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Pouneh K Fazeli, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03DK106410 (FAZELI, POUNEH KHADEJEH) Jul 1, 2015 - Jun 30, 2017
    NIH/NIDDK
    Transdermal Estrogen in Older Premenopausal Women with Anorexia Nervosa
    Role: Principal Investigator
  2. K23DK094820 (FAZELI, POUNEH KHADEJEH) Jul 1, 2012 - Apr 30, 2016
    NIH/NIDDK
    The Role of PTH in the Low Bone Mass of Anorexia Nervosa
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fazeli PK, Klibanski A. Effects of Anorexia Nervosa on Bone Metabolism. Endocr Rev. 2018 12 01; 39(6):895-910. PMID: 30165608.
    Citations:    Fields:    
  2. Fazeli PK, Faje A, Bredella MA, Polineni S, Russell S, Resulaj M, Rosen CJ, Klibanski A. Changes in marrow adipose tissue with short-term changes in weight in premenopausal women with anorexia nervosa. Eur J Endocrinol. 2018 Dec 01. PMID: 30566901.
    Citations:    Fields:    
  3. Steinhauser ML, Olenchock BA, O'Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK. The circulating metabolome of human starvation. JCI Insight. 2018 Aug 23; 3(16). PMID: 30135314.
    Citations:    Fields:    
  4. Fazeli PK, Lee H. Response to the Letter to the Editor: "Higher TSH Levels Within the Normal Range Are Associated With Unexpected Infertility". J Clin Endocrinol Metab. 2018 08 01; 103(8):3112-3113. PMID: 29905799.
    Citations:    Fields:    
  5. Fazeli PK, Klibanski A. The paradox of marrow adipose tissue in anorexia nervosa. Bone. 2019 Jan; 118:47-52. PMID: 29458121.
    Citations:    Fields:    
  6. Orouji Jokar T, Fourman LT, Lee H, Mentzinger K, Fazeli PK. Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility. J Clin Endocrinol Metab. 2018 02 01; 103(2):632-639. PMID: 29272395.
    Citations: 1     Fields:    Translation:Humans
  7. Fazeli PK, Lawson EA, Faje AT, Eddy KT, Lee H, Fiedorek FT, Breggia A, Gaal IM, DeSanti R, Klibanski A. Treatment With a Ghrelin Agonist in Outpatient Women With Anorexia Nervosa: A Randomized Clinical Trial. J Clin Psychiatry. 2018 Jan/Feb; 79(1). PMID: 29325236.
    Citations: 2     Fields:    
  8. Silva PPB, Amlashi FG, Yu EW, Pulaski-Liebert KJ, Gerweck AV, Fazeli PK, Lawson E, Nachtigall LB, Biller BMK, Miller KK, Klibanski A, Bouxsein M, Tritos NA. Bone microarchitecture and estimated bone strength in men with active acromegaly. Eur J Endocrinol. 2017 Nov; 177(5):409-420. PMID: 28780520.
    Citations:    Fields:    Translation:Humans
  9. Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francois-Saint-Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser ML. Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity. JCI Insight. 2017 Mar 09; 2(5):e90349. PMID: 28289709.
    Citations: 1     Fields:    
  10. Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Corrigendum: Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2016 12 08; 7:13775. PMID: 27929114.
    Citations:    Fields:    
  11. Schorr M, Thomas JJ, Eddy KT, Dichtel LE, Lawson EA, Meenaghan E, Lederfine Paskal M, Fazeli PK, Faje AT, Misra M, Klibanski A, Miller KK. Bone density, body composition, and psychopathology of anorexia nervosa spectrum disorders in DSM-IV vs DSM-5. Int J Eat Disord. 2017 Apr; 50(4):343-351. PMID: 27527115.
    Citations:    
  12. Fazeli PK, Teoh JG, Lam EL, Gerweck AV, Wexler TL, Teo EP, Russell BM, Durst R, McCarty D, Weiner RB, Picard MH, Klibanski A, Miller KK. Effect of growth hormone treatment on diastolic function in patients who have developed growth hormone deficiency after definitive treatment of acromegaly. Growth Horm IGF Res. 2016 Feb; 26:17-23. PMID: 26774401; PMCID: PMC4716556.
    Citations: 1     Fields:    Translation:Humans
  13. Fazeli PK, Lun M, Kim SM, Bredella MA, Wright S, Zhang Y, Lee H, Catana C, Klibanski A, Patwari P, Steinhauser ML. FGF21 and the late adaptive response to starvation in humans. J Clin Invest. 2015 Nov 03; 125(12):4601-11. PMID: 26529252; PMCID: PMC4665770.
    Citations: 18     Fields:    Translation:HumansAnimals
  14. Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2015 Aug 06; 6:7808. PMID: 26245716.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  15. Fazeli PK, Faje AT, Cross EJ, Lee H, Rosen CJ, Bouxsein ML, Klibanski A. Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa. Bone. 2015 Aug; 77:6-11. PMID: 25868802; PMCID: PMC4447546.
    Citations: 7     Fields:    Translation:Humans
  16. Fourman LT, Fazeli PK. Neuroendocrine causes of amenorrhea--an update. J Clin Endocrinol Metab. 2015 Mar; 100(3):812-24. PMID: 25581597; PMCID: PMC4333037.
    Citations: 6     Fields:    Translation:Humans
  17. Bachmann KN, Fazeli PK, Lawson EA, Russell BM, Riccio AD, Meenaghan E, Gerweck AV, Eddy K, Holmes T, Goldstein M, Weigel T, Ebrahimi S, Mickley D, Gleysteen S, Bredella MA, Klibanski A, Miller KK. Comparison of hip geometry, strength, and estimated fracture risk in women with anorexia nervosa and overweight/obese women. J Clin Endocrinol Metab. 2014 Dec; 99(12):4664-73. PMID: 25062461; PMCID: PMC4255123.
    Citations: 8     Fields:    Translation:Humans
  18. Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, Ning X, Bree AJ, Schell B, Broome DT, Soliman SS, DelProposto JL, Lumeng CN, Mitra A, Pandit SV, Gallagher KA, Miller JD, Krishnan V, Hui SK, Bredella MA, Fazeli PK, Klibanski A, Horowitz MC, Rosen CJ, MacDougald OA. Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction. Cell Metab. 2014 Aug 05; 20(2):368-375. PMID: 24998914; PMCID: PMC4126847.
    Citations: 83     Fields:    Translation:HumansAnimals
  19. Bredella MA, Fazeli PK, Daley SM, Miller KK, Rosen CJ, Klibanski A, Torriani M. Marrow fat composition in anorexia nervosa. Bone. 2014 Sep; 66:199-204. PMID: 24953711; PMCID: PMC4125432.
    Citations: 23     Fields:    Translation:Humans
  20. Singhal V, Lawson EA, Ackerman KE, Fazeli PK, Clarke H, Lee H, Eddy K, Marengi DA, Derrico NP, Bouxsein ML, Misra M. Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates. PLoS One. 2014; 9(6):e100218. PMID: 24926783; PMCID: PMC4057451.
    Citations: 13     Fields:    Translation:Humans
  21. Fazeli PK, Klibanski A. Anorexia nervosa and bone metabolism. Bone. 2014 Sep; 66:39-45. PMID: 24882734; PMCID: PMC4125514.
    Citations: 3     Fields:    Translation:Humans
  22. Fazeli PK, Klibanski A. Bone metabolism in anorexia nervosa. Curr Osteoporos Rep. 2014 Mar; 12(1):82-9. PMID: 24419863; PMCID: PMC3936314.
    Citations: 8     Fields:    Translation:Humans
  23. Fazeli PK, Klibanski A. Determinants of GH resistance in malnutrition. J Endocrinol. 2014 Mar; 220(3):R57-65. PMID: 24363451; PMCID: PMC3994591.
    Citations: 10     Fields:    Translation:Humans
  24. Fazeli PK, Wang IS, Miller KK, Herzog DB, Misra M, Lee H, Finkelstein JS, Bouxsein ML, Klibanski A. Teriparatide increases bone formation and bone mineral density in adult women with anorexia nervosa. J Clin Endocrinol Metab. 2014 Apr; 99(4):1322-9. PMID: 24456286; PMCID: PMC3973785.
    Citations: 16     Fields:    Translation:Humans
  25. Faje AT, Fazeli PK, Miller KK, Katzman DK, Ebrahimi S, Lee H, Mendes N, Snelgrove D, Meenaghan E, Misra M, Klibanski A. Fracture risk and areal bone mineral density in adolescent females with anorexia nervosa. Int J Eat Disord. 2014 Jul; 47(5):458-66. PMID: 24430890.
    Citations: 28     Fields:    Translation:Humans
  26. Parke E, Hart J, Baldock D, Barchard K, Etcoff L, Allen D, Stolberg P, Nardi N, Cohen J, Jones W, Loe S, Etcoff L, Delgaty L, Tan A, Bunner M, Delgaty L, Tan A, Bunner M, Tan A, Delgaty L, Bunner M, Tan A, Delgaty L, Bunner M, Goodman G, Kim W, Nolty A, Marion S, Davis A, Finch W, Piehl J, Moss L, Nogin R, Dean R, Davis J, Lindstrom W, Poon M, Fonseca F, Bure-Reyes A, Stewart J, Golden C, Fonseca F, Bure-Reyes A, Stewart J, Golden C, Fields K, Hill B, Corley E, Russ K, Boettcher A, Musso M, Rohling M, Rowden A, Downing K, Benners M, Miller D, Maricle D, Dugbartey T, Anum A, Anderson J, Daniel M, Hoskins L, Gillis K, Khen S, Carter K, Ayers C, Neeland I, Cullum M, Weiner M, Rossetti H, Buddin W, Mahal S, Schroeder R, Baade L, Macaluso M, Phelps K, Evans C, Clark J, Vickery C, Chow J, Stokic D, Phelps K, Evans C, Watson S, Odom R, Clark J, Clark J, Odom R, Evans C, Vickery C, Thompson J, Noggle C, Kane C, Kecala N, Lane E, Raymond M, Woods S, Iudicello J, Dawson M, Ghias A, Ellis R, Grant I, Weber E, Woods S, Atkinson J, Grant I, Uderman J, Miele A, Rabinovitz B, Schaffer S, Burns W, Olivier T, Shapiro E, Schleicher-Dilks S, Andrews P, Fontanetta R, Demsky Y, Burns K, Sakamoto M, Woods S, Loftis J, Huckans M, Musso M, Westervelt H, Long J, Morgan E, Woods S, Smith M, Paulsen J, Hahn-Ketter A, Paxton J, Fink J, Kelley K, Lee R, Pliskin N, Segalà L, Vasilev G, Bozgunov K, Naslednikova R, Raynov I, Gonzalez R, Vassileva J, Bonilla X, Fedio A, Johnson K, Sexton J, Blackstone K, Weber E, Moore D, Grant I, Woods S, Pimental P, Welch M, Ring M, Stranks E, Crowe S, Jaehnert S, Ellis C, Prince C, Wheaton V, Schwartz D, Loftis J, Fuller B, Hoffman W, Huckans M, Turecka S, McKeever J, Morse C, Schultheis M, Dinishak D, Dasher N, Vik P, Hachey D, Bowman B, Van Ness E, Williams C, Zamzow J, Sunderaraman P, Kloss J, Spiers M, Swirsky-Sacchetti T, Alhassoon O, Taylor M, Sorg S, Schweinsburg B, Stricker N, Kimmel C, Grant I, Alhassoon O, Taylor M, Sorg S, Schweinsburg B, Stephan R, Stricker N, Grant I, Hertza J, Tyson K, Northington S, Loughan A, Perna R, Davis A, Collier M, Schroeder R, Buddin W, Schroeder R, Moore C, Andrew W, Ghelani A, Kim J, Curri M, Patel S, Denney D, Taylor S, Huberman S, Greenberg B, Lacritz L, Brown D, Hughes S, Greenberg B, Lacritz L, Vargas V, Upshaw N, Whigham K, Peery S, Casto B, Barker L, Otero T, La D, Nunan-Saah J, Phoong M, Gill S, Melville T, Harley A, Gomez R, Adler M, Tsou J, Schleicher-Dilks S, Golden C, Tsou J, Schleicher-Dilks S, Adler M, Golden C, Cowad S, Link J, Barker T, Gulliver K, Golden C, Young K, Moses J, Lum J, Vik P, Legarreta M, Van Ness E, Williams C, Dasher N, Williams C, Vik P, Dasher N, Van Ness E, Bowman B, Nakhutina L, Margolis S, Baek R, Gonzalez J, Hill F, England H, Horne-Moyer L, Stringer A, Defilippis N, Lyon A, Giovannetti T, Fanning M, Heverly-Fitt S, Stambrook E, Price C, Selnes O, Floyd T, Vogt E, Thiruselvam I, Quasney E, Hoelzle J, Grant N, Moses J, Matevosyan A, Delano-Wood L, Alhassoon O, Hanson K, Lanni E, Luc N, Kim R, Schiehser D, Benners M, Downing K, Rowden A, Miller D, Maricle D, Kaminetskaya M, Moses J, Tai C, Kaminetskaya M, Melville T, Poole J, Scott R, Hays F, Walsh B, Mihailescu C, Douangratdy M, Scott B, Draffkorn C, Andrews P, Schmitt A, Waksmunski C, Brady K, Andrews A, Golden C, Olivier T, Espinoza K, Sterk V, Spengler K, Golden C, Olivier T, Spengler K, Sterk V, Espinoza K, Golden C, Gross J, Defilippis N, Neiman-Kimel J, Romers C, Isaacs C, Soper H, Sordahl J, Tai C, Moses J, D'Orio V, Glukhovsky L, Beier M, Shuman M, Spat J, Foley F, Guatney L, Bott N, Moses J, Miranda C, Rentería MA, Rosario A, Sheynin J, Fuentes A, Byrd D, Mindt MR, Batchelor E, Meyers J, Patt V, Thomas M, Minassian A, Geyer M, Brown G, Perry W, Smith C, Kiefel J, Rooney A, Gouaux B, Ellis R, Grant I, Moore D, Graefe A, Wyman-Chick K, Daniel M, Beene K, Jaehnert S, Choi A, Moses J, Iudicello J, Henry B, Minassian A, Perry W, Marquine M, Morgan E, Letendre S, Ellis R, Woods S, et al. Poster sessions schedule. Arch Clin Neuropsychol. 2013 Sep; 28(6):518-626. PMID: 23973776.
    Citations:    
  27. Faje AT, Fazeli PK, Katzman D, Miller KK, Breggia A, Rosen CJ, Mendes N, Misra M, Klibanski A. Inhibition of Pref-1 (preadipocyte factor 1) by oestradiol in adolescent girls with anorexia nervosa is associated with improvement in lumbar bone mineral density. Clin Endocrinol (Oxf). 2013 Sep; 79(3):326-32. PMID: 23331192.
    Citations: 9     Fields:    Translation:HumansCells
  28. Fazeli PK, Ackerman KE, Pierce L, Guereca G, Bouxsein M, Misra M. Sclerostin and Pref-1 have differential effects on bone mineral density and strength parameters in adolescent athletes compared with non-athletes. Osteoporos Int. 2013 Sep; 24(9):2433-40. PMID: 23579340.
    Citations: 9     Fields:    Translation:Humans
  29. Fazeli PK, Horowitz MC, MacDougald OA, Scheller EL, Rodeheffer MS, Rosen CJ, Klibanski A. Marrow fat and bone--new perspectives. J Clin Endocrinol Metab. 2013 Mar; 98(3):935-45. PMID: 23393168; PMCID: PMC3590487.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  30. Fazeli PK, Mendes N, Russell M, Herzog DB, Klibanski A, Misra M. Bone density characteristics and major depressive disorder in adolescents. Psychosom Med. 2013 Feb; 75(2):117-23. PMID: 23362498; PMCID: PMC3570708.
    Citations: 3     Fields:    Translation:Humans
  31. Bredella MA, Fazeli PK, Lecka-Czernik B, Rosen CJ, Klibanski A. IGFBP-2 is a negative predictor of cold-induced brown fat and bone mineral density in young non-obese women. Bone. 2013 Apr; 53(2):336-9. PMID: 23291564; PMCID: PMC3594375.
    Citations: 9     Fields:    Translation:Humans
  32. Lawson EA, Fazeli PK, Calder G, Putnam H, Misra M, Meenaghan E, Miller KK, Klibanski A. Plasma sodium level is associated with bone loss severity in women with anorexia nervosa: a cross-sectional study. J Clin Psychiatry. 2012 Nov; 73(11):e1379-83. PMID: 23218167.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  33. Fazeli PK, Bredella MA, Freedman L, Thomas BJ, Breggia A, Meenaghan E, Rosen CJ, Klibanski A. Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa. J Bone Miner Res. 2012 Sep; 27(9):1864-71. PMID: 22508185.
    Citations: 34     Fields:    Translation:Humans
  34. Holsen LM, Lawson EA, Blum J, Ko E, Makris N, Fazeli PK, Klibanski A, Goldstein JM. Food motivation circuitry hypoactivation related to hedonic and nonhedonic aspects of hunger and satiety in women with active anorexia nervosa and weight-restored women with anorexia nervosa. J Psychiatry Neurosci. 2012 Sep; 37(5):322-32. PMID: 22498079; PMCID: PMC3447131.
    Citations: 26     Fields:    Translation:Humans
  35. Fazeli PK, Calder GL, Miller KK, Misra M, Lawson EA, Meenaghan E, Lee H, Herzog D, Klibanski A. Psychotropic medication use in anorexia nervosa between 1997 and 2009. Int J Eat Disord. 2012 Dec; 45(8):970-6. PMID: 22733643; PMCID: PMC3726215.
    Citations: 10     Fields:    Translation:Humans
  36. Faje AT, Fazeli PK, Katzman DK, Miller KK, Breggia A, Rosen CJ, Mendes N, Klibanski A, Misra M. Sclerostin levels and bone turnover markers in adolescents with anorexia nervosa and healthy adolescent girls. Bone. 2012 Sep; 51(3):474-9. PMID: 22728230.
    Citations: 11     Fields:    Translation:Humans
  37. Fazeli PK, Klibanski A. Neuroendocrine dysregulation and the growth hormone-IGF-1 axis in anorexia nervosa. Expert Rev Endocrinol Metab. 2012 Mar; 7(2):223-231. PMID: 30764013.
    Citations:    
  38. Bredella MA, Fazeli PK, Freedman LM, Calder G, Lee H, Rosen CJ, Klibanski A. Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women. J Clin Endocrinol Metab. 2012 Apr; 97(4):E584-90. PMID: 22259053; PMCID: PMC3319179.
    Citations: 38     Fields:    Translation:Humans
  39. Walsh CJ, Phan CM, Misra M, Bredella MA, Miller KK, Fazeli PK, Bayraktar HH, Klibanski A, Gupta R. Women with anorexia nervosa: finite element and trabecular structure analysis by using flat-panel volume CT. Radiology. 2010 Oct; 257(1):167-74. PMID: 20713613.
    Citations: 20     Fields:    Translation:Humans
  40. Fazeli PK, Lawson EA, Prabhakaran R, Miller KK, Donoho DA, Clemmons DR, Herzog DB, Misra M, Klibanski A. Effects of recombinant human growth hormone in anorexia nervosa: a randomized, placebo-controlled study. J Clin Endocrinol Metab. 2010 Nov; 95(11):4889-97. PMID: 20668047.
    Citations: 28     Fields:    Translation:Humans
  41. Wexler TL, Durst R, McCarty D, Picard MH, Gunnell L, Omer Z, Fazeli P, Miller KK, Klibanski A. Growth hormone status predicts left ventricular mass in patients after cure of acromegaly. Growth Horm IGF Res. 2010 Oct; 20(5):333-7. PMID: 20598930; PMCID: PMC3670701.
    Citations: 3     Fields:    Translation:Humans
  42. Brick DJ, Gerweck AV, Meenaghan E, Lawson EA, Misra M, Fazeli P, Johnson W, Klibanski A, Miller KK. Determinants of IGF1 and GH across the weight spectrum: from anorexia nervosa to obesity. Eur J Endocrinol. 2010 Aug; 163(2):185-91. PMID: 20501597; PMCID: PMC2953770.
    Citations: 13     Fields:    Translation:Humans
  43. Miller KK, Wexler T, Fazeli P, Gunnell L, Graham GJ, Beauregard C, Hemphill L, Nachtigall L, Loeffler J, Swearingen B, Biller BM, Klibanski A. Growth hormone deficiency after treatment of acromegaly: a randomized, placebo-controlled study of growth hormone replacement. J Clin Endocrinol Metab. 2010 Feb; 95(2):567-77. PMID: 20061426; PMCID: PMC2840863.
    Citations: 14     Fields:    Translation:Humans
  44. Fazeli PK, Misra M, Goldstein M, Miller KK, Klibanski A. Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa. J Clin Endocrinol Metab. 2010 Jan; 95(1):369-74. PMID: 19926712.
    Citations: 26     Fields:    Translation:Humans
  45. Fazeli PK, Bredella MA, Misra M, Meenaghan E, Rosen CJ, Clemmons DR, Breggia A, Miller KK, Klibanski A. Preadipocyte factor-1 is associated with marrow adiposity and bone mineral density in women with anorexia nervosa. J Clin Endocrinol Metab. 2010 Jan; 95(1):407-13. PMID: 19850693.
    Citations: 33     Fields:    Translation:Humans
  46. Bredella MA, Fazeli PK, Miller KK, Misra M, Torriani M, Thomas BJ, Ghomi RH, Rosen CJ, Klibanski A. Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab. 2009 Jun; 94(6):2129-36. PMID: 19318450; PMCID: PMC2690416.
    Citations: 111     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.