Harvard Catalyst Profiles

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Naohiko Akimoto, M.D.,Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ugai T, Väyrynen JP, Lau MC, Borowsky J, Akimoto N, Väyrynen SA, Zhao M, Zhong R, Haruki K, Dias Costa A, Fujiyoshi K, Arima K, Wu K, Chan AT, Cao Y, Song M, Fuchs CS, Wang M, Lennerz JK, Ng K, Meyerhardt JA, Giannakis M, Nowak JA, Ogino S. Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer. Cancer Immunol Immunother. 2021 Sep 16. PMID: 34529108.
    Citations:    Fields:    
  2. Ugai T, Zhao M, Shimizu T, Akimoto N, Shi S, Takashima Y, Zhong R, Lau MC, Haruki K, Arima K, Fujiyoshi K, Langworthy B, Masugi Y, da Silva A, Nosho K, Baba Y, Song M, Chan AT, Wang M, Meyerhardt JA, Giannakis M, Väyrynen JP, Nowak JA, Ogino S. Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma. Oncoimmunology. 2021; 10(1):1956173. PMID: 34377593.
    Citations:    Translation:Humans
  3. Sikavi DR, Nguyen LH, Haruki K, Ugai T, Ma W, Wang DD, Thompson KN, Yan Y, Branck T, Wilkinson JE, Akimoto N, Zhong R, Lau MC, Mima K, Kosumi K, Morikawa T, Rimm EB, Garrett WS, Izard J, Cao Y, Song M, Huttenhower C, Ogino S, Chan AT. The Sulfur Microbial Diet and Risk of Colorectal Cancer by Molecular Subtypes and Intratumoral Microbial Species in Adult Men. Clin Transl Gastroenterol. 2021 08 01; 12(8):e00338. PMID: 34333506.
    Citations:    Fields:    
  4. Ugai T, Väyrynen JP, Haruki K, Akimoto N, Lau MC, Zhong R, Kishikawa J, Väyrynen SA, Zhao M, Fujiyoshi K, Costa AD, Borowsky J, Arima K, Guerriero JL, Fuchs CS, Zhang X, Song M, Wang M, Giannakis M, Meyerhardt JA, Nowak JA, Ogino S. Smoking and Incidence of Colorectal Cancer Subclassified by Tumor-Associated Macrophage Infiltrates. J Natl Cancer Inst. 2021 Jul 15. PMID: 34264325.
    Citations:    Fields:    
  5. Higuchi K, Kaise M, Noda H, Kirita K, Koizumi E, Umeda T, Akimoto T, Omori J, Akimoto N, Goto O, Tatsuguchi A, Iwakiri K. Three-dimensional visualization improves the endoscopic diagnosis of superficial gastric neoplasia. BMC Gastroenterol. 2021 May 28; 21(1):242. PMID: 34049479.
    Citations:    Fields:    Translation:Humans
  6. Akimoto N, Zhao M, Ugai T, Zhong R, Lau MC, Fujiyoshi K, Kishikawa J, Haruki K, Arima K, Twombly TS, Zhang X, Giovannucci EL, Wu K, Song M, Chan AT, Cao Y, Meyerhardt JA, Ng K, Giannakis M, Väyrynen JP, Nowak JA, Ogino S. Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis. Cancers (Basel). 2021 Apr 22; 13(9). PMID: 33922024.
    Citations: 2     
  7. Väyrynen JP, Haruki K, Väyrynen SA, Lau MC, Dias Costa A, Borowsky J, Zhao M, Ugai T, Kishikawa J, Akimoto N, Zhong R, Shi S, Chang TW, Fujiyoshi K, Arima K, Twombly TS, Da Silva A, Song M, Wu K, Zhang X, Chan AT, Nishihara R, Fuchs CS, Meyerhardt JA, Giannakis M, Ogino S, Nowak JA. Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment. J Immunother Cancer. 2021 04; 9(4). PMID: 33931472.
    Citations:    Fields:    
  8. Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, Wu K, Cao Y, Ng K, Ogino S. Rising incidence of early-onset colorectal cancer - a call to action. Nat Rev Clin Oncol. 2021 04; 18(4):230-243. PMID: 33219329.
    Citations: 19     Fields:    Translation:Humans
  9. Higuchi K, Kaise M, Noda H, Kirita K, Koizumi E, Umeda T, Akimoto T, Omori J, Akimoto N, Goto O, Tatsuguchi A, Iwakiri K. Three-dimensional flexible endoscopy enables more accurate endoscopic recognition and endoscopic submucosal dissection marking for superficial gastric neoplasia: a pilot study to compare two- and three-dimensional imaging. Surg Endosc. 2021 11; 35(11):6244-6250. PMID: 33128081.
    Citations:    Fields:    
  10. Zhang C, Mei Z, Pei J, Abe M, Zeng X, Huang Q, Nishiyama K, Akimoto N, Haruki K, Nan H, Meyerhardt JA, Zhang R, Li X, Ogino S, Ugai T. A Modified Tumor-Node-Metastasis Classification for Primary Operable Colorectal Cancer. JNCI Cancer Spectr. 2021 Feb; 5(1):pkaa093. PMID: 33554032.
    Citations: 1     
  11. Wang L, He X, Ugai T, Haruki K, Lo CH, Hang D, Akimoto N, Fujiyoshi K, Wang M, Fuchs CS, Meyerhardt JA, Zhang X, Wu K, Chan AT, Giovannucci EL, Ogino S, Song M. Risk Factors and Incidence of Colorectal Cancer According to Major Molecular Subtypes. JNCI Cancer Spectr. 2021 Feb; 5(1):pkaa089. PMID: 33442661.
    Citations:    
  12. Väyrynen JP, Haruki K, Lau MC, Väyrynen SA, Zhong R, Dias Costa A, Borowsky J, Zhao M, Fujiyoshi K, Arima K, Twombly TS, Kishikawa J, Gu S, Aminmozaffari S, Shi S, Baba Y, Akimoto N, Ugai T, Da Silva A, Guerriero JL, Song M, Wu K, Chan AT, Nishihara R, Fuchs CS, Meyerhardt JA, Giannakis M, Ogino S, Nowak JA. The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment. Cancer Immunol Res. 2021 01; 9(1):8-19. PMID: 33023967.
    Citations: 12     Fields:    Translation:Humans
  13. Ugai T, Haruki K, Väyrynen JP, Zhong R, Borowsky J, Fujiyoshi K, Lau MC, Zhao M, Akimoto N, Chang TW, Kishikawa J, Arima K, Shi SS, Gu S, Fuchs CS, Giovannucci EL, Giannakis M, Zhang X, Song M, Meyerhardt JA, Wang M, Nowak JA, Ogino S. Coffee Intake and Colorectal Cancer Incidence According to T-Cell Response. JNCI Cancer Spectr. 2020 Dec; 4(6):pkaa068. PMID: 33409450.
    Citations:    
  14. Fujiyoshi K, Väyrynen JP, Borowsky J, Papke DJ, Arima K, Haruki K, Kishikawa J, Akimoto N, Ugai T, Lau MC, Gu S, Shi S, Zhao M, Da Silva AFL, Twombly TS, Nan H, Meyerhardt JA, Song M, Zhang X, Wu K, Chan AT, Fuchs CS, Lennerz JK, Giannakis M, Nowak JA, Ogino S. Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer. EBioMedicine. 2020 Jul; 57:102860. PMID: 32652320.
    Citations: 9     Fields:    Translation:HumansCells
  15. Väyrynen JP, Lau MC, Haruki K, Väyrynen SA, Dias Costa A, Borowsky J, Zhao M, Fujiyoshi K, Arima K, Twombly TS, Kishikawa J, Gu S, Aminmozaffari S, Shi S, Baba Y, Akimoto N, Ugai T, Da Silva A, Song M, Wu K, Chan AT, Nishihara R, Fuchs CS, Meyerhardt JA, Giannakis M, Ogino S, Nowak JA. Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin-Stained Sections. Clin Cancer Res. 2020 08 15; 26(16):4326-4338. PMID: 32439699.
    Citations: 4     Fields:    
  16. Fujiyoshi K, Chen Y, Haruki K, Ugai T, Kishikawa J, Hamada T, Liu L, Arima K, Borowsky J, Väyrynen JP, Zhao M, Lau MC, Gu S, Shi S, Akimoto N, Twombly TS, Drew DA, Song M, Chan AT, Giovannucci EL, Meyerhardt JA, Fuchs CS, Nishihara R, Lennerz JK, Giannakis M, Nowak JA, Zhang X, Wu K, Ogino S. Smoking Status at Diagnosis and Colorectal Cancer Prognosis According to Tumor Lymphocytic Reaction. JNCI Cancer Spectr. 2020 Aug; 4(5):pkaa040. PMID: 32923934.
    Citations:    
  17. Omori J, Goto O, Higuchi K, Umeda T, Akimoto N, Suzuki M, Kirita K, Koizumi E, Noda H, Akimoto T, Kaise M, Iwakiri K. Three-Dimensional Flexible Endoscopy Can Facilitate Efficient and Reliable Endoscopic Hand Suturing: An ex-vivo Study. Clin Endosc. 2020 May; 53(3):334-338. PMID: 32336050.
    Citations:    
  18. Akimoto N, Wada R, Iwakiri K, Naito Z. Histology and molecular biology studies on the expression and localization of angiopoietin-like protein 8 in human tissues. Biomed Rep. 2019 Nov; 11(5):215-221. PMID: 31632669.
    Citations: 1     
  19. Akimoto N, Kaise M, Iwakiri K. Mucosa-Associated Lymphoid Tissue Lymphoma Presenting as a Subepithelial Tumor. Clin Gastroenterol Hepatol. 2020 10; 18(11):e131. PMID: 31401366.
    Citations:    Fields:    Translation:Humans
  20. Omori J, Fujimori S, Kosugi Y, Yukiko K, Takagi S, Nishimoto T, Sato W, Umeda T, Kataoka H, Akimoto N, Mitsui K, Iwakiri K. Pilot Study Indicates Helicobacter pylori Infection May Induce Small Intestinal Mucosal Injury. Digestion. 2019; 99(1):66-71. PMID: 30554208.
    Citations: 1     Fields:    Translation:HumansCells
  21. Mitsui K, Fujimori S, Tanaka S, Ehara A, Omori J, Akimoto N, Maki K, Suzuki M, Kosugi Y, Ensaka Y, Matsuura Y, Kobayashi T, Yonezawa M, Tatsuguchi A, Sakamoto C. Retrieval of Retained Capsule Endoscopy at Small Bowel Stricture by Double-Balloon Endoscopy Significantly Decreases Surgical Treatment. J Clin Gastroenterol. 2016 Feb; 50(2):141-6. PMID: 25930974.
    Citations: 5     Fields:    Translation:Humans
  22. Akimoto N, Fujimori T, Mitomi H, Ichikawa K, Tomita S, Tatsuguchi A, Fujimori S, Naito Z, Sakamoto C. Micropapillary pattern at the invasive front and its association with unresectable colorectal carcinomas. Dis Markers. 2013; 35(5):451-5. PMID: 24288425.
    Citations: 2     Fields:    Translation:Humans
  23. Tanaka T, Ichikawa K, Maruoka T, Tomita S, Ueda H, Yamaguchi T, Shida Y, Kato H, Nagata H, Kubota K, Akimoto N, Sakamoto C, Imura J, Arita M, Tanaka H, Okamoto Y, Igarashi Y, Fujimori T. Analysis of the anatomic subsites, gender and age in unresectable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab. Mol Clin Oncol. 2013 Mar; 1(2):291-296. PMID: 24649163.
    Citations: 1     
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.