Harvard Catalyst Profiles

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Matthew J Emmett, Ph.D., M.D.


Johns Hopkins UniversityBABiology, Bioethics
Johns Hopkins UniversityMSMolecular and Cellular Biology
University of PennsylvaniaPhDCell and Molecular Biology
University of PennsylvaniaMDMedicine
Massachusetts General HospitalResident, Internal Medicine
Dana-Farber, Mass GeneralHematology-Oncology

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F30DK104513 (EMMETT, MATTHEW J) Aug 28, 2014 - Aug 27, 2017
    Control of Brown Adipose Physiology Via Genomic Recruitment of Histone Deacetylase 3
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Richter HJ, Hauck AK, Batmanov K, Inoue SI, So BN, Kim M, Emmett MJ, Cohen RN, Lazar MA. Balanced control of thermogenesis by nuclear receptor corepressors in brown adipose tissue. Proc Natl Acad Sci U S A. 2022 08 16; 119(33):e2205276119. PMID: 35939699; PMCID: PMC9388101.
    Citations: 1     Fields:    Translation:Animals
  2. Santoleri D, Lim HW, Emmett MJ, Stoute J, Gavin MJ, Sostre-Colón J, Uehara K, Welles JE, Liu KF, Lazar MA, Titchenell PM. Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity. iScience. 2022 Jun 17; 25(6):104410. PMID: 35663017; PMCID: PMC9156944.
  3. Maron SB, Moya S, Morano F, Emmett MJ, Chou JF, Sabwa S, Walch H, Peterson B, Schrock AB, Zhang L, Janjigian YY, Chalasani S, Ku GY, Disel U, Enzinger P, Uboha N, Kato S, Yoshino T, Shitara K, Nakamura Y, Saeed A, Kasi PM, Chao J, Lee J, Capanu M, Wainberg Z, Petty R, Pietrantonio F, Klempner SJ, Catenacci DVT. Epidermal Growth Factor Receptor Inhibition in Epidermal Growth Factor Receptor-Amplified Gastroesophageal Cancer: Retrospective Global Experience. J Clin Oncol. 2022 08 01; 40(22):2458-2467. PMID: 35349370; PMCID: PMC9467681.
    Citations:    Fields:    Translation:Humans
  4. Fucà G, Cohen R, Lonardi S, Shitara K, Elez ME, Fakih M, Chao J, Klempner SJ, Emmett M, Jayachandran P, Bergamo F, García MD, Mazzoli G, Provenzano L, Colle R, Svrcek M, Ambrosini M, Randon G, Shah AT, Salati M, Fenocchio E, Salvatore L, Chida K, Kawazoe A, Conca V, Curigliano G, Corti F, Cremolini C, Overman M, Andre T, Pietrantonio F. Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers. J Immunother Cancer. 2022 02; 10(2). PMID: 35110358; PMCID: PMC8811606.
    Citations: 2     Fields:    Translation:Humans
  5. Angueira AR, Shapira SN, Ishibashi J, Sampat S, Sostre-Colón J, Emmett MJ, Titchenell PM, Lazar MA, Lim HW, Seale P. Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes. Cell Rep. 2020 03 03; 30(9):2869-2878.e4. PMID: 32130892.
    Citations: 8     Fields:    Translation:AnimalsCells
  6. Dierickx P, Emmett MJ, Jiang C, Uehara K, Liu M, Adlanmerini M, Lazar MA. SR9009 has REV-ERB-independent effects on cell proliferation and metabolism. Proc Natl Acad Sci U S A. 2019 06 18; 116(25):12147-12152. PMID: 31127047; PMCID: PMC6589768.
    Citations: 45     Fields:    Translation:Animals
  7. Emmett MJ, Lazar MA. Integrative regulation of physiology by histone deacetylase 3. Nat Rev Mol Cell Biol. 2019 02; 20(2):102-115. PMID: 30390028; PMCID: PMC6347506.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  8. Razzoli M, Emmett MJ, Lazar MA, Bartolomucci A. ß-Adrenergic receptors control brown adipose UCP-1 tone and cold response without affecting its circadian rhythmicity. FASEB J. 2018 10; 32(10):5640-5646. PMID: 29715048; PMCID: PMC6133705.
    Citations: 12     Fields:    Translation:AnimalsCells
  9. Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, Lazar MA. Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature. 2017 06 22; 546(7659):544-548. PMID: 28614293.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  10. Soccio RE, Li Z, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina CJ, Jolivert JF, Kissig M, Rajapurkar SR, Damle M, Lim HW, Won KJ, Seale P, Steger DJ, Lazar MA. Targeting PPAR? in the epigenome rescues genetic metabolic defects in mice. J Clin Invest. 2017 Apr 03; 127(4):1451-1462. PMID: 28240605; PMCID: PMC5373865.
    Citations: 22     Fields:    Translation:AnimalsCells
  11. Teng X, Emmett MJ, Lazar MA, Goldberg E, Rabinowitz JD. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. ACS Chem Biol. 2016 09 16; 11(9):2420-7. PMID: 27333189; PMCID: PMC5317044.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  12. Soccio RE, Chen ER, Rajapurkar SR, Safabakhsh P, Marinis JM, Dispirito JR, Emmett MJ, Briggs ER, Fang B, Everett LJ, Lim HW, Won KJ, Steger DJ, Wu Y, Civelek M, Voight BF, Lazar MA. Genetic Variation Determines PPAR? Function and Anti-diabetic Drug Response In Vivo. Cell. 2015 Jul 02; 162(1):33-44. PMID: 26140591.
    Citations: 75     Fields:    Translation:HumansAnimals
  13. Zhang Y, Fang B, Emmett MJ, Damle M, Sun Z, Feng D, Armour SM, Remsberg JR, Jager J, Soccio RE, Steger DJ, Lazar MA. GENE REGULATION. Discrete functions of nuclear receptor Rev-erba couple metabolism to the clock. Science. 2015 Jun 26; 348(6242):1488-92. PMID: 26044300.
    Citations: 149     Fields:    Translation:AnimalsCells
  14. Koren S, DiPilato LM, Emmett MJ, Shearin AL, Chu Q, Monks B, Birnbaum MJ. The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo. Diabetologia. 2015 May; 58(5):1063-70. PMID: 25740694.
    Citations: 17     Fields:    Translation:AnimalsCells
  15. Chen YJ, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R, Dor Y, Li C, Spence JR, Stanger BZ. De novo formation of insulin-producing "neo-ß cell islets" from intestinal crypts. Cell Rep. 2014 Mar 27; 6(6):1046-1058. PMID: 24613355; PMCID: PMC4245054.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  16. Gerhart-Hines Z, Feng D, Emmett MJ, Everett LJ, Loro E, Briggs ER, Bugge A, Hou C, Ferrara C, Seale P, Pryma DA, Khurana TS, Lazar MA. The nuclear receptor Rev-erba controls circadian thermogenic plasticity. Nature. 2013 Nov 21; 503(7476):410-413. PMID: 24162845.
    Citations: 129     Fields:    Translation:AnimalsCells
  17. Madison BB, Liu Q, Zhong X, Hahn CM, Lin N, Emmett MJ, Stanger BZ, Lee JS, Rustgi AK. LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev. 2013 Oct 15; 27(20):2233-45. PMID: 24142874.
    Citations: 71     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.