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Robert Mark Richardson, Ph.D., M.D.

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Overview
Dr. Richardson is a neurosurgeon-neuroscientist and Director of Functional Neurosurgery at Massachusetts General Hospital. He is also Visiting Associate Professor of Brain and Cognitive Sciences at MIT. Dr. Richardson received his BA from the University of Virginia, his MD-PhD from the Medical College of Virginia, and neurosurgical residency training at the University of California, San Francisco. From 2011-2019, Dr. Richardson was Director of the Epilepsy and Movement Disorders Surgery Program at the University of Pittsburgh Medical Center, where he established a leading program combining clinical innovation and basic and clinical neuroscience research. Dr. Richardson has pioneered the use of intraoperative-MRI in functional neurosurgery, including deep brain stimulation for movement disorders, laser thermal ablation for epilepsy, and experimental gene therapy for Parkinson's disease. His clinical expertise additionally includes awake brain mapping, robotic-assisted surgery for both stereo-EEG and DBS implantation, and Responsive Neurostimulation for epilepsy. Dr. Richardson also leads the Brain Modulation Lab, a human systems neuroscience lab studying motor control and cognition in patients undergoing intracranial recording and stimulation during DBS and epilepsy surgery. His lab has been funded by the NIH BRAIN Initiative, including the study of cortical-subcortical speech networks and the development of novel approaches to closed-loop brain modulation for Parkinson's disease. Unique contributions of the Brain Modulation Lab include the first characterization of simultaneous neural activity in the basal ganglia and cortex during speech, and the first discovery of electrophysiological biomarkers of therapeutic responsive neurostimulation in epilepsy.

Mentoring
Available: 11/01/19, Expires: 11/01/22

The Brain Modulation Lab (www.brainmodulationlab.org) is a human systems neuroscience lab studying brain electrophysiology and cognition in patients undergoing surgery for epilepsy, movement disorders, and psychiatric diseases. The overall goal of our work is to facilitate the development and optimization of electrical and biological brain modulation therapies, by filling critical gaps in our understanding of human brain function.

A variety of potential projects are available to students with an interest/background in computational neuroscience.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01NS098969 (RICHARDSON, ROBERT MARK) Feb 1, 2020 - May 31, 2019
    NIH/NINDS
    Subthalamic and corticosubthalamic coding of speech production
    Role: Principal Investigator
  2. R01NS110424 (RICHARDSON, ROBERT MARK) Sep 30, 2018 - Aug 31, 2021
    NIH/NINDS
    CRCNS: Deep Neural Network Approaches for Closed-Loop Deep Brain Stimulation
    Role: Principal Investigator
  3. F32NS064692 (RICHARDSON, ROBERT MARK) Jul 1, 2009 - Jun 30, 2010
    NIH/NINDS
    Effect of AADC gene transfer on L-dopa induced dyskinesia in MPTP monkeys
    Role: Principal Investigator
  4. F31NS042420 (RICHARDSON, ROBERT MARK) Aug 1, 2001
    NIH/NINDS
    Telomerase re-expression in postmorterm CNS Progenitors.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Richardson RM. Decision Making in Epilepsy Surgery. Neurosurg Clin N Am. 2020 Jul; 31(3):471-479. PMID: 32475494.
    Citations:    
  2. Shaikh H, Jin XH, Harniman RL, Richardson RM, Whittell GR, Manners I. Solid-State Donor-Acceptor Coaxial Heterojunction Nanowires via Living Crystallization-Driven Self-Assembly. J Am Chem Soc. 2020 Jun 28. PMID: 32594739.
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  3. Kokkinos V, Richardson RM, Urban A. The Hippocampal Barque: An Epileptiform but Non-epileptic Hippocampal Entity. Front Hum Neurosci. 2020; 14:92. PMID: 32256330.
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  4. Fischer P, Lipski WJ, Neumann WJ, Turner RS, Fries P, Brown P, Richardson RM. Movement-related coupling of human subthalamic nucleus spikes to cortical gamma. Elife. 2020 Mar 11; 9. PMID: 32159515.
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  5. Fox LJ, Slastanova A, Taylor N, Wlodek M, Bikondoa O, Richardson RM, Briscoe WH. Interactions between PAMAM dendrimers and DOPC lipid multilayers: Membrane thinning and structural disorder. Biochim Biophys Acta Gen Subj. 2020 Jan 24; 129542. PMID: 31987955.
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  6. Fox LJ, Matthews L, Stockdale H, Pichai S, Snow T, Richardson RM, Briscoe WH. Structural changes in lipid mesophases due to intercalation of dendritic polymer nanoparticles: Swollen lamellae, suppressed curvature, and augmented structural disorder. Acta Biomater. 2020 03 01; 104:198-209. PMID: 31904557.
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  7. Alhourani A, Fish KN, Wozny TA, Sudhakar V, Hamilton RL, Richardson RM. GABA bouton subpopulations in the human dentate gyrus are differentially altered in mesial temporal lobe epilepsy. J Neurophysiol. 2020 Jan 01; 123(1):392-406. PMID: 31800363.
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  8. Ward MJ, Karim HT, Jessen ZF, Ghuman AS, Richardson RM, Reynolds CF, Karp JF. Association between increased theta cordance and early response to ECT in late-life depression. Int J Geriatr Psychiatry. 2020 02; 35(2):147-152. PMID: 31617234.
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  9. He Y, Eloi JC, Harniman RL, Richardson RM, Whittell GR, Mathers RT, Dove AP, O'Reilly RK, Manners I. Uniform Biodegradable Fiber-Like Micelles and Block Comicelles via "Living" Crystallization-Driven Self-Assembly of Poly(l-lactide) Block Copolymers: The Importance of Reducing Unimer Self-Nucleation via Hydrogen Bond Disruption. J Am Chem Soc. 2019 12 04; 141(48):19088-19098. PMID: 31657915.
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  10. Ramirez-Zamora A, Giordano J, Boyden ES, Gradinaru V, Gunduz A, Starr PA, Sheth SA, McIntyre CC, Fox MD, Vitek J, Vedam-Mai V, Akbar U, Almeida L, Bronte-Stewart HM, Mayberg HS, Pouratian N, Gittis AH, Singer AC, Creed MC, Lazaro-Munoz G, Richardson M, Rossi MA, Cendejas-Zaragoza L, D'Haese PF, Chiong W, Gilron R, Chizeck H, Ko A, Baker KB, Wagenaar J, Harel N, Deeb W, Foote KD, Okun MS. Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics. Front Neurosci. 2019; 13:936. PMID: 31572109.
    Citations:    
  11. Yeh FC, Zaydan IM, Suski VR, Lacomis D, Richardson RM, Maroon JC, Barrios-Martinez J. Differential tractography as a track-based biomarker for neuronal injury. Neuroimage. 2019 11 15; 202:116131. PMID: 31472253.
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  12. Richardson RM. Explaining Variability in Cognitive Outcomes From Subthalamic Stimulation: Motor Territory Stimulation Produces Nonmotor Benefit. Neurosurgery. 2019 08 01; 85(2):E182-E183. PMID: 30829377.
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  13. Li Y, Richardson RM, Ghuman AS. Posterior Fusiform and Midfusiform Contribute to Distinct Stages of Facial Expression Processing. Cereb Cortex. 2019 07 05; 29(7):3209-3219. PMID: 30124788.
    Citations:    
  14. Kokkinos V, Sisterson ND, Wozny TA, Richardson RM. Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy. JAMA Neurol. 2019 07 01; 76(7):800-808. PMID: 30985902.
    Citations:    
  15. Boring MJ, Jessen ZF, Wozny TA, Ward MJ, Whiteman AC, Richardson RM, Ghuman AS. Quantitatively validating the efficacy of artifact suppression techniques to study the cortical consequences of deep brain stimulation with magnetoencephalography. Neuroimage. 2019 10 01; 199:366-374. PMID: 31154045.
    Citations:    
  16. Christine CW, Bankiewicz KS, Van Laar AD, Richardson RM, Ravina B, Kells AP, Boot B, Martin AJ, Nutt J, Thompson ME, Larson PS. Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease. Ann Neurol. 2019 05; 85(5):704-714. PMID: 30802998.
    Citations:    
  17. Mettenburg JM, Branstetter BF, Wiley CA, Lee P, Richardson RM. Improved Detection of Subtle Mesial Temporal Sclerosis: Validation of a Commercially Available Software for Automated Segmentation of Hippocampal Volume. AJNR Am J Neuroradiol. 2019 03; 40(3):440-445. PMID: 30733255.
    Citations:    
  18. Chrabaszcz A, Neumann WJ, Stretcu O, Lipski WJ, Bush A, Dastolfo-Hromack CA, Wang D, Crammond DJ, Shaiman S, Dickey MW, Holt LL, Turner RS, Fiez JA, Richardson RM. Subthalamic Nucleus and Sensorimotor Cortex Activity During Speech Production. J Neurosci. 2019 04 03; 39(14):2698-2708. PMID: 30700532.
    Citations:    
  19. Richardson RM, Abel TJ. A New Era for Surgical Neurotherapeutics. Neurotherapeutics. 2019 01; 16(1):1-2. PMID: 30652252.
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  20. Neumann WJ, Turner RS, Blankertz B, Mitchell T, Kühn AA, Richardson RM. Toward Electrophysiology-Based Intelligent Adaptive Deep Brain Stimulation for Movement Disorders. Neurotherapeutics. 2019 01; 16(1):105-118. PMID: 30607748.
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  21. Faraji AH, Richardson RM. Deep Brain Stimulation in Early Parkinson's Disease May Slow Rest Tremor Progression. Neurosurgery. 2019 01 01; 84(1):E13-E14. PMID: 30551192.
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  22. Sudhakar V, Richardson RM. Gene Therapy for Neurodegenerative Diseases. Neurotherapeutics. 2019 01; 16(1):166-175. PMID: 30542906.
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  23. Sisterson ND, Wozny TA, Kokkinos V, Constantino A, Richardson RM. Closed-Loop Brain Stimulation for Drug-Resistant Epilepsy: Towards an Evidence-Based Approach to Personalized Medicine. Neurotherapeutics. 2019 01; 16(1):119-127. PMID: 30378004.
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  24. Antony AR, Abramovici S, Krafty RT, Pan J, Richardson RM, Bagic A, Haneef Z. Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy. Seizure. 2019 Jan; 64:8-15. PMID: 30502684.
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  25. Peña CE, Faraji AH, Richardson RM. Deep Brain Stimulation for Tourette Syndrome. Neurosurgery. 2018 07 01; 83(1):E13. PMID: 29917136.
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  26. Lipski WJ, Alhourani A, Pirnia T, Jones PW, Dastolfo-Hromack C, Helou LB, Crammond DJ, Shaiman S, Dickey MW, Holt LL, Turner RS, Fiez JA, Richardson RM. Subthalamic Nucleus Neurons Differentially Encode Early and Late Aspects of Speech Production. J Neurosci. 2018 06 13; 38(24):5620-5631. PMID: 29789378.
    Citations:    
  27. Faraji AH, Richardson RM. New Antiepileptic Drugs Have Not Improved Treatment Outcomes. Neurosurgery. 2018 05 01; 82(5):E99. PMID: 29669126.
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  28. Lee PS, Weiner GM, Corson D, Kappel J, Chang YF, Suski VR, Berman SB, Homayoun H, Van Laar AD, Crammond DJ, Richardson RM. Outcomes of Interventional-MRI Versus Microelectrode Recording-Guided Subthalamic Deep Brain Stimulation. Front Neurol. 2018; 9:241. PMID: 29695996.
    Citations:    
  29. Bari AA, Mikell CB, Abosch A, Ben-Haim S, Buchanan RJ, Burton AW, Carcieri S, Cosgrove GR, D'Haese PF, Daskalakis ZJ, Eskandar EN, Gerrard JL, Goodman WK, Greenberg BD, Gross RE, Hamani C, Kiss ZHT, Konrad P, Kopell BH, Krinke L, Langevin JP, Lozano AM, Malone D, Mayberg HS, Miller JP, Patil PG, Peichel D, Petersen EA, Rezai AR, Richardson RM, Riva-Posse P, Sankar T, Schwalb JM, Simpson HB, Slavin K, Stypulkowski PH, Tosteson T, Warnke P, Willie JT, Zaghloul KA, Neimat JS, Pouratian N, Sheth SA. Charting the road forward in psychiatric neurosurgery: proceedings of the 2016 American Society for Stereotactic and Functional Neurosurgery workshop on neuromodulation for psychiatric disorders. J Neurol Neurosurg Psychiatry. 2018 08; 89(8):886-896. PMID: 29371415.
    Citations:    Fields:    
  30. Sudhakar V, Richardson RM. Gene Therapy for Parkinson's Disease. Prog Neurol Surg. 2018; 33:253-264. PMID: 29332089.
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  31. Lee PS, Crammond DJ, Richardson RM. Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus for Parkinson's Disease. Prog Neurol Surg. 2018; 33:207-221. PMID: 29332085.
    Citations:    
  32. Sisterson ND, Richardson RM. Long-Term Results of Responsive Neurostimulation in Different Seizure Onset Locations. Neurosurgery. 2018 01 01; 82(1):N3-N4. PMID: 29244138.
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  33. Abramovici S, Antony A, Baldwin ME, Urban A, Ghearing G, Pan J, Sun T, Krafty RT, Richardson RM, Bagic A. Features of Simultaneous Scalp and Intracranial EEG That Predict Localization of Ictal Onset Zone. Clin EEG Neurosci. 2018 May; 49(3):206-212. PMID: 29067832.
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  34. Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM. Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):E7997-E8006. PMID: 28874589.
    Citations:    
  35. Li Y, Richardson RM, Ghuman AS. Multi-Connection Pattern Analysis: Decoding the representational content of neural communication. Neuroimage. 2017 11 15; 162:32-44. PMID: 28813643.
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  36. Tonetti DA, Ares WJ, Richardson RM, Hamilton RL, Lieberman FS. Long-term recurrence of dysembryoplastic neuroepithelial tumor: Clinical case report. Surg Neurol Int. 2017; 8:140. PMID: 28781917.
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  37. Lee PS, Richardson RM. Interventional MRI-Guided Deep Brain Stimulation Lead Implantation. Neurosurg Clin N Am. 2017 Oct; 28(4):535-544. PMID: 28917282.
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  38. Lipski WJ, Wozny TA, Alhourani A, Kondylis ED, Turner RS, Crammond DJ, Richardson RM. Dynamics of human subthalamic neuron phase-locking to motor and sensory cortical oscillations during movement. J Neurophysiol. 2017 09 01; 118(3):1472-1487. PMID: 28592690.
    Citations:    
  39. Wozny TA, Lipski WJ, Alhourani A, Kondylis ED, Antony A, Richardson RM. Effects of hippocampal low-frequency stimulation in idiopathic non-human primate epilepsy assessed via a remote-sensing-enabled neurostimulator. Exp Neurol. 2017 08; 294:68-77. PMID: 28495218.
    Citations:    
  40. Richardson RM. Global Brain Initiatives. Neurosurgery. 2017 05 01; 80(5):N21-N22. PMID: 28586494.
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  41. Alhourani A, Wozny TA, Richardson RM. Real-Time Electrocorticography-Based Functional Mapping of Language Cortex. Neurosurgery. 2016 10; 79(4):N21-2. PMID: 27635975.
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  42. Miragaia AS, Alhourani A, Richardson RM. Amygdala Activation and Perception of Harmful Intent. Neurosurgery. 2016 08; 79(2):N14-6. PMID: 27428637.
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  43. Lee PS, Pardini J, Hendrickson R, Destefino V, Popescu A, Ghearing G, Antony A, Pan J, Bagic A, Wagner D, Richardson RM. Short-term neurocognitive outcomes following anterior temporal lobectomy. Epilepsy Behav. 2016 09; 62:140-6. PMID: 27474963.
    Citations:    
  44. Alhourani A, Wozny TA, Krishnaswamy D, Pathak S, Walls SA, Ghuman AS, Krieger DN, Okonkwo DO, Richardson RM, Niranjan A. Magnetoencephalography-based identification of functional connectivity network disruption following mild traumatic brain injury. J Neurophysiol. 2016 10 01; 116(4):1840-1847. PMID: 27466136.
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  45. Aminoff EM, Li Y, Pyles JA, Ward MJ, Richardson RM, Ghuman AS. Associative hallucinations result from stimulating left ventromedial temporal cortex. Cortex. 2016 10; 83:139-44. PMID: 27533133.
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  46. Kondylis ED, Randazzo MJ, Alhourani A, Lipski WJ, Wozny TA, Pandya Y, Ghuman AS, Turner RS, Crammond DJ, Richardson RM. Movement-related dynamics of cortical oscillations in Parkinson's disease and essential tremor. Brain. 2016 08; 139(Pt 8):2211-23. PMID: 27329771.
    Citations:    
  47. Hirshorn EA, Li Y, Ward MJ, Richardson RM, Fiez JA, Ghuman AS. Decoding and disrupting left midfusiform gyrus activity during word reading. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8162-7. PMID: 27325763.
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  48. Richardson RM. Increasing the Relevance of Optogenetics to the Human Brain: Novel Platform for Nonhuman Primates. Neurosurgery. 2016 06; 78(6):N14-5. PMID: 27191808.
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  49. Khattar NK, Yablonska S, Baranov SV, Baranova OV, Kretz ES, Larkin TM, Carlisle DL, Richardson RM, Friedlander RM. Isolation of functionally active and highly purified neuronal mitochondria from human cortex. J Neurosci Methods. 2016 Apr 01; 263:1-6. PMID: 26808294.
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  50. Kondylis ED, Randazzo MJ, Alhourani A, Wozny TA, Lipski WJ, Crammond DJ, Richardson RM. High frequency activation data used to validate localization of cortical electrodes during surgery for deep brain stimulation. Data Brief. 2016 Mar; 6:204-7. PMID: 26862560.
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  51. Wozny TA, Richardson RM. The Future of Neural Recording Devices: Nanoscale, Flexible, and Injectable. Neurosurgery. 2015 Dec; 77(6):N17-9. PMID: 26584322.
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  52. Modo M, Hitchens TK, Liu JR, Richardson RM. Detection of aberrant hippocampal mossy fiber connections: Ex vivo mesoscale diffusion MRI and microtractography with histological validation in a patient with uncontrolled temporal lobe epilepsy. Hum Brain Mapp. 2016 Feb; 37(2):780-95. PMID: 26611565.
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  53. Randazzo MJ, Kondylis ED, Alhourani A, Wozny TA, Lipski WJ, Crammond DJ, Richardson RM. Three-dimensional localization of cortical electrodes in deep brain stimulation surgery from intraoperative fluoroscopy. Neuroimage. 2016 Jan 15; 125:515-521. PMID: 26520771.
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  54. Alhourani A, McDowell MM, Randazzo MJ, Wozny TA, Kondylis ED, Lipski WJ, Beck S, Karp JF, Ghuman AS, Richardson RM. Network effects of deep brain stimulation. J Neurophysiol. 2015 Oct; 114(4):2105-17. PMID: 26269552.
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  55. Richardson RM, Ghuman AS, Karp JF. Results of the First Randomized Controlled Trial of Deep Brain Stimulation in Treatment-Resistant Depression. Neurosurgery. 2015 Aug; 77(2):N23-4. PMID: 26181793.
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  56. Alhourani A, Richardson RM. Inherent limitations of tractography for accurate connectivity maps. Neurosurgery. 2015 Apr; 76(4):N11-2. PMID: 25784006.
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  57. Ghuman AS, Brunet NM, Li Y, Konecky RO, Pyles JA, Walls SA, Destefino V, Wang W, Richardson RM. Dynamic encoding of face information in the human fusiform gyrus. Nat Commun. 2014 Dec 08; 5:5672. PMID: 25482825.
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  58. Lipski WJ, DeStefino VJ, Stanslaski SR, Antony AR, Crammond DJ, Cameron JL, Richardson RM. Sensing-enabled hippocampal deep brain stimulation in idiopathic nonhuman primate epilepsy. J Neurophysiol. 2015 Feb 15; 113(4):1051-62. PMID: 25429118.
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  59. Shin SS, Dixon CE, Okonkwo DO, Richardson RM. Neurostimulation for traumatic brain injury. J Neurosurg. 2014 Nov; 121(5):1219-31. PMID: 25170668.
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  60. Kondylis ED, Wozny TA, Lipski WJ, Popescu A, DeStefino VJ, Esmaeili B, Raghu VK, Bagic A, Richardson RM. Detection of high-frequency oscillations by hybrid depth electrodes in standard clinical intracranial EEG recordings. Front Neurol. 2014; 5:149. PMID: 25147541.
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  61. Abhinav K, Pathak S, Richardson RM, Engh J, Gardner P, Yeh FC, Friedlander RM, Fernandez-Miranda JC. Application of high-definition fiber tractography in the management of supratentorial cavernous malformations: a combined qualitative and quantitative approach. Neurosurgery. 2014 Jun; 74(6):668-80; discussion 680-1. PMID: 24589561.
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  62. Nguyen L, Zwagerman NT, Grandhi R, McFadden K, Richardson RM. Intraosseous Angiolipoma of the Cranium: Case report and review of the literature. Surg Neurol Int. 2014; 5:79. PMID: 24949222.
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  63. Reid CA, Leaw B, Richards KL, Richardson R, Wimmer V, Yu C, Hill-Yardin EL, Lerche H, Scheffer IE, Berkovic SF, Petrou S. Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndrome. Brain. 2014 Jun; 137(Pt 6):1701-15. PMID: 24747835.
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  64. Zwagerman NT, Richardson RM. Neuropathology indicates a need for earlier neurorestorative intervention in Parkinson's disease. Neurosurgery. 2013 Dec; 73(6):N14-5. PMID: 24257338.
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  65. Zwagerman NT, Richardson RM. Inhibitory neuron therapy for epilepsy. Neurosurgery. 2013 Oct; 73(4):N18-9. PMID: 24051716.
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  66. Niranjan A, Laing EJ, Laghari FJ, Richardson RM, Lunsford LD. Preoperative magnetoencephalographic sensory cortex mapping. Stereotact Funct Neurosurg. 2013; 91(5):314-22. PMID: 23797479.
    Citations:    
  67. Richardson RM. Abnormal cortical brain rhythms in Parkinson disease. Neurosurgery. 2013 Jun; 72(6):N23-4. PMID: 23685517.
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  68. Zwagerman NT, Turner RS, Richardson RM. Sustained reduction of parkinsonian symptoms after "coordinated reset" neuromodulation. Neurosurgery. 2013 Apr; 72(4):N22-3. PMID: 23511835.
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  69. Zwagerman NT, Richardson RM. Suppressed excitement for epilepsy gene therapy. Neurosurgery. 2013 Feb; 72(2):N10-1. PMID: 23328653.
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  70. DeStefino VJ, Richardson RM. Circuitry of the adult hippocampal neural stem cell niche. Neurosurgery. 2012 Dec; 71(6):N11-3. PMID: 23160391.
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  71. Zwagerman NT, Richardson RM. Gene therapy for aromatic L-amino acid decarboxylase deficiency. Neurosurgery. 2012 Oct; 71(4):N10-2. PMID: 22989964.
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  72. Richardson RM. Closing the loop in neuromodulation: concurrent sensing and stimulation. Neurosurgery. 2012 Aug; 71(2):N19-20. PMID: 22811201.
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  73. Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J. Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain. Hum Gene Ther. 2012 Aug; 23(8):891-902. PMID: 22574943.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  74. Kucukyuruk B, Richardson RM, Wen HT, Fernandez-Miranda JC, Rhoton AL. Microsurgical anatomy of the temporal lobe and its implications on temporal lobe epilepsy surgery. Epilepsy Res Treat. 2012; 2012:769825. PMID: 22957242.
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  75. Larson PS, Starr PA, Bates G, Tansey L, Richardson RM, Martin AJ. An optimized system for interventional magnetic resonance imaging-guided stereotactic surgery: preliminary evaluation of targeting accuracy. Neurosurgery. 2012 Mar; 70(1 Suppl Operative):95-103; discussion 103. PMID: 21796000.
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  76. San Sebastian W, Richardson RM, Kells AP, Lamarre C, Bringas J, Pivirotto P, Salegio EA, Dearmond SJ, Forsayeth J, Bankiewicz KS. Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum. Hum Gene Ther. 2012 Feb; 23(2):210-7. PMID: 22017504.
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  77. Cheng JS, Richardson RM, Gean AD, Stiver SI. Delayed acute spinal cord injury following intracranial gunshot trauma: case report. J Neurosurg. 2012 Apr; 116(4):921-5. PMID: 22242667.
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  78. Tomycz ND, Richardson RM, Friedlander RM. Seizures and free radicals: the antioxidant may become the next anticonvulsant. Neurosurgery. 2011 Dec; 69(6):N12-3. PMID: 22067342.
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  79. Richardson RM, Gimenez F, Salegio EA, Su X, Bringas J, Berger MS, Bankiewicz KS. T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery. Neurosurgery. 2011 Jul; 69(1):154-63; discussion 163. PMID: 21430597.
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  80. Richardson RM, Kells AP, Martin AJ, Larson PS, Starr PA, Piferi PG, Bates G, Tansey L, Rosenbluth KH, Bringas JR, Berger MS, Bankiewicz KS. Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain. Stereotact Funct Neurosurg. 2011; 89(3):141-51. PMID: 21494065.
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  81. Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS. Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. Mol Ther. 2011 Jun; 19(6):1048-57. PMID: 21343917.
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  82. Chang EF, Cheng JS, Richardson RM, Lee C, Starr PA, Larson PS. Incidence and management of venous air embolisms during awake deep brain stimulation surgery in a large clinical series. Stereotact Funct Neurosurg. 2011; 89(2):76-82. PMID: 21293166.
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  83. Fiandaca MS, Salegio EA, Yin D, Richardson RM, Valles FE, Larson PS, Starr PA, Lonser RR, Bankiewicz KS. Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements. J Neurosci Methods. 2011 Mar 15; 196(1):124-30. PMID: 21185868.
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  84. Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson RM, Su X, Aminoff MJ, Bankiewicz KS. Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease. Neurosurgery. 2010 Nov; 67(5):1377-85. PMID: 20871425.
    Citations: 14     Fields:    Translation:HumansCellsCTClinical Trials
  85. Salegio EA, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi SP, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz KS. Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders. Hum Gene Ther. 2010 Sep; 21(9):1093-103. PMID: 20408734.
    Citations:    
  86. Richardson RM, Freed CR, Shimamoto SA, Starr PA. Pallidal neuronal discharge in Parkinson's disease following intraputamenal fetal mesencephalic allograft. J Neurol Neurosurg Psychiatry. 2011 Mar; 82(3):266-71. PMID: 20802212.
    Citations:    
  87. Yin D, Richardson RM, Fiandaca MS, Bringas J, Forsayeth J, Berger MS, Bankiewicz KS. Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics. J Neurosurg. 2010 Aug; 113(2):240-8. PMID: 20367078.
    Citations:    
  88. Clark AJ, Lu DC, Richardson RM, Tihan T, Parsa AT, Chou D, Barbaro NM, Kunwar S, Weinstein PR, Lawton MT, Berger MS, McDermott MW. Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomas. World Neurosurg. 2010 Jul; 74(1):200-5. PMID: 21300014.
    Citations:    
  89. Su X, Kells AP, Salegio EA, Salegio EA, Richardson RM, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS. Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors. Mol Ther. 2010 08; 18(8):1490-5. PMID: 20551915.
    Citations:    
  90. Richardson RM, Singh A, Sun D, Fillmore HL, Dietrich DW, Bullock MR. Stem cell biology in traumatic brain injury: effects of injury and strategies for repair. J Neurosurg. 2010 May; 112(5):1125-38. PMID: 19499984.
    Citations:    
  91. Richardson RM, Ostrem JL, Starr PA. Surgical repositioning of misplaced subthalamic electrodes in Parkinson's disease: location of effective and ineffective leads. Stereotact Funct Neurosurg. 2009; 87(5):297-303. PMID: 19641340.
    Citations:    
  92. Richardson RM, Varenika V, Forsayeth JR, Bankiewicz KS. Future applications: gene therapy. Neurosurg Clin N Am. 2009 Apr; 20(2):205-10. PMID: 19555883.
    Citations:    
  93. Richardson RM, Larson PS, Bankiewicz KS. Gene and cell delivery to the degenerated striatum: status of preclinical efforts in primate models. Neurosurgery. 2008 Oct; 63(4):629-442; dicussion 642-4. PMID: 18981876.
    Citations:    
  94. Richardson RM, Barbaro NM, Alvarez-Buylla A, Baraban SC. Developing cell transplantation for temporal lobe epilepsy. Neurosurg Focus. 2008; 24(3-4):E17. PMID: 18341393.
    Citations:    
  95. Larson PS, Richardson RM, Starr PA, Martin AJ. Magnetic resonance imaging of implanted deep brain stimulators: experience in a large series. Stereotact Funct Neurosurg. 2008; 86(2):92-100. PMID: 18073522.
    Citations:    
  96. Richardson RM, Nguyen B, Holt SE, Broaddus WC, Fillmore HL. Ectopic telomerase expression inhibits neuronal differentiation of NT2 neural progenitor cells. Neurosci Lett. 2007 Jun 27; 421(2):168-72. PMID: 17566647.
    Citations:    
  97. Richardson RM, Sun D, Bullock MR. Neurogenesis after traumatic brain injury. Neurosurg Clin N Am. 2007 Jan; 18(1):169-81, xi. PMID: 17244562.
    Citations:    
  98. Richardson RM, Holloway KL, Bullock MR, Broaddus WC, Fillmore HL. Isolation of neuronal progenitor cells from the adult human neocortex. Acta Neurochir (Wien). 2006 Jul; 148(7):773-7. PMID: 16708171.
    Citations:    
  99. Richardson RM, Broaddus WC, Holloway KL, Sun D, Bullock MR, Fillmore HL. Heterotypic neuronal differentiation of adult subependymal zone neuronal progenitor cells transplanted to the adult hippocampus. Mol Cell Neurosci. 2005 Apr; 28(4):674-82. PMID: 15797714.
    Citations:    
  100. Richardson RM, Broaddus WC, Holloway KL, Fillmore HL. Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline. Brain Res. 2005 Jan 25; 1032(1-2):11-22. PMID: 15680936.
    Citations:    
  101. Richardson RM, Fillmore HL, Holloway KL, Broaddus WC. Progress in cerebral transplantation of expanded neuronal stem cells. J Neurosurg. 2004 Apr; 100(4):659-71. PMID: 15070121.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.