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Sondra Downey-Kopyscinski, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sanderson MP, Friese-Hamim M, Walter-Bausch G, Busch M, Gaus S, Musil D, Rohdich F, Zanelli U, Downey-Kopyscinski SL, Mitsiades CS, Schadt O, Klein M, Esdar C. M3258 is a selective inhibitor of the immunoproteasome subunit LMP7 (ß5i) delivering efficacy in multiple myeloma models. Mol Cancer Ther. 2021 May 27. PMID: 34045234.
    Citations:    Fields:    
  2. Jenkins TW, Downey-Kopyscinski SL, Fields JL, Rahme GJ, Colley WC, Israel MA, Maksimenko AV, Fiering SN, Kisselev AF. Activity of immunoproteasome inhibitor ONX-0914 in acute lymphoblastic leukemia expressing MLL-AF4 fusion protein. Sci Rep. 2021 May 25; 11(1):10883. PMID: 34035431.
    Citations:    Fields:    
  3. Shirasaki R, Matthews GM, Gandolfi S, de Matos Simoes R, Buckley DL, Raja Vora J, Sievers QL, Brüggenthies JB, Dashevsky O, Poarch H, Tang H, Bariteau MA, Sheffer M, Hu Y, Downey-Kopyscinski SL, Hengeveld PJ, Glassner BJ, Dhimolea E, Ott CJ, Zhang T, Kwiatkowski NP, Laubach JP, Schlossman RL, Richardson PG, Culhane AC, Groen RWJ, Fischer ES, Vazquez F, Tsherniak A, Hahn WC, Levy J, Auclair D, Licht JD, Keats JJ, Boise LH, Ebert BL, Bradner JE, Gray NS, Mitsiades CS. Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Cell Rep. 2021 01 05; 34(1):108532. PMID: 33406420.
    Citations:    Fields:    
  4. Downey-Kopyscinski S, Daily EW, Gautier M, Bhatt A, Florea BI, Mitsiades CS, Richardson PG, Driessen C, Overkleeft HS, Kisselev AF. An inhibitor of proteasome ß2 sites sensitizes myeloma cells to immunoproteasome inhibitors. Blood Adv. 2018 10 09; 2(19):2443-2451. PMID: 30266819.
    Citations: 4     Fields:    Translation:HumansAnimals
  5. Allaway RJ, Wood MD, Downey SL, Bouley SJ, Traphagen NA, Wells JD, Batra J, Melancon SN, Ringelberg C, Seibel W, Ratner N, Sanchez Y. Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells. Oncotarget. 2018 Mar 23; 9(22):15860-15875. PMID: 29662612.
    Citations:    Fields:    
  6. Downey SL, Florea BI, Overkleeft HS, Kisselev AF. Use of proteasome inhibitors. Curr Protoc Immunol. 2015 Apr 01; 109:9.10.1-9.10.8. PMID: 25845565.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Wilkins OM, Downey SL, Weyburne ES, Williams DA, Mirabella AC, Overkleeft HS, Kisselev AF. Cell-line-specific high background in the Proteasome-Glo assay of proteasome trypsin-like activity. Anal Biochem. 2014 Apr 15; 451:1-3. PMID: 24486333.
    Citations:    Fields:    Translation:HumansCells
  8. Shabaneh TB, Downey SL, Goddard AL, Screen M, Lucas MM, Eastman A, Kisselev AF. Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib. PLoS One. 2013; 8(2):e56132. PMID: 23460792.
    Citations: 21     Fields:    Translation:HumansCells
  9. Cherukuri P, DeCastro AJ, Balboni AL, Downey SL, Liu JY, Hutchinson JA, DiRenzo J. Phosphorylation of ?Np63a via a novel TGFß/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFß. PLoS One. 2012; 7(11):e50066. PMID: 23166821.
    Citations: 4     Fields:    Translation:HumansCells
  10. Mirabella AC, Pletnev AA, Downey SL, Florea BI, Shabaneh TB, Britton M, Verdoes M, Filippov DV, Overkleeft HS, Kisselev AF. Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib. Chem Biol. 2011 May 27; 18(5):608-18. PMID: 21609842.
    Citations: 36     Fields:    Translation:HumansCells
  11. Screen M, Britton M, Downey SL, Verdoes M, Voges MJ, Blom AE, Geurink PP, Risseeuw MD, Florea BI, van der Linden WA, Pletnev AA, Overkleeft HS, Kisselev AF. Nature of pharmacophore influences active site specificity of proteasome inhibitors. J Biol Chem. 2010 Dec 17; 285(51):40125-34. PMID: 20937826.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  12. Geurink PP, Liu N, Spaans MP, Downey SL, van den Nieuwendijk AM, van der Marel GA, Kisselev AF, Florea BI, Overkleeft HS. Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites. J Med Chem. 2010 Mar 11; 53(5):2319-23. PMID: 20131905.
    Citations: 7     Fields:    Translation:Cells
  13. Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF. Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites. Chem Biol. 2009 Dec 24; 16(12):1278-89. PMID: 20064438.
    Citations: 57     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.