Harvard Catalyst Profiles

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Taslim Ahmed Al-Hilal, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Al-Hilal TA, Hossain MA, Alobaida A, Alam F, Keshavarz A, Nozik-Grayck E, Stenmark KR, German NA, Ahsan F. Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects. J Control Release. 2021 Jun 10; 334:237-247. PMID: 33915222.
    Citations:    Fields:    
  2. Al Shoyaib A, Alamri FF, Biggers A, Karamyan ST, Arumugam TV, Ahsan F, Mikelis CM, Al-Hilal TA, Karamyan VT. Delayed Exercise-induced Upregulation of Angiogenic Proteins and Recovery of Motor Function after Photothrombotic Stroke in Mice. Neuroscience. 2021 05 01; 461:57-71. PMID: 33667592.
    Citations:    Fields:    Translation:AnimalsCells
  3. Kadry H, Lagares D, Al-Hilal TA. Method for Investigating Fibroblast Durotaxis. Methods Mol Biol. 2021; 2299:227-236. PMID: 34028747.
    Citations:    Fields:    
  4. Al-Hilal TA, Keshavarz A, Kadry H, Lahooti B, Al-Obaida A, Ding Z, Li W, Kamm R, McMurtry IF, Lahm T, Nozik-Grayck E, Stenmark KR, Ahsan F. Pulmonary-arterial-hypertension (PAH)-on-a-chip: fabrication, validation and application. Lab Chip. 2020 09 21; 20(18):3334-3345. PMID: 32749432.
    Citations: 1     Fields:    
  5. Deaguero IG, Huda MN, Rodriguez V, Zicari J, Al-Hilal TA, Badruddoza AZM, Nurunnabi M. Nano-Vesicle Based Anti-Fungal Formulation Shows Higher Stability, Skin Diffusion, Biosafety and Anti-Fungal Efficacy In Vitro. Pharmaceutics. 2020 Jun 05; 12(6). PMID: 32517047.
  6. Lim M, Badruddoza AZM, Firdous J, Azad M, Mannan A, Al-Hilal TA, Cho CS, Islam MA. Engineered Nanodelivery Systems to Improve DNA Vaccine Technologies. Pharmaceutics. 2020 Jan 01; 12(1). PMID: 31906277.
    Citations: 10     
  7. Rashid J, Alobaida A, Al-Hilal TA, Hammouda S, McMurtry IF, Nozik-Grayck E, Stenmark KR, Ahsan F. Repurposing rosiglitazone, a PPAR-? agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH. J Control Release. 2018 06 28; 280:113-123. PMID: 29723610.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  8. Kadry H, Al-Hilal TA, Keshavarz A, Alam F, Xu C, Joy A, Ahsan F. Multi-purposable filaments of HPMC for 3D printing of medications with tailored drug release and timed-absorption. Int J Pharm. 2018 Jun 10; 544(1):285-296. PMID: 29680281.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  9. Seo J, Al-Hilal TA, Jee JG, Kim YL, Kim HJ, Lee BH, Kim S, Kim IS. A targeted ferritin-microplasmin based thrombolytic nanocage selectively dissolves blood clots. Nanomedicine. 2018 04; 14(3):633-642. PMID: 29309907.
    Citations: 4     Fields:    Translation:Animals
  10. Choi JU, Chung SW, Al-Hilal TA, Alam F, Park J, Mahmud F, Jeong JH, Kim SY, Byun Y. A heparin conjugate, LHbisD4, inhibits lymphangiogenesis and attenuates lymph node metastasis by blocking VEGF-C signaling pathway. Biomaterials. 2017 Sep; 139:56-66. PMID: 28586719.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  11. Haque MR, Kim J, Park H, Lee HS, Lee KW, Al-Hilal TA, Jeong JH, Ahn CH, Lee DS, Kim SJ, Byun Y. Xenotransplantation of layer-by-layer encapsulated non-human primate islets with a specified immunosuppressive drug protocol. J Control Release. 2017 07 28; 258:10-21. PMID: 28433740.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Park J, Jeon OC, Yun J, Nam H, Hwang J, Al-Hilal TA, Kim K, Kim K, Byun Y. Correction to End-Site-Specific Conjugation of Enoxaparin and Tetradeoxycholic Acid Using Nonenzymatic Glycosylation for Oral Delivery. J Med Chem. 2017 01 12; 60(1):524-525. PMID: 28005363.
    Citations:    Fields:    
  13. Park J, Jeon OC, Yun J, Nam H, Hwang J, Al-Hilal TA, Kim K, Kim K, Byun Y. End-Site-Specific Conjugation of Enoxaparin and Tetradeoxycholic Acid Using Nonenzymatic Glycosylation for Oral Delivery. J Med Chem. 2016 12 08; 59(23):10520-10529. PMID: 27933952.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Al-Hilal TA, Chung SW, Choi JU, Alam F, Park J, Kim SW, Kim SY, Ahsan F, Kim IS, Byun Y. Targeting prion-like protein doppel selectively suppresses tumor angiogenesis. J Clin Invest. 2016 Apr 01; 126(4):1251-66. PMID: 26950422.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  15. Alam F, Al-Hilal TA, Park J, Choi JU, Mahmud F, Jeong JH, Kim IS, Kim SY, Hwang SR, Byun Y. Multi-stage inhibition in breast cancer metastasis by orally active triple conjugate, LHTD4 (low molecular weight heparin-taurocholate-tetrameric deoxycholate). Biomaterials. 2016 Apr; 86:56-67. PMID: 26890038.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Alam F, Hwang SR, Al-Hilal TA, Chung SW, Kim HS, Kang BH, Zhang HS, Shin SH, Lee JY, Kang MS, Kwon GH, Jeon OC, Kim SY, Byun Y. Safety studies on intravenous infusion of a potent angiogenesis inhibitor: taurocholate-conjugated low molecular weight heparin derivative LHT7 in preclinical models. Drug Dev Ind Pharm. 2016 Aug; 42(8):1247-57. PMID: 26612099.
    Citations: 1     Fields:    Translation:HumansAnimals
  17. Al-Hilal TA, Chung SW, Alam F, Park J, Lee KE, Jeon H, Kim K, Kwon IC, Kim IS, Kim SY, Byun Y. Corrigendum: Functional transformations of bile acid transporters induced by high-affinity macromolecules. Sci Rep. 2015 Aug 05; 5:9407. PMID: 26244565.
    Citations:    Fields:    
  18. Park J, Al-Hilal TA, Jeong JH, Choi Ju, Byun Y. Design, Synthesis, and Therapeutic Evaluation of Poly(acrylic acid)-tetraDOCA Conjugate as a Bile Acid Transporter Inhibitor. Bioconjug Chem. 2015 Aug 19; 26(8):1597-605. PMID: 26086474.
    Citations: 4     Fields:    Translation:AnimalsCells
  19. Park J, Jeong JH, Al-Hilal TA, Kim JY, Byun Y. Size Controlled Heparin Fragment-Deoxycholic Acid Conjugate Showed Anticancer Property by Inhibiting VEGF165. Bioconjug Chem. 2015 May 20; 26(5):932-40. PMID: 25894217.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  20. Mahmud F, Jeon OC, Al-Hilal TA, Kweon S, Yang VC, Lee DS, Byun Y. Absorption Mechanism of a Physical Complex of Monomeric Insulin and Deoxycholyl-l-lysyl-methylester in the Small Intestine. Mol Pharm. 2015 Jun 01; 12(6):1911-20. PMID: 25892399.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  21. Shin JY, Jeong JH, Han J, Bhang SH, Jeong GJ, Haque MR, Al-Hilal TA, Noh M, Byun Y, Kim BS. Transplantation of heterospheroids of islet cells and mesenchymal stem cells for effective angiogenesis and antiapoptosis. Tissue Eng Part A. 2015 Mar; 21(5-6):1024-35. PMID: 25344077.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Kim JY, Al-Hilal TA, Chung SW, Kim SY, Ryu GH, Son WC, Byun Y. Antiangiogenic and anticancer effect of an orally active low molecular weight heparin conjugates and its application to lung cancer chemoprevention. J Control Release. 2015 Feb 10; 199:122-31. PMID: 25523032.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  23. Alam F, Al-Hilal TA, Chung SW, Park J, Mahmud F, Seo D, Kim HS, Lee DS, Byun Y. Functionalized heparin-protamine based self-assembled nanocomplex for efficient anti-angiogenic therapy. J Control Release. 2015 Jan 10; 197:180-9. PMID: 25445701.
    Citations:    Fields:    Translation:HumansAnimalsCells
  24. Chung SW, Bae SM, Lee M, Al-Hilal TA, Lee CK, Kim JK, Kim IS, Kim SY, Byun Y. LHT7, a chemically modified heparin, inhibits multiple stages of angiogenesis by blocking VEGF, FGF2 and PDGF-B signaling pathways. Biomaterials. 2015 Jan; 37:271-8. PMID: 25453957.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  25. Al-Hilal TA, Alam F, Park JW, Kim K, Kwon IC, Ryu GH, Byun Y. Prevention effect of orally active heparin conjugate on cancer-associated thrombosis. J Control Release. 2014 Dec 10; 195:155-61. PMID: 24862320.
    Citations: 2     Fields:    Translation:HumansAnimals
  26. Alam F, Al-Hilal TA, Chung SW, Seo D, Mahmud F, Kim HS, Kim SY, Byun Y. Oral delivery of a potent anti-angiogenic heparin conjugate by chemical conjugation and physical complexation using deoxycholic acid. Biomaterials. 2014 Aug; 35(24):6543-52. PMID: 24816287.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  27. Al-Hilal TA, Chung SW, Alam F, Park J, Lee KE, Jeon H, Kim K, Kwon IC, Kim IS, Kim SY, Byun Y. Functional transformations of bile acid transporters induced by high-affinity macromolecules. Sci Rep. 2014 Feb 25; 4:4163. PMID: 24566561.
    Citations: 10     Fields:    Translation:HumansCells
  28. Al-Hilal TA, Park J, Alam F, Chung SW, Park JW, Kim K, Kwon IC, Kim IS, Kim SY, Byun Y. Oligomeric bile acid-mediated oral delivery of low molecular weight heparin. J Control Release. 2014 Feb 10; 175:17-24. PMID: 24333628.
    Citations: 12     Fields:    Translation:AnimalsCells
  29. Jeon OC, Hwang SR, Al-Hilal TA, Park JW, Moon HT, Lee S, Park JH, Byun Y. Oral delivery of ionic complex of ceftriaxone with bile acid derivative in non-human primates. Pharm Res. 2013 Apr; 30(4):959-67. PMID: 23292220.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  30. Al-Hilal TA, Alam F, Byun Y. Oral drug delivery systems using chemical conjugates or physical complexes. Adv Drug Deliv Rev. 2013 Jun 15; 65(6):845-64. PMID: 23220326.
    Citations: 11     Fields:    Translation:Humans
  31. Hwang SR, Seo DH, Al-Hilal TA, Jeon OC, Kang JH, Kim SH, Kim HS, Chang YT, Kang YM, Yang VC, Byun Y. Orally active desulfated low molecular weight heparin and deoxycholic acid conjugate, 6ODS-LHbD, suppresses neovascularization and bone destruction in arthritis. J Control Release. 2012 Nov 10; 163(3):374-84. PMID: 23041275.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  32. Park JW, Jeon OC, Kim SK, Al-Hilal TA, Lim KM, Moon HT, Kim CY, Byun Y. Pharmacokinetic evaluation of an oral tablet form of low-molecular-weight heparin and deoxycholic acid conjugate as a novel oral anticoagulant. Thromb Haemost. 2011 Jun; 105(6):1060-71. PMID: 21437357.
    Citations:    Fields:    Translation:HumansAnimals
  33. Park JW, Jeon OC, Kim SK, Al-Hilal TA, Jin SJ, Moon HT, Yang VC, Kim SY, Byun Y. High antiangiogenic and low anticoagulant efficacy of orally active low molecular weight heparin derivatives. J Control Release. 2010 Dec 20; 148(3):317-26. PMID: 20869408.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  34. Eom JS, Koh KS, Al-Hilal TA, Park JW, Jeon OC, Moon HT, Byun Y. Antithrombotic efficacy of an oral low molecular weight heparin conjugated with deoxycholic asset on microsurgical anastomosis in rats. Thromb Res. 2010 Sep; 126(3):e220-4. PMID: 20619883.
    Citations: 5     Fields:    Translation:Animals
  35. Park JW, Jeon OC, Kim SK, Al-Hilal TA, Moon HT, Kim CY, Byun Y. Anticoagulant efficacy of solid oral formulations containing a new heparin derivative. Mol Pharm. 2010 Jun 07; 7(3):836-43. PMID: 20349950.
    Citations: 5     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.