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Sophie Helaine, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rizvanovic A, Michaux C, Panza M, Iloglu Z, Helaine S, Wagner EGH, Holmqvist E. The RNA-Binding Protein ProQ Promotes Antibiotic Persistence in Salmonella. mBio. 2022 Nov 21; e0289122. PMID: 36409088; PMCID: PMC9765298.
    Citations:    Fields:    
  2. Michaux C, Ronneau S, Giorgio RT, Helaine S. Antibiotic tolerance and persistence have distinct fitness trade-offs. PLoS Pathog. 2022 11; 18(11):e1010963. PMID: 36374854; PMCID: PMC9704765.
    Citations:    Fields:    Translation:Cells
  3. Paulini S, Fabiani FD, Weiss AS, Moldoveanu AL, Helaine S, Stecher B, Jung K. The Biological Significance of Pyruvate Sensing and Uptake in Salmonella enterica Serovar Typhimurium. Microorganisms. 2022 Aug 30; 10(9). PMID: 36144354; PMCID: PMC9504724.
  4. Bikmetov D, Hall AMJ, Livenskyi A, Gollan B, Ovchinnikov S, Gilep K, Kim JY, Larrouy-Maumus G, Zgoda V, Borukhov S, Severinov K, Helaine S, Dubiley S. GNAT toxins evolve toward narrow tRNA target specificities. Nucleic Acids Res. 2022 06 10; 50(10):5807-5817. PMID: 35609997; PMCID: PMC9177977.
    Citations:    Fields:    
  5. de Castro GV, Worm DJ, Grabe GJ, Rowan FC, Haggerty L, de la Lastra AL, Popescu O, Helaine S, Barnard A. Characterization of the Key Determinants of Phd Antitoxin Mediated Doc Toxin Inactivation in Salmonella. ACS Chem Biol. 2022 06 17; 17(6):1598-1606. PMID: 35647667; PMCID: PMC9207808.
    Citations:    Fields:    Translation:Cells
  6. Tomasi FG, Hall AMJ, Schweber JTP, Dulberger CL, McGowen K, Liu Q, Fortune SM, Helaine S, Rubin EJ. A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis. Microbiol Spectr. 2022 06 29; 10(3):e0058022. PMID: 35638832; PMCID: PMC9241777.
    Citations:    Fields:    Translation:HumansCells
  7. Hill PWS, Moldoveanu AL, Sargen M, Ronneau S, Glegola-Madejska I, Beetham C, Fisher RA, Helaine S. The vulnerable versatility of Salmonella antibiotic persisters during infection. Cell Host Microbe. 2021 12 08; 29(12):1757-1773.e10. PMID: 34731646.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  8. Ronneau S, Hill PW, Helaine S. Antibiotic persistence and tolerance: not just one and the same. Curr Opin Microbiol. 2021 12; 64:76-81. PMID: 34634678.
    Citations:    Fields:    Translation:HumansCells
  9. Grabe GJ, Giorgio RT, Hall AMJ, Morgan RML, Dubois L, Sisley TA, Rycroft JA, Hare SA, Helaine S. Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nat Chem Biol. 2021 12; 17(12):1296-1304. PMID: 34556858.
    Citations:    Fields:    Translation:Cells
  10. Michaux C, Ronneau S, Helaine S. Studying Antibiotic Persistence During Infection. Methods Mol Biol. 2021; 2357:273-289. PMID: 34590265.
    Citations:    Fields:    Translation:Cells
  11. Michaux C, Ronneau S, Helaine S. Correction to: Studying Antibiotic Persistence During Infection. Methods Mol Biol. 2021; 2357:C1. PMID: 35304730.
    Citations:    Fields:    
  12. Moldoveanu AL, Rycroft JA, Helaine S. Impact of bacterial persisters on their host. Curr Opin Microbiol. 2021 02; 59:65-71. PMID: 32866708.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  13. Pham THM, Brewer SM, Thurston T, Massis LM, Honeycutt J, Lugo K, Jacobson AR, Vilches-Moure JG, Hamblin M, Helaine S, Monack DM. Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection. Cell Host Microbe. 2020 01 08; 27(1):54-67.e5. PMID: 31883922.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  14. Panagi I, Jennings E, Zeng J, Günster RA, Stones CD, Mak H, Jin E, Stapels DAC, Subari NZ, Pham THM, Brewer SM, Ong SYQ, Monack DM, Helaine S, Thurston TLM. Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization. Cell Host Microbe. 2020 01 08; 27(1):41-53.e6. PMID: 31862381; PMCID: PMC6953433.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  15. Gollan B, Grabe G, Michaux C, Helaine S. Bacterial Persisters and Infection: Past, Present, and Progressing. Annu Rev Microbiol. 2019 09 08; 73:359-385. PMID: 31500532.
    Citations: 52     Fields:    Translation:Cells
  16. Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A. Definitions and guidelines for research on antibiotic persistence. Nat Rev Microbiol. 2019 07; 17(7):441-448. PMID: 30980069; PMCID: PMC7136161.
    Citations: 236     Fields:    Translation:Cells
  17. Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A. Publisher Correction: Definitions and guidelines for research on antibiotic persistence. Nat Rev Microbiol. 2019 Jul; 17(7):460. PMID: 31036919.
    Citations: 8     Fields:    
  18. Ronneau S, Helaine S. Clarifying the Link between Toxin-Antitoxin Modules and Bacterial Persistence. J Mol Biol. 2019 08 23; 431(18):3462-3471. PMID: 30914294.
    Citations: 34     Fields:    Translation:Cells
  19. Stapels DAC, Hill PWS, Westermann AJ, Fisher RA, Thurston TL, Saliba AE, Blommestein I, Vogel J, Helaine S. Salmonella persisters undermine host immune defenses during antibiotic treatment. Science. 2018 12 07; 362(6419):1156-1160. PMID: 30523110.
    Citations: 75     Fields:    Translation:AnimalsCells
  20. Wilcox B, Osterman I, Serebryakova M, Lukyanov D, Komarova E, Gollan B, Morozova N, Wolf YI, Makarova KS, Helaine S, Sergiev P, Dubiley S, Borukhov S, Severinov K. Escherichia coli ItaT is a type II toxin that inhibits translation by acetylating isoleucyl-tRNAIle. Nucleic Acids Res. 2018 09 06; 46(15):7873-7885. PMID: 29931259.
    Citations: 17     Fields:    Translation:Cells
  21. Rycroft JA, Gollan B, Grabe GJ, Hall A, Cheverton AM, Larrouy-Maumus G, Hare SA, Helaine S. Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection. Nat Commun. 2018 05 18; 9(1):1993. PMID: 29777131; PMCID: PMC5959882.
    Citations: 41     Fields:    Translation:HumansCells
  22. Fisher RA, Gollan B, Helaine S. Persistent bacterial infections and persister cells. Nat Rev Microbiol. 2017 Aug; 15(8):453-464. PMID: 28529326.
    Citations: 274     Fields:    Translation:HumansCells
  23. Hall AM, Gollan B, Helaine S. Toxin-antitoxin systems: reversible toxicity. Curr Opin Microbiol. 2017 Apr; 36:102-110. PMID: 28279904.
    Citations: 38     Fields:    Translation:Cells
  24. Saliba AE, Li L, Westermann AJ, Appenzeller S, Stapels DA, Schulte LN, Helaine S, Vogel J. Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella. Nat Microbiol. 2016 Nov 14; 2:16206. PMID: 27841856.
    Citations: 59     Fields:    Translation:AnimalsCells
  25. Santos AJM, Durkin CH, Helaine S, Boucrot E, Holden DW. Clustered Intracellular Salmonella enterica Serovar Typhimurium Blocks Host Cell Cytokinesis. Infect Immun. 2016 07; 84(7):2149-2158. PMID: 27185791; PMCID: PMC4936369.
    Citations: 5     Fields:    Translation:AnimalsCells
  26. Cheverton AM, Gollan B, Przydacz M, Wong CT, Mylona A, Hare SA, Helaine S. A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA. Mol Cell. 2016 07 07; 63(1):86-96. PMID: 27264868; PMCID: PMC4942678.
    Citations: 91     Fields:    Translation:Cells
  27. Mouton JM, Helaine S, Holden DW, Sampson SL. Elucidating population-wide mycobacterial replication dynamics at the single-cell level. Microbiology (Reading). 2016 06; 162(6):966-978. PMID: 27027532; PMCID: PMC5042079.
    Citations: 16     Fields:    Translation:AnimalsCells
  28. Fisher RA, Cheverton AM, Helaine S. Analysis of Macrophage-Induced Salmonella Persisters. Methods Mol Biol. 2016; 1333:177-87. PMID: 26468109.
    Citations: 1     Fields:    Translation:Cells
  29. Figueira R, Brown DR, Ferreira D, Eldridge MJ, Burchell L, Pan Z, Helaine S, Wigneshweraraj S. Adaptation to sustained nitrogen starvation by Escherichia coli requires the eukaryote-like serine/threonine kinase YeaG. Sci Rep. 2015 Dec 01; 5:17524. PMID: 26621053; PMCID: PMC4664914.
    Citations: 19     Fields:    Translation:Cells
  30. Caly DL, Coulthurst SJ, An SQ, Helaine S, Malone JG, Ryan RP. Communication, cooperation, and social interactions: a report from the third Young Microbiologists Symposium on microbe signalling, organisation, and pathogenesis. J Bacteriol. 2014 Oct; 196(20):3527-33. PMID: 25070739; PMCID: PMC4187693.
    Citations:    Fields:    Translation:Cells
  31. Helaine S, Kugelberg E. Bacterial persisters: formation, eradication, and experimental systems. Trends Microbiol. 2014 Jul; 22(7):417-24. PMID: 24768561.
    Citations: 73     Fields:    Translation:HumansCells
  32. Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW. Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science. 2014 Jan 10; 343(6167):204-8. PMID: 24408438; PMCID: PMC6485627.
    Citations: 276     Fields:    Translation:AnimalsCells
  33. Figueira R, Watson KG, Holden DW, Helaine S. Identification of salmonella pathogenicity island-2 type III secretion system effectors involved in intramacrophage replication of S. enterica serovar typhimurium: implications for rational vaccine design. mBio. 2013 Apr 16; 4(2):e00065. PMID: 23592259; PMCID: PMC3634603.
    Citations: 59     Fields:    Translation:AnimalsCells
  34. Helaine S, Holden DW. Heterogeneity of intracellular replication of bacterial pathogens. Curr Opin Microbiol. 2013 Apr; 16(2):184-91. PMID: 23485258.
    Citations: 29     Fields:    Translation:Cells
  35. Thompson JA, Liu M, Helaine S, Holden DW. Contribution of the PhoP/Q regulon to survival and replication of Salmonella enterica serovar Typhimurium in macrophages. Microbiology (Reading). 2011 Jul; 157(Pt 7):2084-2093. PMID: 21511762; PMCID: PMC3167890.
    Citations: 21     Fields:    Translation:AnimalsCells
  36. Brown DR, Helaine S, Carbonnelle E, Pelicic V. Systematic functional analysis reveals that a set of seven genes is involved in fine-tuning of the multiple functions mediated by type IV pili in Neisseria meningitidis. Infect Immun. 2010 Jul; 78(7):3053-63. PMID: 20439474.
    Citations: 35     Fields:    Translation:HumansCells
  37. Helaine S, Thompson JA, Watson KG, Liu M, Boyle C, Holden DW. Dynamics of intracellular bacterial replication at the single cell level. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3746-51. PMID: 20133586; PMCID: PMC2840444.
    Citations: 132     Fields:    Translation:AnimalsCells
  38. Helaine S, Dyer DH, Nassif X, Pelicic V, Forest KT. 3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV pili. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15888-93. PMID: 17893339; PMCID: PMC2000383.
    Citations: 65     Fields:    Translation:Cells
  39. Carbonnelle E, Helaine S, Nassif X, Pelicic V. A systematic genetic analysis in Neisseria meningitidis defines the Pil proteins required for assembly, functionality, stabilization and export of type IV pili. Mol Microbiol. 2006 Sep; 61(6):1510-22. PMID: 16968224.
    Citations: 103     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.