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James Kennedy Hartsfield, Ph.D., D.M.D.

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Biography
education and training
University of South Carolina, Columbia, SCBS05/1977Biology
Medical University of South Carolina, Charleston, SCDMD05/1981Dental Medicine
Indiana Univeristy School of Medicine, Indianapolis, INCertificate06/1983Medical Genetics Residency
Indiana University, Bloomington, INMS08/1983Medical Genetics
Harvard School of Dental Medicine, Boston, MACertificate06/1986Orthodontics and Dentofacial Orthopedics
Massachusetts General Hospital, Boston, MACertificate12/1986Research Fellow in Pediatrics, Embryology-Teratology Unit
Harvard Medical School, Boston, MAMMSc05/1987Oral Biology
University of South Florida College of Medicine, Tampa, FL Certificate06/1987Medical Genetics Residency
University of South Florida College of Medicine, Tampa, FL PhD12/1993Medical Sciences
awards and honors
2001
B.F. Dewell Memorial Biomedical Research Award
2003
Distinguished Faculty Award for Research
2004
Indiana Dental Association Outstanding Faculty Member of the Year
2008 - 2025
E. Preston Hicks Endowed Professor of Craniofacial Genetics, Orthodontics and Oral Health Research
2010
Dr. Dan L. Blackwell Lecture
2012
Mentor Award
2013
Caring and Sharing Award for Outstanding Contributions to People with Dental Needs
2018
Diana Tamari Sabbah Scholars Program Visiting Scholar
2019
Kokich-Shapiro Lecture

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hartsfield JK, Jacob GJ, Morford LA. Heredity, Genetics and Orthodontics - How Much Has This Research Really Helped? Semin Orthod. 2017 12; 23(4):336-347. PMID: 29290679.
    Citations: 1     Fields:    
  2. Iglesias-Linares A, Morford LA, Hartsfield JK. Bone Density and Dental External Apical Root Resorption. Curr Osteoporos Rep. 2016 12; 14(6):292-309. PMID: 27766484.
    Citations: 11     Fields:    Translation:Humans
  3. Iglesias-Linares A, Hartsfield JK. Cellular and Molecular Pathways Leading to External Root Resorption. J Dent Res. 2017 Feb; 96(2):145-152. PMID: 27811065.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  4. Ebersole JL, Graves CL, Gonzalez OA, Dawson D, Morford LA, Huja PE, Hartsfield JK, Huja SS, Pandruvada S, Wallet SM. Aging, inflammation, immunity and periodontal disease. Periodontol 2000. 2016 10; 72(1):54-75. PMID: 27501491.
    Citations: 25     Fields:    Translation:Humans
  5. Subramani K, Pandruvada SN, Puleo DA, Hartsfield JK, Huja SS. In vitro evaluation of osteoblast responses to carbon nanotube-coated titanium surfaces. Prog Orthod. 2016 Dec; 17(1):23. PMID: 27459973.
    Citations:    Fields:    Translation:AnimalsCells
  6. Sharab LY, Morford LA, Dempsey J, Falcão-Alencar G, Mason A, Jacobson E, Kluemper GT, Macri JV, Hartsfield JK. Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia. Orthod Craniofac Res. 2015 Apr; 18 Suppl 1:71-82. PMID: 25865535.
    Citations: 15     Fields:    Translation:Humans
  7. Roedig JJ, Phillips BA, Morford LA, Van Sickels JE, Falcao-Alencar G, Fardo DW, Hartsfield JK, Ding X, Kluemper GT. Comparison of BMI, AHI, and apolipoprotein E e4 (APOE-e4) alleles among sleep apnea patients with different skeletal classifications. J Clin Sleep Med. 2014 Apr 15; 10(4):397-402. PMID: 24733985.
    Citations:    Fields:    Translation:Humans
  8. McCarlie VW, Hartsfield JK, Blum JS, González-Cabezas C, Chin JR, Eckert GJ, Morford LA, Pescovitz MD, Rodriguez H, Fontana M, Gregory RL. Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects. Open J Immunol. 2013 Sep 01; 3(3). PMID: 24386612.
    Citations: 1     
  9. Lawrence C, Hong-McAtee I, Hall B, Hartsfield J, Rutherford A, Bonilla T, Bay C. Endocrine abnormalities in Townes-Brocks syndrome. . 2013 Sep; 161A(9):2266-73. PMID: 23894113.
    Citations: 2     Translation:Humans
  10. Ghoneima A, Sachdeva K, Hartsfield J, Weaver D, Kula K. The use of cone beam computed tomography for the assessment of trichorhinophalangeal syndrome, type I - a case report. J Orthod. 2013 Mar; 40(1):47-52. PMID: 23524547.
    Citations: 1     Fields:    Translation:Humans
  11. Hartsfield JK, Morford LA, Otero LM, Fardo DW. Genetics and non-syndromic facial growth. J Pediatr Genet. 2013 Mar; 2(1):9-20. PMID: 27625834.
    Citations: 1     
  12. He S, Hartsfield JK, Guo Y, Cao Y, Wang S, Chen S. Association between CYP19A1 genotype and pubertal sagittal jaw growth. Am J Orthod Dentofacial Orthop. 2012 Nov; 142(5):662-70. PMID: 23116507.
    Citations: 7     Fields:    Translation:Humans
  13. Ghoneima A, Abdel-Fattah E, Hartsfield J, El-Bedwehi A, Kamel A, Kula K. Effects of rapid maxillary expansion on the cranial and circummaxillary sutures. Am J Orthod Dentofacial Orthop. 2011 Oct; 140(4):510-9. PMID: 21967938.
    Citations: 18     Fields:    Translation:Humans
  14. Pratt MC, Kluemper GT, Hartsfield JK, Fardo D, Nash DA. Evaluation of retention protocols among members of the American Association of Orthodontists in the United States. Am J Orthod Dentofacial Orthop. 2011 Oct; 140(4):520-6. PMID: 21967939.
    Citations: 17     Fields:    Translation:Humans
  15. Weddell LS, Hartsfield JK. Dental maturity of Caucasian children in the Indianapolis area. Pediatr Dent. 2011 May-Jun; 33(3):221-7. PMID: 21703074.
    Citations: 4     Fields:    Translation:Humans
  16. Alford TJ, Roberts WE, Hartsfield JK, Eckert GJ, Snyder RJ. Clinical outcomes for patients finished with the SureSmile™ method compared with conventional fixed orthodontic therapy. Angle Orthod. 2011 May; 81(3):383-8. PMID: 21261488.
    Citations: 13     Fields:    Translation:Humans
  17. Ghoneima A, Abdel-Fattah E, Eraso F, Fardo D, Kula K, Hartsfield J. Skeletal and dental changes after rapid maxillary expansion: a computed tomography study. Aust Orthod J. 2010 Nov; 26(2):141-8. PMID: 21175023.
    Citations: 7     Fields:    Translation:Humans
  18. Hartsfield JK. Pathways in external apical root resorption associated with orthodontia. Orthod Craniofac Res. 2009 Aug; 12(3):236-42. PMID: 19627526.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  19. Chien PC, Parks ET, Eraso F, Hartsfield JK, Roberts WE, Ofner S. Comparison of reliability in anatomical landmark identification using two-dimensional digital cephalometrics and three-dimensional cone beam computed tomography in vivo. Dentomaxillofac Radiol. 2009 Jul; 38(5):262-73. PMID: 19474253.
    Citations: 26     Fields:    Translation:Humans
  20. Viecilli RF, Katona TR, Chen J, Hartsfield JK, Roberts WE. Orthodontic mechanotransduction and the role of the P2X7 receptor. Am J Orthod Dentofacial Orthop. 2009 Jun; 135(6):694.e1-16; discussion 694-5. PMID: 19524819.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  21. Standerwick RG, Roberts EW, Hartsfield JK, Babler WJ, Katona TR. Comparison of the Bolton Standards to longitudinal cephalograms superimposed on the occipital condyle (I-point). J Orthod. 2009 Mar; 36(1):23-35; discussion 13-4. PMID: 19286873.
    Citations: 2     Fields:    Translation:Humans
  22. Viecilli R, Katona T, Chen J, Roberts E, Hartsfield J. Comparison of dentoalveolar morphology in WT and P2X7R KO mice for the development of biomechanical orthodontic models. Anat Rec (Hoboken). 2009 Feb; 292(2):292-8. PMID: 19051251.
    Citations: 2     Fields:    Translation:Animals
  23. Standerwick R, Roberts E, Hartsfield J, Babler W, Kanomi R. Cephalometric superimposition on the occipital condyles as a longitudinal growth assessment reference: I-point and I-curve. Anat Rec (Hoboken). 2008 Dec; 291(12):1603-10. PMID: 18833570.
    Citations: 2     Fields:    Translation:Humans
  24. Abass SK, Hartsfield JK, Al-Qawasmi RA, Everett ET, Foroud TM, Roberts WE. Inheritance of susceptibility to root resorption associated with orthodontic force in mice. Am J Orthod Dentofacial Orthop. 2008 Dec; 134(6):742-50. PMID: 19061800.
    Citations: 3     Fields:    Translation:Animals
  25. McKnight DA, Suzanne Hart P, Hart TC, Hartsfield JK, Wilson A, Wright JT, Fisher LW. A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene. Hum Mutat. 2008 Dec; 29(12):1392-404. PMID: 18521831.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  26. Park Y, Hartsfield JK, Katona TR, Eugene Roberts W. Tooth positioner effects on occlusal contacts and treatment outcomes. Angle Orthod. 2008 Nov; 78(6):1050-6. PMID: 18947270.
    Citations: 2     Fields:    Translation:Humans
  27. Viecilli RF, Katona TR, Chen J, Hartsfield JK, Roberts WE. Three-dimensional mechanical environment of orthodontic tooth movement and root resorption. Am J Orthod Dentofacial Orthop. 2008 Jun; 133(6):791.e11-26. PMID: 18538239.
    Citations: 14     Fields:    
  28. Vu CQ, Roberts WE, Hartsfield JK, Ofner S. Treatment complexity index for assessing the relationship of treatment duration and outcomes in a graduate orthodontics clinic. Am J Orthod Dentofacial Orthop. 2008 Jan; 133(1):9.e1-13. PMID: 18174061.
    Citations: 8     Fields:    Translation:Humans
  29. Cruz RM, Krieger H, Ferreira R, Mah J, Hartsfield J, Oliveira S. Major gene and multifactorial inheritance of mandibular prognathism. . 2008 Jan 01; 146A(1):71-7. PMID: 18074368.
    Citations: 21     Translation:HumansCells
  30. Campbell CL, Roberts WE, Hartsfield JK, Qi R. Treatment outcomes in a graduate orthodontic clinic for cases defined by the American Board of Orthodontics malocclusion categories. Am J Orthod Dentofacial Orthop. 2007 Dec; 132(6):822-9. PMID: 18068603.
    Citations: 7     Fields:    Translation:Humans
  31. Hartsfield JK. Review of the etiologic heterogeneity of the oculo-auriculo-vertebral spectrum (Hemifacial Microsomia). Orthod Craniofac Res. 2007 Aug; 10(3):121-8. PMID: 17651128.
    Citations: 19     Fields:    Translation:Humans
  32. Knierim K, Roberts WE, Hartsfield J. Assessing treatment outcomes for a graduate orthodontics program: follow-up study for the classes of 2001-2003. Am J Orthod Dentofacial Orthop. 2006 Nov; 130(5):648-55, 655.e1-3. PMID: 17110263.
    Citations: 5     Fields:    Translation:Humans
  33. Al-Qawasmi RA, Hartsfield JK, Everett ET, Weaver MR, Foroud TM, Faust DM, Roberts WE. Root resorption associated with orthodontic force in inbred mice: genetic contributions. Eur J Orthod. 2006 Feb; 28(1):13-9. PMID: 16373453.
    Citations: 7     Fields:    Translation:Animals
  34. Al-Qawasmi RA, Hartsfield JK, Hartsfield JK, Everett ET, Weaver MR, Foroud TM, Roberts WE. Root resorption associated with orthodontic force in IL-1Beta knockout mouse. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):383-5. PMID: 15758271.
    Citations: 5     Fields:    Translation:Animals
  35. Pinskaya YB, Hsieh TJ, Roberts WE, Hartsfield JK. Comprehensive clinical evaluation as an outcome assessment for a graduate orthodontics program. Am J Orthod Dentofacial Orthop. 2004 Nov; 126(5):533-43. PMID: 15520685.
    Citations: 10     Fields:    Translation:Humans
  36. Hartsfield JK, Everett ET, Al-Qawasmi RA. GENETIC FACTORS IN EXTERNAL APICAL ROOT RESORPTION AND ORTHODONTIC TREATMENT. Crit Rev Oral Biol Med. 2004 Jan 01; 15(2):115-122. PMID: 15059946.
    Citations: 28     Fields:    
  37. Deguchi T, Takano-Yamamoto T, Kanomi R, Hartsfield JK, Roberts WE, Garetto LP. The use of small titanium screws for orthodontic anchorage. J Dent Res. 2003 May; 82(5):377-81. PMID: 12709505.
    Citations: 26     Fields:    Translation:Animals
  38. Al-Qawasmi RA, Hartsfield JK, Everett ET, Flury L, Liu L, Foroud TM, Macri JV, Roberts WE. Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker. J Dent Res. 2003 May; 82(5):356-60. PMID: 12709501.
    Citations: 26     Fields:    Translation:HumansCells
  39. Al-Qawasmi RA, Hartsfield JK, Everett ET, Flury L, Liu L, Foroud TM, Macri JV, Roberts WE. Genetic predisposition to external apical root resorption. Am J Orthod Dentofacial Orthop. 2003 Mar; 123(3):242-52. PMID: 12637896.
    Citations: 29     Fields:    Translation:HumansCells
  40. Toutain A, Dessay B, Ronce N, Ferrante MI, Tranchemontagne J, Newbury-Ecob R, Wallgren-Pettersson C, Burn J, Kaplan J, Rossi A, Russo S, Walpole I, Hartsfield JK, Oyen N, Nemeth A, Bitoun P, Trump D, Moraine C, Franco B. Refinement of the NHS locus on chromosome Xp22.13 and analysis of five candidate genes. Eur J Hum Genet. 2002 Sep; 10(9):516-20. PMID: 12173028.
    Citations: 5     Fields:    Translation:HumansCells
  41. Amador AG, Righi PD, Radpour S, Everett ET, Weisberger E, Langer M, Eckert GJ, Christen AG, Campbell S, Summerlin DJ, Reynolds N, Hartsfield JK. Polymorphisms of xenobiotic metabolizing genes in oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Apr; 93(4):440-5. PMID: 12029283.
    Citations: 10     Fields:    Translation:Humans
  42. Hartsfield JK, Hickman TA, Everett ET, Shaw GM, Lammer EJ, Finnell RA. Analysis of the EPHX1 113 polymorphism and GSTM1 homozygous null polymorphism and oral clefting associated with maternal smoking. Am J Med Genet. 2001 Jul 22; 102(1):21-4. PMID: 11471167.
    Citations: 10     Fields:    Translation:Humans
  43. Hartsfield JK, Everett ET. The Ephx1(d) allele encoding an Arg338Cys substitution is associated with heat lability. Mamm Genome. 2000 Oct; 11(10):915-8. PMID: 11003708.
    Citations:    Fields:    Translation:AnimalsCells
  44. Everett ET, Britto DA, Ward RE, Hartsfield JK. A novel FGFR2 gene mutation in Crouzon syndrome associated with apparent nonpenetrance. Cleft Palate Craniofac J. 1999 Nov; 36(6):533-41. PMID: 10574673.
    Citations: 2     Fields:    Translation:Humans
  45. Cook L, Weaver DD, Hartsfield JK, Vance GH. De novo 10q22 interstitial deletion. J Med Genet. 1999 Jan; 36(1):71-2. PMID: 9950372.
    Citations: 3     Fields:    Translation:HumansCells
  46. Cook L, Hartsfield JK, Vance GH. Partners with reciprocal translocations: genetic counseling for the 'double translocation'. Clin Genet. 1998 May; 53(5):403-7. PMID: 9660061.
    Citations: 1     Fields:    Translation:Humans
  47. Hartsfield JK, Sutcliffe MJ, Everett ET, Hassett C, Omiecinski CJ, Saari JA. Assignment1 of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization. Cytogenet Cell Genet. 1998; 83(1-2):44-5. PMID: 9925921.
    Citations: 7     Fields:    Translation:HumansCells
  48. Dean JA, Hartsfield JK, Wright JT, Hart TC. Dentin dysplasia, type II linkage to chromosome 4q. J Craniofac Genet Dev Biol. 1997 Oct-Dec; 17(4):172-7. PMID: 9493074.
    Citations: 7     Fields:    Translation:HumansCells
  49. Roberts WE, Hartsfield JK. Multidisciplinary management of congenital and acquired compensated malocclusions: diagnosis, etiology and treatment planning. J Indiana Dent Assoc. 1997; 76(2):42-3, 45-8, 50-1; quiz 52. PMID: 9517363.
    Citations: 1     Fields:    Translation:Humans
  50. Romie SS, Hartsfield JK, Sutcliffe MJ, Dumont DP, Kousseff BG. Monosomy 6q1: syndrome delineation. Am J Med Genet. 1996 Mar 15; 62(2):105-8. PMID: 8882389.
    Citations: 2     Fields:    Translation:HumansCells
  51. Hartsfield JK, Holmes LB, Morel JG. Phenytoin embryopathy: effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL/6J mice. Biochem Mol Med. 1995 Dec; 56(2):131-43. PMID: 8825076.
    Citations:    Fields:    Translation:AnimalsCells
  52. Hartsfield JK, Benford SA, Hilbelink DR. Induction of microsomal epoxide hydrolase activity in inbred mice by chronic phenytoin exposure. Biochem Mol Med. 1995 Dec; 56(2):144-51. PMID: 8825077.
    Citations:    Fields:    Translation:AnimalsCells
  53. Hartsfield JK. Premature exfoliation of teeth in childhood and adolescence. Adv Pediatr. 1994; 41:453-70. PMID: 7992695.
    Citations: 4     Fields:    Translation:Humans
  54. Hartsfield JK, Hall BD, Grix AW, Kousseff BG, Salazar JF, Haufe SM. Pleiotropy in Coffin-Lowry syndrome: sensorineural hearing deficit and premature tooth loss as early manifestations. Am J Med Genet. 1993 Mar 01; 45(5):552-7. PMID: 7681250.
    Citations: 6     Fields:    Translation:Humans
  55. Mueller OT, Hartsfield JK, Gallardo LA, Essig YP, Miller KL, Papenhausen PR, Tedesco TA. Lowe oculocerebrorenal syndrome in a female with a balanced X;20 translocation: mapping of the X chromosome breakpoint. Am J Hum Genet. 1991 Oct; 49(4):804-10. PMID: 1897526.
    Citations: 9     Fields:    Translation:HumansCells
  56. Hartsfield JK, Holmes LB. Comparison of two methods for linear measurement of ossified tissue in cleared mouse fetuses. J Craniofac Genet Dev Biol. 1988; 8(4):345-50. PMID: 2464613.
    Citations:    Fields:    Translation:Animals
  57. Bixler D, Higgins M, Hartsfield J. The Nance-Horan syndrome: a rare X-linked ocular-dental trait with expression in heterozygous females. Clin Genet. 1984 Jul; 26(1):30-5. PMID: 6467651.
    Citations: 14     Fields:    Translation:HumansCells
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