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Rajat Gupta, M.D.

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Biography
Broad Institute, Cambridge, MA07/2018Post-doctoral Fellowship, Genetics
Brigham and Women's Hospital, Boston, MA07/2014Cardiovascular Medicine
Massachusetts General Hospital, Boston, MA06/2010Internal Medicine
University of Pennsylvania, Philadelphia, PAM.D.04/2007Medicine

Overview
Rajat Gupta, MD is an Instructor of Medicine at Harvard Medical School with a research laboratory in the Divisions of Cardiovascular Medicine and Genetics at Brigham and Women’s Hospital. His research is focused on identifying new treatments for vascular disease using human genetics to discover novel biologic pathways. His post-doctoral work identified non-coding variants in the 6p24 locus as distal regulators of Endothelin-1 (Cell, 2017). Dr. Gupta’s laboratory recently identified the transcriptional signature of distinct endothelial cell populations using single cell RNA-sequencing (Circulation, 2019).

Dr. Gupta graduated from the University of Pennsylvania School of Medicine (2007) where he was awarded the Adolf J. Creskoff Prize. He completed Internal Medicine residency training at Massachusetts General Hospital (2010), cardiology fellowship at Brigham and Women’s Hospital (2014), and a post-doctoral fellowship in Human Genetics at the Broad Institute of Harvard and MIT (2016). Dr. Gupta has been named the Thomas W. Smith Fellow at Brigham and Women’s Hospital and received the Lerner Junior Faculty Award. His research is funded by grants from the NIH (New Innovator Award), the Broad Institute, the Sperling Family Fellowship, and the Chan Zuckerberg Initiative.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP2HL152423 (GUPTA, RAJAT M) Sep 1, 2019 - Apr 30, 2024
    NIH/NHLBI
    A genetic approach to identify the common mechanisms of vascular disease
    Role: Principal Investigator
  2. R03HL148483 (GUPTA, RAJAT M) Aug 1, 2019 - Jul 31, 2021
    NIH/NHLBI
    Single cell analysis of gene expression in human vascular cells
    Role: Principal Investigator
  3. K08HL128810 (GUPTA, RAJAT M) Jul 3, 2016 - Jun 30, 2021
    NIH/NHLBI
    From association to function at the PHACTR1 GWAS locus for coronary atherosclerosis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gupta RM, Lee-Kim VS, Libby P. The March of Monocytes in Atherosclerosis: One Cell at a Time. Circ Res. 2020 May 08; 126(10):1324-1326. PMID: 32379573.
    Citations:    
  2. Gupta RM, Libby P, Barton M. Linking regulation of nitric oxide to endothelin-1: The Yin and Yang of vascular tone in the atherosclerotic plaque. Atherosclerosis. 2020 01; 292:201-203. PMID: 31810569.
    Citations:    
  3. Kalluri AS, Vellarikkal SK, Edelman ER, Nguyen L, Subramanian A, Ellinor PT, Regev A, Kathiresan S, Gupta RM. Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations. Circulation. 2019 07 09; 140(2):147-163. PMID: 31146585.
    Citations:    
  4. Raychaudhuri S, Gupta RM. Immunoprofiling comes of age. Nat Med. 2019 03; 25(3):362-364. PMID: 30842672.
    Citations:    
  5. Gupta RM. Hippo Pathway Looms Large for the Function of the JCAD (Junctional Protein Associated With Coronary Artery Disease) on Endothelial Cells. Arterioscler Thromb Vasc Biol. 2018 11; 38(11):2546-2547. PMID: 30354250.
    Citations:    Fields:    
  6. Musunuru K, Sheikh F, Gupta RM, Houser SR, Maher KO, Milan DJ, Terzic A, Wu JC. Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2018 01; 11(1):e000043. PMID: 29874173.
    Citations: 1     
  7. Gupta RM, Hadaya J, Trehan A, Zekavat SM, Roselli C, Klarin D, Emdin CA, Hilvering CRE, Bianchi V, Mueller C, Khera AV, Ryan RJH, Engreitz JM, Issner R, Shoresh N, Epstein CB, de Laat W, Brown JD, Schnabel RB, Bernstein BE, Kathiresan S. A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression. Cell. 2017 Jul 27; 170(3):522-533.e15. PMID: 28753427.
    Citations: 21     Fields:    Translation:HumansCells
  8. Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep. 2017 06 13; 19(11):2410. PMID: 28614725.
    Citations: 1     Fields:    
  9. Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep. 2016 12 20; 17(12):3292-3304. PMID: 28009297.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Mital S, Musunuru K, Garg V, Russell MW, Lanfear DE, Gupta RM, Hickey KT, Ackerman MJ, Perez MV, Roden DM, Woo D, Fox CS, Ware S. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2016 Oct; 9(5):448-467. PMID: 27672144.
    Citations: 6     Fields:    Translation:Humans
  11. Gupta RM, Meissner TB, Cowan CA, Musunuru K. Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport--Brief Report. Arterioscler Thromb Vasc Biol. 2016 Jan; 36(1):15-8. PMID: 26543098.
    Citations: 10     Fields:    Translation:HumansCells
  12. Beaudoin M, Gupta RM, Won HH, Lo KS, Do R, Henderson CA, Lavoie-St-Amour C, Langlois S, Rivas D, Lehoux S, Kathiresan S, Tardif JC, Musunuru K, Lettre G. Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries. Arterioscler Thromb Vasc Biol. 2015 Jun; 35(6):1472-1479. PMID: 25838425.
    Citations: 17     Fields:    Translation:HumansCells
  13. Gupta RM, Pilbrow AP, Weeke PE. Top advances in functional genomics and translational biology for 2014. Circ Cardiovasc Genet. 2015 Feb; 8(1):207-10. PMID: 25691690.
    Citations:    Fields:    Translation:HumansAnimals
  14. Gupta RM. One-shot, one cure with genome editing for dyslipidemia. Circ Cardiovasc Genet. 2014 Dec; 7(6):967-8. PMID: 25516627.
    Citations:    Fields:    Translation:HumansAnimals
  15. Gupta RM, Musunuru K. Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9. J Clin Invest. 2014 Oct; 124(10):4154-61. PMID: 25271723.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  16. Gupta RM. Digenic inheritance of myocardial infarction risk implicates dysfunctional nitric oxide signaling. Circ Cardiovasc Genet. 2014 Feb; 7(1):93-4. PMID: 24550432.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Gupta RM. Exome sequencing in congenital heart disease points to importance of DNA methylation. Circ Cardiovasc Genet. 2013 Oct; 6(5):522. PMID: 24129593.
    Citations:    Fields:    Translation:Humans
  18. Gupta RM, Musunuru K. Mapping Novel Pathways in Cardiovascular Disease Using eQTL Data: The Past, Present, and Future of Gene Expression Analysis. Front Genet. 2012; 3:232. PMID: 23755065.
    Citations: 3     
  19. Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 2013 Feb 07; 12(2):238-51. PMID: 23246482.
    Citations: 187     Fields:    Translation:HumansCells
  20. Gupta RM, Weiner RB, Baggish AL, Fifer MA. Still a kid at heart: hypertrophic cardiomyopathy in the elderly. Circulation. 2011 Aug 16; 124(7):857-63. PMID: 21844092.
    Citations: 4     Fields:    Translation:Humans
  21. Gupta R, Ejebe K, Butler J, Lettre G, Lyon H, Guiducci C, Wilks R, Bennett F, Forrester T, Tayo B, Musunuru K, Hirschhorn J, Kathiresan S, Cooper RS, McKenzie CA. Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica. Hum Genet. 2010 Nov; 128(5):557-61. PMID: 20839009.
    Citations: 5     Fields:    Translation:Humans
  22. Gotsman I, Gupta R, Lichtman AH. The influence of the regulatory T lymphocytes on atherosclerosis. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2493-5. PMID: 17901372.
    Citations: 13     Fields:    Translation:AnimalsCells
  23. Tran CN, Lundy SK, White PT, Endres JL, Motyl CD, Gupta R, Wilke CM, Shelden EA, Chung KC, Urquhart AG, Fox DA. Molecular interactions between T cells and fibroblast-like synoviocytes: role of membrane tumor necrosis factor-alpha on cytokine-activated T cells. Am J Pathol. 2007 Nov; 171(5):1588-98. PMID: 17823284.
    Citations: 22     Fields:    Translation:HumansCells
  24. Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 Nov 07; 114(19):2047-55. PMID: 17060381.
    Citations: 75     Fields:    Translation:AnimalsCells
  25. Morita Y, Gupta R, Seidl KM, McDonagh KT, Fox DA. Cytokine production by dendritic cells genetically engineered to express IL-4: induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis. J Gene Med. 2005 Jul; 7(7):869-77. PMID: 15712252.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Morita Y, Yang J, Gupta R, Shimizu K, Shelden EA, Endres J, Mulé JJ, McDonagh KT, Fox DA. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest. 2001 May; 107(10):1275-84. PMID: 11375417.
    Citations: 57     Fields:    Translation:AnimalsCells
  27. Yamamura Y, Gupta R, Morita Y, He X, Pai R, Endres J, Freiberg A, Chung K, Fox DA. Effector function of resting T cells: activation of synovial fibroblasts. J Immunol. 2001 Feb 15; 166(4):2270-5. PMID: 11160281.
    Citations: 24     Fields:    Translation:HumansCells
  28. Pocket Medicine 4th edition (edited by Marc Sabatine). Cardiology. 2010.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.