Harvard Catalyst Profiles

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David Andrew Sinclair, Ph.D.

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Mentoring
The Role of CD38, NAD Levels, and Sirtuins on Neuronal Cell Survival During Ischemia
Summer, 06/13/11 - 08/05/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21HG011850 (SINCLAIR, DAVID A.) Sep 17, 2021 - Aug 31, 2023
    NIH
    Tagmentation-based Indexing for Methylation Sequencing as a novel method of high-throughput methylation clock measurement
    Role: Principal Investigator
  2. R21DE027490 (SINCLAIR, DAVID A.) Sep 1, 2018 - Aug 31, 2020
    NIH
    Nicotinamide Mononucleotide (NMN) as a Novel Therapeutic in the Treatment of Oral Mucositis
    Role: Principal Investigator
  3. DP1AG058605 (SINCLAIR, DAVID A.) Sep 15, 2017 - May 31, 2022
    NIH
    Uncovering the Human Secretome
    Role: Principal Investigator
  4. R01DK100263 (SINCLAIR, DAVID A.) Jul 15, 2016 - Jun 30, 2021
    NIH
    Elucidating mechanisms of SIRT1 activation
    Role: Principal Investigator
  5. R13AG033466 (SINCLAIR, DAVID A.) Sep 30, 2008 - Aug 31, 2009
    NIH
    2009 Biology of Aging Gordon Research Conference
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mach J, Kane AE, Howlett SE, Sinclair DA, Hilmer SN. Applying the AFRAID and FRIGHT clocks to novel preclinical mouse models of polypharmacy. J Gerontol A Biol Sci Med Sci. 2022 Mar 21. PMID: 35313348.
    Citations:    Fields:    
  2. Osborne B, Reznick J, Wright LE, Sinclair DA, Cooney GJ, Turner N. Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice. Biochem Biophys Res Commun. 2022 06 04; 607:131-137. PMID: 35367825.
    Citations:    Fields:    Translation:Animals
  3. Zheng M, Schultz MB, Sinclair DA. NAD+ in COVID-19 and viral infections. Trends Immunol. 2022 04; 43(4):283-295. PMID: 35221228.
    Citations: 1     Fields:    Translation:Humans
  4. Amorim JA, Coppotelli G, Rolo AP, Palmeira CM, Ross JM, Sinclair DA. Mitochondrial and metabolic dysfunction in ageing and age-related diseases. Nat Rev Endocrinol. 2022 Apr; 18(4):243-258. PMID: 35145250.
    Citations: 1     Fields:    Translation:HumansCells
  5. Tran T, Pencina KM, Schultz MB, Li Z, Ghattas C, Lau J, Sinclair DA, Montano M. Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults. J Acquir Immune Defic Syndr. 2022 02 01; 89(Suppl 1):S15-S22. PMID: 35015741.
    Citations: 1     Fields:    Translation:Humans
  6. Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Jensen MB, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegué E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. Meeting Report: Aging Research and Drug Discovery. Aging (Albany NY). 2022 Jan 28; 14(2):530-543. PMID: 35089871.
    Citations:    Fields:    
  7. Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura EK. Dynamic stem cell selection safeguards the genomic integrity of the epidermis. Dev Cell. 2021 12 20; 56(24):3309-3320.e5. PMID: 34932948.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Gorbunova V, Buschbeck M, Cambronne XA, Chellappa K, Corda D, Du J, Freichel M, Gigas J, Green AE, Gu F, Guberovic I, Jayabalan A, Khansahib I, Mukherjee S, Seluanov A, Simon MA, Sverkeli LJ, Kory N, Levine DC, Matic I, Nikiforov A, Rack JGM, Imai SI, Sinclair DA, Toiber D, Zhao Y, Mostoslavsky R, Kraus L, Guse AH. The 2021 FASEB science research conference on NAD metabolism and signaling. Aging (Albany NY). 2021 Dec 09; 13(23):24924-24930. PMID: 34890368.
    Citations:    Fields:    
  9. Ke S, Mitchell SJ, MacArthur MR, Kane AE, Sinclair DA, Venable EM, Chadaideh KS, Carmody RN, Grodstein F, Mitchell JR, Liu Y. Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice. Nutrients. 2021 Sep 21; 13(9). PMID: 34579167.
    Citations: 2     Fields:    Translation:HumansAnimals
  10. Martínez-Greene JA, Hernández-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godínez MDP, Martínez-Martínez E. Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. J Extracell Vesicles. 2021 04; 10(6):e12087. PMID: 33936570.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Montay-Gruel P, Zhu Y, Petit B, Leavitt R, Warn M, Giedzinski E, Ollivier J, Sinclair DA, Vozenin MC, Limoli CL. Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung. Front Oncol. 2020; 10:602763. PMID: 33738245.
    Citations: 2     
  12. Amorim JA, Sinclair DA. Measuring PGC-1a and Its Acetylation Status in Mouse Primary Myotubes. Methods Mol Biol. 2021; 2310:301-309. PMID: 34096010.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 12 30; 12(24):24484-24503. PMID: 33378272.
    Citations: 4     Fields:    Translation:Humans
  14. Chen X, Amorim JA, Moustafa GA, Lee JJ, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG. Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging (Albany NY). 2020 12 29; 12(24):24504-24521. PMID: 33373320.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 12; 588(7836):124-129. PMID: 33268865.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  16. Palliyaguru DL, Minor RK, Mitchell SJ, Palacios HH, Licata JJ, Ward TM, Abulwerdi G, Elliott P, Westphal C, Ellis JL, Sinclair DA, Price NL, Bernier M, de Cabo R. Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet. J Gerontol A Biol Sci Med Sci. 2020 10 15; 75(11):2037-2041. PMID: 32556267.
    Citations: 4     Fields:    Translation:Animals
  17. Schultz MB, Kane AE, Mitchell SJ, MacArthur MR, Warner E, Vogel DS, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty. Nat Commun. 2020 Oct 08; 11(1):5143. PMID: 33033247.
    Citations: 1     Fields:    
  18. Schultz MB, Kane AE, Mitchell SJ, MacArthur MR, Warner E, Vogel DS, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Age and life expectancy clocks based on machine learning analysis of mouse frailty. Nat Commun. 2020 09 15; 11(1):4618. PMID: 32934233.
    Citations: 14     Fields:    Translation:HumansAnimals
  19. Teodoro JS, Amorim JA, Machado IF, Castela AC, Steegborn C, Sinclair DA, Rolo AP, Palmeira CM. The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function. Int J Mol Sci. 2020 Jul 11; 21(14). PMID: 32664470.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Schultz MB, Vera D, Sinclair DA. Can artificial intelligence identify effective COVID-19 therapies? EMBO Mol Med. 2020 08 07; 12(8):e12817. PMID: 32569446.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  21. Al Kharusi S, Anton G, Badhrees I, Barbeau PS, Beck D, Belov V, Bhatta T, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, Darroch L, Daugherty SJ, Davis J, Delaquis S, Der Mesrobian-Kabakian A, DeVoe R, Dilling J, Dolgolenko A, Dolinski MJ, Echevers J, Fairbank W, Fairbank D, Farine J, Feyzbakhsh S, Fierlinger P, Fudenberg D, Gautam P, Gornea R, Gratta G, Hall C, Hansen EV, Hoessl J, Hufschmidt P, Hughes M, Iverson A, Jamil A, Jessiman C, Jewell MJ, Johnson A, Karelin A, Kaufman LJ, Koffas T, Kostensalo J, Krücken R, Kuchenkov A, Kumar KS, Lan Y, Larson A, Lenardo BG, Leonard DS, Li GS, Li S, Li Z, Licciardi C, Lin YH, MacLellan R, McElroy T, Michel T, Mong B, Moore DC, Murray K, Nakarmi P, Njoya O, Nusair O, Odian A, Ostrovskiy I, Piepke A, Pocar A, Retière F, Robinson AL, Rowson PC, Ruddell D, Runge J, Schmidt S, Sinclair D, Skarpaas K, Soma AK, Stekhanov V, Suhonen J, Tarka M, Thibado S, Todd J, Tolba T, Totev TI, Tsang R, Veenstra B, Veeraraghavan V, Vogel P, Vuilleumier JL, Wagenpfeil M, Watkins J, Weber M, Wen LJ, Wichoski U, Wrede G, Wu SX, Xia Q, Yahne DR, Yang L, Yen YR, Zeldovich OY, Ziegler T. Measurement of the Spectral Shape of the ß-Decay of ^{137}Xe to the Ground State of ^{137}Cs in EXO-200 and Comparison with Theory. Phys Rev Lett. 2020 Jun 12; 124(23):232502. PMID: 32603173.
    Citations:    Fields:    
  22. Mueller AL, McNamara MS, Sinclair DA. Why does COVID-19 disproportionately affect older people? Aging (Albany NY). 2020 05 29; 12(10):9959-9981. PMID: 32470948.
    Citations: 227     Fields:    Translation:HumansCellsPHPublic Health
  23. Lauc G, Sinclair D. Biomarkers of biological age as predictors of COVID-19 disease severity. Aging (Albany NY). 2020 Apr 08; 12(8):6490-6491. PMID: 32268300.
    Citations: 26     Fields:    Translation:HumansCellsPHPublic Health
  24. Uddin GM, Youngson NA, Chowdhury SS, Hagan C, Sinclair DA, Morris MJ. Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers. Cells. 2020 03 25; 9(4). PMID: 32218167.
    Citations: 3     Fields:    Translation:Animals
  25. Solon-Biet SM, McMahon AC, Ballard JWO, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ. The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metab. 2020 Mar 03; 31(3):654. PMID: 32130886.
    Citations: 4     Fields:    
  26. Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE. NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell Rep. 2020 02 11; 30(6):1670-1681.e7. PMID: 32049001.
    Citations: 37     Fields:    Translation:Animals
  27. Bolderson E, Burgess JT, Li J, Gandhi NS, Boucher D, Croft LV, Beard S, Plowman JJ, Suraweera A, Adams MN, Naqi A, Zhang SD, Sinclair DA, O'Byrne KJ, Richard DJ. Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage. Nat Commun. 2019 12 03; 10(1):5501. PMID: 31796734.
    Citations: 14     Fields:    Translation:HumansCells
  28. Anton G, Badhrees I, Barbeau PS, Beck D, Belov V, Bhatta T, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, Danilov M, Darroch L, Daugherty SJ, Davis J, Delaquis S, Der Mesrobian-Kabakian A, DeVoe R, Dilling J, Dolgolenko A, Dolinski MJ, Echevers J, Fairbank W, Fairbank D, Farine J, Feyzbakhsh S, Fierlinger P, Fudenberg D, Gautam P, Gornea R, Gratta G, Hall C, Hansen EV, Hoessl J, Hufschmidt P, Hughes M, Iverson A, Jamil A, Jessiman C, Jewell MJ, Johnson A, Karelin A, Kaufman LJ, Koffas T, Krücken R, Kuchenkov A, Kumar KS, Lan Y, Larson A, Lenardo BG, Leonard DS, Li GS, Li S, Li Z, Licciardi C, Lin YH, MacLellan R, McElroy T, Michel T, Mong B, Moore DC, Murray K, Njoya O, Nusair O, Odian A, Ostrovskiy I, Piepke A, Pocar A, Retière F, Robinson AL, Rowson PC, Ruddell D, Runge J, Schmidt S, Sinclair D, Soma AK, Stekhanov V, Tarka M, Todd J, Tolba T, Totev TI, Veenstra B, Veeraraghavan V, Vogel P, Vuilleumier JL, Wagenpfeil M, Watkins J, Weber M, Wen LJ, Wichoski U, Wrede G, Wu SX, Xia Q, Yahne DR, Yang L, Yen YR, Zeldovich OY, Ziegler T. Search for Neutrinoless Double-ß Decay with the Complete EXO-200 Dataset. Phys Rev Lett. 2019 Oct 18; 123(16):161802. PMID: 31702371.
    Citations: 2     Fields:    
  29. Lautrup S, Sinclair DA, Mattson MP, Fang EF. NAD+ in Brain Aging and Neurodegenerative Disorders. Cell Metab. 2019 10 01; 30(4):630-655. PMID: 31577933.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  30. Montano M, Bhasin S, D'Aquila RT, Erlandson KM, Evans WJ, Funderburg NT, Justice A, Ndhlovu LC, Ojikutu B, Pahor M, Pahwa S, Ryan AS, Schrack J, Schultz MB, Sebastiani P, Sinclair DA, Tripp J, Walker B, Womack JA, Yung R, Reeves RK. Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research. AIDS Res Hum Retroviruses. 2019 Nov-Dec; 35(11-12):999-1012. PMID: 31456412.
    Citations: 3     Fields:    Translation:Humans
  31. Ross JM, Coppotelli G, Branca RM, Kim KM, Lehtiö J, Sinclair DA, Olson L. Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice. Aging Cell. 2019 12; 18(6):e13029. PMID: 31489782.
    Citations: 9     Fields:    Translation:Animals
  32. Youngson NA, Uddin GM, Das A, Martinez C, Connaughton HS, Whiting S, Yu J, Sinclair DA, Aitken RJ, Morris MJ. Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice. Reproduction. 2019 08 01; 158(2):169-179. PMID: 31226694.
    Citations: 4     Fields:    Translation:AnimalsCells
  33. Palmeira CM, Teodoro JS, Amorim JA, Steegborn C, Sinclair DA, Rolo AP. Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins. Free Radic Biol Med. 2019 09; 141:483-491. PMID: 31349039.
    Citations: 38     Fields:    Translation:HumansCells
  34. Kane AE, Sinclair DA. Frailty biomarkers in humans and rodents: Current approaches and future advances. Mech Ageing Dev. 2019 06; 180:117-128. PMID: 31002925.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  35. Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019 06; 24:101192. PMID: 31015147.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  36. Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metab. 2019 06 04; 29(6):1274-1290.e9. PMID: 30930169.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  37. Feng J, LaChance A, Sinclair DA, Asgari MM. Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1. BMJ Case Rep. 2019 Mar 08; 12(3). PMID: 30852496.
    Citations: 1     Fields:    Translation:Humans
  38. Kane AE, Sinclair DA. Epigenetic changes during aging and their reprogramming potential. Crit Rev Biochem Mol Biol. 2019 02; 54(1):61-83. PMID: 30822165.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  39. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2019 Feb 07; 176(4):944-945. PMID: 30735637.
    Citations: 8     Fields:    
  40. Schultz MB, Rinaldi C, Lu Y, Amorim JA, Sinclair DA. Molecular and Cellular Characterization of SIRT1 Allosteric Activators. Methods Mol Biol. 2019; 1983:133-149. PMID: 31087296.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  41. Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P, Galluzzi L. Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles. Nat Rev Cardiol. 2019 01; 16(1):33-55. PMID: 30177752.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  42. Wu LE, Sinclair DA. The elusive NMN transporter is found. Nat Metab. 2019 Jan; 1(1):8-9. PMID: 32694812.
    Citations: 2     Fields:    
  43. Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG. Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Rep. 2018 11 20; 25(8):2234-2243.e6. PMID: 30463018.
    Citations: 32     Fields:    Translation:AnimalsCells
  44. Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G. Publisher Correction: Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects. Sci Rep. 2018 Nov 08; 8(1):16778. PMID: 30405144.
    Citations:    Fields:    
  45. Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G. Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects. Sci Rep. 2018 10 02; 8(1):14685. PMID: 30279436.
    Citations: 5     Fields:    Translation:HumansCells
  46. Kane AE, Sinclair DA. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018 09 14; 123(7):868-885. PMID: 30355082.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  47. Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JM. Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. Mol Cell. 2018 09 06; 71(5):718-732.e9. PMID: 30193097.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  48. Bertoldo MJ, Uddin GM, Youngson NA, Agapiou D, Walters KA, Sinclair DA, Morris MJ, Gilchrist RB. Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide. Hum Reprod Open. 2018; 2018(3):hoy010. PMID: 30895251.
    Citations: 4     
  49. Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF. Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell. 2018 08; 17(4):e12751. PMID: 29654651.
    Citations: 14     Fields:    Translation:AnimalsCells
  50. Kane AE, Sinclair DA, Mitchell JR, Mitchell SJ. Sex differences in the response to dietary restriction in rodents. Curr Opin Physiol. 2018 Dec; 6:28-34. PMID: 31231711.
    Citations: 13     
  51. Dai H, Sinclair DA, Ellis JL, Steegborn C. Sirtuin activators and inhibitors: Promises, achievements, and challenges. Pharmacol Ther. 2018 08; 188:140-154. PMID: 29577959.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  52. Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018 03 22; 173(1):117-129.e14. PMID: 29570992.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  53. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018 03 22; 173(1):74-89.e20. PMID: 29570999.
    Citations: 126     Fields:    Translation:HumansAnimalsCells
  54. Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018 03 06; 27(3):529-547. PMID: 29514064.
    Citations: 195     Fields:    Translation:HumansAnimalsCells
  55. Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metab. 2018 03 06; 27(3):667-676.e4. PMID: 29514072.
    Citations: 91     Fields:    Translation:Animals
  56. Albert JB, Anton G, Badhrees I, Barbeau PS, Bayerlein R, Beck D, Belov V, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Cree W, Daniels T, Danilov M, Daugherty SJ, Daughhetee J, Davis J, Delaquis S, Der Mesrobian-Kabakian A, DeVoe R, Didberidze T, Dilling J, Dolgolenko A, Dolinski MJ, Fairbank W, Farine J, Feyzbakhsh S, Fierlinger P, Fudenberg D, Gornea R, Graham K, Gratta G, Hall C, Hansen EV, Hoessl J, Hufschmidt P, Hughes M, Jamil A, Jewell MJ, Johnson A, Johnston S, Karelin A, Kaufman LJ, Koffas T, Kravitz S, Krücken R, Kuchenkov A, Kumar KS, Lan Y, Leonard DS, Li GS, Li S, Licciardi C, Lin YH, MacLellan R, Michel T, Mong B, Moore D, Murray K, Nelson R, Njoya O, Odian A, Ostrovskiy I, Piepke A, Pocar A, Retière F, Rowson PC, Russell JJ, Schmidt S, Schubert A, Sinclair D, Stekhanov V, Tarka M, Tolba T, Tsang R, Vogel P, Vuilleumier JL, Wagenpfeil M, Waite A, Walton T, Weber M, Wen LJ, Wichoski U, Wrede G, Yang L, Yen YR, Zeldovich OY, Zettlemoyer J, Ziegler T. Search for Neutrinoless Double-Beta Decay with the Upgraded EXO-200 Detector. Phys Rev Lett. 2018 Feb 16; 120(7):072701. PMID: 29542972.
    Citations: 3     Fields:    
  57. Schultz MB, Lu Y, Braidy N, Sinclair DA. Assays for NAD+-Dependent Reactions and NAD+ Metabolites. Methods Mol Biol. 2018; 1813:77-90. PMID: 30097862.
    Citations:    Fields:    Translation:HumansCells
  58. Bustamante S, Jayasena T, Richani D, Gilchrist RB, Wu LE, Sinclair DA, Sachdev PS, Braidy N. Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach. Metabolomics. 2017 12 23; 14(1):15. PMID: 30830318.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  59. Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, Crandall JP. Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults. J Gerontol A Biol Sci Med Sci. 2017 Nov 09; 72(12):1703-1709. PMID: 28329397.
    Citations: 28     Fields:    Translation:HumansCells
  60. Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ. Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise. Sci Rep. 2017 11 08; 7(1):15063. PMID: 29118320.
    Citations: 27     Fields:    Translation:AnimalsCells
  61. Costford SR, Brouwers B, Hopf ME, Sparks LM, Dispagna M, Gomes AP, Cornnell HH, Petucci C, Phelan P, Xie H, Yi F, Walter GA, Osborne TF, Sinclair DA, Mynatt RL, Ayala JE, Gardell SJ, Smith SR. Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance. Mol Metab. 2018 01; 7:1-11. PMID: 29146412.
    Citations: 18     Fields:    Translation:AnimalsCells
  62. Glass LJ, Sinclair D, Boerrigter D, Naude K, Fung SJ, Brown D, Catts VS, Tooney P, O'Donnell M, Lenroot R, Galletly C, Liu D, Weickert TW, Shannon Weickert C. Brain antibodies in the cortex and blood of people with schizophrenia and controls. Transl Psychiatry. 2017 08 08; 7(8):e1192. PMID: 28786974.
    Citations: 11     Fields:    Translation:HumansAnimals
  63. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science. 2017 03 24; 355(6331):1312-1317. PMID: 28336669.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  64. Sinclair D, Featherstone R, Naschek M, Nam J, Du A, Wright S, Pance K, Melnychenko O, Weger R, Akuzawa S, Matsumoto M, Siegel SJ. GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome. eNeuro. 2017 Jan-Feb; 4(1). PMID: 28451631.
    Citations: 33     Fields:    Translation:Animals
  65. Cronise RJ, Sinclair DA, Bremer AA. Response to: "If the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3). Metab Syndr Relat Disord. 2017 02; 15(1):4-5. PMID: 28165301.
    Citations:    Fields:    Translation:Humans
  66. Prola A, Pires Da Silva J, Guilbert A, Lecru L, Piquereau J, Ribeiro M, Mateo P, Gressette M, Fortin D, Boursier C, Gallerne C, Caillard A, Samuel JL, François H, Sinclair DA, Eid P, Ventura-Clapier R, Garnier A, Lemaire C. SIRT1 protects the heart from ER stress-induced cell death through eIF2a deacetylation. Cell Death Differ. 2017 02; 24(2):343-356. PMID: 27911441.
    Citations: 69     Fields:    Translation:AnimalsCells
  67. Cronise RJ, Sinclair DA, Bremer AA. Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease. Metab Syndr Relat Disord. 2017 02; 15(1):6-17. PMID: 27869525.
    Citations: 3     Fields:    Translation:HumansCells
  68. Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016 10 11; 24(4):566-581. PMID: 27732836.
    Citations: 171     Fields:    Translation:AnimalsCells
  69. Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A. JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Rep. 2016 09 06; 16(10):2641-2650. PMID: 27568560.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  70. Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 11; 17(11):679-690.