Title Assistant Professor of Medicine Institution Brigham and Women's Hospital Address Brigham and Women's Hospital PBB-1, Cardiovascular Medicine 75 Francis St Boston MA 02115
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Biography
University of Pennsylvania | M.D. | 04/2007 | Medicine |
Massachusetts General Hospital | | 06/2010 | Internal Medicine |
Brigham and Women's Hospital | | 07/2014 | Cardiovascular Medicine |
Broad Institute | | 07/2018 | Human Genetics |

Overview
Rajat Gupta, MD is an Assistant Professor of Medicine at Harvard Medical School with a research laboratory in the Divisions of Cardiovascular Medicine and Genetics at Brigham and Women’s Hospital. His research is focused on identifying new treatments for vascular disease using human genetics to discover novel biologic pathways. His post-doctoral work identified non-coding variants in the 6p24 locus as distal regulators of Endothelin-1 (Cell, 2017). Dr. Gupta’s laboratory recently identified the transcriptional signature of distinct endothelial cell populations using single cell RNA-sequencing (Circulation, 2019).
Dr. Gupta graduated from the University of Pennsylvania School of Medicine (2007) where he was awarded the Adolf J. Creskoff Prize. He completed Internal Medicine residency training at Massachusetts General Hospital (2010), cardiology fellowship at Brigham and Women’s Hospital (2014), and a post-doctoral fellowship in Human Genetics at the Broad Institute of Harvard and MIT (2016). Dr. Gupta has been named the Thomas W. Smith Fellow at Brigham and Women’s Hospital and received the Lerner Junior Faculty Award. His research is funded by grants from the NIH (New Innovator Award), the Broad Institute, the Sperling Family Fellowship, and the Chan Zuckerberg Initiative.

Research
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U01HL166060
(GUPTA, RAJAT M)
Jul 1, 2022 - Jun 30, 2026
Identifying the organotypic and disease-specific vascular cell populations by integrating single cell data with polygenic risk
Role: Principal Investigator
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DP2HL152423
(GUPTA, RAJAT M)
Sep 1, 2019 - Apr 30, 2024
A genetic approach to identify the common mechanisms of vascular disease
Role: Principal Investigator
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R03HL148483
(GUPTA, RAJAT M)
Aug 1, 2019 - Jul 31, 2021
Single cell analysis of gene expression in human vascular cells
Role: Principal Investigator
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K08HL128810
(GUPTA, RAJAT M)
Jul 3, 2016 - Jun 30, 2021
From association to function at the PHACTR1 GWAS locus for coronary atherosclerosis
Role: Principal Investigator

Bibliographic
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