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Benjamin H Kann, M.D.

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Mentoring
Available: 10/08/19, Expires: 10/10/23

Head and Neck Cancers are diagnosed in approximately 60,000 patients in the U.S. annually. The goal of this project is to utilize advanced techniques in machine learning and artificial intelligence, including deep learning neural networks, to predict underlying characteristics of head and neck cancers and patient outcomes based on diagnostic imaging studies. Preliminary work (Kann et al, Nature Scientific Reports, 2018: https://doi.org/10.1038/s41598-018-32441-y) has demonstrated that deep learning can predict lymph node malignancy and extranodal extension, two factors that are critical in determining proper patient management and risk-stratification. The goal of the Student Project will be explore ways to optimize the deep learning platform and experiment with various cutting-edge neural network algorithms. The expectation is that the project will result in a clinically usable AI-application for head and neck cancer patients. Students with an interest in oncology, cancer imaging, computer science, data science, bioinformatics, artificial intelligence are encouraged.

The project aims and time commitment are flexible and can be tailored to the availability of the student. There are also several other machine-learning and digital health related projects ongoing in our group, and I would be happy to discuss.

Available: 10/08/19, Expires: 10/10/22

Head and Neck Cancers are diagnosed in approximately 60,000 patients in the U.S. annually. The goal of this project is to utilize advanced techniques in machine learning and artificial intelligence, including deep learning neural networks, to predict underlying characteristics of head and neck cancers and patient outcomes based on diagnostic imaging studies. Preliminary work (Kann et al, Nature Scientific Reports, 2018: https://doi.org/10.1038/s41598-018-32441-y) has demonstrated that deep learning can predict lymph node malignancy and extranodal extension, two factors that are critical in determining proper patient management and risk-stratification.

The goal of the Student Project will be explore ways to optimize the deep learning platform and experiment with various cutting-edge neural network algorithms. The expectation is that the project will result in a clinically usable AI-application for head and neck cancer patients. Students with an interest in oncology, cancer imaging, computer science, data science, bioinformatics, artificial intelligence are encouraged. The project aims and time commitment are flexible and can be tailored to the availability of the student. There are also several other machine-learning and digital health related projects ongoing in our group, and I would be happy to discuss.

https://aim.hms.harvard.edu/


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Haider SP, Zeevi T, Baumeister P, Reichel C, Sharaf K, Forghani R, Kann BH, Judson BL, Prasad ML, Burtness B, Mahajan A, Payabvash S. Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma. Cancers (Basel). 2020 Jul 03; 12(7). PMID: 32635216.
    Citations:    
  2. Haider SP, Mahajan A, Zeevi T, Baumeister P, Reichel C, Sharaf K, Forghani R, Kucukkaya AS, Kann BH, Judson BL, Prasad ML, Burtness B, Payabvash S. PET/CT radiomics signature of human papilloma virus association in oropharyngeal squamous cell carcinoma. Eur J Nucl Med Mol Imaging. 2020 May 12. PMID: 32399621.
    Citations:    
  3. Kann BH, Payabvash S, Aneja S. Reply to A.B. Simon et al. J Clin Oncol. 2020 Jun 01; 38(16):1869-1870. PMID: 32271673.
    Citations:    
  4. Kann BH, Johnson SB, Aerts HJWL, Mak RH, Nguyen PL. Changes in Length and Complexity of Clinical Practice Guidelines in Oncology, 1996-2019. JAMA Netw Open. 2020 Mar 02; 3(3):e200841. PMID: 32167566.
    Citations:    
  5. Johung K, Kann B, Lacy J, Stein S, Kortmansky J, Zaheer W, Cheng Y, Lam W, Liu S, Decker R, Hochster H, Higgins S. Pilot trial of YIV-906 with neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer. Ann Oncol. 2018 Jun; 29 Suppl 5:v90. PMID: 32177310.
    Citations:    
  6. Kann BH, Hicks DF, Payabvash S, Mahajan A, Du J, Gupta V, Park HS, Yu JB, Yarbrough WG, Burtness BA, Husain ZA, Aneja S. Multi-Institutional Validation of Deep Learning for Pretreatment Identification of Extranodal Extension in Head and Neck Squamous Cell Carcinoma. J Clin Oncol. 2020 Apr 20; 38(12):1304-1311. PMID: 31815574.
    Citations:    
  7. Miccio JA, Verma V, Kelly J, Kann BH, An Y, Park HS, Eskander A, Burtness B, Husain Z. Impact of contralateral lymph nodal involvement and extranodal extension on survival of surgically managed HPV-positive oropharyngeal cancer staged with the AJCC eighth edition. Oral Oncol. 2019 12; 99:104447. PMID: 31630059.
    Citations:    
  8. Loganadane G, Kann BH, Park HS, Johnson SB, Mehra S, Judson BL, Bhatia A, Belkacemi Y, Yarbrough WG, Burtness B, Husain ZA. Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy. Anticancer Res. 2019 Sep; 39(9):4885-4890. PMID: 31519591.
    Citations:    
  9. Loganadane G, Kassick M, Kann BH, Young MR, Knowlton CA, Evans SB, Higgins SA, Belkacemi Y, Potenziani M, Saltmarsh N, Wilson LD, Moran MS. Standard Tangential Radiation Fields Do Not Provide Incidental Coverage to the Internal Mammary Nodes. Pract Radiat Oncol. 2020 Jan - Feb; 10(1):21-28. PMID: 31394256.
    Citations:    
  10. Jairam V, Kann BH, Park HS, Miccio JA, Beckta JM, Yu JB, Prabhu RS, Gao SJ, Mehta MP, Curran WJ, Bindra RS, Contessa JN, Patel KR. Defining an Intermediate-risk Group for Low-grade Glioma: A National Cancer Database Analysis. Anticancer Res. 2019 Jun; 39(6):2911-2918. PMID: 31177129.
    Citations:    
  11. Verma V, Wegner RE, Brooks ED, Miccio JA, Kann BH, Finley GG, Raj MS, Grover S, Mohindra P, Simone CB. Chemotherapy Versus Supportive Care for Unresected Malignant Pleural Mesothelioma. Clin Lung Cancer. 2019 07; 20(4):263-269. PMID: 30992187.
    Citations:    
  12. Kann BH, Thompson R, Thomas CR, Dicker A, Aneja S. Artificial Intelligence in Oncology: Current Applications and Future Directions. Oncology (Williston Park). 2019 Feb 15; 33(2):46-53. PMID: 30784028.
    Citations:    
  13. Kann BH, Verma V, Stahl JM, Ross R, Dosoretz AP, Shafman TD, Gross CP, Park HS, Yu JB, Decker RH. Multi-institutional analysis of stereotactic body radiation therapy for operable early-stage non-small cell lung carcinoma. Radiother Oncol. 2019 05; 134:44-49. PMID: 31005223.
    Citations:    
  14. Miccio JA, Wilson LD, Kann BH, Jairam V, Beckta J, Foss FM, Yeboa DN. Cutaneous T-Cell Lymphoma: Trends in Radiation Doses and Patterns of Care 2004-2015. Anticancer Res. 2019 Jan; 39(1):253-259. PMID: 30591466.
    Citations:    
  15. Yeboa DN, Yu JB, Liao E, Huse J, Penas-Prado M, Kann BH, Sulman E, Grosshans D, Contessa J. Differences in patterns of care and outcomes between grade II and grade III molecularly defined 1p19q co-deleted gliomas. Clin Transl Radiat Oncol. 2019 Feb; 15:46-52. PMID: 30656222.
    Citations:    
  16. Kann BH, Miccio JA, Stahl JM, Ross R, Verma V, Dosoretz AP, Park HS, Shafman TD, Gross CP, Yu JB, Decker RH. Stereotactic body radiotherapy with adjuvant systemic therapy for early-stage non-small cell lung carcinoma: A multi-institutional analysis. Radiother Oncol. 2019 03; 132:188-196. PMID: 30391106.
    Citations:    Fields:    
  17. Kann BH, Aneja S, Loganadane GV, Kelly JR, Smith SM, Decker RH, Yu JB, Park HS, Yarbrough WG, Malhotra A, Burtness BA, Husain ZA. Pretreatment Identification of Head and Neck Cancer Nodal Metastasis and Extranodal Extension Using Deep Learning Neural Networks. Sci Rep. 2018 09 19; 8(1):14036. PMID: 30232350.
    Citations:    Fields:    
  18. Hicks DF, Bakst R, Doucette J, Kann BH, Miles B, Genden E, Misiukiewicz K, Posner M, Gupta V. Impact of obesity on outcomes for patients with head and neck cancer. Oral Oncol. 2018 08; 83:11-17. PMID: 30098765.
    Citations:    
  19. Loganadane G, Kelly JR, Lee NC, Kann BH, Mahajan A, Hansen JE, Belkacémi Y, Yarbrough W, Husain ZA. Incidence of radiographically occult nodal metastases in HPV+ oropharyngeal carcinoma: Implications for reducing elective nodal coverage. Pract Radiat Oncol. 2018 Nov - Dec; 8(6):397-403. PMID: 29730282.
    Citations:    
  20. Kann BH, Park HS, Johnson SB, Chiang VL, Yu JB. Radiosurgery for Brain Metastases: Changing Practice Patterns and Disparities in the United States. J Natl Compr Canc Netw. 2017 12; 15(12):1494-1502. PMID: 29223987.
    Citations: 2     Fields:    Translation:Humans
  21. Johnson SB, Lester-Coll NH, Kelly JR, Kann BH, Yu JB, Nath SK. Brachytherapy Boost Utilization and Survival in Unfavorable-risk Prostate Cancer. Eur Urol. 2017 11; 72(5):738-744. PMID: 28688613.
    Citations:    Fields:    Translation:Humans
  22. Kann BH, Park HS, Yeboa DN, Aneja S, Girardi M, Foss FM, Roberts KB, Wilson LD. Annual Facility Treatment Volume and Patient Survival for Mycosis Fungoides and Sézary Syndrome. Clin Lymphoma Myeloma Leuk. 2017 08; 17(8):520-526.e2. PMID: 28655598.
    Citations:    
  23. Khan AJ, Kann BH, Pan W, Drachtman R, Roberts K, Parikh RR. Underutilization of proton therapy in the treatment of pediatric central nervous system tumors: an analysis of the National Cancer Database. Acta Oncol. 2017 08; 56(8):1122-1125. PMID: 28562200.
    Citations:    
  24. Kann BH, Lester-Coll NH, Park HS, Yeboa DN, Kelly JR, Baehring JM, Becker KP, Yu JB, Bindra RS, Roberts KB. Adjuvant chemotherapy and overall survival in adult medulloblastoma. Neuro Oncol. 2017 02 01; 19(2):259-269. PMID: 27540083.
    Citations: 3     Fields:    Translation:Humans
  25. Kann BH, Park HS, Lester-Coll NH, Yeboa DN, Benitez V, Khan AJ, Bindra RS, Marks AM, Roberts KB. Postoperative Radiotherapy Patterns of Care and Survival Implications for Medulloblastoma in Young Children. JAMA Oncol. 2016 Dec 01; 2(12):1574-1581. PMID: 27491009.
    Citations:    
  26. Kann BH, Yu JB, Stahl JM, Bond JE, Loiselle C, Chiang VL, Bindra RS, Gerrard JL, Carlson DJ. The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery. J Neurosurg. 2016 12; 125(Suppl 1):154-159. PMID: 27903196.
    Citations:    
  27. Stahl JM, Hong JC, Lester-Coll NH, Kann BH, Wilson LD, Higgins SA, Evans SB. Chest Wall Deformity in the Radiation Oncology Clinic. Anticancer Res. 2016 10; 36(10):5295-5300. PMID: 27798891.
    Citations:    
  28. Liu JT, Kann BH, De B, Buckstein M, Bakst RL, Genden EM, Posner MR, Som PM, Gupta V. Prognostic value of radiographic extracapsular extension in locally advanced head and neck squamous cell cancers. Oral Oncol. 2016 Jan; 52:52-7. PMID: 26728104.
    Citations:    
  29. Carpenter TJ, Kann B, Buckstein MH, Ko EC, Bakst RL, Misiukiewicz KJ, Posner MR, Genden EM, Gupta V. Tolerability, toxicity, and temporal implications of transoral robotic surgery (TORS) on adjuvant radiation therapy in carcinoma of the head and neck. Ann Otol Rhinol Laryngol. 2014 Nov; 123(11):791-7. PMID: 24847162.
    Citations:    
  30. Cotter R, Blacksburg S, Carpenter T, Kann B, Bakst R, Misiukiewicz K, Posner M, Som P, Gupta V. Does response to induction chemotherapy (IC) predict locoregional control after concurrent chemoradiotherapy (CCRT) in locally advanced head and neck cancer (LAHNC)? Oral Oncol. 2014 Jun; 50(6):e27-8. PMID: 24680084.
    Citations:    
  31. Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V. Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma. Head Neck. 2014 Dec; 36(12):1689-94. PMID: 24123603.
    Citations:    
  32. Jarzyna PA, Deddens LH, Kann BH, Ramachandran S, Calcagno C, Chen W, Gianella A, Dijkhuizen RM, Griffioen AW, Fayad ZA, Mulder WJ. Tumor angiogenesis phenotyping by nanoparticle-facilitated magnetic resonance and near-infrared fluorescence molecular imaging. Neoplasia. 2012 Oct; 14(10):964-73. PMID: 23097630.
    Citations:    
  33. Gianella A, Jarzyna PA, Mani V, Ramachandran S, Calcagno C, Tang J, Kann B, Dijk WJ, Thijssen VL, Griffioen AW, Storm G, Fayad ZA, Mulder WJ. Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer. ACS Nano. 2011 Jun 28; 5(6):4422-33. PMID: 21557611.
    Citations:    
  34. Killoran JH, Allen AM, Kann BH, Lyatskaya Y. Inter fractional variability of breathing phase definition as determined by fiducial location. Med Phys. 2008 Feb; 35(2):753-63. PMID: 18383697.
    Citations: 5     Fields:    Translation:Humans
  35. Albaugh G, Kann B, Puc MM, Vemulapalli P, Marra S, Ross S. Age-adjusted outcomes in traumatic flail chest injuries in the elderly. Am Surg. 2000 Oct; 66(10):978-81. PMID: 11261629.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.