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Gilles Philippe Berger, Ph.D.

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Biography
Université Libre de Bruxelles, Brussels, BelgiumB.Sc.06/2001Pharmaceutical Sciences
Université Libre de Bruxelles, Brussels, BelgiumPharm.D.06/2005Pharmaceutical Sciences
Université Libre de Bruxelles, Brussels, BelgiumPh.D.12/2013Medicinal Chemistry
Université de Montréal, Montreal, CanadaPost-doc01/2015Organic and Theoretical Chemistry
Massachusetts Institute of Technology, Cambridge, MAPost-doc01/2017Chemistry and Cancer Biology
2010
Best scientific communication - PhD Day, Belgium
2011
UCB-Pharma Award - Medicinal Chemistry Days, Belgium
2015
BAEF and Hoover Foundation Fellow
2015
Fulbright Scholar Award
2016
UCB-Servier Young Investigator Award - Pharmaceutical Chemistry
2018
Research Fellow of the Belgian Science Foundation (FRS-FNRS)

Overview
Chemist and pharmacist with broad interest in organic and theoretical chemistry, drug discovery and design, biomedical sciences and oncology. Over ten-years of hands-on experience in synthetic and computational chemistry, in vitro assays related to drug development, drug delivery and nanotechnologies. Involved in project management and mentoring and in depth experience in collaborative and multi-disciplinary projects, with a proven track record of publications in all these fields, in collaboration with research groups from all around Europe, Canada and the US. Developed in the recent years as a translational scientist, allowing the use of complementary multi-disciplinary skills toward the advancement of fundamental projects as well as in applications such as drug discovery, as evidenced by numerous publications aimed at developing novel anticancer medicines and other agents including peroxidase inhibitors and anti-tuberculosis compounds.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Berger G, Frangville P, Meyer F. Halogen bonding for molecular recognition: new developments in materials and biological sciences. Chem Commun (Camb). 2020 May 07; 56(37):4970-4981. PMID: 32297598.
    Citations:    
  2. Hocine S, Berger G, Hanessian S . Design and Synthesis of Backbone-Fused, Conformationally Constrained Morpholine-Proline Chimeras. The Journal of Organic Chemistry. 2020. View Publication.
  3. Berger G. Pharmaceutical patent landscape for cancer immunotherapy: an interview with Gilles Berger. Pharm Pat Anal. 2019 Sep; 8(5):163-164. PMID: 31612797.
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  4. Yang D, Vandenbussche G, Vertommen D, Evrard D, Abskharon R, Cavalier JF, Berger G, Canaan S, Khan MS, Zeng S, Wohlkönig A, Prévost M, Soumillion P, Fontaine V. Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility. FEBS Lett. 2020 Jan; 594(1):79-93. PMID: 31388991.
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  5. Marloye M, Lawler SE, Berger G. Current patent and clinical status of stimulator of interferon genes (STING) agonists for cancer immunotherapy. Pharm Pat Anal. 2019 07; 8(4):87-90. PMID: 31354104.
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  6. Kim JH, Mertens RT, Agarwal A, Parkin S, Berger G, Awuah SG. Direct intramolecular carbon(sp2)-nitrogen(sp2) reductive elimination from gold(iii). Dalton Trans. 2019 May 07; 48(18):6273-6282. PMID: 30989158.
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  7. Berger G, Marloye M, Lawler SE. Pharmacological Modulation of the STING Pathway for Cancer Immunotherapy. Trends Mol Med. 2019 05; 25(5):412-427. PMID: 30885429.
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  8. Berger G, Lawler SE. Novel non-nucleotidic STING agonists for cancer immunotherapy. Future Med Chem. 2018 12; 10(24):2767-2769. PMID: 30526033.
    Citations:    Fields:    
  9. Vernekar AA, Berger G, Czapar AE, Veliz FA, Wang DI, Steinmetz NF, Lippard SJ. Speciation of Phenanthriplatin and Its Analogs in the Core of Tobacco Mosaic Virus. J Am Chem Soc. 2018 03 28; 140(12):4279-4287. PMID: 29553267.
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  10. Berger, G.; Soubhye, J.; Robijns, K.; Meyer, F. Crystal packing and theoretical analysis of halogen- and hydrogen-bonded hydrazones from pharmaceuticals. Acta Cryst. 2018; B74:618-627. View Publication.
  11. Berger G, Grauwet K, Zhang H, Hussey AM, Nowicki MO, Wang DI, Chiocca EA, Lawler SE, Lippard SJ. Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models. Cancer Lett. 2018 03 01; 416:138-148. PMID: 29246647.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Chen, B.; Berger, G; Hanessian, S. Metal Coordination Controlled and Bifunctional H-Bonded Catalysis in Stereoselective Intramolecular Aldol Cyclizations toward Carbocyclic Tertiary ß-Ketols. Eur. J. Org. Chem. 2017; (18):2631-2636. View Publication.
  13. Chikh Alard, I.; Soubhye, J.; Berger, G.; Gelbcke, M.; Spassov, S.; Amighi, K.; Goole, J.; Meyer, F. Triple-stimuli responsive polymers with fine tuneable magnetic responses. Polym. Chem. 2017; 8(16):2450-2456. View Publication.
  14. Berger, G.; Chab-Majdalani, I.; Hanessian, S. Properties of the Amide Bond Involving Proline 4,5-methanologues: an Experimental and Theoretical Study. Isr. J. Chem. 2016; 57(3-4):292-302. View Publication.
  15. Marloye M, Berger G, Gelbcke M, Dufrasne F. A survey of the mechanisms of action of anticancer transition metal complexes. Future Med Chem. 2016 12; 8(18):2263-2286. PMID: 27874280.
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  16. Levet V, Rosière R, Merlos R, Fusaro L, Berger G, Amighi K, Wauthoz N. Development of controlled-release cisplatin dry powders for inhalation against lung cancers. Int J Pharm. 2016 Dec 30; 515(1-2):209-220. PMID: 27737810.
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  17. Aldib I, Gelbcke M, Soubhye J, Prévost M, Furtmüller PG, Obinger C, Elfving B, Alard IC, Roos G, Delporte C, Berger G, Dufour D, Zouaoui Boudjeltia K, Nève J, Dufrasne F, Van Antwerpen P. Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study. Eur J Med Chem. 2016 Nov 10; 123:746-762. PMID: 27537923.
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  18. Chattopadhyay AK, Berger G, Hanessian S. Strategies toward the Total Synthesis of Calyciphylline B-type Alkaloids: A Computational Perspective Aided by DFT Analysis. J Org Chem. 2016 06 17; 81(12):5074-86. PMID: 27251014.
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  19. Sá J, Czapla-Masztafiak J, Lipiec E, Kayser Y, Fernandes DL, Szlachetko J, Dufrasne F, Berger G. Resonant X-ray emission spectroscopy of platinum(II) anticancer complexes. Analyst. 2016 Feb 21; 141(4):1226-32. PMID: 26805912.
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  20. Chattopadhyay AK, Ly VL, Jakkepally S, Berger G, Hanessian S. Total Synthesis of Isodaphlongamine H: A Possible Biogenetic Conundrum. Angew Chem Int Ed Engl. 2016 Feb 12; 55(7):2577-81. PMID: 26765928.
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  21. Berger, G.; Robeyns, K.; Soubhye, J.; Wintjens, R.; Meyer, F. Halogen bonding in a multi-connected 1,2,2-triiodo-alkene involving geminal and/or vicinal iodines: a crystallographic and DFT study. CrystEngComm. 2015; 18(5):683-690. View Publication.
  22. Berger G, Vilchis-Reyes M, Hanessian S. Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano-L-Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer. Angew Chem Int Ed Engl. 2015 Nov 02; 54(45):13268-72. PMID: 26346999.
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  23. Sá J, Czapla-Masztafiak J, Lipiec E, Kayser Y, Kwiatek W, Wood B, Deacon GB, Berger G, Dufrasne F, Fernandes DL, Szlachetko J. The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules. Drug Discov Today Technol. 2015 Sep; 16:1-6. PMID: 26547415.
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  24. Berger G, Fusaro L, Luhmer M, Czapla-Masztafiak J, Lipiec E, Szlachetko J, Kayser Y, Fernandes DL, Sá J, Dufrasne F, Bombard S. Insights into the structure-activity relationships of chiral 1,2-diaminophenylalkane platinum(II) anticancer derivatives. J Biol Inorg Chem. 2015 Jul; 20(5):841-53. PMID: 25982100.
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  25. Berger, G.; Soubhye, J.; Meyer, F. Halogen bonding in polymer science: from crystal engineering to functional supramolecular polymers and materials . Polym. Chem. 2015; 6(19):3559-3580 . View Publication.
  26. Berger, G.; Fusaro, L.; Luhmer, M.; van der Lee, A.; Crousse, B.; Meyer, F. Synthesis of a-CF3 azanorbornene and azetidines by aza Diels-Alder or iodine-mediated cyclizations: application in ROMP and ligand design. Tetrahedron Lett. 2014; 55(46):6339-6342. View Publication.
  27. Berger, G.; Wintjens, R.; Meyer, F. Targets in Heterocyclic Systems. 2014; 29-47.
  28. Berger G, Leclercqz H, Derenne A, Gelbcke M, Goormaghtigh E, Nève J, Mathieu V, Dufrasne F. Synthesis and in vitro characterization of platinum(II) anticancer coordinates using FTIR spectroscopy and NCI COMPARE: A fast method for new compound discovery. Bioorg Med Chem. 2014 Jul 01; 22(13):3527-36. PMID: 24818960.
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  29. Berger, G.; Soubhye, J.; van der Lee, A.; Vande Velde, C.; Wintjens, R.; Dubois, P.; Clément, S.; Meyer, F. Interplay between Halogen Bonding and Lone Pair–p Interactions: A Computational and Crystal Packing Study. ChemPlusChem. 2014; 79(4):552-558. View Publication.
  30. Berger, G. Using conceptual density functional theory to rationalize regioselectivity: A case study on the nucleophilic ring-opening of activated aziridines. Comput. Theor. Chem. 2013; 1010:11-18. View Publication.
  31. Berger, G.; Gelbcke, M.; Cauët, E.; Luhmer, M.; Nève, J.; Dufrasne, F. Synthesis of 15N-labeled vicinal diamines through N-activated chiral aziridines: tools for the NMR study of platinum-based anticancer compounds. Tetrahedron Lett. 2013; 54(6):545-548. View Publication.
  32. Berger G, Gasper R, Lamoral-Theys D, Wellner A, Gelbcke M, Gust R, Nève J, Kiss R, Goormaghtigh E, Dufrasne F. Fourier transform infrared (FTIR) spectroscopy to monitor the cellular impact of newly synthesized platinum derivatives. Int J Oncol. 2010 Sep; 37(3):679-86. PMID: 20664937.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.