Harvard Catalyst Profiles

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Shinichi Goto, Ph.D.

Title
Institution
Department
Address

Biography
education and training
Keio University School of Medicine, Tokyo, JapanMD03/2013Medicine
Keio University School of Medicine, Tokyo, JapanPhD03/2018Biochemistry

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shiraishi Y, Goto S, Niimi N, Katsumata Y, Goda A, Takei M, Saji M, Sano M, Fukuda K, Kohno T, Yoshikawa T, Kohsaka S. Improved prediction of sudden cardiac death in patients with heart failure through digital processing of electrocardiography. Europace. 2023 Jan 04. PMID: 36610062.
    Citations:    Fields:    
  2. Yagi R, Goto S, Katsumata Y, MacRae CA, Deo RC. Importance of external validation and subgroup analysis of artificial intelligence in the detection of low ejection fraction from electrocardiograms. Eur Heart J Digit Health. 2022 Dec; 3(4):654-657. PMID: 36710903; PMCID: PMC9779862.
    Citations:    
  3. Hioki H, Watanabe Y, Kozuma K, Ryuzaki T, Goto S, Inohara T, Katsumata Y, Tsunaki T, Kawahata R, Kobayashi T, Asami M, Otsuka T, Yamamoto M, Hayashida K. Validation of reliability and predictivity of membrane septum length measurements for pacemaker need after transcatheter aortic valve replacement. Catheter Cardiovasc Interv. 2022 11; 100(5):868-876. PMID: 36073020.
    Citations:    Fields:    Translation:Humans
  4. Gearhart A, Goto S, Deo RC, Powell AJ. An Automated View Classification Model for Pediatric Echocardiography Using Artificial Intelligence. J Am Soc Echocardiogr. 2022 12; 35(12):1238-1246. PMID: 36049595.
    Citations:    Fields:    Translation:Humans
  5. Goto S, Solanki D, John JE, Yagi R, Homilius M, Ichihara G, Katsumata Y, Gaggin HK, Itabashi Y, MacRae CA, Deo RC. Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection. Circulation. 2022 09 06; 146(10):755-769. PMID: 35916132; PMCID: PMC9439630.
    Citations: 1     Fields:    Translation:Humans
  6. Moriyama H, Endo J, Kataoka M, Shimanaka Y, Kono N, Sugiura Y, Goto S, Kitakata H, Hiraide T, Yoshida N, Isobe S, Yamamoto T, Shirakawa K, Anzai A, Katsumata Y, Suematsu M, Kosaki K, Fukuda K, Arai H, Sano M. Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling. Nat Commun. 2022 05 31; 13(1):3013. PMID: 35641514; PMCID: PMC9156667.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Truslow JG, Goto S, Homilius M, Mow C, Higgins JM, MacRae CA, Deo RC. Cardiovascular Risk Assessment Using Artificial Intelligence-Enabled Event Adjudication and Hematologic Predictors. Circ Cardiovasc Qual Outcomes. 2022 06; 15(6):e008007. PMID: 35477255; PMCID: PMC9208816.
    Citations:    Fields:    Translation:Humans
  8. Goto S, Goto S. A Patient-Level Meta-Analysis: The End of the Era of Direct Oral Anticoagulant Developmental Trials in Patients With Atrial Fibrillation? Circulation. 2022 01 25; 145(4):256-258. PMID: 35073174.
    Citations: 1     Fields:    Translation:Humans
  9. Kitakata H, Endo J, Matsushima H, Yamamoto S, Ikura H, Hirai A, Koh S, Ichihara G, Hiraide T, Moriyama H, Shirakawa K, Goto S, Katsumata Y, Anzai A, Kataoka M, Tokuyama T, Ishido S, Yanagi S, Fukuda K, Sano M. MITOL/MARCH5 determines the susceptibility of cardiomyocytes to doxorubicin-induced ferroptosis by regulating GSH homeostasis. J Mol Cell Cardiol. 2021 12; 161:116-129. PMID: 34390730.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Kitakata H, Endo J, Hashimoto S, Mizuno E, Moriyama H, Shirakawa K, Goto S, Katsumata Y, Fukuda K, Sano M. Imeglimin prevents heart failure with preserved ejection fraction by recovering the impaired unfolded protein response in mice subjected to cardiometabolic stress. Biochem Biophys Res Commun. 2021 10 01; 572:185-190. PMID: 34375928.
    Citations: 2     Fields:    Translation:AnimalsCells
  11. Goto S, Mahara K, Beussink-Nelson L, Ikura H, Katsumata Y, Endo J, Gaggin HK, Shah SJ, Itabashi Y, MacRae CA, Deo RC. Artificial intelligence-enabled fully automated detection of cardiac amyloidosis using electrocardiograms and echocardiograms. Nat Commun. 2021 05 11; 12(1):2726. PMID: 33976142.
    Citations: 13     Fields:    
  12. Goto S, Ichihara G, Katsumata Y, Ko S, Anzai A, Shirakawa K, Endo J, Kataoka M, Moriyama H, Hiraide T, Kitakata H, Kobayashi T, Fukuda K, Sano M. Time-Series Transcriptome Analysis Reveals the miR-27a-5p-Ppm1l Axis as a New Pathway Regulating Macrophage Alternative Polarization After Myocardial Infarction. Circ J. 2021 05 25; 85(6):929-938. PMID: 33658455.
    Citations:    Fields:    Translation:AnimalsCells
  13. Shinya Y, Hiraide T, Momoi M, Goto S, Suzuki H, Katsumata Y, Kurebayashi Y, Endo J, Sano M, Fukuda K, Kosaki K, Kataoka M. TNFRSF13B c.226G>A (p.Gly76Ser) as a Novel Causative Mutation for Pulmonary Arterial Hypertension. J Am Heart Assoc. 2021 02; 10(5):e019245. PMID: 33586470.
    Citations: 3     Fields:    Translation:Humans
  14. Miura K, Goto S, Katsumata Y, Ikura H, Shiraishi Y, Sato K, Fukuda K. Feasibility of the deep learning method for estimating the ventilatory threshold with electrocardiography data. NPJ Digit Med. 2020; 3:141. PMID: 33145437.
    Citations: 4     
  15. Yabushita H, Goto S, Nakamura S, Oka H, Nakayama M, Goto S. Development of Novel Artificial Intelligence to Detect the Presence of Clinically Meaningful Coronary Atherosclerotic Stenosis in Major Branch from Coronary Angiography Video. J Atheroscler Thromb. 2021 Aug 01; 28(8):835-843. PMID: 33012741; PMCID: PMC8326176.
    Citations: 4     Fields:    Translation:Humans
  16. Goto S, Goto S, Pieper KS, Bassand JP, Camm AJ, Fitzmaurice DA, Goldhaber SZ, Haas S, Parkhomenko A, Oto A, Misselwitz F, Turpie AGG, Verheugt FWA, Fox KAA, Gersh BJ, Kakkar AK. New artificial intelligence prediction model using serial prothrombin time international normalized ratio measurements in atrial fibrillation patients on vitamin K antagonists: GARFIELD-AF. Eur Heart J Cardiovasc Pharmacother. 2020 09 01; 6(5):301-309. PMID: 31821482.
    Citations: 11     Fields:    Translation:Humans
  17. Shirakawa K, Endo J, Kataoka M, Katsumata Y, Anzai A, Moriyama H, Kitakata H, Hiraide T, Ko S, Goto S, Ichihara G, Fukuda K, Minamino T, Sano M. MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin-Producing Reparative Macrophages After Myocardial Infarction. J Am Heart Assoc. 2020 09 15; 9(18):e017071. PMID: 32865099.
    Citations: 10     Fields:    Translation:AnimalsCells
  18. Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Isobe S, Moriyama H, Goto S, Shimanaka Y, Kono N, Arai H, Shinmura K, Fukuda K, Sano M. Palmitate induces cardiomyocyte death via inositol requiring enzyme-1 (IRE1)-mediated signaling independent of X-box binding protein 1 (XBP1). Biochem Biophys Res Commun. 2020 05 21; 526(1):122-127. PMID: 32199617.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Yamashita K, Ito K, Endo J, Matsuhashi T, Katsumata Y, Yamamoto T, Shirakawa K, Isobe S, Kataoka M, Yoshida N, Goto S, Moriyama H, Kitakata H, Mitani F, Fukuda K, Goda N, Ichihara A, Sano M. Adrenal cortex hypoxia modulates aldosterone production in heart failure. Biochem Biophys Res Commun. 2020 03 26; 524(1):184-189. PMID: 31982132.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  20. Hiraide T, Kataoka M, Suzuki H, Aimi Y, Chiba T, Isobe S, Katsumata Y, Goto S, Kanekura K, Yamada Y, Moriyama H, Kitakata H, Endo J, Yuasa S, Arai Y, Hirose N, Satoh T, Hakamata Y, Sano M, Gamou S, Kosaki K, Fukuda K. Poor outcomes in carriers of the RNF213 variant (p.Arg4810Lys) with pulmonary arterial hypertension. J Heart Lung Transplant. 2020 02; 39(2):103-112. PMID: 31542298.
    Citations: 9     Fields:    Translation:HumansCells
  21. Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Yoshida N, Isobe S, Moriyama H, Goto S, Yamashita K, Ohto-Nakanishi T, Nakanishi H, Shimanaka Y, Kono N, Shinmura K, Arai H, Fukuda K, Sano M. Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload. J Mol Cell Cardiol. 2019 08; 133:1-11. PMID: 31145942.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Sano M, Goto S. Possible Mechanism of Hematocrit Elevation by Sodium Glucose Cotransporter 2 Inhibitors and Associated Beneficial Renal and Cardiovascular Effects. Circulation. 2019 04 23; 139(17):1985-1987. PMID: 31009585.
    Citations: 56     Fields:    Translation:Humans
  23. Matsuhashi T, Endo J, Katsumata Y, Yamamoto T, Shimizu N, Yoshikawa N, Kataoka M, Isobe S, Moriyama H, Goto S, Fukuda K, Tanaka H, Sano M. Pressure overload inhibits glucocorticoid receptor transcriptional activity in cardiomyocytes and promotes pathological cardiac hypertrophy. J Mol Cell Cardiol. 2019 05; 130:122-130. PMID: 30946837.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Goto S, Goto S. Letter by Goto and Goto Regarding Article, "Fully Automated Echocardiogram Interpretation in Clinical Practice: Feasibility and Diagnostic Accuracy". Circulation. 2019 03 26; 139(13):1646-1647. PMID: 30908106.
    Citations: 1     Fields:    Translation:Humans
  25. Goto S, Kimura M, Katsumata Y, Goto S, Kamatani T, Ichihara G, Ko S, Sasaki J, Fukuda K, Sano M. Artificial intelligence to predict needs for urgent revascularization from 12-leads electrocardiography in emergency patients. PLoS One. 2019; 14(1):e0210103. PMID: 30625197; PMCID: PMC6326503.
    Citations: 20     Fields:    Translation:Humans
  26. Horisawa S, Ochiai T, Goto S, Nakajima T, Takeda N, Fukui A, Hanada T, Kawamata T, Taira T. Safety and long-term efficacy of ventro-oral thalamotomy for focal hand dystonia: A retrospective study of 171 patients. Neurology. 2019 01 22; 92(4):e371-e377. PMID: 30587520; PMCID: PMC6345121.
    Citations: 12     Fields:    Translation:Humans
  27. Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Yoshida N, Isobe S, Moriyama H, Goto S, Yamashita K, Nakanishi H, Shimanaka Y, Kono N, Shinmura K, Arai H, Fukuda K, Sano M. Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction. PLoS One. 2018; 13(12):e0208396. PMID: 30533011; PMCID: PMC6289418.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Shirakawa K, Endo J, Kataoka M, Katsumata Y, Yoshida N, Yamamoto T, Isobe S, Moriyama H, Goto S, Kitakata H, Hiraide T, Fukuda K, Sano M. IL (Interleukin)-10-STAT3-Galectin-3 Axis Is Essential for Osteopontin-Producing Reparative Macrophage Polarization After Myocardial Infarction. Circulation. 2018 10 30; 138(18):2021-2035. PMID: 29967195.
    Citations: 50     Fields:    Translation:AnimalsCells
  29. Yamamoto T, Kanazawa H, Tanosaki S, Goto S, Kimura M, Tsuruta H, Itabashi Y, Murata M, Kunitomi A, Aizawa Y, Nishiyama T, Kohno T, Maekawa Y, Takatsuki S, Sano M, Igawa O, Fukuda K. A Novel Mechanism of Atrioventricular Block Following Transcatheter Closure of an Atrial Septal Defect. JACC Cardiovasc Interv. 2016 10 10; 9(19):2067-2069. PMID: 27639905.
    Citations: 3     Fields:    Translation:Humans
  30. Goto S, Goto S. Selection of a suitable patient population for new antiplatelet therapy from the large clinical trial database of the thrombin receptor antagonist in secondary prevention of atherothrombotic ischemic events-thrombolysis in myocardial infarction 50 (TRA-2P-TIMI50) trial. Circulation. 2015 Mar 24; 131(12):1041-3. PMID: 25681465.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
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© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.