Harvard Catalyst Profiles

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Jaclyn LoPiccolo, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lopiccolo J, Kawabata S, Gills JJ, Dennis PA. Combining Nelfinavir With Chloroquine Inhibits In Vivo Growth of Human Lung Cancer Xenograft Tumors. In Vivo. 2021 Jan-Feb; 35(1):141-145. PMID: 33402459; PMCID: PMC7880743.
    Citations: 2     Fields:    Translation:HumansCells
  2. LoPiccolo J, Schollenberger MD, Dakhil S, Rosner S, Ali O, Sharfman WH, Silk AW, Bhatia S, Lipson EJ. Rescue therapy for patients with anti-PD-1-refractory Merkel cell carcinoma: a multicenter, retrospective case series. J Immunother Cancer. 2019 07 08; 7(1):170. PMID: 31287031.
    Citations: 11     Fields:    Translation:Humans
  3. LoPiccolo J, Brener MI, Oshima K, Lipson EJ, Hamilton JP. Nodular Regenerative Hyperplasia Associated With Immune Checkpoint Blockade. Hepatology. 2018 12; 68(6):2431-2433. PMID: 30014512.
    Citations: 3     Fields:    Translation:Humans
  4. LoPiccolo J, Mehta SA, Lipson EJ. Corticosteroid Use and Pneumocystis Pneumonia Prophylaxis: A Teachable Moment. JAMA Intern Med. 2018 Aug 01; 178(8):1106-1107. PMID: 29913012.
    Citations: 2     Fields:    Translation:HumansAnimals
  5. Erami Z, Khalil BD, Salloum G, Yao Y, LoPiccolo J, Shymanets A, Nürnberg B, Bresnick AR, Backer JM. Rac1-stimulated macropinocytosis enhances Gß? activation of PI3Kß. Biochem J. 2017 11 16; 474(23):3903-3914. PMID: 29046393; PMCID: PMC5858185.
    Citations: 12     Fields:    Translation:HumansCells
  6. LoPiccolo J, Kim SJ, Shi Y, Wu B, Wu H, Chait BT, Singer RH, Sali A, Brenowitz M, Bresnick AR, Backer JM. Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85a Homodimer. J Biol Chem. 2015 Dec 18; 290(51):30390-405. PMID: 26475863.
    Citations: 11     Fields:    Translation:HumansCells
  7. Shymanets A, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B. Different inhibition of Gß?-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gß?-dependent regulator of PI3K? enzymatic activity. Biochem J. 2015 Jul 01; 469(1):59-69. PMID: 26173259; PMCID: PMC4655608.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Salamon RS, Dbouk HA, Collado D, Lopiccolo J, Bresnick AR, Backer JM. Identification of the Rab5 binding site in p110ß: assays for PI3Kß binding to Rab5. Methods Mol Biol. 2015; 1298:271-81. PMID: 25800850; PMCID: PMC4440688.
    Citations: 9     Fields:    Translation:HumansCells
  9. Blumenthal GM, Gills JJ, Ballas MS, Bernstein WB, Komiya T, Dechowdhury R, Morrow B, Root H, Chun G, Helsabeck C, Steinberg SM, LoPiccolo J, Kawabata S, Gardner ER, Figg WD, Dennis PA. A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors. Oncotarget. 2014 Sep 30; 5(18):8161-72. PMID: 25327558.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  10. Granville CA, Memmott RM, Balogh A, Mariotti J, Kawabata S, Han W, Lopiccolo J, Foley J, Liewehr DJ, Steinberg SM, Fowler DH, Hollander MC, Dennis PA. A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. PLoS One. 2009; 4(3):e5061. PMID: 19330036; PMCID: PMC2659439.
    Citations: 37     Fields:    Translation:AnimalsCells
  11. LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA. Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat. 2008 Feb-Apr; 11(1-2):32-50. PMID: 18166498; PMCID: PMC2442829.
    Citations: 311     Fields:    Translation:HumansAnimalsCells
  12. Gills JJ, Lopiccolo J, Dennis PA. Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy. Autophagy. 2008 Jan; 4(1):107-9. PMID: 18000394.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  13. LoPiccolo J, Granville CA, Gills JJ, Dennis PA. Targeting Akt in cancer therapy. Anticancer Drugs. 2007 Sep; 18(8):861-74. PMID: 17667591.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  14. Gills JJ, Lopiccolo J, Tsurutani J, Shoemaker RH, Best CJ, Abu-Asab MS, Borojerdi J, Warfel NA, Gardner ER, Danish M, Hollander MC, Kawabata S, Tsokos M, Figg WD, Steeg PS, Dennis PA. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin Cancer Res. 2007 Sep 01; 13(17):5183-94. PMID: 17785575.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  15. Lopiccolo J, Ballas MS, Dennis PA. PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development. Crit Rev Oncol Hematol. 2007 Sep; 63(3):203-14. PMID: 17643312.
    Citations: 6     Fields:    Translation:HumansCells
  16. Tsurutani J, Steinberg SM, Ballas M, Robertson M, LoPiccolo J, Soda H, Kohno S, Egilsson V, Dennis PA. Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. Lung Cancer. 2007 Jan; 55(1):115-21. PMID: 17097759.
    Citations: 13     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.