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Naama Kanarek, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 03 18; 375(6586):1254-1261. PMID: 35298263; PMCID: PMC9273333.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  2. Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD, Sabatini DM. Author Correction: Histidine catabolism is a major determinant of methotrexate sensitivity. Nature. 2022 Feb; 602(7895):E17-E18. PMID: 35017686.
    Citations:    Fields:    
  3. Heppler LN, Attarha S, Persaud R, Brown JI, Wang P, Petrova B, Tošic I, Burton FB, Flamand Y, Walker SR, Yeh JE, Zubarev RA, Gaetani M, Kanarek N, Page BDG, Frank DA. The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase. J Biol Chem. 2022 02; 298(2):101531. PMID: 34953855; PMCID: PMC8800111.
    Citations: 1     Fields:    Translation:HumansCells
  4. Petrova B, Warren A, Vital NY, Culhane AJ, Maynard AG, Wong A, Kanarek N. Redox Metabolism Measurement in Mammalian Cells and Tissues by LC-MS. Metabolites. 2021 May 13; 11(5). PMID: 34068241.
    Citations: 1     
  5. Diray-Arce J, Conti MG, Petrova B, Kanarek N, Angelidou A, Levy O. Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections. Metabolites. 2020 Nov 30; 10(12). PMID: 33266347.
    Citations: 16     
  6. Petrova B, Kanarek N. Potential Benefits and Pitfalls of Histidine Supplementation for Cancer Therapy Enhancement. J Nutr. 2020 10 01; 150(Suppl 1):2580S-2587S. PMID: 33000153.
    Citations: 1     Fields:    Translation:HumansAnimals
  7. Maynard AG, Kanarek N. NADH Ties One-Carbon Metabolism to Cellular Respiration. Cell Metab. 2020 04 07; 31(4):660-662. PMID: 32268110.
    Citations: 5     Fields:    
  8. Kanarek N, Petrova B, Sabatini DM. Dietary modifications for enhanced cancer therapy. Nature. 2020 03; 579(7800):507-517. PMID: 32214253.
    Citations: 71     Fields:    Translation:HumansAnimals
  9. Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD, Sabatini DM. Histidine catabolism is a major determinant of methotrexate sensitivity. Nature. 2018 07; 559(7715):632-636. PMID: 29995852; PMCID: PMC6082631.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  10. Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint A, Lewis CA, Sabatini DM. Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell. 2017 Apr 06; 169(2):258-272.e17. PMID: 28388410.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  11. Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014 Aug 28; 158(5):1094-1109. PMID: 25171410.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  12. Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E. Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment. Cancer Discov. 2014 Jun; 4(6):730-43. PMID: 24687604.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  13. Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y. Critical role for IL-1ß in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):E702-11. PMID: 24469832.
    Citations: 21     Fields:    Translation:AnimalsCells
  14. Kanarek N, Ben-Neriah Y. Regulation of NF-?B by ubiquitination and degradation of the I?Bs. Immunol Rev. 2012 Mar; 246(1):77-94. PMID: 22435548.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  15. Duan S, Skaar JR, Kuchay S, Toschi A, Kanarek N, Ben-Neriah Y, Pagano M. mTOR generates an auto-amplification loop by triggering the ßTrCP- and CK1a-dependent degradation of DEPTOR. Mol Cell. 2011 Oct 21; 44(2):317-24. PMID: 22017877; PMCID: PMC3212871.
    Citations: 118     Fields:    Translation:HumansCells
  16. Kanarek N, Horwitz E, Mayan I, Leshets M, Cojocaru G, Davis M, Tsuberi BZ, Pikarsky E, Pagano M, Ben-Neriah Y. Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion. Genes Dev. 2010 Mar 01; 24(5):470-7. PMID: 20194439.
    Citations: 20     Fields:    Translation:AnimalsCells
  17. Kanarek N, London N, Schueler-Furman O, Ben-Neriah Y. Ubiquitination and degradation of the inhibitors of NF-kappaB. Cold Spring Harb Perspect Biol. 2010 Feb; 2(2):a000166. PMID: 20182612.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  18. Zach N, Kanarek N, Inbar D, Grinvald Y, Milestein T, Vaadia E. Segregation between acquisition and long-term memory in sensorimotor learning. Eur J Neurosci. 2005 Nov; 22(9):2357-62. PMID: 16262674.
    Citations: 8     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.