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Sophie Helaine, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pham THM, Brewer SM, Thurston T, Massis LM, Honeycutt J, Lugo K, Jacobson AR, Vilches-Moure JG, Hamblin M, Helaine S, Monack DM. Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection. Cell Host Microbe. 2020 01 08; 27(1):54-67.e5. PMID: 31883922.
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  2. Panagi I, Jennings E, Zeng J, Günster RA, Stones CD, Mak H, Jin E, Stapels DAC, Subari NZ, Pham THM, Brewer SM, Ong SYQ, Monack DM, Helaine S, Thurston TLM. Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization. Cell Host Microbe. 2020 01 08; 27(1):41-53.e6. PMID: 31862381.
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  3. Gollan B, Grabe G, Michaux C, Helaine S. Bacterial Persisters and Infection: Past, Present, and Progressing. Annu Rev Microbiol. 2019 09 08; 73:359-385. PMID: 31500532.
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  4. Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A. Publisher Correction: Definitions and guidelines for research on antibiotic persistence. Nat Rev Microbiol. 2019 Jul; 17(7):460. PMID: 31036919.
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  5. Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A. Definitions and guidelines for research on antibiotic persistence. Nat Rev Microbiol. 2019 07; 17(7):441-448. PMID: 30980069.
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  6. Ronneau S, Helaine S. Clarifying the Link between Toxin-Antitoxin Modules and Bacterial Persistence. J Mol Biol. 2019 08 23; 431(18):3462-3471. PMID: 30914294.
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  7. Stapels DAC, Hill PWS, Westermann AJ, Fisher RA, Thurston TL, Saliba AE, Blommestein I, Vogel J, Helaine S. Salmonella persisters undermine host immune defenses during antibiotic treatment. Science. 2018 12 07; 362(6419):1156-1160. PMID: 30523110.
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  8. Wilcox B, Osterman I, Serebryakova M, Lukyanov D, Komarova E, Gollan B, Morozova N, Wolf YI, Makarova KS, Helaine S, Sergiev P, Dubiley S, Borukhov S, Severinov K. Escherichia coli ItaT is a type II toxin that inhibits translation by acetylating isoleucyl-tRNAIle. Nucleic Acids Res. 2018 09 06; 46(15):7873-7885. PMID: 29931259.
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  9. Rycroft JA, Gollan B, Grabe GJ, Hall A, Cheverton AM, Larrouy-Maumus G, Hare SA, Helaine S. Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection. Nat Commun. 2018 05 18; 9(1):1993. PMID: 29777131.
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  10. Fisher RA, Gollan B, Helaine S. Persistent bacterial infections and persister cells. Nat Rev Microbiol. 2017 Aug; 15(8):453-464. PMID: 28529326.
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  11. Hall AM, Gollan B, Helaine S. Toxin-antitoxin systems: reversible toxicity. Curr Opin Microbiol. 2017 Apr; 36:102-110. PMID: 28279904.
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  12. Saliba AE, Li L, Westermann AJ, Appenzeller S, Stapels DA, Schulte LN, Helaine S, Vogel J. Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella. Nat Microbiol. 2016 Nov 14; 2:16206. PMID: 27841856.
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  13. Santos AJM, Durkin CH, Helaine S, Boucrot E, Holden DW. Clustered Intracellular Salmonella enterica Serovar Typhimurium Blocks Host Cell Cytokinesis. Infect Immun. 2016 07; 84(7):2149-2158. PMID: 27185791.
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  14. Cheverton AM, Gollan B, Przydacz M, Wong CT, Mylona A, Hare SA, Helaine S. A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA. Mol Cell. 2016 07 07; 63(1):86-96. PMID: 27264868.
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  15. Mouton JM, Helaine S, Holden DW, Sampson SL. Elucidating population-wide mycobacterial replication dynamics at the single-cell level. Microbiology. 2016 06; 162(6):966-978. PMID: 27027532.
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  16. Fisher RA, Cheverton AM, Helaine S. Analysis of Macrophage-Induced Salmonella Persisters. Methods Mol Biol. 2016; 1333:177-87. PMID: 26468109.
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  17. Figueira R, Brown DR, Ferreira D, Eldridge MJ, Burchell L, Pan Z, Helaine S, Wigneshweraraj S. Adaptation to sustained nitrogen starvation by Escherichia coli requires the eukaryote-like serine/threonine kinase YeaG. Sci Rep. 2015 Dec 01; 5:17524. PMID: 26621053.
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  18. Caly DL, Coulthurst SJ, An SQ, Helaine S, Malone JG, Ryan RP. Communication, cooperation, and social interactions: a report from the third Young Microbiologists Symposium on microbe signalling, organisation, and pathogenesis. J Bacteriol. 2014 Oct; 196(20):3527-33. PMID: 25070739.
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  19. Helaine S, Kugelberg E. Bacterial persisters: formation, eradication, and experimental systems. Trends Microbiol. 2014 Jul; 22(7):417-24. PMID: 24768561.
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  20. Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW. Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science. 2014 Jan 10; 343(6167):204-8. PMID: 24408438.
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  21. Figueira R, Watson KG, Holden DW, Helaine S. Identification of salmonella pathogenicity island-2 type III secretion system effectors involved in intramacrophage replication of S. enterica serovar typhimurium: implications for rational vaccine design. mBio. 2013 Apr 16; 4(2):e00065. PMID: 23592259.
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  22. Helaine S, Holden DW. Heterogeneity of intracellular replication of bacterial pathogens. Curr Opin Microbiol. 2013 Apr; 16(2):184-91. PMID: 23485258.
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  23. Thompson JA, Liu M, Helaine S, Holden DW. Contribution of the PhoP/Q regulon to survival and replication of Salmonella enterica serovar Typhimurium in macrophages. Microbiology. 2011 Jul; 157(Pt 7):2084-2093. PMID: 21511762.
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  24. Brown DR, Helaine S, Carbonnelle E, Pelicic V. Systematic functional analysis reveals that a set of seven genes is involved in fine-tuning of the multiple functions mediated by type IV pili in Neisseria meningitidis. Infect Immun. 2010 Jul; 78(7):3053-63. PMID: 20439474.
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  25. Helaine S, Thompson JA, Watson KG, Liu M, Boyle C, Holden DW. Dynamics of intracellular bacterial replication at the single cell level. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3746-51. PMID: 20133586.
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  26. Helaine S, Dyer DH, Nassif X, Pelicic V, Forest KT. 3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV pili. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15888-93. PMID: 17893339.
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  27. Carbonnelle E, Helaine S, Nassif X, Pelicic V. A systematic genetic analysis in Neisseria meningitidis defines the Pil proteins required for assembly, functionality, stabilization and export of type IV pili. Mol Microbiol. 2006 Sep; 61(6):1510-22. PMID: 16968224.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.