Harvard Catalyst Profiles

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Jeffrey Michael Karp, Ph.D.

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Overview
Dr. Jeff Karp is an Associate Professor at Brigham and Women's Hospital, Harvard Medical School, and is Principal Faculty at the Harvard Stem Cell Institute, an affiliate faculty at MIT through the Harvard-MIT Division of Health Sciences and Technology, and affiliate faculty at the Broad Institute.

His research harnesses materials science and stem cell biology to solve medical problems with emphasis on nanoscale/microscale materials and bio-inspired approaches. He has published more than 100 peer-reviewed papers and book chapters and has given over 200 national and international invited lectures and has 65 issued or pending patents.

Several technologies that Dr. Karp has developed have formed the foundation for multiple products on the market and currently under development and for the launch of two companies, Gecko Biomedical and Skintifique.

Dr. Karp's work has been recognized by CNN, NPR Science Fridays, Boston Globe, ABC News, MSNBC, Fox News, CBC Quirks and Quarks, CanadaAM, BBC, LA Times, Forbes, National Geographic, Popular Science, the Washington Post, the New York Post, and by Wired Magazine.

In 2011 the Boston Business Journal recognized Dr. Karp as a Champion in Healthcare Innovation. Two years later the Institute for Chemical Engineers (IChemE) honored one of his technologies as the Most Innovative Product of the Year. In 2008 MIT’s Technology Review Magazine (TR35) also recognized Dr. Karp as being one of the top innovators in the world under the age of 35 (3 members from his laboratory have already received this award).

He has received the Society for Biomaterials Young Investigator Award and his work has been selected as one of Popular Mechanic's "Top 20 New Biotech Breakthroughs that Will Change Medicine.” Dr. Karp was also elected in 2013 to the American Institute for Medical and Biological Engineering's College of Fellows and as a Kavli Fellow.

In 2014 he gave a TEDMED talk on bioinspired medical innovation and in 2015 became a member of the TEDMED Editorial Advisory Board to help curate the stage program’s themes, topics, speakers and performers. In 2015 he received a Breakthrough Award from the Kenneth Rainin Foundation and was a commencement speaker for the Faculty of Dentistry and Faculty of Pharmacy at the University of Toronto. He also recently was named to the Top 40 Under 40 business leaders by the Boston Business Journal.

An acclaimed mentor, Dr. Karp was selected as the Outstanding Faculty Undergraduate Mentor among all Faculty at MIT. He has also received the HST McMahon Mentoring award for being the top mentor among all faculty who mentor Harvard-MIT students. To date, 17 trainees from his laboratory have secured faculty positions at institutions throughout the world.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56AR063866 (KARP, JEFFREY MICHAEL) Sep 16, 2013 - Aug 31, 2014
    NIH/NIAMS
    A Drug Delivery Platform For Near-Term Treatment of Proteolytic Disease
    Role: Principal Investigator
  2. R21DE023432 (KARP, JEFFREY MICHAEL) Apr 1, 2013 - Mar 31, 2015
    NIH/NIDCR
    Targeting mucositis with inflammation responsive hydrogel microparticles
    Role: Principal Investigator
  3. R01GM086433 (KARP, JEFFREY MICHAEL) Apr 15, 2010 - Feb 28, 2015
    NIH/NIGMS
    Biomedical adhesives with precisely engineered surface topography and chemistry
    Role: Principal Investigator
  4. R21HL097172 (KARP, JEFFREY MICHAEL) Apr 15, 2010 - Mar 31, 2012
    NIH/NHLBI
    Examining firm adhesion and transmigration of surface engineered MSCs
    Role: Principal Investigator
  5. R03DE019191 (KARP, JEFFREY MICHAEL) Jul 1, 2009 - Jun 30, 2011
    NIH/NIDCR
    Characterization of endogenous stem cells within endosseous wounds
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Brennen WN, Denmeade SR. A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer. Stem Cells Transl Med. 2019 Feb 08. PMID: 30735000.
    Citations:    
  2. Fries CA, Lawson SD, Wang LC, Slaughter KV, Vemula PK, Dhayani A, Joshi N, Karp JM, Rickard RF, Gorantla VS, Davis MR. Graft-implanted, enzyme responsive, tacrolimus-eluting hydrogel enables long-term survival of orthotopic porcine limb vascularized composite allografts: A proof of concept study. PLoS One. 2019; 14(1):e0210914. PMID: 30677062.
    Citations:    Fields:    
  3. Lam C, Meinert E, Alturkistani A, Carter AR, Karp J, Yang A, Brindley D, Cui Z. Decision Support Tools for Regenerative Medicine: Systematic Review. J Med Internet Res. 2018 Dec 19; 20(12):e12448. PMID: 30567696.
    Citations:    Fields:    
  4. Ng KS, Smith JA, McAteer MP, Mead BE, Ware J, Jackson FO, Carter A, Ferreira L, Bure K, Rowley JA, Reeve B, Brindley DA, Karp JM. Bioprocess decision support tool for scalable manufacture of extracellular vesicles. Biotechnol Bioeng. 2019 Feb; 116(2):307-319. PMID: 30063243.
    Citations:    Fields:    
  5. Lee Y, Deelman TE, Chen K, Lin DSY, Tavakkoli A, Karp JM. Therapeutic luminal coating of the intestine. Nat Mater. 2018 Sep; 17(9):834-842. PMID: 29891893.
    Citations:    Fields:    
  6. Mead BE, Ordovas-Montanes J, Braun AP, Levy LE, Bhargava P, Szucs MJ, Ammendolia DA, MacMullan MA, Yin X, Hughes TK, Wadsworth MH, Ahmad R, Rakoff-Nahoum S, Carr SA, Langer R, Collins JJ, Shalek AK, Karp JM. Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types. BMC Biol. 2018 06 05; 16(1):62. PMID: 29871632.
    Citations:    Fields:    
  7. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Author Correction: Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 05 11; 9(1):1954. PMID: 29752435.
    Citations:    Fields:    
  8. Rosenblum D, Joshi N, Tao W, Karp JM, Peer D. Progress and challenges towards targeted delivery of cancer therapeutics. Nat Commun. 2018 04 12; 9(1):1410. PMID: 29650952.
    Citations: 11     Fields:    Translation:Humans
  9. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 04 03; 9(1):1275. PMID: 29615615.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Mitsouras D, Tao M, de Vries MR, Trocha K, Miranda OR, Vemula PK, Ding K, Imanzadeh A, Schoen FJ, Karp JM, Ozaki CK, Rybicki FJ. Early animal model evaluation of an implantable contrast agent to enhance magnetic resonance imaging of arterial bypass vein grafts. Acta Radiol. 2018 Sep; 59(9):1074-1081. PMID: 29378421.
    Citations:    Fields:    Translation:Animals
  11. Karp JM. A Slick and Stretchable Surgical Adhesive. N Engl J Med. 2017 11 23; 377(21):2092-2094. PMID: 29166237.
    Citations:    Fields:    Translation:Animals
  12. Tong Z, Martyn K, Yang A, Yin X, Mead BE, Joshi N, Sherman NE, Langer RS, Karp JM. Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells. Biomaterials. 2018 Feb; 154:60-73. PMID: 29120819.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Feins EN, Lee Y, O'Cearbhaill ED, Vasilyev NV, Shimada S, Friehs I, Perrin D, Hammer PE, Yamauchi H, Marx G, Gosline A, Arabagi V, Karp JM, Del Nido PJ. A Growth-Accommodating Implant for Paediatric Applications. Nat Biomed Eng. 2017; 1:818-825. PMID: 29900036.
    Citations:    
  14. Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Multiscale technologies for treatment of ischemic cardiomyopathy. Nat Nanotechnol. 2017 Sep 06; 12(9):845-855. PMID: 28875984.
    Citations: 1     Fields:    
  15. Pettitt D, Arshad Z, Davies B, Smith J, French A, Cole D, Bure K, Dopson S, DiGiusto D, Karp J, Reeve B, Barker R, Holländer G, Brindley D. An assessment of the factors affecting the commercialization of cell-based therapeutics: a systematic review protocol. Syst Rev. 2017 06 26; 6(1):120. PMID: 28651620.
    Citations:    Fields:    Translation:Humans
  16. Alvarez MM, Aizenberg J, Analoui M, Andrews AM, Bisker G, Boyden ES, Kamm RD, Karp JM, Mooney DJ, Oklu R, Peer D, Stolzoff M, Strano MS, Trujillo-de Santiago G, Webster TJ, Weiss PS, Khademhosseini A. Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation. ACS Nano. 2017 06 27; 11(6):5195-5214. PMID: 28524668.
    Citations: 4     Fields:    
  17. Holmberg FE, Seidelin JB, Yin X, Mead BE, Tong Z, Li Y, Karp JM, Nielsen OH. Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease. EMBO Mol Med. 2017 05; 9(5):558-570. PMID: 28283650.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Qasaimeh MA, Wu YC, Bose S, Menachery A, Talluri S, Gonzalez G, Fulciniti M, Karp JM, Prabhala RH, Karnik R. Isolation of Circulating Plasma Cells in Multiple Myeloma Using CD138 Antibody-Based Capture in a Microfluidic Device. Sci Rep. 2017 04 04; 7:45681. PMID: 28374831.
    Citations: 1     Fields:    Translation:HumansCells
  19. Seong KY, Seo MS, Hwang DY, O'Cearbhaill ED, Sreenan S, Karp JM, Yang SY. A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin. J Control Release. 2017 Nov 10; 265:48-56. PMID: 28344013.
    Citations: 2     Fields:    Translation:HumansAnimals
  20. Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, Timmons JJ, Morgan TM, Wang Y, Levantini E, Clohessy JG, Kelly K, Pandolfi PP, Rosenblatt JM, Avigan DE, Ye H, Karp JM, Signoretti S, Balk SP, Cantley LC. Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity. Cancer Discov. 2017 07; 7(7):750-765. PMID: 28274958.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  21. Hanwatkar P, Gajendra S, Veazie P, Karp JM, McIntosh S. Fluoride Varnish: Knowledge, Preferences and Practices of General and Pediatric Dentists. N Y State Dent J. 2017 Mar; 83(2):37-42. PMID: 29920030.
    Citations:    Fields:    Translation:Humans
  22. McLean WJ, Yin X, Lu L, Lenz DR, McLean D, Langer R, Karp JM, Edge ASB. Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells. Cell Rep. 2017 02 21; 18(8):1917-1929. PMID: 28228258.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  23. Yang Z, Concannon J, Ng KS, Seyb K, Mortensen LJ, Ranganath S, Gu F, Levy O, Tong Z, Martyn K, Zhao W, Lin CP, Glicksman MA, Karp JM. Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation. Sci Rep. 2016 07 26; 6:30263. PMID: 27457881.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  24. Ranganath SH, Tong Z, Levy O, Martyn K, Karp JM, Inamdar MS. Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering. Stem Cell Reports. 2016 06 14; 6(6):926-939. PMID: 27264972.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  25. Levy O, Brennen WN, Han E, Rosen DM, Musabeyezu J, Safaee H, Ranganath S, Ngai J, Heinelt M, Milton Y, Wang H, Bhagchandani SH, Joshi N, Bhowmick N, Denmeade SR, Isaacs JT, Karp JM. A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. Biomaterials. 2016 Jun; 91:140-150. PMID: 27019026; PMCID: PMC4824400.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  26. Fischer SCL, Levy O, Kroner E, Hensel R, Karp JM, Arzt E. Bioinspired polydimethylsiloxane-based composites with high shear resistance against wet tissue. J Mech Behav Biomed Mater. 2016 08; 61:87-95. PMID: 26849031.
    Citations:    Fields:    Translation:Animals
  27. Yin X, Mead BE, Safaee H, Langer R, Karp JM, Levy O. Engineering Stem Cell Organoids. Cell Stem Cell. 2016 Jan 07; 18(1):25-38. PMID: 26748754; PMCID: PMC4728053.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  28. Sarvas EW, Schwantes SA, Karp JM. Preparing the Pediatric Dentist for Palliative and End-of-life Care. Pediatr Dent. 2016; 38(4):295-9. PMID: 27557917.
    Citations:    Fields:    Translation:Humans
  29. Petrova E, Miller WP, Myers SL, Karp JM. Management of Red Teeth in an International Patient with X-Linked Adrenoleukodystrophy. Pediatr Dent. 2015 Nov-Dec; 37(7):550-3. PMID: 26883615.
    Citations:    Fields:    Translation:Humans
  30. Lee Y, Xu C, Sebastin M, Lee A, Holwell N, Xu C, Miranda Nieves D, Mu L, Langer RS, Lin C, Karp JM. Medical Adhesives: Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair (Adv. Healthcare Mater. 16/2015). Adv Healthc Mater. 2015 Nov; 4(16):2318. PMID: 26767735.
    Citations:    
  31. Ng KS, Kuncewicz TM, Karp JM. Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory. Cell Metab. 2015 Oct 06; 22(4):541-3. PMID: 26445510.
    Citations: 2     Fields:    Translation:AnimalsCells
  32. Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Casar Berazaluce AM, Bueno A, Lang N, Pereira MJ, Feins E, Wasserman S, O'Cearbhaill ED, Vasilyev NV, Mooney DJ, Karp JM, Del Nido PJ, Walsh CJ. A light-reflecting balloon catheter for atraumatic tissue defect repair. Sci Transl Med. 2015 Sep 23; 7(306):306ra149. PMID: 26400910.
    Citations: 4     Fields:    Translation:Animals
  33. Yin X, Karp JM. Stomaching Notch. EMBO J. 2015 Oct 14; 34(20):2489-91. PMID: 26358838; PMCID: PMC4609181.
    Citations:    Fields:    Translation:AnimalsCells
  34. Zhang S, Ermann J, Succi MD, Zhou A, Hamilton MJ, Cao B, Korzenik JR, Glickman JN, Vemula PK, Glimcher LH, Traverso G, Langer R, Karp JM. An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease. Sci Transl Med. 2015 Aug 12; 7(300):300ra128. PMID: 26268315; PMCID: PMC4825054.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  35. Lee Y, Xu C, Sebastin M, Lee A, Holwell N, Xu C, Miranda Nieves D, Mu L, Langer RS, Lin C, Karp JM. Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair. Adv Healthc Mater. 2015 Nov 18; 4(16):2587-96. PMID: 26227833; PMCID: PMC4715574.
    Citations: 3     Fields:    Translation:Animals
  36. Heinelt M, Karp JM, Levy O. Cell therapy--showing cells the way home. Oncotarget. 2015 Jul 20; 6(20):17857-8. PMID: 26257004; PMCID: PMC4627214.
    Citations:    Fields:    Translation:HumansAnimalsCells
  37. Mitragotri S, Anderson DG, Chen X, Chow EK, Ho D, Kabanov AV, Karp JM, Kataoka K, Mirkin CA, Petrosko SH, Shi J, Stevens MM, Sun S, Teoh S, Venkatraman SS, Xia Y, Wang S, Gu Z, Xu C. Accelerating the Translation of Nanomaterials in Biomedicine. ACS Nano. 2015 Jul 28; 9(7):6644-54. PMID: 26115196.
    Citations: 20     Fields:    
  38. Tong Z, Solanki A, Hamilos A, Levy O, Wen K, Yin X, Karp JM. Application of biomaterials to advance induced pluripotent stem cell research and therapy. EMBO J. 2015 Apr 15; 34(8):987-1008. PMID: 25766254; PMCID: PMC4406648.
    Citations: 13     Fields:    Translation:HumansCells
  39. Levy O, Mortensen LJ, Boquet G, Tong Z, Perrault C, Benhamou B, Zhang J, Stratton T, Han E, Safaee H, Musabeyezu J, Yang Z, Multon MC, Rothblatt J, Deleuze JF, Lin CP, Karp JM. A small-molecule screen for enhanced homing of systemically infused cells. Cell Rep. 2015 Mar 03; 10(8):1261-1268. PMID: 25732817; PMCID: PMC4361231.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  40. French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams D, García-Cardeña G, Sipp D, Oh S, Loring JF, Rao MS, Reeve B, Wall I, Carr AJ, Bure K, Stacey G, Karp JM, Snyder EY, Brindley DA. Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards. Stem Cells Transl Med. 2015 Mar; 4(3):217-23. PMID: 25650438; PMCID: PMC4339854.
    Citations: 9     Fields:    Translation:HumansCells
  41. Silva M, Daheron L, Hurley H, Bure K, Barker R, Carr AJ, Williams D, Kim HW, French A, Coffey PJ, Cooper-White JJ, Reeve B, Rao M, Snyder EY, Ng KS, Mead BE, Smith JA, Karp JM, Brindley DA, Wall I. Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies. Cell Stem Cell. 2015 Jan 08; 16(1):13-7. PMID: 25575079.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  42. Teo GS, Yang Z, Carman CV, Karp JM, Lin CP. Intravital imaging of mesenchymal stem cell trafficking and association with platelets and neutrophils. Stem Cells. 2015 Jan; 33(1):265-77. PMID: 25263183; PMCID: PMC4270897.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  43. Laulicht B, Traverso G, Deshpande V, Langer R, Karp JM. Simple battery armor to protect against gastrointestinal injury from accidental ingestion. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16490-5. PMID: 25368176; PMCID: PMC4246317.
    Citations: 2     Fields:    Translation:HumansAnimals
  44. Davies BM, Rikabi S, French A, Pinedo-Villanueva R, Morrey ME, Wartolowska K, Judge A, MacLaren RE, Mathur A, Williams DJ, Wall I, Birchall M, Reeve B, Atala A, Barker RW, Cui Z, Furniss D, Bure K, Snyder EY, Karp JM, Price A, Carr A, Brindley DA. Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study. J Tissue Eng. 2014; 5:2041731414551764. PMID: 25383173; PMCID: PMC4221931.
    Citations: 6     
  45. Gajanayake T, Olariu R, Leclère FM, Dhayani A, Yang Z, Bongoni AK, Banz Y, Constantinescu MA, Karp JM, Vemula PK, Rieben R, Vögelin E. A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft. Sci Transl Med. 2014 Aug 13; 6(249):249ra110. PMID: 25122638.
    Citations: 11     Fields:    Translation:AnimalsCells
  46. Sridharan R, Karp JM, Zhao W. Bioengineering tools to elucidate and control the fate of transplanted stem cells. Biochem Soc Trans. 2014 Jun; 42(3):679-87. PMID: 24849237.
    Citations: 4     Fields:    Translation:Humans
  47. Ankrum JA, Dastidar RG, Ong JF, Levy O, Karp JM. Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids. Sci Rep. 2014 Apr 10; 4:4645. PMID: 24717973; PMCID: PMC3982175.
    Citations: 17     Fields:    Translation:HumansCells
  48. Vemula PK, Kohler JE, Blass A, Williams M, Xu C, Chen L, Jadhav SR, John G, Soybel DI, Karp JM. Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu. Sci Rep. 2014 Mar 26; 4:4466. PMID: 24667734; PMCID: PMC3966031.
    Citations: 1     Fields:    Translation:Cells
  49. Law CS, Karp JM. Behavior guidance symposium Workshop B report - training implications. Pediatr Dent. 2014 Mar-Apr; 36(2):154-7. PMID: 24717755.
    Citations:    Fields:    Translation:HumansPHPublic Health
  50. Ankrum JA, Ong JF, Karp JM. Mesenchymal stem cells: immune evasive, not immune privileged. Nat Biotechnol. 2014 Mar; 32(3):252-60. PMID: 24561556; PMCID: PMC4320647.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  51. O'Cearbhaill ED, Ng KS, Karp JM. Emerging medical devices for minimally invasive cell therapy. Mayo Clin Proc. 2014 Feb; 89(2):259-73. PMID: 24485137.
    Citations: 7     Fields:    Translation:Humans
  52. Ankrum JA, Miranda OR, Ng KS, Sarkar D, Xu C, Karp JM. Engineering cells with intracellular agent-loaded microparticles to control cell phenotype. Nat Protoc. 2014 Feb; 9(2):233-45. PMID: 24407352; PMCID: PMC4320648.
    Citations: 19     Fields:    
  53. Lang N, Pereira MJ, Lee Y, Friehs I, Vasilyev NV, Feins EN, Ablasser K, O'Cearbhaill ED, Xu C, Fabozzo A, Padera R, Wasserman S, Freudenthal F, Ferreira LS, Langer R, Karp JM, del Nido PJ. A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects. Sci Transl Med. 2014 Jan 08; 6(218):218ra6. PMID: 24401941; PMCID: PMC4157752.
    Citations: 20     Fields:    Translation:HumansAnimals
  54. Choi S, Levy O, Coelho MB, Cabral JM, Karp JM, Karnik R. A cell rolling cytometer reveals the correlation between mesenchymal stem cell dynamic adhesion and differentiation state. Lab Chip. 2014 Jan 07; 14(1):161-6. PMID: 24146063; PMCID: PMC3886723.
    Citations: 4     Fields:    Translation:HumansCells
  55. Brindley DA, French A, Suh J, Roberts M, Davies B, Pinedo-Villanueva R, Wartolowska K, Rooke K, Kramm A, Judge A, Morrey M, Chandra A, Hurley H, Grover L, Bingham I, Siegel B, Rattley MS, Buckler RL, McKeon D, Krumholz K, Hook L, May M, Rikabi S, Pigott R, Morys M, Sabokbar A, Titus E, Laabi Y, Lemaitre G, Zahkia R, Sipp D, Horne R, Bravery C, Williams D, Wall I, Snyder EY, Karp JM, Barker RW, Bure K, Carr AJ, Reeve B. The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation. Stem Cells Dev. 2013 Dec; 22 Suppl 1:63-72. PMID: 24304079.
    Citations: 3     Fields:    Translation:HumansCells
  56. Yin X, Farin HF, van Es JH, Clevers H, Langer R, Karp JM. Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nat Methods. 2014 Jan; 11(1):106-12. PMID: 24292484; PMCID: PMC3951815.
    Citations: 79     Fields:    Translation:AnimalsCells
  57. Mortensen LJ, Levy O, Phillips JP, Stratton T, Triana B, Ruiz JP, Gu F, Karp JM, Lin CP. Quantification of Mesenchymal Stem Cell (MSC) delivery to a target site using in vivo confocal microscopy. PLoS One. 2013; 8(10):e78145. PMID: 24205131; PMCID: PMC3812161.
    Citations: 8     Fields:    Translation:AnimalsCells
  58. Levy O, Anandakumaran P, Ngai J, Karnik R, Karp JM. Systematic analysis of in vitro cell rolling using a multi-well plate microfluidic system. J Vis Exp. 2013 Oct 16; (80):e50866. PMID: 24193253; PMCID: PMC3892982.
    Citations: 2     Fields:    Translation:HumansCells
  59. Pereira MJ, Sundback CA, Lang N, Cho WK, Pomerantseva I, Ouyang B, Tao SL, McHugh K, Mwizerwa O, Vemula PK, Mochel MC, Carter DJ, Borenstein JT, Langer R, Ferreira LS, Karp JM, Masiakos PT. Combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation. Adv Healthc Mater. 2014 Apr; 3(4):565-71. PMID: 24106240; PMCID: PMC4170832.
    Citations: 2     Fields:    Translation:Animals
  60. Levy O, Zhao W, Mortensen LJ, Leblanc S, Tsang K, Fu M, Phillips JA, Sagar V, Anandakumaran P, Ngai J, Cui CH, Eimon P, Angel M, Lin CP, Yanik MF, Karp JM. mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation. Blood. 2013 Oct 03; 122(14):e23-32. PMID: 23980067; PMCID: PMC3790516.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  61. Vemula PK, Wiradharma N, Ankrum JA, Miranda OR, John G, Karp JM. Prodrugs as self-assembled hydrogels: a new paradigm for biomaterials. Curr Opin Biotechnol. 2013 Dec; 24(6):1174-82. PMID: 23465753.
    Citations: 7     Fields:    Translation:Humans
  62. Yang SY, O'Cearbhaill ED, Sisk GC, Park KM, Cho WK, Villiger M, Bouma BE, Pomahac B, Karp JM. A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue. Nat Commun. 2013; 4:1702. PMID: 23591869; PMCID: PMC3660066.
    Citations: 26     Fields:    
  63. Bose S, Singh R, Hanewich-Hollatz M, Shen C, Lee CH, Dorfman DM, Karp JM, Karnik R. Affinity flow fractionation of cells via transient interactions with asymmetric molecular patterns. Sci Rep. 2013; 3:2329. PMID: 23900203; PMCID: PMC3728592.
    Citations: 9     Fields:    Translation:HumansCells
  64. Pereira MJ, Ouyang B, Sundback CA, Lang N, Friehs I, Mureli S, Pomerantseva I, McFadden J, Mochel MC, Mwizerwa O, Del Nido P, Sarkar D, Masiakos PT, Langer R, Ferreira LS, Karp JM. A highly tunable biocompatible and multifunctional biodegradable elastomer. Adv Mater. 2013 Feb 25; 25(8):1209-15. PMID: 23239051.
    Citations: 4     Fields:    Translation:HumansAnimals
  65. Cho WK, Ankrum JA, Guo D, Chester SA, Yang SY, Kashyap A, Campbell GA, Wood RJ, Rijal RK, Karnik R, Langer R, Karp JM. Microstructured barbs on the North American porcupine quill enable easy tissue penetration and difficult removal. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21289-94. PMID: 23236138; PMCID: PMC3535670.
    Citations: 12     Fields:    Translation:HumansAnimals
  66. Phillips JA, Mortensen LJ, Ruiz JP, Sridharan R, Kumar S, Torres M, Sharma P, Lin CP, Karp JM, Hauschka PV. Advances in Single-cell Tracking of Mesenchymal Stem Cells (MSCs) During Musculoskeletal Regeneration. Orthop J Harv Med Sch. 2012 Dec 01; 14:22-28. PMID: 24244929.
    Citations: 2     
  67. Zhao W, Cui CH, Bose S, Guo D, Shen C, Wong WP, Halvorsen K, Farokhzad OC, Teo GS, Phillips JA, Dorfman DM, Karnik R, Karp JM. Bioinspired multivalent DNA network for capture and release of cells. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19626-31. PMID: 23150586.
    Citations: 30     Fields:    Translation:HumansCells
  68. Teo GS, Ankrum JA, Martinelli R, Boetto SE, Simms K, Sciuto TE, Dvorak AM, Karp JM, Carman CV. Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-a-activated endothelial cells via both leukocyte-like and novel mechanisms. Stem Cells. 2012 Nov; 30(11):2472-86. PMID: 22887987; PMCID: PMC3479371.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  69. Laulicht B, Langer R, Karp JM. Quick-release medical tape. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18803-8. PMID: 23112196; PMCID: PMC3503228.
    Citations: 5     Fields:    Translation:Humans
  70. Xu C, Poh YK, Roes I, O'Cearbhaill ED, Matthiesen ME, Mu L, Yang SY, Miranda-Nieves D, Irimia D, Karp JM. A portable chemotaxis platform for short and long term analysis. PLoS One. 2012; 7(9):e44995. PMID: 23028729; PMCID: PMC3444504.
    Citations: 2     Fields:    Translation:HumansCells
  71. Xu C, Miranda-Nieves D, Ankrum JA, Matthiesen ME, Phillips JA, Roes I, Wojtkiewicz GR, Juneja V, Kultima JR, Zhao W, Vemula PK, Lin CP, Nahrendorf M, Karp JM. Tracking mesenchymal stem cells with iron oxide nanoparticle loaded poly(lactide-co-glycolide) microparticles. Nano Lett. 2012 Aug 08; 12(8):4131-9. PMID: 22769232; PMCID: PMC3552518.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  72. Ali MM, Kang DK, Tsang K, Fu M, Karp JM, Zhao W. Cell-surface sensors: lighting the cellular environment. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Sep-Oct; 4(5):547-61. PMID: 22761045; PMCID: PMC3425956.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  73. Ranganath SH, Levy O, Inamdar MS, Karp JM. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell. 2012 Mar 02; 10(3):244-58. PMID: 22385653; PMCID: PMC3294273.
    Citations: 198     Fields:    Translation:HumansCells
  74. Choi S, Karp JM, Karnik R. Cell sorting by deterministic cell rolling. Lab Chip. 2012 Apr 21; 12(8):1427-30. PMID: 22327803; PMCID: PMC3331973.
    Citations: 19     Fields:    Translation:HumansCells
  75. Coelho MB, Cabral JM, Karp JM. Intraoperative stem cell therapy. Annu Rev Biomed Eng. 2012; 14:325-49. PMID: 22809140; PMCID: PMC3646373.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  76. Gill JB, Karp JM, Kopycka-Kedzierawski DT. Oral piercing injuries treated in United States emergency departments, 2002-2008. Pediatr Dent. 2012 Jan-Feb; 34(1):56-60. PMID: 22353459.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  77. Zhao W, Karp JM, Ferrari M, Serda R. Bioengineering nanotechnology: towards the clinic. Nanotechnology. 2011 Dec 09; 22(49):490201. PMID: 22101146.
    Citations: 3     Fields:    Translation:Humans
  78. Xu C, Mu L, Roes I, Miranda-Nieves D, Nahrendorf M, Ankrum JA, Zhao W, Karp JM. Nanoparticle-based monitoring of cell therapy. Nanotechnology. 2011 Dec 09; 22(49):494001. PMID: 22101191.
    Citations: 12     Fields:    Translation:HumansAnimals
  79. Sarkar D, Spencer JA, Phillips JA, Zhao W, Schafer S, Spelke DP, Mortensen LJ, Ruiz JP, Vemula PK, Sridharan R, Kumar S, Karnik R, Lin CP, Karp JM. Engineered cell homing. Blood. 2011 Dec 15; 118(25):e184-91. PMID: 22034631; PMCID: PMC3242725.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  80. Karp JM, Langer R. Materials science: Dry solution to a sticky problem. Nature. 2011 Aug 31; 477(7362):42-3. PMID: 21886155; PMCID: PMC3236562.
    Citations: 8     Fields:    Translation:HumansAnimals
  81. Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jain RK, Lammerding J, Love JC, Lin CP, Sarkar D, Karnik R, Karp JM. Cell-surface sensors for real-time probing of cellular environments. Nat Nanotechnol. 2011 Jul 17; 6(8):524-31. PMID: 21765401; PMCID: PMC3163485.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  82. Pereira MJ, Carvalho IF, Karp JM, Ferreira LS. Sensing the cardiac environment: exploiting cues for regeneration. J Cardiovasc Transl Res. 2011 Oct; 4(5):616-30. PMID: 21735303; PMCID: PMC3334359.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  83. Zhao W, Loh W, Droujinine IA, Teo W, Kumar N, Schafer S, Cui CH, Zhang L, Sarkar D, Karnik R, Karp JM. Mimicking the inflammatory cell adhesion cascade by nucleic acid aptamer programmed cell-cell interactions. FASEB J. 2011 Sep; 25(9):3045-56. PMID: 21653192; PMCID: PMC3157693.
    Citations: 10     Fields:    Translation:AnimalsCells
  84. Vemula PK, Anderson RR, Karp JM. Nanoparticles reduce nickel allergy by capturing metal ions. Nat Nanotechnol. 2011 May; 6(5):291-5. PMID: 21460828.
    Citations: 5     Fields:    Translation:HumansAnimals
  85. Vemula PK, Boilard E, Syed A, Campbell NR, Muluneh M, Weitz DA, Lee DM, Karp JM. On-demand drug delivery from self-assembled nanofibrous gels: a new approach for treatment of proteolytic disease. J Biomed Mater Res A. 2011 May; 97(2):103-10. PMID: 21404422.
    Citations: 5     Fields:    Translation:HumansAnimals
  86. Lee CH, Bose S, Van Vliet KJ, Karp JM, Karnik R. Studying cell rolling trajectories on asymmetric receptor patterns. J Vis Exp. 2011 Feb 13; (48). PMID: 21372779; PMCID: PMC3110418.
    Citations: 1     Fields:    Translation:HumansCells
  87. Sarkar D, Ankrum JA, Teo GS, Carman CV, Karp JM. Cellular and extracellular programming of cell fate through engineered intracrine-, paracrine-, and endocrine-like mechanisms. Biomaterials. 2011 Apr; 32(11):3053-61. PMID: 21262537; PMCID: PMC3043463.
    Citations: 18     Fields:    Translation:HumansCells
  88. Sarkar D, Zhao W, Gupta A, Loh WL, Karnik R, Karp JM. Cell surface engineering of mesenchymal stem cells. Methods Mol Biol. 2011; 698:505-23. PMID: 21431540.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  89. Mitsouras D, Vemula PK, Yu P, Tao M, Nguyen BT, Campagna CM, Karp JM, Mulkern RV, Ozaki CK, Rybicki FJ. Immobilized contrast-enhanced MRI: Gadolinium-based long-term MR contrast enhancement of the vein graft vessel wall. Magn Reson Med. 2011 Jan; 65(1):176-83. PMID: 20859994; PMCID: PMC3005031.
    Citations:    Fields:    Translation:Humans
  90. Chan EP, Karp JM, Langer RS. A "Self-Pinning" Adhesive Based on Responsive Surface Wrinkles. J Polym Sci B Polym Phys. 2011 Jan 01; 49(1):40-44. PMID: 21293787.
    Citations: 2     
  91. Spelke DP, Ortmann D, Khademhosseini A, Ferreira L, Karp JM. Methods for embryoid body formation: the microwell approach. Methods Mol Biol. 2011; 690:151-62. PMID: 21042991.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  92. Karp JM. Delayed tooth emergence. Pediatr Rev. 2011 Jan; 32(1):e4-17. PMID: 21196499.
    Citations:    Fields:    Translation:Humans
  93. Bose S, Das SK, Karp JM, Karnik R. A semianalytical model to study the effect of cortical tension on cell rolling. Biophys J. 2010 Dec 15; 99(12):3870-9. PMID: 21156128; PMCID: PMC3000478.
    Citations: 6     Fields:    Translation:Cells
  94. Lee CH, Bose S, Van Vliet KJ, Karp JM, Karnik R. Examining the lateral displacement of HL60 cells rolling on asymmetric P-selectin patterns. Langmuir. 2011 Jan 04; 27(1):240-9. PMID: 21141947; PMCID: PMC3068857.
    Citations: 9     Fields:    Translation:HumansCells
  95. Kang SM, You I, Cho WK, Shon HK, Lee TG, Choi IS, Karp JM, Lee H. One-step modification of superhydrophobic surfaces by a mussel-inspired polymer coating. Angew Chem Int Ed Engl. 2010 Dec 03; 49(49):9401-4. PMID: 21031386; PMCID: PMC3013060.
    Citations: 15     Fields:    Translation:Animals
  96. Nguyen BT, Vemula PK, Mitsouras D, Yu P, Tao M, Campagna C, Mulkern RV, Rybicki FJ, Karp JM, Ozaki CK. Immobilization of iron oxide magnetic nanoparticles for enhancement of vessel wall magnetic resonance imaging--an ex vivo feasibility study. Bioconjug Chem. 2010 Aug 18; 21(8):1408-12. PMID: 20608720; PMCID: PMC2923466.
    Citations: 1     Fields:    Translation:HumansCells
  97. Sarkar D, Vemula PK, Zhao W, Gupta A, Karnik R, Karp JM. Engineered mesenchymal stem cells with self-assembled vesicles for systemic cell targeting. Biomaterials. 2010 Jul; 31(19):5266-74. PMID: 20381141; PMCID: PMC2875866.
    Citations: 33     Fields:    Translation:HumansCells
  98. Zhao W, Teo GS, Kumar N, Karp JM. Chemistry and material science at the cell surface. Mater Today (Kidlington). 2010 Apr; 13(4):14-21. PMID: 21857791.
    Citations: 5     
  99. Ankrum J, Karp JM. Mesenchymal stem cell therapy: Two steps forward, one step back. Trends Mol Med. 2010 May; 16(5):203-9. PMID: 20335067; PMCID: PMC2881950.
    Citations: 157     Fields:    Translation:HumansAnimalsCells
  100. Zhao W, Karp JM. Controlling cell fate in vivo. Chembiochem. 2009 Sep 21; 10(14):2308-10. PMID: 19672913.
    Citations: 2     Fields:    Translation:Cells
  101. Zhao W, Karp JM. Tumour targeting: Nanoantennas heat up. Nat Mater. 2009 Jun; 8(6):453-4. PMID: 19458645.
    Citations: 7     Fields:    Translation:Humans
  102. Lancet JE, Karp J, Cripe L, Roboz G, Wollman M, Berman C, Conroy A, Hawtin R, Fox J, Michelson G. Phase Ib/II pharmacokinetic/pharmacodynamic (PK/PD) study of combination voreloxin and cytarabine in relapsed or refractory AML patients. J Clin Oncol. 2009 May 20; 27(15_suppl):7005. PMID: 27961377.
    Citations:    
  103. Bassett EK, Slocum AH, Masiakos PT, Pryor HI, Farokhzad OC, Karp JM. Design of a mechanical clutch-based needle-insertion device. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5540-5. PMID: 19307560; PMCID: PMC2667015.
    Citations: 1     Fields:    Translation:Animals
  104. Karp JM, Leng Teo GS. Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell. 2009 Mar 06; 4(3):206-16. PMID: 19265660.
    Citations: 308     Fields:    Translation:HumansAnimalsCells
  105. Sarkar D, Vemula PK, Teo GS, Spelke D, Karnik R, Wee le Y, Karp JM. Chemical engineering of mesenchymal stem cells to induce a cell rolling response. Bioconjug Chem. 2008 Nov 19; 19(11):2105-9. PMID: 18973352.
    Citations: 26     Fields:    Translation:HumansCells
  106. Vemula PK, Cruikshank GA, Karp JM, John G. Self-assembled prodrugs: an enzymatically triggered drug-delivery platform. Biomaterials. 2009 Jan; 30(3):383-93. PMID: 18930313.
    Citations: 13     Fields:    Translation:HumansCells
  107. Ferreira L, Karp JM, Nobre L, Langer R. New opportunities: the use of nanotechnologies to manipulate and track stem cells. Cell Stem Cell. 2008 Aug 07; 3(2):136-46. PMID: 18682237.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  108. Wright D, Rajalingam B, Karp JM, Selvarasah S, Ling Y, Yeh J, Langer R, Dokmeci MR, Khademhosseini A. Reusable, reversibly sealable parylene membranes for cell and protein patterning. J Biomed Mater Res A. 2008 May; 85(2):530-8. PMID: 17729252; PMCID: PMC2841044.
    Citations: 25     Fields:    Translation:AnimalsCells
  109. Karnik R, Hong S, Zhang H, Mei Y, Anderson DG, Karp JM, Langer R. Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors. Nano Lett. 2008 Apr; 8(4):1153-8. PMID: 18321075; PMCID: PMC2911031.
    Citations: 13     Fields:    Translation:HumansCells
  110. Mahdavi A, Ferreira L, Sundback C, Nichol JW, Chan EP, Carter DJ, Bettinger CJ, Patanavanich S, Chignozha L, Ben-Joseph E, Galakatos A, Pryor H, Pomerantseva I, Masiakos PT, Faquin W, Zumbuehl A, Hong S, Borenstein J, Vacanti J, Langer R, Karp JM. A biodegradable and biocompatible gecko-inspired tissue adhesive. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2307-12. PMID: 18287082.
    Citations: 47     Fields:    Translation:AnimalsCells
  111. Luo y, Engelmayr G, Karp JM, Ferreira L, Auguste ET, Saigal R, Langer R. Scaffolds for Tissue Engineering. Principles of Tissue Engineering. 2008; 1:359-368.
  112. Ma H, Karp JM. Microfluidic Cell Filtering Device. 2008.
  113. Farokhzad O, Slocum A, Karp JM, Basset E, Langer R. A device for sensing tissues. 2008.
  114. Chan EP, Karp JM, Langer R. Stimuli responsive surfaces. 2008.
  115. Karp JM, Sarkar D, KV Praveen. Engineering cell function. 2008.
  116. Karp JM, Sarkar D, Graneli C. Methods and compositions relating to connective tissue progenitor cells. 2008.
  117. Yang, Neeley WL, Moore MJ, Karp JM, Shukla A, Langer R. Tissue Engineering: The Therapeutic Strategy of the 21st Century. Nanotechnology and Tissue Engineering: The Scaffold. 2008; 3-32.
  118. Karp JM, Mahdavi A, Hong S, Khademhosseini A, Langer R. Microscale apporaches for bone tissue engineering. Mico and Nanoengineering of the Cellular Microenvironment: Applications and Technologies. 2008; 1:417-430.
  119. Kumar Vemula P, John G, Karp JM. Methods and Compositions Relating to Self-Assembling Amphiphiles as Drug Delivery Devices. 2008.
  120. Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2007 Dec; 2(12):751-60. PMID: 18654426.
    Citations: 1020     Fields:    
  121. Karp JM, Langer R. Development and therapeutic applications of advanced biomaterials. Curr Opin Biotechnol. 2007 Oct; 18(5):454-9. PMID: 17981454.
    Citations: 18     Fields:    
  122. Hong S, Lee D, Zhang H, Zhang JQ, Resvick JN, Khademhosseini A, King MR, Langer R, Karp JM. Covalent immobilization of p-selectin enhances cell rolling. Langmuir. 2007 Nov 20; 23(24):12261-8. PMID: 17949112; PMCID: PMC2546510.
    Citations: 12     Fields:    Translation:HumansCells
  123. Nijst CL, Bruggeman JP, Karp JM, Ferreira L, Zumbuehl A, Bettinger CJ, Langer R. Synthesis and characterization of photocurable elastomers from poly(glycerol-co-sebacate). Biomacromolecules. 2007 Oct; 8(10):3067-73. PMID: 17725319.
    Citations: 18     Fields:    Translation:HumansCells
  124. Kim GY, Tyler BM, Tupper MM, Karp JM, Langer RS, Brem H, Cima MJ. Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model. J Control Release. 2007 Nov 06; 123(2):172-8. PMID: 17884232.
    Citations: 11     Fields:    Translation:Animals
  125. Ling Y, Rubin J, Deng Y, Huang C, Demirci U, Karp JM, Khademhosseini A. A cell-laden microfluidic hydrogel. Lab Chip. 2007 Jun; 7(6):756-62. PMID: 17538718.
    Citations: 70     Fields:    Translation:Animals
  126. Karp JM, Yeh J, Eng G, Fukuda J, Blumling J, Suh KY, Cheng J, Mahdavi A, Borenstein J, Langer R, Khademhosseini A. Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells. Lab Chip. 2007 Jun; 7(6):786-94. PMID: 17538722.
    Citations: 74     Fields:    Translation:HumansCells
  127. Gerecht S, Townsend S, Pressler H, Karp JM, Langer R. Bioelastomer material for the encapsulation of cells. 2007.
  128. Karp JM, Gu F, Khademhosseini A, Berry DA, Langer R. Methods and compositions to alter biological surfaces. 2007.
  129. Karp JM, Nijst C, Zumbuehl A, Ferreira, Bruggeman J, Bettinger C, Burdick JA, Langer R. Robust biodegradable elastomers. 2007.
  130. Nijst C, Bruggemann J, Karp JM, Zumbheul A, Ferreira L, Bettinger C, Langer R. “Development of multifunctional photocurable degradable elastomers. Tissue Engineering and Regenerative Medicine International Conference. 2007.
  131. Karp JM, Hong S, Khademhosseini, A, Moore M, Langer R. Materials for influencing cell motility. 2007.
  132. Karnik RN, Hong S, Karp JM, Mei Y, Anderson DG, Langer RS. Methods for Cell Separation and Cytometry Based on Directed Cell Rolling on Patterned Substrates. 2007.
  133. Karp JM, Mahdavi A, Ferreira L, Carter D, Zumbuehl A, Borenstein J, Bettinger C, Langer R. Gecko Mimicking Adhesives. 2007.
  134. Karp JM, Langer R. Injectable Stem Cell Formulation. 2007.
  135. Karp JM, Peer D*, Hong S, Farokhzad O, Margalit R, Langer R. Nanocarriers: Emerging Platforms for Cancer Therapy. Nature Nanotechnology. 2007; 2:751-760.
  136. Rivest C, Morrison D, Rubin J, Ni B, Mahdavi A, Karp JM, Khademhosseini A. Microscale hydrogels: fabrication, applications and mechnical properties. Journal of Mechanics of Materials and Structures. 2007; 2(6):1103-19.
  137. Karp JM, Gu F, Khademhosseini A, Berry DA, Langer R. Methods for targeting osteoporosis. 2007.
  138. Karp JM, Ferreira LS, Khademhosseini A, Langer R. In vitro Differentiation of Human ES Cells Along Osteogenic Pathways. Human Embryonic Stem Cells - A Practical Handbook. 2007; 1:249-271.
  139. Karp JM, Ganoza GG. Dental trauma after cardiac syncope in a patient with long QT syndrome. Pediatr Dent. 2006 Nov-Dec; 28(6):547-52. PMID: 17249438.
    Citations:    Fields:    Translation:Humans
  140. Farokhzad OC, Dimitrakov JD, Karp JM, Khademhosseini A, Freeman MR, Langer R. Drug delivery systems in urology--getting "smarter". Urology. 2006 Sep; 68(3):463-9. PMID: 17010721; PMCID: PMC1618825.
    Citations: 6     Fields:    Translation:Humans
  141. Khademhosseini A, Ferreira L, Blumling J, Yeh J, Karp JM, Fukuda J, Langer R. Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates. Biomaterials. 2006 Dec; 27(36):5968-77. PMID: 16901537.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  142. Yeh J, Ling Y, Karp JM, Gantz J, Chandawarkar A, Eng G, Blumling J, Langer R, Khademhosseini A. Micromolding of shape-controlled, harvestable cell-laden hydrogels. Biomaterials. 2006 Nov; 27(31):5391-8. PMID: 16828863.
    Citations: 60     Fields:    Translation:AnimalsCells
  143. Kark LR, Karp JM, Davies JE. Platelet releasate increases the proliferation and migration of bone marrow-derived cells cultured under osteogenic conditions. Clin Oral Implants Res. 2006 Jun; 17(3):321-7. PMID: 16672028.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  144. Karp JM, Yeo Y, Geng W, Cannizarro C, Yan K, Kohane DS, Vunjak-Novakovic G, Langer RS, Radisic M. A photolithographic method to create cellular micropatterns. Biomaterials. 2006 Sep; 27(27):4755-64. PMID: 16730059.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  145. Karp J, Bryk J, Menke E, McTigue D. The complete endodontic obturation of an avulsed immature permanent incisor with mineral trioxide aggregate: a case report. Pediatr Dent. 2006 May-Jun; 28(3):273-8. PMID: 16805362.
    Citations: 2     Fields:    Translation:Humans
  146. Karp JM, Moss AJ. Dental treatment of patients with long QT syndrome. J Am Dent Assoc. 2006 May; 137(5):630-7. PMID: 16739543.
    Citations:    Fields:    Translation:Humans
  147. Farokhzad OC, Karp JM, Langer R. Nanoparticle-aptamer bioconjugates for cancer targeting. Expert Opin Drug Deliv. 2006 May; 3(3):311-24. PMID: 16640493.
    Citations: 38     Fields:    Translation:HumansAnimals
  148. Karp JM, Bettinger C, Zumbuehl A, Ferreira L, Langer R. A method for low temperature crosslinking of biodegradable polymers. 2006.
  149. Karp JM, Ferreria L, Yeo Y, Khademhosseini A, Langer R. Development of highly regenerative desiccants. 2006.
  150. Karp JM, Farokhzad O, Dimitrakov J, Langer R. Drug delivery systems in urology – getting “smarter". Urology. 2006; 68(3):463-9.
  151. Karp JM, Khademhosseini A, Ferreira L, Blumling J, Yeh J, Fukuda J, Eng K, Gantz J, Langer R. Micropatterned co-cultures of human embryonic stem cells with murine embryonic fibroblasts. Canadian Society for Biomaterials. 2006.
  152. Khademhosseini A, Ling Y, Karp JM, Langer R. Micro and Nanoscale Control of Cellular Environment for Tissue Engineering. Innovations in Nanotechnology. 2006.
  153. Khademhosseini A, Ling y, Karp JM, Langer R. Micro- and nanoscale control of cellular environment for tissue engineering. Nanobiotechnology: Concepts, Applications and Perspectives. 2006; 349-366.
  154. Khademhosseini A, Moore M, Karp JM, Langer R. A platform technology based on bioactive hydrogels. 2006.
  155. Ling Y, Rubin J, Karp JM, Khademhosseini A. Agarose Microfluidics Devices for Diagnostics and Tissue Engineering. 2006 Materials Research Society Fall Meeting. 2006.
  156. Khademhosseini A, Eng G, Yeh J, Fukuda J, Blumling J, Karp JM, Langer R, Burdick JA. Micromolding of photocrosslinkable hyaluronic acid for cell encapsulation and entrapment. Society for Biomaterials Meeting. 2006.
  157. Farokhzad O., Karp JM, Langer R. Nanoparticle-Aptamer Conjugates for targeted Cancer Therapy. Expert Opinion Drug Delivery. 2006; 3(3):311-324.
  158. Karp JM, Khademhosseini A, Gerecht-Ni S, Perreira L, Vunjak-Novakovic G, Langer R. Embryonic Stem Cells For a Source For Tissue Engineering. Principles of Tissue Engineering. 2006.
  159. Ling, Y, Yeh J, Karp JM, Chandawarkar A, Gantz J, Langer R, Khademhosseini . Shape and size-controlled photocrosslinkable microgels for encapsulation of embryonic stem cells. 2006 International Society of Stem cell Research Meeting. 2006.
  160. Khademhosseini A, Farokhzad, O, Karp JM, Langer R. Microencapsulation of cells within shape-controlled biomaterials as building blocks for engineering tissues and organs. 2006.
  161. Nijst C, Karp JM, Bruggemann J, Zumbheul A, Ferreira L, Bettinger C, Langer R. Development of multifunctional photocurable degradable elastomers. 2006 Materials Research Society Fall Meeting. 2006.
  162. Khademhosseini A, Bettinger C, Karp JM, Yeh J, Ling Y, Borenstein J, Fukuda J, Langer R. Interplay of biomaterials and microscale technologies: building on each other to advance biomedical applications. Journal of Biomaterials Science - Polymer Edition. 2006; 17(11):1221-40.
  163. Khademhosseini A, Bettinger C, Karp JM, Yeh J, Ling Y, Borenstein J, Fukuda J, Langer R. Interplay of biomaterials and micro-scale technologies for advancing biomedical applications. J Biomater Sci Polym Ed. 2006; 17(11):1221-40. PMID: 17176747.
    Citations: 9     Fields:    Translation:Cells
  164. Karp JM, Ferreira LS, Khademhosseini A, Kwon AH, Yeh J, Langer RS. Cultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitro. Stem Cells. 2006 Apr; 24(4):835-43. PMID: 16253980.
    Citations: 44     Fields:    Translation:HumansCells
  165. Khademhosseini A, Yeh J, Eng G, Karp J, Kaji H, Borenstein J, Farokhzad OC, Langer R. Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays. Lab Chip. 2005 Dec; 5(12):1380-6. PMID: 16286969.
    Citations: 38     Fields:    
  166. Karp JM, Tanaka TS, Zohar R, Sodek J, Shoichet MS, Davies JE, Stanford WL. Thrombin mediated migration of osteogenic cells. Bone. 2005 Sep; 37(3):337-48. PMID: 15964256.
    Citations: 9     Fields:    Translation:AnimalsCells
  167. Kim G, Tyler B, Karp JM, Brem H, Cima MJ, Langer R. Polymer microchip for drug delivery. 8th US-JAPAN symposium on Drug Delivery Systems. 2005.
  168. Karp JM, Ferreira L, Khademhosseini A, Langer R. Amplification of cell populations from embryonic stem cells. 2005.
  169. Khademhosseini A, Eng G, Yeh J, Fukuda J, Karp JM, Langer R. Homogenous spheroid arrays and patterned spheriod co-cultures on micropatterened surfaces. 2005.
  170. Yeh J, Khademhosseini A, Ferreira L, Karp JM, Fukuda J, Eng G, Blumbling J, Morin-Leisk J, Gantz J, Langer R, Burdick J. Microstructure mediated patterned co-cultures. 2005 Materials Research Society Fall Meeting. 2005.
  171. Karp JM, Sarraf F, Shoichet MS, Davies JE. Fibrin-filled scaffolds for bone-tissue engineering: An in vivo study. J Biomed Mater Res A. 2004 Oct 01; 71(1):162-71. PMID: 15368266.
    Citations: 21     Fields:    Translation:Animals
  172. Karp JM, Friis EA, Dee KC, Winet H. Opinions and trends in biomaterials education: report of a 2003 Society for Biomaterials survey. J Biomed Mater Res A. 2004 Jul 01; 70(1):1-9. PMID: 15174103.
    Citations: 1     Fields:    Translation:Humans
  173. Karp JM. Effects of Thrombin on the Migration of Primary Osteogenic Cells through fibrin-filled scaffolds [Ph.D. dissertation]. 2004.
  174. Oprea WE, Karp JM, Hosseini MM, Davies JE. Effect of platelet releasate on bone cell migration and recruitment in vitro. J Craniofac Surg. 2003 May; 14(3):292-300. PMID: 12826799.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  175. Karp JM, Rzeszutek K, Shoichet MS, Davies JE. Fabrication of precise cylindrical three-dimensional tissue engineering scaffolds for in vitro and in vivo bone engineering applications. J Craniofac Surg. 2003 May; 14(3):317-23. PMID: 12826802.
    Citations:    Fields:    Translation:AnimalsCells
  176. Karp JM, Shoichet MS, Davies JE. Bone formation on two-dimensional poly(DL-lactide-co-glycolide) (PLGA) films and three-dimensional PLGA tissue engineering scaffolds in vitro. J Biomed Mater Res A. 2003 Feb 01; 64(2):388-96. PMID: 12522827.
    Citations: 19     Fields:    Translation:AnimalsCells
  177. Karp JM, Dalton PD, Shoichet, MS. Scaffolds for tissue engineering. MRS Bulletin on cellular solids. 2003; 28(4):301-306.
  178. Jeffrey M. Karp. Biomaterials Surgical Video Library. 2002.
  179. Davies JE, Karp JM, Baksh D. Mesenchymal cell culture: bone. Methods of Tissue Engineering. 2001; 333-334.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.