Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Login and Edit functionaility is currently unavailable.

Rajat Gupta, M.D.

Title
Institution
Department
Address
Phone
Profile Picture

Biography
Broad Institute, Cambridge, MA07/2018Post-doctoral Fellowship, Genetics
Brigham and Women's Hospital, Boston, MA07/2014Cardiovascular Medicine
Massachusetts General Hospital, Boston, MA06/2010Internal Medicine
University of Pennsylvania, Philadelphia, PAM.D.04/2007Medicine

Overview
Rajat Gupta, MD is an Instructor of Medicine at Harvard Medical School with a research laboratory in the Divisions of Cardiovascular Medicine and Genetics at Brigham and Women’s Hospital. His research is focused on identifying new treatments for vascular disease using human genetics to discover novel biologic pathways. His post-doctoral work identified non-coding variants in the 6p24 locus as distal regulators of Endothelin-1 (Cell, 2017). Dr. Gupta’s laboratory recently identified the transcriptional signature of distinct endothelial cell populations using single cell RNA-sequencing (Circulation, 2019).

Dr. Gupta graduated from the University of Pennsylvania School of Medicine (2007) where he was awarded the Adolf J. Creskoff Prize. He completed Internal Medicine residency training at Massachusetts General Hospital (2010), cardiology fellowship at Brigham and Women’s Hospital (2014), and a post-doctoral fellowship in Human Genetics at the Broad Institute of Harvard and MIT (2016). Dr. Gupta has been named the Thomas W. Smith Fellow at Brigham and Women’s Hospital and received the Lerner Junior Faculty Award. His research is funded by grants from the NIH (New Innovator Award), the Broad Institute, the Sperling Family Fellowship, and the Chan Zuckerberg Initiative.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP2HL152423 (GUPTA, RAJAT M) Sep 1, 2019 - Apr 30, 2024
    NIH
    A genetic approach to identify the common mechanisms of vascular disease
    Role: Principal Investigator
  2. R03HL148483 (GUPTA, RAJAT M) Aug 1, 2019 - Jul 31, 2021
    NIH
    Single cell analysis of gene expression in human vascular cells
    Role: Principal Investigator
  3. K08HL128810 (GUPTA, RAJAT M) Jul 3, 2016 - Jun 30, 2021
    NIH
    From association to function at the PHACTR1 GWAS locus for coronary atherosclerosis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Biermann J, Bloom-Ackermann Z, Barkas N, Ganna A, Gomez J, Melms JC, Katsyv I, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Wang Y, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jané-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hibshoosh H, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Ellinor PT, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Jiang ZG, Juric D, Babadi M, Farhi SL, Izar B, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. 2021 Apr 29. PMID: 33915569.
    Citations:    Fields:    
  2. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Bloom-Ackerman Z, Barkas N, Ganna A, Gomez J, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jane-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Gordon Jiang Z, Juric D, Babadi M, Farhi SL, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. bioRxiv. 2021 Feb 25. PMID: 33655247.
    Citations:    
  3. Gupta RM, Lee-Kim VS, Libby P. The March of Monocytes in Atherosclerosis: One Cell at a Time. Circ Res. 2020 05 08; 126(10):1324-1326. PMID: 32379573.
    Citations: 1     Fields:    Translation:HumansCells
  4. Gupta RM, Libby P, Barton M. Linking regulation of nitric oxide to endothelin-1: The Yin and Yang of vascular tone in the atherosclerotic plaque. Atherosclerosis. 2020 01; 292:201-203. PMID: 31810569.
    Citations: 2     Fields:    Translation:Humans
  5. Kalluri AS, Vellarikkal SK, Edelman ER, Nguyen L, Subramanian A, Ellinor PT, Regev A, Kathiresan S, Gupta RM. Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations. Circulation. 2019 07 09; 140(2):147-163. PMID: 31146585.
    Citations: 30     Fields:    Translation:AnimalsCells
  6. Raychaudhuri S, Gupta RM. Immunoprofiling comes of age. Nat Med. 2019 03; 25(3):362-364. PMID: 30842672.
    Citations:    Fields:    
  7. Gupta RM. Hippo Pathway Looms Large for the Function of the JCAD (Junctional Protein Associated With Coronary Artery Disease) on Endothelial Cells. Arterioscler Thromb Vasc Biol. 2018 11; 38(11):2546-2547. PMID: 30354250.
    Citations:    Fields:    Translation:HumansCells
  8. Musunuru K, Sheikh F, Gupta RM, Houser SR, Maher KO, Milan DJ, Terzic A, Wu JC. Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2018 01; 11(1):e000043. PMID: 29874173.
    Citations: 42     Fields:    Translation:HumansCells
  9. Gupta RM, Hadaya J, Trehan A, Zekavat SM, Roselli C, Klarin D, Emdin CA, Hilvering CRE, Bianchi V, Mueller C, Khera AV, Ryan RJH, Engreitz JM, Issner R, Shoresh N, Epstein CB, de Laat W, Brown JD, Schnabel RB, Bernstein BE, Kathiresan S. A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression. Cell. 2017 Jul 27; 170(3):522-533.e15. PMID: 28753427.
    Citations: 79     Fields:    Translation:HumansCells
  10. Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep. 2017 06 13; 19(11):2410. PMID: 28614725.
    Citations: 3     Fields:    
  11. Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep. 2016 12 20; 17(12):3292-3304. PMID: 28009297.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  12. Mital S, Musunuru K, Garg V, Russell MW, Lanfear DE, Gupta RM, Hickey KT, Ackerman MJ, Perez MV, Roden DM, Woo D, Fox CS, Ware S. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2016 Oct; 9(5):448-467. PMID: 27672144.
    Citations: 12     Fields:    Translation:Humans
  13. Gupta RM, Meissner TB, Cowan CA, Musunuru K. Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport--Brief Report. Arterioscler Thromb Vasc Biol. 2016 Jan; 36(1):15-8. PMID: 26543098.
    Citations: 15     Fields:    Translation:HumansCells
  14. Beaudoin M, Gupta RM, Won HH, Lo KS, Do R, Henderson CA, Lavoie-St-Amour C, Langlois S, Rivas D, Lehoux S, Kathiresan S, Tardif JC, Musunuru K, Lettre G. Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries. Arterioscler Thromb Vasc Biol. 2015 Jun; 35(6):1472-1479. PMID: 25838425.
    Citations: 25     Fields:    Translation:HumansCells
  15. Gupta RM, Pilbrow AP, Weeke PE. Top advances in functional genomics and translational biology for 2014. Circ Cardiovasc Genet. 2015 Feb; 8(1):207-10. PMID: 25691690.
    Citations:    Fields:    Translation:HumansAnimals
  16. Gupta RM. One-shot, one cure with genome editing for dyslipidemia. Circ Cardiovasc Genet. 2014 Dec; 7(6):967-8. PMID: 25516627.
    Citations:    Fields:    Translation:HumansAnimals
  17. Gupta RM, Musunuru K. Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9. J Clin Invest. 2014 Oct; 124(10):4154-61. PMID: 25271723.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  18. Gupta RM. Digenic inheritance of myocardial infarction risk implicates dysfunctional nitric oxide signaling. Circ Cardiovasc Genet. 2014 Feb; 7(1):93-4. PMID: 24550432.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  19. Gupta RM. Exome sequencing in congenital heart disease points to importance of DNA methylation. Circ Cardiovasc Genet. 2013 Oct; 6(5):522. PMID: 24129593.
    Citations: 1     Fields:    Translation:Humans
  20. Gupta RM, Musunuru K. Mapping Novel Pathways in Cardiovascular Disease Using eQTL Data: The Past, Present, and Future of Gene Expression Analysis. Front Genet. 2012; 3:232. PMID: 23755065.
    Citations: 7     
  21. Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 2013 Feb 07; 12(2):238-51. PMID: 23246482.
    Citations: 217     Fields:    Translation:HumansCells
  22. Gupta RM, Weiner RB, Baggish AL, Fifer MA. Still a kid at heart: hypertrophic cardiomyopathy in the elderly. Circulation. 2011 Aug 16; 124(7):857-63. PMID: 21844092.
    Citations: 4     Fields:    Translation:Humans
  23. Gupta R, Ejebe K, Butler J, Lettre G, Lyon H, Guiducci C, Wilks R, Bennett F, Forrester T, Tayo B, Musunuru K, Hirschhorn J, Kathiresan S, Cooper RS, McKenzie CA. Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica. Hum Genet. 2010 Nov; 128(5):557-61. PMID: 20839009.
    Citations: 8     Fields:    Translation:Humans
  24. Gotsman I, Gupta R, Lichtman AH. The influence of the regulatory T lymphocytes on atherosclerosis. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2493-5. PMID: 17901372.
    Citations: 14     Fields:    Translation:AnimalsCells
  25. Tran CN, Lundy SK, White PT, Endres JL, Motyl CD, Gupta R, Wilke CM, Shelden EA, Chung KC, Urquhart AG, Fox DA. Molecular interactions between T cells and fibroblast-like synoviocytes: role of membrane tumor necrosis factor-alpha on cytokine-activated T cells. Am J Pathol. 2007 Nov; 171(5):1588-98. PMID: 17823284.
    Citations: 25     Fields:    Translation:HumansCells
  26. Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 Nov 07; 114(19):2047-55. PMID: 17060381.
    Citations: 83     Fields:    Translation:AnimalsCells
  27. Morita Y, Gupta R, Seidl KM, McDonagh KT, Fox DA. Cytokine production by dendritic cells genetically engineered to express IL-4: induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis. J Gene Med. 2005 Jul; 7(7):869-77. PMID: 15712252.
    Citations: 5     Fields:    Translation:AnimalsCells
  28. Morita Y, Yang J, Gupta R, Shimizu K, Shelden EA, Endres J, Mulé JJ, McDonagh KT, Fox DA. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest. 2001 May; 107(10):1275-84. PMID: 11375417.
    Citations: 60     Fields:    Translation:AnimalsCells
  29. Yamamura Y, Gupta R, Morita Y, He X, Pai R, Endres J, Freiberg A, Chung K, Fox DA. Effector function of resting T cells: activation of synovial fibroblasts. J Immunol. 2001 Feb 15; 166(4):2270-5. PMID: 11160281.
    Citations: 27     Fields:    Translation:HumansCells
  30. Pocket Medicine 4th edition (edited by Marc Sabatine). Cardiology. 2010.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Gupta's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (184)
Explore
_
Co-Authors (65)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.