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Jean Schaffer, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP1DK119141 (SCHAFFER, JEAN E.) Sep 1, 2018 - Aug 31, 2023
    NIH/NIDDK
    Ribosome Heterogeneity as a Mechanism for Metabolic Regulation
    Role: Principal Investigator
  2. R01DK108357 (SCHAFFER, JEAN E.) Jan 15, 2016 - Dec 31, 2019
    NIH/NIDDK
    Tissue Responses to Metabolic Stress
    Role: Principal Investigator
  3. R01NS081985 (ORY, DANIEL S) Jun 1, 2013 - May 31, 2018
    NIH/NINDS
    OXYSTEROL BIOMARKERS FOR NIEMANN-PICK C DISEASE
    Role: Co-Principal Investigator
  4. P20HL113444 (SCHAFFER, JEAN E.) Apr 15, 2012 - Feb 28, 2017
    NIH/NHLBI
    Lipid Biomarkers for Diabetic Heart Disease
    Role: Principal Investigator
  5. P30HL101263 (SCHAFFER, JEAN E) Sep 30, 2009 - Aug 31, 2012
    NIH/NHLBI
    Faculty Recruit for Washington University Diabetic Cardiovascular Disease Center
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Schaffer JE. Death by lipids: The role of small nucleolar RNAs in metabolic stress. J Biol Chem. 2020 Jun 19; 295(25):8628-8635. PMID: 32393576.
    Citations:    
  2. Peterson LR, Jiang X, Chen L, Goldberg AC, Farmer MS, Ory DS, Schaffer JE. Alterations in plasma triglycerides and ceramides: links with cardiac function in humans with type 2 diabetes. J Lipid Res. 2020 Jul; 61(7):1065-1074. PMID: 32393551.
    Citations:    
  3. Feltes M, Gale SE, Moores S, Ory DS, Schaffer JE. Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick Type C1-deficient cells after cyclodextrin treatment. J Lipid Res. 2020 03; 61(3):403-412. PMID: 31988149.
    Citations:    
  4. Sidhu R, Kell P, Dietzen DJ, Farhat NY, Do AND, Porter FD, Berry-Kravis E, Vite CH, Reunert J, Marquardt T, Giugliani R, Lourenço CM, Bodamer O, Wang RY, Plummer E, Schaffer JE, Ory DS, Jiang X. Application of N-palmitoyl-O-phosphocholineserine for diagnosis and assessment of response to treatment in Niemann-Pick type C disease. Mol Genet Metab. 2020 04; 129(4):292-302. PMID: 32033912.
    Citations:    
  5. McGrath ER, Himali JJ, Xanthakis V, Duncan MS, Schaffer JE, Ory DS, Peterson LR, DeCarli C, Pase MP, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating ceramide ratios and risk of vascular brain aging and dementia. Ann Clin Transl Neurol. 2020 02; 7(2):160-168. PMID: 31950603.
    Citations:    
  6. Cresci S, Zhang R, Yang Q, Duncan MS, Xanthakis V, Jiang X, Vasan RS, Schaffer JE, Peterson LR. Genetic Architecture of Circulating Very-Long-Chain (C24:0 and C22:0) Ceramide Concentrations. J Lipid Atheroscler. 2020; 9(1):172-183. PMID: 32489964.
    Citations:    
  7. Sidhu R, Mondjinou Y, Qian M, Song H, Kumar AB, Hong X, Hsu FF, Dietzen DJ, Yanjanin NM, Porter FD, Berry-Kravis E, Vite CH, Gelb MH, Schaffer JE, Ory DS, Jiang X. N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease. J Lipid Res. 2019 08; 60(8):1410-1424. PMID: 31201291.
    Citations:    
  8. Davidson J, Molitor E, Moores S, Gale SE, Subramanian K, Jiang X, Sidhu R, Kell P, Zhang J, Fujiwara H, Davidson C, Helquist P, Melancon BJ, Grigalunas M, Liu G, Salahi F, Wiest O, Xu X, Porter FD, Pipalia NH, Cruz DL, Holson EB, Schaffer JE, Walkley SU, Maxfield FR, Ory DS. 2-Hydroxypropyl-ß-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 10; 1864(10):1545-1561. PMID: 31051283.
    Citations:    
  9. Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE. Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking. J Lipid Res. 2019 03; 60(3):707-716. PMID: 30617147.
    Citations:    
  10. Jiang X, Sidhu R, Orsini JJ, Farhat NY, Porter FD, Berry-Kravis E, Schaffer JE, Ory DS. Diagnosis of niemann-pick C1 by measurement of bile acid biomarkers in archived newborn dried blood spots. Mol Genet Metab. 2019 02; 126(2):183-187. PMID: 30172462.
    Citations:    
  11. Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J. Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop. Circulation. 2018 07 17; 138(3):305-315. PMID: 30012703.
    Citations:    Fields:    
  12. Rimer JM, Lee J, Holley CL, Crowder RJ, Chen DL, Hanson PI, Ory DS, Schaffer JE. Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation. J Biol Chem. 2018 08 24; 293(34):13284-13296. PMID: 29980600.
    Citations:    
  13. Peterson LR, Xanthakis V, Duncan MS, Gross S, Friedrich N, Völzke H, Felix SB, Jiang H, Sidhu R, Nauck M, Jiang X, Ory DS, Dörr M, Vasan RS, Schaffer JE. Ceramide Remodeling and Risk of Cardiovascular Events and Mortality. J Am Heart Assoc. 2018 05 03; 7(10). PMID: 29728014.
    Citations:    
  14. Sidhu R, Mikulka CR, Fujiwara H, Sands MS, Schaffer JE, Ory DS, Jiang X. A HILIC-MS/MS method for simultaneous quantification of the lysosomal disease markers galactosylsphingosine and glucosylsphingosine in mouse serum. Biomed Chromatogr. 2018 Jul; 32(7):e4235. PMID: 29516569.
    Citations:    
  15. Mikhalkova D, Holman SR, Jiang H, Saghir M, Novak E, Coggan AR, O'Connor R, Bashir A, Jamal A, Ory DS, Schaffer JE, Eagon JC, Peterson LR. Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction. Obesity (Silver Spring). 2018 02; 26(2):284-290. PMID: 29243396.
    Citations:    
  16. Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. Circ Res. 2018 01 05; 122(1):58-73. PMID: 29092894.
    Citations:    
  17. Li MW, Sletten AC, Lee J, Pyles KD, Matkovich SJ, Ory DS, Schaffer JE. Nuclear export factor 3 regulates localization of small nucleolar RNAs. J Biol Chem. 2017 12 08; 292(49):20228-20239. PMID: 29021253.
    Citations:    
  18. Jackson CE, Scruggs BS, Schaffer JE, Hanson PI. Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis. Biophys J. 2017 09 19; 113(6):1342-1352. PMID: 28629620.
    Citations:    
  19. McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, Finck BN. Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology. 2017 05; 65(5):1543-1556. PMID: 28027586.
    Citations:    
  20. Lee J, Harris AN, Holley CL, Mahadevan J, Pyles KD, Lavagnino Z, Scherrer DE, Fujiwara H, Sidhu R, Zhang J, Huang SC, Piston DW, Remedi MS, Urano F, Ory DS, Schaffer JE. Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest. 2016 12 01; 126(12):4616-4625. PMID: 27820699.
    Citations:    
  21. Caputa G, Schaffer JE. RNA Regulation of Lipotoxicity and Metabolic Stress. Diabetes. 2016 07; 65(7):1816-23. PMID: 27288006.
    Citations:    
  22. Schaffer JE. Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death: Introduction to a Thematic Review Series. J Lipid Res. 2016 08; 57(8):1327-8. PMID: 27260998.
    Citations:    
  23. Jiang X, Sidhu R, Mydock-McGrane L, Hsu FF, Covey DF, Scherrer DE, Earley B, Gale SE, Farhat NY, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Reunert J, Marquardt T, Runz H, Giugliani R, Schaffer JE, Ory DS. Development of a bile acid-based newborn screen for Niemann-Pick disease type C. Sci Transl Med. 2016 05 04; 8(337):337ra63. PMID: 27147587.
    Citations:    
  24. Airhart S, Cade WT, Jiang H, Coggan AR, Racette SB, Korenblat K, Spearie CA, Waller S, O'Connor R, Bashir A, Ory DS, Schaffer JE, Novak E, Farmer M, Waggoner AD, Dávila-Román VG, Javidan-Nejad C, Peterson LR. A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study. J Clin Endocrinol Metab. 2016 Feb; 101(2):504-12. PMID: 26652763.
    Citations:    
  25. Iaea DB, Gale SE, Bielska AA, Krishnan K, Fujiwara H, Jiang H, Maxfield FR, Schlesinger PH, Covey DF, Schaffer JE, Ory DS. A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. J Lipid Res. 2015 Dec; 56(12):2408-19. PMID: 26497473.
    Citations:    
  26. Praggastis M, Tortelli B, Zhang J, Fujiwara H, Sidhu R, Chacko A, Chen Z, Chung C, Lieberman AP, Sikora J, Davidson C, Walkley SU, Pipalia NH, Maxfield FR, Schaffer JE, Ory DS. A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele. J Neurosci. 2015 May 27; 35(21):8091-106. PMID: 26019327.
    Citations:    
  27. Jinn S, Brandis KA, Ren A, Chacko A, Dudley-Rucker N, Gale SE, Sidhu R, Fujiwara H, Jiang H, Olsen BN, Schaffer JE, Ory DS. snoRNA U17 regulates cellular cholesterol trafficking. Cell Metab. 2015 Jun 02; 21(6):855-67. PMID: 25980348.
    Citations:    
  28. Sidhu R, Jiang H, Farhat NY, Carrillo-Carrasco N, Woolery M, Ottinger E, Porter FD, Schaffer JE, Ory DS, Jiang X. A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid. J Lipid Res. 2015 Jun; 56(6):1222-33. PMID: 25866316.
    Citations:    
  29. Holley CL, Li MW, Scruggs BS, Matkovich SJ, Ory DS, Schaffer JE. Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. J Biol Chem. 2015 May 01; 290(18):11741-8. PMID: 25792744.
    Citations:    
  30. Bowler RP, Jacobson S, Cruickshank C, Hughes GJ, Siska C, Ory DS, Petrache I, Schaffer JE, Reisdorph N, Kechris K. Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes. Am J Respir Crit Care Med. 2015 Feb 01; 191(3):275-84. PMID: 25494452.
    Citations:    
  31. Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Colucci WS, Miller EJ. Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol. 2015 Feb; 79:275-83. PMID: 25497302.
    Citations:    
  32. Tortelli B, Fujiwara H, Bagel JH, Zhang J, Sidhu R, Jiang X, Yanjanin NM, Shankar RK, Carillo-Carasco N, Heiss J, Ottinger E, Porter FD, Schaffer JE, Vite CH, Ory DS. Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1). Hum Mol Genet. 2014 Nov 15; 23(22):6022-33. PMID: 24964810.
    Citations:    
  33. Brandis KA, Gale S, Jinn S, Langmade SJ, Dudley-Rucker N, Jiang H, Sidhu R, Ren A, Goldberg A, Schaffer JE, Ory DS. Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular cholesterol trafficking. J Biol Chem. 2013 Dec 13; 288(50):35703-13. PMID: 24174535.
    Citations:    
  34. Fan M, Sidhu R, Fujiwara H, Tortelli B, Zhang J, Davidson C, Walkley SU, Bagel JH, Vite C, Yanjanin NM, Porter FD, Schaffer JE, Ory DS. Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling. J Lipid Res. 2013 Oct; 54(10):2800-14. PMID: 23881911.
    Citations:    
  35. Jiang H, Hsu FF, Farmer MS, Peterson LR, Schaffer JE, Ory DS, Jiang X. Development and validation of LC-MS/MS method for determination of very long acyl chain (C22:0 and C24:0) ceramides in human plasma. Anal Bioanal Chem. 2013 Sep; 405(23):7357-65. PMID: 23857140.
    Citations:    
  36. Schilling JD, Machkovech HM, He L, Diwan A, Schaffer JE. TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway. J Immunol. 2013 Feb 01; 190(3):1285-96. PMID: 23275600.
    Citations:    
  37. Schilling JD, Machkovech HM, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, Schaffer JE. Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages. J Biol Chem. 2013 Feb 01; 288(5):2923-32. PMID: 23250746.
    Citations:    
  38. Li X, Gonzalez O, Shen X, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Tsuchiya K, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JE, Bornfeldt KE. Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):232-40. PMID: 23241406.
    Citations:    
  39. Schilling JD, Machkovech HM, Kim AH, Schwendener R, Schwedwener R, Schaffer JE. Macrophages modulate cardiac function in lipotoxic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2012 Dec 01; 303(11):H1366-73. PMID: 23042950.
    Citations:    
  40. Scruggs BS, Michel CI, Ory DS, Schaffer JE. SmD3 regulates intronic noncoding RNA biogenesis. Mol Cell Biol. 2012 Oct; 32(20):4092-103. PMID: 22869524.
    Citations:    
  41. Crawford PA, Schaffer JE. Metabolic stress in the myocardium: adaptations of gene expression. J Mol Cell Cardiol. 2013 Feb; 55:130-8. PMID: 22728216.
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  42. Peterson LR, McKenzie CR, Schaffer JE. Diabetic cardiovascular disease: getting to the heart of the matter. J Cardiovasc Transl Res. 2012 Aug; 5(4):436-45. PMID: 22639341.
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  43. Michel CI, Holley CL, Scruggs BS, Sidhu R, Brookheart RT, Listenberger LL, Behlke MA, Ory DS, Schaffer JE. Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metab. 2011 Jul 06; 14(1):33-44. PMID: 21723502.
    Citations:    
  44. Jiang X, Sidhu R, Porter FD, Yanjanin NM, Speak AO, te Vruchte DT, Platt FM, Fujiwara H, Scherrer DE, Zhang J, Dietzen DJ, Schaffer JE, Ory DS. A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. J Lipid Res. 2011 Jul; 52(7):1435-45. PMID: 21518695.
    Citations:    
  45. Anderson CC, Gibson AA, Schaffer JE, Peterson LR, Holland MR, Miller JG. Bayesian parameter estimation for characterizing the cyclic variation of echocardiographic backscatter to assess the hearts of asymptomatic type 2 diabetes mellitus subjects. Ultrasound Med Biol. 2011 May; 37(5):805-12. PMID: 21439721.
    Citations:    
  46. Porter FD, Scherrer DE, Lanier MH, Langmade SJ, Molugu V, Gale SE, Olzeski D, Sidhu R, Dietzen DJ, Fu R, Wassif CA, Yanjanin NM, Marso SP, House J, Vite C, Schaffer JE, Ory DS. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Sci Transl Med. 2010 Nov 03; 2(56):56ra81. PMID: 21048217.
    Citations:    
  47. Holland MR, Gibson AA, Bauer AQ, Peterson LR, Schaffer JE, Bach RG, Cresci S, Miller JG. Echocardiographic tissue characterization demonstrates differences in the left and right sides of the ventricular septum. Ultrasound Med Biol. 2010 Oct; 36(10):1653-61. PMID: 20800946.
    Citations:    
  48. Ory DS, Schaffer JE. ApoA-1 in diabetes: damaged goods. Diabetes. 2010 Oct; 59(10):2358-9. PMID: 20876728.
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  49. Jungheim ES, Schoeller EL, Marquard KL, Louden ED, Schaffer JE, Moley KH. Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology. 2010 Aug; 151(8):4039-46. PMID: 20573727.
    Citations:    
  50. Liu L, Shi X, Bharadwaj KG, Ikeda S, Yamashita H, Yagyu H, Schaffer JE, Yu YH, Goldberg IJ. DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity. J Biol Chem. 2009 Dec 25; 284(52):36312-23. PMID: 19778901.
    Citations:    
  51. Gibson AA, Schaffer JE, Peterson LR, Bilhorn KR, Robert KM, Haider TA, Farmer MS, Holland MR, Miller JG. Quantitative analysis of the magnitude and time delay of cyclic variation of myocardial backscatter from asymptomatic type 2 diabetes mellitus subjects. Ultrasound Med Biol. 2009 Sep; 35(9):1458-67. PMID: 19616360.
    Citations:    
  52. Brookheart RT, Michel CI, Schaffer JE. As a matter of fat. Cell Metab. 2009 Jul; 10(1):9-12. PMID: 19583949.
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  53. Brookheart RT, Michel CI, Listenberger LL, Ory DS, Schaffer JE. The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress. J Biol Chem. 2009 Mar 20; 284(12):7446-54. PMID: 19150982.
    Citations:    
  54. Flagg TP, Cazorla O, Remedi MS, Haim TE, Tones MA, Bahinski A, Numann RE, Kovacs A, Schaffer JE, Nichols CG, Nerbonne JM. Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy. Circ Res. 2009 Jan 02; 104(1):95-103. PMID: 19023131.
    Citations:    
  55. Gale SE, Westover EJ, Dudley N, Krishnan K, Merlin S, Scherrer DE, Han X, Zhai X, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, Ory DS. Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. J Biol Chem. 2009 Jan 16; 284(3):1755-64. PMID: 18996837.
    Citations:    
  56. Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS. Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. J Clin Invest. 2008 Jun; 118(6):2281-90. PMID: 18483620.
    Citations:    
  57. Gelsthorpe ME, Baumann N, Millard E, Gale SE, Langmade SJ, Schaffer JE, Ory DS. Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding. J Biol Chem. 2008 Mar 28; 283(13):8229-36. PMID: 18216017.
    Citations:    
  58. O'Connor RD, Gropler RJ, Peterson L, Schaffer J, Ackerman JJ. Limits of a localized magnetic resonance spectroscopy assay for ex vivo myocardial triacylglycerol. J Pharm Biomed Anal. 2007 Nov 05; 45(3):382-9. PMID: 17931816.
    Citations:    
  59. Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, Schaffer JE. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res. 2006 Dec; 47(12):2726-37. PMID: 16960261.
    Citations:    
  60. Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13807-12. PMID: 16940355.
    Citations:    
  61. Lee Y, Naseem RH, Park BH, Garry DJ, Richardson JA, Schaffer JE, Unger RH. Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice. Biochem Biophys Res Commun. 2006 May 26; 344(1):446-52. PMID: 16603124.
    Citations:    
  62. Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS. A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. J Biol Chem. 2006 Apr 21; 281(16):11082-9. PMID: 16495223.
    Citations:    
  63. Holland MR, Gibson AA, Peterson LR, Areces M, Schaffer JE, Perez JE, Miller JG. Measurements of the cyclic variation of myocardial backscatter from two-dimensional echocardiographic images as an approach for characterizing diabetic cardiomyopathy. J Cardiometab Syndr. 2006; 1(2):149-52. PMID: 17694597.
    Citations:    
  64. Richards MR, Harp JD, Ory DS, Schaffer JE. Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes. J Lipid Res. 2006 Mar; 47(3):665-72. PMID: 16357361.
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  65. Borradaile NM, Schaffer JE. Lipotoxicity in the heart. Curr Hypertens Rep. 2005 Dec; 7(6):412-7. PMID: 16386196.
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  66. Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto ET, Ory DS, Schaffer JE. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Mol Biol Cell. 2006 Feb; 17(2):770-8. PMID: 16319173.
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  67. Millard EE, Gale SE, Dudley N, Zhang J, Schaffer JE, Ory DS. The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol. J Biol Chem. 2005 Aug 05; 280(31):28581-90. PMID: 15908696.
    Citations:    
  68. Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res. 2005 Feb 04; 96(2):225-33. PMID: 15618539.
    Citations:    
  69. Lee Y, Naseem RH, Duplomb L, Park BH, Garry DJ, Richardson JA, Schaffer JE, Unger RH. Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13624-9. PMID: 15347805.
    Citations:    
  70. Mashek DG, Bornfeldt KE, Coleman RA, Berger J, Bernlohr DA, Black P, DiRusso CC, Farber SA, Guo W, Hashimoto N, Khodiyar V, Kuypers FA, Maltais LJ, Nebert DW, Renieri A, Schaffer JE, Stahl A, Watkins PA, Vasiliou V, Yamamoto TT. Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. J Lipid Res. 2004 Oct; 45(10):1958-61. PMID: 15292367.
    Citations: 36     Fields:    Translation:HumansAnimals
  71. Kwon G, Pappan KL, Marshall CA, Schaffer JE, McDaniel ML. cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells. J Biol Chem. 2004 Mar 05; 279(10):8938-45. PMID: 14688288.
    Citations:    
  72. Zhang J, Dudley-Rucker N, Crowley JR, Lopez-Perez E, Issandou M, Schaffer JE, Ory DS. The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking. J Lipid Res. 2004 Feb; 45(2):223-31. PMID: 14617742.
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  73. Schaffer JE. Lipotoxicity: when tissues overeat. Curr Opin Lipidol. 2003 Jun; 14(3):281-7. PMID: 12840659.
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  74. Frolov A, Zielinski SE, Crowley JR, Dudley-Rucker N, Schaffer JE, Ory DS. NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. J Biol Chem. 2003 Jul 11; 278(28):25517-25. PMID: 12719428.
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  75. Moulson CL, Martin DR, Lugus JJ, Schaffer JE, Lind AC, Miner JH. Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5274-9. PMID: 12697906.
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  76. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV, Ory DS, Schaffer JE. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3077-82. PMID: 12629214.
    Citations: 452     Fields:    Translation:AnimalsCells
  77. Richards MR, Listenberger LL, Kelly AA, Lewis SE, Ory DS, Schaffer JE. Oligomerization of the murine fatty acid transport protein 1. J Biol Chem. 2003 Mar 21; 278(12):10477-83. PMID: 12533547.
    Citations:    
  78. Listenberger LL, Schaffer JE. Mechanisms of lipoapoptosis: implications for human heart disease. Trends Cardiovasc Med. 2002 Apr; 12(3):134-8. PMID: 12007739.
    Citations:    
  79. Meloni I, Muscettola M, Raynaud M, Longo I, Bruttini M, Moizard MP, Gomot M, Chelly J, des Portes V, Fryns JP, Ropers HH, Magi B, Bellan C, Volpi N, Yntema HG, Lewis SE, Schaffer JE, Renieri A. FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. Nat Genet. 2002 Apr; 30(4):436-40. PMID: 11889465.
    Citations:    
  80. Schaffer JE. Fatty acid transport: the roads taken. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E239-46. PMID: 11788354.
    Citations:    
  81. Souza SC, Muliro KV, Liscum L, Lien P, Yamamoto MT, Schaffer JE, Dallal GE, Wang X, Kraemer FB, Obin M, Greenberg AS. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J Biol Chem. 2002 Mar 08; 277(10):8267-72. PMID: 11751901.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.