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Sondra Downey-Kopyscinski, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Downey-Kopyscinski S, Daily EW, Gautier M, Bhatt A, Florea BI, Mitsiades CS, Richardson PG, Driessen C, Overkleeft HS, Kisselev AF. An inhibitor of proteasome ß2 sites sensitizes myeloma cells to immunoproteasome inhibitors. Blood Adv. 2018 10 09; 2(19):2443-2451. PMID: 30266819.
    Citations:    
  2. Allaway RJ, Wood MD, Downey SL, Bouley SJ, Traphagen NA, Wells JD, Batra J, Melancon SN, Ringelberg C, Seibel W, Ratner N, Sanchez Y. Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells. Oncotarget. 2018 Mar 23; 9(22):15860-15875. PMID: 29662612.
    Citations:    
  3. Downey SL, Florea BI, Overkleeft HS, Kisselev AF. Use of proteasome inhibitors. Curr Protoc Immunol. 2015 Apr 01; 109:9.10.1-9.10.8. PMID: 25845565.
    Citations:    
  4. Wilkins OM, Downey SL, Weyburne ES, Williams DA, Mirabella AC, Overkleeft HS, Kisselev AF. Cell-line-specific high background in the Proteasome-Glo assay of proteasome trypsin-like activity. Anal Biochem. 2014 Apr 15; 451:1-3. PMID: 24486333.
    Citations:    
  5. Shabaneh TB, Downey SL, Goddard AL, Screen M, Lucas MM, Eastman A, Kisselev AF. Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib. PLoS One. 2013; 8(2):e56132. PMID: 23460792.
    Citations:    
  6. Cherukuri P, DeCastro AJ, Balboni AL, Downey SL, Liu JY, Hutchinson JA, DiRenzo J. Phosphorylation of ?Np63a via a novel TGFß/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFß. PLoS One. 2012; 7(11):e50066. PMID: 23166821.
    Citations: 2     Fields:    Translation:HumansCells
  7. Mirabella AC, Pletnev AA, Downey SL, Florea BI, Shabaneh TB, Britton M, Verdoes M, Filippov DV, Overkleeft HS, Kisselev AF. Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib. Chem Biol. 2011 May 27; 18(5):608-18. PMID: 21609842.
    Citations:    
  8. Screen M, Britton M, Downey SL, Verdoes M, Voges MJ, Blom AE, Geurink PP, Risseeuw MD, Florea BI, van der Linden WA, Pletnev AA, Overkleeft HS, Kisselev AF. Nature of pharmacophore influences active site specificity of proteasome inhibitors. J Biol Chem. 2010 Dec 17; 285(51):40125-34. PMID: 20937826.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  9. Geurink PP, Liu N, Spaans MP, Downey SL, van den Nieuwendijk AM, van der Marel GA, Kisselev AF, Florea BI, Overkleeft HS. Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites. J Med Chem. 2010 Mar 11; 53(5):2319-23. PMID: 20131905.
    Citations:    
  10. Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF. Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites. Chem Biol. 2009 Dec 24; 16(12):1278-89. PMID: 20064438.
    Citations: 46     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.