citations: 311     Fields:    Translation:HumansAnimalsCells
  80. Frolov A, Zielinski SE, Crowley JR, Dudley-Rucker N, Schaffer JE, Ory DS. NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. J Biol Chem. 2003 Jul 11; 278(28):25517-25. PMID: 12719428.
    Citations: 73     Fields:    Translation:HumansCells
  81. Moulson CL, Martin DR, Lugus JJ, Schaffer JE, Lind AC, Miner JH. Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5274-9. PMID: 12697906; PMCID: PMC154335.
    Citations: 43     Fields:    Translation:AnimalsCells
  82. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV, Ory DS, Schaffer JE. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3077-82. PMID: 12629214; PMCID: PMC152249.
    Citations: 719     Fields:    Translation:AnimalsCells
  83. Richards MR, Listenberger LL, Kelly AA, Lewis SE, Ory DS, Schaffer JE. Oligomerization of the murine fatty acid transport protein 1. J Biol Chem. 2003 Mar 21; 278(12):10477-83. PMID: 12533547.
    Citations: 12     Fields:    Translation:AnimalsCells
  84. Listenberger LL, Schaffer JE. Mechanisms of lipoapoptosis: implications for human heart disease. Trends Cardiovasc Med. 2002 Apr; 12(3):134-8. PMID: 12007739.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  85. Meloni I, Muscettola M, Raynaud M, Longo I, Bruttini M, Moizard MP, Gomot M, Chelly J, des Portes V, Fryns JP, Ropers HH, Magi B, Bellan C, Volpi N, Yntema HG, Lewis SE, Schaffer JE, Renieri A. FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. Nat Genet. 2002 Apr; 30(4):436-40. PMID: 11889465.
    Citations: 41     Fields:    Translation:HumansCells
  86. Schaffer JE. Fatty acid transport: the roads taken. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E239-46. PMID: 11788354.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  87. Carley ME, McIntire D, Carley JM, Schaffer J. Incidence, risk factors and morbidity of unintended bladder or ureter injury during hysterectomy. Int Urogynecol J Pelvic Floor Dysfunct. 2002; 13(1):18-21. PMID: 11999200.
    Citations: 6     Fields:    Translation:Humans
  88. Souza SC, Muliro KV, Liscum L, Lien P, Yamamoto MT, Schaffer JE, Dallal GE, Wang X, Kraemer FB, Obin M, Greenberg AS. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J Biol Chem. 2002 Mar 08; 277(10):8267-72. PMID: 11751901.
    Citations: 76     Fields:    Translation:AnimalsCells
  89. Frolov A, Srivastava K, Daphna-Iken D, Traub LM, Schaffer JE, Ory DS. Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function. J Biol Chem. 2001 Dec 07; 276(49):46414-21. PMID: 11571306.
    Citations: 15     Fields:    Translation:AnimalsCells
  90. Lewis SE, Listenberger LL, Ory DS, Schaffer JE. Membrane topology of the murine fatty acid transport protein 1. J Biol Chem. 2001 Oct 05; 276(40):37042-50. PMID: 11470793.
    Citations: 29     Fields:    Translation:AnimalsCells
  91. Chiu HC, Kovacs A, Ford DA, Hsu FF, Garcia R, Herrero P, Saffitz JE, Schaffer JE. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 2001 Apr; 107(7):813-22. PMID: 11285300; PMCID: PMC199569.
    Citations: 281     Fields:    Translation:AnimalsCells
  92. Listenberger LL, Ory DS, Schaffer JE. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem. 2001 May 04; 276(18):14890-5. PMID: 11278654.
    Citations: 222     Fields:    Translation:AnimalsCells
  93. Millard EE, Srivastava K, Traub LM, Schaffer JE, Ory DS. Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis. J Biol Chem. 2000 Dec 08; 275(49):38445-51. PMID: 10964915.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  94. Snyder-Halpern R, Thompson CB, Schaffer J. Comparison of mailed vs. Internet applications of the Delphi technique in clinical informatics research. Proc AMIA Symp. 2000; 809-13. PMID: 11079996.
    Citations: 14     Fields:    
  95. Stuhlsatz-Krouper SM, Bennett NE, Schaffer JE. Molecular aspects of fatty acid transport: mutations in the IYTSGTTGXPK motif impair fatty acid transport protein function. Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun; 60(5-6):285-9. PMID: 10471110.
    Citations: 7     Fields:    Translation:AnimalsCells
  96. Gargiulo CE, Stuhlsatz-Krouper SM, Schaffer JE. Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane. J Lipid Res. 1999 May; 40(5):881-92. PMID: 10224157.
    Citations: 54     Fields:    Translation:AnimalsCells
  97. Stuhlsatz-Krouper SM, Bennett NE, Schaffer JE. Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transport. J Biol Chem. 1998 Oct 30; 273(44):28642-50. PMID: 9786857.
    Citations: 19     Fields:    Translation:AnimalsCells
  98. Hui TY, Frohnert BI, Smith AJ, Schaffer JE, Bernlohr DA. Characterization of the murine fatty acid transport protein gene and its insulin response sequence. J Biol Chem. 1998 Oct 16; 273(42):27420-9. PMID: 9765271.
    Citations: 13     Fields:    Translation:AnimalsCells
  99. Schaffer J, Fantl JA. Urogenital effects of the menopause. Baillieres Clin Obstet Gynaecol. 1996 Sep; 10(3):401-17. PMID: 8931902.
    Citations: 5     Fields:    Translation:Humans
  100. Man MZ, Hui TY, Schaffer JE, Lodish HF, Bernlohr DA. Regulation of the murine adipocyte fatty acid transporter gene by insulin. Mol Endocrinol. 1996 Aug; 10(8):1021-8. PMID: 8843418.
    Citations: 18     Fields:    Translation:AnimalsCells
  101. Schaffer JE. A novel adipocyte long chain fatty acid transport protein. Eur J Med Res. 1996 Jan 19; 1(4):176-80. PMID: 9386266.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  102. Schaffer JE, Lodish HF. Molecular mechanism of long-chain fatty acid uptake. Trends Cardiovasc Med. 1995 Nov-Dec; 5(6):218-24. PMID: 21232263.
    Citations: 12     Fields:    
  103. Schaffer JE, Lodish HF. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell. 1994 Nov 04; 79(3):427-36. PMID: 7954810.
    Citations: 211     Fields:    Translation:AnimalsCells
  104. Weller SK, Spadaro A, Schaffer JE, Murray AW, Maxam AM, Schaffer PA. Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis. Mol Cell Biol. 1985 May; 5(5):930-42. PMID: 2987682.
    Citations: 117     Fields:    Translation:Cells
    Citations: 11     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.