Harvard Catalyst Profiles

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David Andrew Sinclair, Ph.D.

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Mentoring
The Role of CD38, NAD Levels, and Sirtuins on Neuronal Cell Survival During Ischemia
Summer, 06/13/11 - 08/05/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21DE027490 (SINCLAIR, DAVID A.) Sep 1, 2018 - Aug 31, 2020
    NIH/NIDCR
    Nicotinamide Mononucleotide (NMN) as a Novel Therapeutic in the Treatment of Oral Mucositis
    Role: Principal Investigator
  2. DP1AG058605 (SINCLAIR, DAVID A.) Sep 15, 2017 - May 31, 2022
    NIH/NIA
    Uncovering the Human Secretome
    Role: Principal Investigator
  3. R01DK100263 (SINCLAIR, DAVID A.) Jul 15, 2016 - Jun 30, 2021
    NIH/NIDDK
    Elucidating mechanisms of SIRT1 activation
    Role: Principal Investigator
  4. R13AG033466 (SINCLAIR, DAVID A.) Sep 30, 2008 - Aug 31, 2009
    NIH/NIA
    2009 Biology of Aging Gordon Research Conference
    Role: Principal Investigator
  5. R01AG028730 (SINCLAIR, DAVID A.) Apr 1, 2007 - Mar 31, 2012
    NIH/NIA
    SIRT as a regulator of health and lifespan of mammals
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Youngson NA, Uddin GM, Das A, Martinez C, Connaughton HS, Whiting S, Yu J, Sinclair DA, Aitken RJ, Morris MJ. Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice. Reproduction. 2019 Aug 01; 158(2):171-181. PMID: 31226694.
    Citations:    
  2. Kane AE, Sinclair DA. Frailty biomarkers in humans and rodents: Current approaches and future advances. Mech Ageing Dev. 2019 06; 180:117-128. PMID: 31002925.
    Citations:    
  3. Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019 Jun; 24:101192. PMID: 31015147.
    Citations:    
  4. Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metab. 2019 Jun 04; 29(6):1274-1290.e9. PMID: 30930169.
    Citations:    
  5. Kane AE, Sinclair DA. Epigenetic changes during aging and their reprogramming potential. Crit Rev Biochem Mol Biol. 2019 Feb; 54(1):61-83. PMID: 30822165.
    Citations:    
  6. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2019 Feb 07; 176(4):944-945. PMID: 30735637.
    Citations:    
  7. Schultz MB, Rinaldi C, Lu Y, Amorim JA, Sinclair DA. Molecular and Cellular Characterization of SIRT1 Allosteric Activators. Methods Mol Biol. 2019; 1983:133-149. PMID: 31087296.
    Citations:    
  8. Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P, Galluzzi L. Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles. Nat Rev Cardiol. 2019 Jan; 16(1):33-55. PMID: 30177752.
    Citations:    Fields:    
  9. Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG. Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Rep. 2018 Nov 20; 25(8):2234-2243.e6. PMID: 30463018.
    Citations:    Fields:    
  10. Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G. Publisher Correction: Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects. Sci Rep. 2018 Nov 08; 8(1):16778. PMID: 30405144.
    Citations:    Fields:    
  11. Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G. Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects. Sci Rep. 2018 Oct 02; 8(1):14685. PMID: 30279436.
    Citations:    Fields:    
  12. Kane AE, Sinclair DA. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018 Sep 14; 123(7):868-885. PMID: 30355082.
    Citations:    Fields:    
  13. Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JM. Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. Mol Cell. 2018 09 06; 71(5):718-732.e9. PMID: 30193097.
    Citations:    Fields:    
  14. Bertoldo MJ, Uddin GM, Youngson NA, Agapiou D, Walters KA, Sinclair DA, Morris MJ, Gilchrist RB. Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide. Hum Reprod Open. 2018; 2018(3):hoy010. PMID: 30895251.
    Citations:    
  15. Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF. Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell. 2018 Aug; 17(4):e12751. PMID: 29654651.
    Citations: 1     Fields:    
  16. Kane AE, Sinclair DA, Mitchell JR, Mitchell SJ. Sex differences in the response to dietary restriction in rodents. Curr Opin Physiol. 2018 Dec; 6:28-34. PMID: 31231711.
    Citations:    
  17. Dai H, Sinclair DA, Ellis JL, Steegborn C. Sirtuin activators and inhibitors: Promises, achievements, and challenges. Pharmacol Ther. 2018 08; 188:140-154. PMID: 29577959.
    Citations: 1     Fields:    
  18. Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018 03 22; 173(1):117-129.e14. PMID: 29570992.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  19. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018 03 22; 173(1):74-89.e20. PMID: 29570999.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  20. Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018 03 06; 27(3):529-547. PMID: 29514064.
    Citations: 10     Fields:    
  21. Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metab. 2018 03 06; 27(3):667-676.e4. PMID: 29514072.
    Citations: 3     Fields:    
  22. Albert JB, Anton G, Badhrees I, Barbeau PS, Bayerlein R, Beck D, Belov V, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Cree W, Daniels T, Danilov M, Daugherty SJ, Daughhetee J, Davis J, Delaquis S, Der Mesrobian-Kabakian A, DeVoe R, Didberidze T, Dilling J, Dolgolenko A, Dolinski MJ, Fairbank W, Farine J, Feyzbakhsh S, Fierlinger P, Fudenberg D, Gornea R, Graham K, Gratta G, Hall C, Hansen EV, Hoessl J, Hufschmidt P, Hughes M, Jamil A, Jewell MJ, Johnson A, Johnston S, Karelin A, Kaufman LJ, Koffas T, Kravitz S, Krücken R, Kuchenkov A, Kumar KS, Lan Y, Leonard DS, Li GS, Li S, Licciardi C, Lin YH, MacLellan R, Michel T, Mong B, Moore D, Murray K, Nelson R, Njoya O, Odian A, Ostrovskiy I, Piepke A, Pocar A, Retière F, Rowson PC, Russell JJ, Schmidt S, Schubert A, Sinclair D, Stekhanov V, Tarka M, Tolba T, Tsang R, Vogel P, Vuilleumier JL, Wagenpfeil M, Waite A, Walton T, Weber M, Wen LJ, Wichoski U, Wrede G, Yang L, Yen YR, Zeldovich OY, Zettlemoyer J, Ziegler T. Search for Neutrinoless Double-Beta Decay with the Upgraded EXO-200 Detector. Phys Rev Lett. 2018 Feb 16; 120(7):072701. PMID: 29542972.
    Citations:    Fields:    
  23. Schultz MB, Lu Y, Braidy N, Sinclair DA. Assays for NAD+-Dependent Reactions and NAD+ Metabolites. Methods Mol Biol. 2018; 1813:77-90. PMID: 30097862.
    Citations:    Fields:    
  24. Bustamante S, Jayasena T, Richani D, Gilchrist RB, Wu LE, Sinclair DA, Sachdev PS, Braidy N. Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach. Metabolomics. 2017 12 23; 14(1):15. PMID: 30830318.
    Citations:    
  25. Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, Crandall JP. Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults. J Gerontol A Biol Sci Med Sci. 2017 Nov 09; 72(12):1703-1709. PMID: 28329397.
    Citations: 3     Fields:    Translation:HumansCells
  26. Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ. Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise. Sci Rep. 2017 11 08; 7(1):15063. PMID: 29118320.
    Citations: 3     Fields:    
  27. Costford SR, Brouwers B, Hopf ME, Sparks LM, Dispagna M, Gomes AP, Cornnell HH, Petucci C, Phelan P, Xie H, Yi F, Walter GA, Osborne TF, Sinclair DA, Mynatt RL, Ayala JE, Gardell SJ, Smith SR. Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance. Mol Metab. 2018 01; 7:1-11. PMID: 29146412.
    Citations: 2     Fields:    
  28. Glass LJ, Sinclair D, Boerrigter D, Naude K, Fung SJ, Brown D, Catts VS, Tooney P, O'Donnell M, Lenroot R, Galletly C, Liu D, Weickert TW, Shannon Weickert C. Brain antibodies in the cortex and blood of people with schizophrenia and controls. Transl Psychiatry. 2017 08 08; 7(8):e1192. PMID: 28786974.
    Citations: 1     Fields:    Translation:HumansAnimals
  29. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science. 2017 03 24; 355(6331):1312-1317. PMID: 28336669.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Sinclair D, Featherstone R, Naschek M, Nam J, Du A, Wright S, Pance K, Melnychenko O, Weger R, Akuzawa S, Matsumoto M, Siegel SJ. GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome. eNeuro. 2017 Jan-Feb; 4(1). PMID: 28451631.
    Citations: 2     Fields:    Translation:Animals
  31. Prola A, Pires Da Silva J, Guilbert A, Lecru L, Piquereau J, Ribeiro M, Mateo P, Gressette M, Fortin D, Boursier C, Gallerne C, Caillard A, Samuel JL, François H, Sinclair DA, Eid P, Ventura-Clapier R, Garnier A, Lemaire C. SIRT1 protects the heart from ER stress-induced cell death through eIF2a deacetylation. Cell Death Differ. 2017 02; 24(2):343-356. PMID: 27911441.
    Citations: 13     Fields:    Translation:AnimalsCells
  32. Cronise RJ, Sinclair DA, Bremer AA. Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease. Metab Syndr Relat Disord. 2017 02; 15(1):6-17. PMID: 27869525.
    Citations: 2     Fields:    Translation:HumansCells
  33. Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016 10 11; 24(4):566-581. PMID: 27732836.
    Citations: 25     Fields:    Translation:AnimalsCells
  34. Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A. JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Rep. 2016 09 06; 16(10):2641-2650. PMID: 27568560.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  35. Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 11; 17(11):679-690. PMID: 27552971.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  36. Uddin GM, Youngson NA, Sinclair DA, Morris MJ. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Front Pharmacol. 2016; 7:258. PMID: 27594836.
    Citations: 9     
  37. Ferrer CM, Lu TY, Bacigalupa ZA, Katsetos CD, Sinclair DA, Reginato MJ. O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway. Oncogene. 2017 01 26; 36(4):559-569. PMID: 27345396.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  38. Wu LE, Sinclair DA. Restoring stem cells - all you need is NAD(.). Cell Res. 2016 09; 26(9):971-2. PMID: 27339086.
    Citations: 2     Fields:    
  39. Schultz MB, Sinclair DA. Why NAD(+) Declines during Aging: It's Destroyed. Cell Metab. 2016 Jun 14; 23(6):965-966. PMID: 27304496.
    Citations: 5     Fields:    Translation:AnimalsCells
  40. Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016 06 14; 23(6):1093-1112. PMID: 27304509.
    Citations: 36     Fields:    Translation:AnimalsCells
  41. Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, Simpson SJ, de Cabo R, Le Couteur DG, Cogger VC. Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell. 2016 08; 15(4):706-15. PMID: 27095270.
    Citations: 4     Fields:    Translation:AnimalsCells
  42. Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, St John JC. Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Sci Rep. 2016 Mar 18; 6:23229. PMID: 26987907.
    Citations: 9     Fields:    Translation:AnimalsCells
  43. Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC. C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mech Ageing Dev. 2016 Mar; 154:30-42. PMID: 26854551.
    Citations: 10     Fields:    Translation:AnimalsCells
  44. Dai H, Ellis JL, Sinclair DA, Hubbard BP. Synthesis and Assay of SIRT1-Activating Compounds. Methods Enzymol. 2016; 574:213-244. PMID: 27423864.
    Citations:    Fields:    Translation:HumansAnimalsCells
  45. Schultz MB, Sinclair DA. When stem cells grow old: phenotypes and mechanisms of stem cell aging. Development. 2016 Jan 01; 143(1):3-14. PMID: 26732838.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  46. Kim J, Sturgill D, Tran AD, Sinclair DA, Oberdoerffer P. Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability. Nucleic Acids Res. 2016 Apr 20; 44(7):e64. PMID: 26687720.
    Citations: 8     Fields:    Translation:AnimalsCells
  47. Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Ben Hamidane H, Billing AM, Pasquier J, Bonkowski MS, Halabi N, Dalloul R, Sheriff MZ, Mesaeli N, ElRayess M, Sinclair DA, Graumann J, Mazloum NA. SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition. J Biol Chem. 2016 Jan 29; 291(5):2119-35. PMID: 26655722.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  48. Garg N, Sinclair DA. Oogonial stem cells as a model to study age-associated infertility in women. Reprod Fertil Dev. 2015 Jul; 27(6):969-74. PMID: 25897831.
    Citations: 1     Fields:    Translation:HumansCells
  49. Winnik S, Auwerx J, Sinclair DA, Matter CM. Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. Eur Heart J. 2015 Dec 21; 36(48):3404-12. PMID: 26112889.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  50. Riepsamen A, Wu L, Lau L, Listijono D, Ledger W, Sinclair DA, Homer H. Correction: nicotinamide impairs entry into and exit from meiosis I in mouse oocytes. PLoS One. 2015; 10(6):e0130058. PMID: 26038838.
    Citations:    Fields:    
  51. Zhang QS, Deater M, Schubert K, Marquez-Loza L, Pelz C, Sinclair DA, Grompe M. The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice. Stem Cell Res. 2015 Jul; 15(1):130-40. PMID: 26046330.
    Citations: 3     Fields:    Translation:AnimalsCells
  52. Riepsamen A, Wu L, Lau L, Listijono D, Ledger W, Sinclair D, Homer H. Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes. PLoS One. 2015; 10(5):e0126194. PMID: 25938585.
    Citations: 3     Fields:    Translation:AnimalsCells
  53. Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug; 14(4):497-510. PMID: 25902704.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  54. Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015 Feb 12; 6:6263. PMID: 25672491.
    Citations: 19     Fields:    Translation:HumansCells
  55. Gomes AP, Sinclair DA. Measuring PGC-1a and its acetylation status in mouse primary myotubes. Methods Mol Biol. 2015; 1241:49-57. PMID: 25308487.
    Citations:    Fields:    Translation:AnimalsCells
  56. Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD? -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 2014 Dec; 13(6):1075-85. PMID: 25257342.
    Citations: 25     Fields:    Translation:AnimalsCells
  57. Twelker K, Kravitz S, Montero Díez M, Gratta G, Fairbank W, Albert JB, Auty DJ, Barbeau PS, Beck D, Benitez-Medina C, Breidenbach M, Brunner T, Cao GF, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, Daugherty SJ, Davis CG, DeVoe R, Delaquis S, Didberidze T, Dilling J, Dolinski MJ, Dunford M, Fabris L, Farine J, Feldmeier W, Fierlinger P, Fudenberg D, Giroux G, Gornea R, Graham K, Hall C, Heffner M, Herrin S, Hughes M, Jiang XS, Johnson TN, Johnston S, Karelin A, Kaufman LJ, Killick R, Koffas T, Krücken R, Kuchenkov A, Kumar KS, Leonard DS, Leonard F, Licciardi C, Lin YH, MacLellan R, Marino MG, Mong B, Moore D, Odian A, Ostrovskiy I, Ouellet C, Piepke A, Pocar A, Retiere F, Rowson PC, Rozo MP, Schubert A, Sinclair D, Smith E, Stekhanov V, Tarka M, Tolba T, Tosi D, Vuilleumier JL, Walton J, Walton T, Weber M, Wen LJ, Wichoski U, Yang L, Yen YR, Zhao YB. An apparatus to manipulate and identify individual Ba ions from bulk liquid Xe. Rev Sci Instrum. 2014 Sep; 85(9):095114. PMID: 25273779.
    Citations:    Fields:    
  58. Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell. 2014 Oct; 13(5):787-96. PMID: 24931715.
    Citations: 34     Fields:    Translation:HumansAnimals
  59. Cronise RJ, Sinclair DA, Bremer AA. The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease. Metab Syndr Relat Disord. 2014 Sep; 12(7):355-61. PMID: 24918620.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  60. Rimmelé P, Bigarella CL, Liang R, Izac B, Dieguez-Gonzalez R, Barbet G, Donovan M, Brugnara C, Blander JM, Sinclair DA, Ghaffari S. Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells. Stem Cell Reports. 2014 Jul 08; 3(1):44-59. PMID: 25068121.
    Citations: 37     Fields:    Translation:AnimalsCells
  61. Uthman OA, Saunders R, Sinclair D, Graves P, Gelband H, Clarke A, Garner P. Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies. BMJ Open. 2014 May 14; 4(5):e004664. PMID: 24833685.
    Citations: 4     Fields:    Translation:Humans
  62. Wu LE, Sinclair DA. SIRT2 controls the pentose phosphate switch. EMBO J. 2014 Jun 17; 33(12):1287-8. PMID: 24825350.
    Citations: 1     Fields:    Translation:HumansAnimals
  63. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 2014 Jul 01; 33(13):1438-53. PMID: 24825348.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  64. Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Lüscher TF, Matter CM. The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. Eur Heart J. 2015 Jan 01; 36(1):51-9. PMID: 24603306.
    Citations: 17     Fields:    Translation:AnimalsCells
  65. Solon-Biet SM, McMahon AC, Ballard JW, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab. 2014 Mar 04; 19(3):418-30. PMID: 24606899.
    Citations: 143     Fields:    Translation:AnimalsCells
  66. Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, Dawson J, Allison DB, Zhang Y, Becker KG, Bernier M, de Cabo R. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep. 2014 Mar 13; 6(5):836-43. PMID: 24582957.
    Citations: 82     Fields:    Translation:AnimalsCells
  67. Fillman SG, Sinclair D, Fung SJ, Webster MJ, Shannon Weickert C. Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder. Transl Psychiatry. 2014 Feb 25; 4:e365. PMID: 24569695.
    Citations: 33     Fields:    Translation:Humans
  68. Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3781-6. PMID: 24556985.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  69. Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci. 2014 Mar; 35(3):146-54. PMID: 24439680.
    Citations: 106     Fields:    Translation:HumansAnimals
  70. Wu LE, Gomes AP, Sinclair DA. Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis. Cancer Cell. 2014 Jan 13; 25(1):12-9. PMID: 24434207.
    Citations: 20     Fields:    Translation:HumansAnimals
  71. Michan S, Juan AM, Hurst CG, Cui Z, Evans LP, Hatton CJ, Pei DT, Ju M, Sinclair DA, Smith LE, Chen J. Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. PLoS One. 2014; 9(1):e85031. PMID: 24416337.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  72. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013 Dec 19; 155(7):1624-38. PMID: 24360282.
    Citations: 244     Fields:    Translation:AnimalsCells
  73. Sinclair DA, Guarente L. Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol. 2014; 54:363-80. PMID: 24160699.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  74. Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol. 2013 Nov; 9(11):693-700. PMID: 24077178.
    Citations: 50     Fields:    Translation:AnimalsCells
  75. Franco SS, De Falco L, Ghaffari S, Brugnara C, Sinclair DA, Matte' A, Iolascon A, Mohandas N, Bertoldi M, An X, Siciliano A, Rimmelé P, Cappellini MD, Michan S, Zoratti E, Anne J, De Franceschi L. Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. Haematologica. 2014 Feb; 99(2):267-75. PMID: 23975182.
    Citations: 21     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  76. Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem. 2013 Aug 16; 288(33):24160. PMID: 23956323.
    Citations:    
  77. Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, Pei DT, Joyal JS, Evans LP, Cui Z, Stahl A, Sapieha P, Sinclair DA, Smith LE. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 2013 Oct; 16(4):985-92. PMID: 23912262.
    Citations: 11     Fields:    Translation:AnimalsCells
  78. Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism. Cell Cycle. 2013 Jul 15; 12(14):2233-40. PMID: 23892437.
    Citations: 7     Fields:    Translation:HumansCells
  79. Tilly JL, Sinclair DA. Germline energetics, aging, and female infertility. Cell Metab. 2013 Jun 04; 17(6):838-50. PMID: 23747243.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  80. Sinclair D, Isba R, Kredo T, Zani B, Smith H, Garner P. World Health Organization guideline development: an evaluation. PLoS One. 2013; 8(5):e63715. PMID: 23741299.
    Citations: 8     Fields:    Translation:Humans
  81. Stottmann RW, Donlin M, Hafner A, Bernard A, Sinclair DA, Beier DR. A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse. Hum Mol Genet. 2013 Oct 15; 22(20):4053-63. PMID: 23727838.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  82. Rouvinen-Lagerström N, Lahti J, Alho H, Kovanen L, Aalto M, Partonen T, Silander K, Sinclair D, Räikkönen K, Eriksson JG, Palotie A, Koskinen S, Saarikoski ST. µ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption. Alcohol Alcohol. 2013 Sep-Oct; 48(5):519-25. PMID: 23729673.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  83. Lai L, Yan L, Gao S, Hu CL, Ge H, Davidow A, Park M, Bravo C, Iwatsubo K, Ishikawa Y, Auwerx J, Sinclair DA, Vatner SF, Vatner DE. Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway. Circulation. 2013 Apr 23; 127(16):1692-701. PMID: 23536361.
    Citations: 23     Fields:    Translation:AnimalsCells
  84. Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science. 2013 Mar 08; 339(6124):1216-9. PMID: 23471411.
    Citations: 168     Fields:    Translation:HumansAnimalsCells
  85. Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, Zulewski H, Geier A, Cermak JM, Elliott P, Ellis JL, Westphal C, Knobel U, Eloranta JJ, Kerr-Conte J, Pattou F, Konrad D, Matter CM, Fontana A, Rogler G, Schlapbach R, Regairaz C, Carballido JM, Glaser B, McBurney MW, Pociot F, Sinclair DA, Donath MY. Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metab. 2013 Mar 05; 17(3):448-455. PMID: 23473037.
    Citations: 36     Fields:    Translation:HumansCells
  86. Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol Cell Biol. 2013 Apr; 33(8):1487-502. PMID: 23382074.
    Citations: 19     Fields:    Translation:HumansCells
  87. Sinclair DA. Studying the replicative life span of yeast cells. Methods Mol Biol. 2013; 1048:49-63. PMID: 23929097.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  88. Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R. Metformin improves healthspan and lifespan in mice. Nat Commun. 2013; 4:2192. PMID: 23900241.
    Citations: 210     Fields:    Translation:AnimalsCells
  89. Hubbard BP, Sinclair DA. Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay. Methods Mol Biol. 2013; 1077:167-77. PMID: 24014406.
    Citations: 11     Fields:    Translation:HumansCells
  90. Sinclair D, Verdin E. The longevity of sirtuins. Cell Rep. 2012 Dec 27; 2(6):1473-4. PMID: 23273894.
    Citations: 6     Fields:    Translation:Animals
  91. Qu BX, Gong Y, Sinclair D, Fu M, Perl D, Diaz-Arrastia R. cPLA2a knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons. Brain Res. 2013 Feb 25; 1497:101-5. PMID: 23266724.
    Citations: 4     Fields:    Translation:AnimalsCells
  92. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013 Apr; 62(4):1084-93. PMID: 23172919.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  93. Rascón B, Hubbard BP, Sinclair DA, Amdam GV. The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging (Albany NY). 2012 Jul; 4(7):499-508. PMID: 22868943.
    Citations: 20     Fields:    Translation:Animals
  94. Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev. 2012 Jul; 92(3):1479-514. PMID: 22811431.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  95. Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP. Prolyl isomerase Pin1 regulates neuronal differentiation via ß-catenin. Mol Cell Biol. 2012 Aug; 32(15):2966-78. PMID: 22645310.
    Citations: 21     Fields:    Translation:AnimalsCells
  96. Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 2012 May 02; 15(5):675-90. PMID: 22560220.
    Citations: 296     Fields:    Translation:AnimalsCells
  97. North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res. 2012 Apr 13; 110(8):1097-108. PMID: 22499900.
    Citations: 90     Fields:    Translation:HumansAnimals
  98. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
    Citations: 1363     Fields:    Translation:HumansAnimals
  99. Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2013 Jan; 68(1):6-16. PMID: 22451473.
    Citations: 46     Fields:    Translation:Animals
  100. Han J, Hubbard BP, Lee J, Montagna C, Lee HW, Sinclair DA, Suh Y. Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell Cycle. 2013 Jan 15; 12(2):263-70. PMID: 23255128.
    Citations: 5     Fields:    Translation:HumansCells
  101. Ackerman N, Aharmim B, Auger M, Auty DJ, Barbeau PS, Barry K, Bartoszek L, Beauchamp E, Belov V, Benitez-Medina C, Breidenbach M, Burenkov A, Cleveland B, Conley R, Conti E, Cook J, Cook S, Coppens A, Counts I, Craddock W, Daniels T, Danilov MV, Davis CG, Davis J, deVoe R, Djurcic Z, Dobi A, Dolgolenko AG, Dolinski MJ, Donato K, Dunford M, Fairbank W, Farine J, Fierlinger P, Franco D, Freytag D, Giroux G, Gornea R, Graham K, Gratta G, Green MP, Hägemann C, Hall C, Hall K, Haller G, Hargrove C, Herbst R, Herrin S, Hodgson J, Hughes M, Johnson A, Karelin A, Kaufman LJ, Koffas T, Kuchenkov A, Kumar A, Kumar KS, Leonard DS, Leonard F, LePort F, Mackay D, MacLellan R, Marino M, Martin Y, Mong B, Díez MM, Morgan P, Müller AR, Neilson R, Nelson R, Odian A, O'Sullivan K, Ouellet C, Piepke A, Pocar A, Prescott CY, Pushkin K, Rivas A, Rollin E, Rowson PC, Russell JJ, Sabourov A, Sinclair D, Skarpaas K, Slutsky S, Stekhanov V, Strickland V, Swift M, Tosi D, Twelker K, Vogel P, Vuilleumier JL, Vuilleumier JM, Waite A, Waldman S, Walton T, Wamba K, Weber M, Wichoski U, Wodin J, Wright JD, Yang L, Yen YR, Zeldovich OY. Observation of two-neutrino double-beta decay in 136Xe with the EXO-200 detector. Phys Rev Lett. 2011 Nov 18; 107(21):212501. PMID: 22181874.
    Citations: 2     Fields:    
  102. Accili D, de Cabo R, Sinclair DA. An unSIRTain role in longevity. Nat Med. 2011 Nov 07; 17(11):1350-1. PMID: 22064411.
    Citations: 4     Fields:    Translation:HumansAnimals
  103. Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochim Biophys Acta. 2012 Feb; 1822(2):185-95. PMID: 22027215.
    Citations: 25     Fields:    Translation:AnimalsCells
  104. Bercik P, Park AJ, Sinclair D, Khoshdel A, Lu J, Huang X, Deng Y, Blennerhassett PA, Fahnestock M, Moine D, Berger B, Huizinga JD, Kunze W, McLean PG, Bergonzelli GE, Collins SM, Verdu EF. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil. 2011 Dec; 23(12):1132-9. PMID: 21988661.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  105. LePort F, Neilson R, Barbeau PS, Barry K, Bartoszek L, Counts I, Davis J, deVoe R, Dolinski MJ, Gratta G, Green M, Montero Díez M, Müller AR, O'Sullivan K, Rivas A, Twelker K, Aharmim B, Auger M, Belov V, Benitez-Medina C, Breidenbach M, Burenkov A, Cleveland B, Conley R, Cook J, Cook S, Craddock W, Daniels T, Dixit M, Dobi A, Donato K, Fairbank W, Farine J, Fierlinger P, Franco D, Giroux G, Gornea R, Graham K, Green C, Hägemann C, Hall C, Hall K, Hallman D, Hargrove C, Herrin S, Hughes M, Hodgson J, Juget F, Kaufman LJ, Karelin A, Ku J, Kuchenkov A, Kumar K, Leonard DS, Lutter G, Mackay D, MacLellan R, Marino M, Mong B, Morgan P, Odian A, Piepke A, Pocar A, Prescott CY, Pushkin K, Rollin E, Rowson PC, Schmoll B, Sinclair D, Skarpaas K, Slutsky S, Stekhanov V, Strickland V, Swift M, Vuilleumier JL, Vuilleumier JM, Wichoski U, Wodin J, Yang L, Yen YR. A magnetically driven piston pump for ultra-clean applications. Rev Sci Instrum. 2011 Oct; 82(10):105114. PMID: 22047336.
    Citations:    Fields:    
  106. Vendrell A, Martínez-Pastor M, González-Novo A, Pascual-Ahuir A, Sinclair DA, Proft M, Posas F. Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. EMBO Rep. 2011 Sep 30; 12(10):1062-8. PMID: 21836634.
    Citations: 15     Fields:    Translation:Animals
  107. Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):E952-61. PMID: 21949390.
    Citations: 48     Fields:    Translation:AnimalsCells
  108. Ramadori G, Fujikawa T, Anderson J, Berglund ED, Frazao R, Michán S, Vianna CR, Sinclair DA, Elias CF, Coppari R. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metab. 2011 Sep 07; 14(3):301-12. PMID: 21907137.
    Citations: 60     Fields:    Translation:AnimalsCells
  109. Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. SRT1720 improves survival and healthspan of obese mice. Sci Rep. 2011; 1:70. PMID: 22355589.
    Citations: 86     Fields:    Translation:Animals
  110. Hua J, Guerin KI, Chen J, Michán S, Stahl A, Krah NM, Seaward MR, Dennison RJ, Juan AM, Hatton CJ, Sapieha P, Sinclair DA, Smith LE. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2809-16. PMID: 21282584.
    Citations: 28     Fields:    Translation:Animals
  111. Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R. Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem. 2011 Jun 03; 286(22):19270-9. PMID: 21467030.
    Citations: 40     Fields:    Translation:AnimalsCells
  112. Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY). 2010 Dec; 2(12):914-23. PMID: 21212461.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  113. Yang Y, Hubbard BP, Sinclair DA, Tong Q. Characterization of murine SIRT3 transcript variants and corresponding protein products. J Cell Biochem. 2010 Nov 01; 111(4):1051-8. PMID: 20677216.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  114. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011 Feb; 66(2):191-201. PMID: 20974732.
    Citations: 301     Fields:    Translation:Animals
  115. Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Dietary restriction: standing up for sirtuins. Science. 2010 Aug 27; 329(5995):1012-3; author reply 1013-4. PMID: 20798296.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  116. Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. PMID: 20660252.
    Citations: 114     Fields:    Translation:AnimalsCells
  117. Le Couteur DG, Sinclair DA. A blueprint for developing therapeutic approaches that increase healthspan and delay death. J Gerontol A Biol Sci Med Sci. 2010 Jul; 65(7):693-4. PMID: 20375077.
    Citations:    Fields:    Translation:Humans
  118. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21. PMID: 20351400.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  119. Sinclair D, Webster MJ, Wong J, Weickert CS. Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development. Mol Psychiatry. 2011 May; 16(5):504-15. PMID: 20308989.
    Citations: 21     Fields:    Translation:Humans
  120. Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes. 2010 Apr; 59(4):829-35. PMID: 20107110.
    Citations: 33     Fields:    Translation:HumansAnimals
  121. Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol. 2010; 5:253-95. PMID: 20078221.
    Citations: 537     Fields:    Translation:HumansAnimals
  122. Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging (Albany NY). 2009 Jun 03; 1(6):515-28. PMID: 20157535.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  123. Sinclair DA, Oberdoerffer P. The ageing epigenome: damaged beyond repair? Ageing Res Rev. 2009 Jul; 8(3):189-98. PMID: 19439199.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  124. Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, Hoffmann E, Carney DP, Perni RB, Jirousek MR, Bemis JE, Milne JC, Sinclair DA, Westphal CH. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci. 2009 Mar; 18(3):514-25. PMID: 19241369.
    Citations: 44     Fields:    Translation:AnimalsCells
  125. Jiménez-Hidalgo M, Santos-Ocaña C, Padilla S, Villalba JM, López-Lluch G, Martín-Montalvo A, Minor RK, Sinclair DA, de Cabo R, Navas P. NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell. 2009 Apr; 8(2):140-51. PMID: 19239415.
    Citations: 13     Fields:    Translation:AnimalsCells
  126. Blagosklonny MV, Campisi J, Sinclair DA. Aging: past, present and future. Aging (Albany NY). 2009 Jan 07; 1(1):1-5. PMID: 20157590.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  127. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18. PMID: 19041753.
    Citations: 290     Fields:    Translation:HumansAnimalsCells
  128. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008 Aug; 8(2):157-68. PMID: 18599363.
    Citations: 365     Fields:    Translation:AnimalsCells
  129. Howitz KT, Sinclair DA. Xenohormesis: sensing the chemical cues of other species. Cell. 2008 May 02; 133(3):387-91. PMID: 18455976.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  130. Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One. 2008 Apr 16; 3(4):e2020. PMID: 18414679.
    Citations: 212     Fields:    Translation:HumansAnimalsCells
  131. Baur JA, Sinclair DA. What is Xenohormesis? Am J Pharmacol Toxicol. 2008 Mar 31; 3(1):152-159. PMID: 26949380.
    Citations: 4     
  132. Sinclair DA. David A. Sinclair, Ph.D is interviewed by Vicki Glaser. Rejuvenation Res. 2008 Feb; 11(1):265-8. PMID: 18279035.
    Citations:    Fields:    Translation:Animals
  133. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170):712-6. PMID: 18046409.
    Citations: 528     Fields:    Translation:HumansAnimalsCells
  134. Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol. 2007 Oct 02; 5(10):e261. PMID: 17914901.
    Citations: 128     Fields:    Translation:AnimalsCells
  135. Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007 Sep 21; 130(6):1095-107. PMID: 17889652.
    Citations: 312     Fields:    Translation:HumansAnimalsCells
  136. Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S. Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation. Cell Death Differ. 2007 Dec; 14(12):2058-67. PMID: 17885668.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  137. Oberdoerffer P, Sinclair DA. The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol. 2007 Sep; 8(9):692-702. PMID: 17700626.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  138. Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J. 2007 Nov; 21(13):3629-39. PMID: 17585054.
    Citations: 49     Fields:    Translation: