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profileArthur Yu-Shin Kim, M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Division of Infectious Diseases
55 Fruit St
Boston MA 02114
Phone617/726-3812
Fax617/726-5411
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Collapse Overview 
Collapse overview
The ultimate goal of my current efforts is to engage the difficult clinical problem of HCV infection, particularly in special populations, in a meaningful and effective way within academic medicine. Special populations include those with HIV-1/HCV coinfection, post-transplantation HCV, and HCV in the prison population. Current projects include identification and diagnosis of acute HCV, racial differences in injection drug use (particularly heroin), immunology of acute HCV, the role of HLA and other genes in the spontaneous control of HCV infection, and the immunopathogenesis of HIV-1/HCV coinfection.


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DA033541     (CHUNG, RAYMOND T)Sep 15, 2011 - Aug 31, 2016
NIH/NIDA
Discovery and Assessment of Genetic Determinants of HCV and HIV Control
Role: Co-Principal Investigator

R56AI091649     (CHUNG, RAYMOND T)Sep 15, 2010 - Sep 14, 2011
NIH/NIAID
Discovery and Assessment of Genetic Determinants of HCV and HIV Control
Role: Co-Principal Investigator

U19AI082630     (CHUNG, RAYMOND T)Jun 8, 2009 - May 31, 2019
NIH/NIAID
Reversal of Immune Failure with Viral Cure in Chronic HCV Infection
Role: Co-Principal Investigator

U19AI066345     (LAUER, GEORG MICHAEL)Aug 17, 2005 - Jul 31, 2015
NIH/NIAID
Immune Control and Evasion during Acute HCV Infection
Role: Co-Principal Investigator

K23AI054379     (KIM, ARTHUR Y)Apr 1, 2003 - Feb 28, 2009
NIH/NIAID
Cell mediated Immunity to HCV in HIV+ Persons
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kim AY. The National Academy Report on the Elimination of Viral Hepatitis: An Infectious Disease Physician's Perspective. Clin Infect Dis. 2017 May 27. PMID: 28575213.
    View in: PubMed
  2. Kim AY. Donor-derived hepatitis C virus infections: Are they "high-risk" anymore? Transpl Infect Dis. 2017 04; 19(2). PMID: 28378953.
    View in: PubMed
  3. Chasser Y, Kim AY, Freudenreich O. Hepatitis C Treatment: Clinical Issues for Psychiatrists in the Post-Interferon Era. Psychosomatics. 2017 Jan - Feb; 58(1):1-10. PMID: 27871760.
    View in: PubMed
  4. Barocas JA, Linas BP, Kim AY, Fangman J, Westergaard RP. Acceptability of Rapid Point-of-Care Hepatitis C Tests Among People Who Inject Drugs and Utilize Syringe-Exchange Programs. Open Forum Infect Dis. 2016 Mar; 3(2):ofw075. PMID: 27191007; PMCID: PMC4867657.
  5. Kim JB, Ejiofor JI, Yammine M, Ando M, Camuso JM, Youngster I, Nelson SB, Kim AY, Melnitchouk SI, Rawn JD, MacGillivray TE, Cohn LH, Byrne JG, Sundt TM. Surgical outcomes of infective endocarditis among intravenous drug users. J Thorac Cardiovasc Surg. 2016 Sep; 152(3):832-841.e1. PMID: 27068439.
    View in: PubMed
  6. Sise ME, Bloom AK, Wisocky J, Lin MV, Gustafson JL, Lundquist AL, Steele D, Thiim M, Williams WW, Hashemi N, Kim AY, Thadhani R, Chung RT. Treatment of hepatitis C virus-associated mixed cryoglobulinemia with direct-acting antiviral agents. Hepatology. 2016 Feb; 63(2):408-17. PMID: 26474537; PMCID: PMC4718772 [Available on 02/01/17].
  7. Simon TG, Kim AY, Stamm LM, Liu L, Mo H, Doehle B, Pang PS, Brainard DM, McHutchison JG, Gustafson J, Lauer GM, Chung RT. The safety and efficacy of ledipasvir/sofosbuvir for the treatment of a nosocomial outbreak of HCV in patients with significant cardiovascular disease. Antivir Ther. 2016; 21(3):185-94. PMID: 26440471.
    View in: PubMed
  8. Sise ME, Backman ES, Wenger JB, Wood BR, Sax PE, Chung RT, Thadhani R, Kim AY. Short and long-term effects of telaprevir on kidney function in patients with hepatitis C virus infection: a retrospective cohort study. PLoS One. 2015; 10(4):e0124139. PMID: 25923243; PMCID: PMC4414554.
  9. Cosgrove C, Berger CT, Kroy DC, Cheney PC, Ghebremichael M, Aneja J, Tomlinson M, Kim AY, Lauer GM, Alter G. Chronic HCV infection affects the NK cell phenotype in the blood more than in the liver. PLoS One. 2014; 9(8):e105950. PMID: 25148254; PMCID: PMC4141847.
  10. Linas BP, Barter DM, Leff JA, DiLorenzo M, Schackman BR, Horsburgh CR, Assoumou SA, Salomon JA, Weinstein MC, Kim AY, Freedberg KA. The cost-effectiveness of improved hepatitis C virus therapies in HIV/hepatitis C virus coinfected patients. AIDS. 2014 Jan 28; 28(3):365-76. PMID: 24670522; PMCID: PMC4045405.
  11. Kroy DC, Ciuffreda D, Cooperrider JH, Tomlinson M, Hauck GD, Aneja J, Berger C, Wolski D, Carrington M, Wherry EJ, Chung RT, Tanabe KK, Elias N, Freeman GJ, de Kruyff RH, Misdraji J, Kim AY, Lauer GM. Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology. 2014 Feb; 146(2):550-61. PMID: 24148617; PMCID: PMC3946973.
  12. Kim AY, Page K. Hepatitis C virus serosorting in people who inject drugs: sorting out the details. J Infect Dis. 2013 Dec 15; 208(12):1929-31. PMID: 24136791; PMCID: PMC3836470.
  13. Nitschke K, Barriga A, Schmidt J, Timm J, Viazov S, Kuntzen T, Kim AY, Lauer GM, Allen TM, Gaudieri S, Rauch A, Lange CM, Sarrazin C, Eiermann T, Sidney J, Sette A, Thimme R, López D, Neumann-Haefelin C. HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope. J Hepatol. 2014 Jan; 60(1):22-9. PMID: 23978718; PMCID: PMC3867523.
  14. Kim AY. Management algorithm for genotype 1 hepatitis C virus. F1000Prime Rep. 2013; 5:24. PMID: 23864931; PMCID: PMC3702221.
  15. Kim AY, Onofrey S, Church DR. An epidemiologic update on hepatitis C infection in persons living with or at risk of HIV infection. J Infect Dis. 2013 Mar; 207 Suppl 1:S1-6. PMID: 23390299; PMCID: PMC3565593.
  16. Duggal P, Thio CL, Wojcik GL, Goedert JJ, Mangia A, Latanich R, Kim AY, Lauer GM, Chung RT, Peters MG, Kirk GD, Mehta SH, Cox AL, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Tobler LH, Busch MP, Alexander G, Rosen HR, Gao X, Abdel-Hamid M, Apps R, Carrington M, Thomas DL. Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. Ann Intern Med. 2013 Feb 19; 158(4):235-45. PMID: 23420232; PMCID: PMC3638215.
  17. Kim AY, Nagami EH, Birch CE, Bowen MJ, Lauer GM, McGovern BH. A simple strategy to identify acute hepatitis C virus infection among newly incarcerated injection drug users. Hepatology. 2013 Mar; 57(3):944-52. PMID: 23111904; PMCID: PMC3712277.
  18. Berger CT, Kim AY. IL28B polymorphisms as a pretreatment predictor of response to HCV treatment. Infect Dis Clin North Am. 2012 Dec; 26(4):863-77. PMID: 23083820; PMCID: PMC3730261.
  19. Grebely J, Morris MD, Rice TM, Bruneau J, Cox AL, Kim AY, McGovern BH, Shoukry NH, Lauer G, Maher L, Lloyd AR, Hellard M, Prins M, Dore GJ, Page K. Cohort profile: the international collaboration of incident HIV and hepatitis C in injecting cohorts (InC3) study. Int J Epidemiol. 2013 Dec; 42(6):1649-59. PMID: 23203695; PMCID: PMC3887561.
  20. Nagami EH, Kim AY, Baden RP, McGovern BH. Syphilis negatively influences the response to hepatitis C virus treatment in an HIV-infected patient. Top Antivir Med. 2012 Oct-Nov; 20(4):134-8. PMID: 23154253; PMCID: PMC3985605.
  21. Linas BP, Wong AY, Schackman BR, Kim AY, Freedberg KA. Cost-effective screening for acute hepatitis C virus infection in HIV-infected men who have sex with men. Clin Infect Dis. 2012 Jul; 55(2):279-90. PMID: 22491339; PMCID: PMC3403839.
  22. Schulze Zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, Kasprowicz V, Nolan BE, Streeck H, Aneja J, Reyor LL, Allen TM, Lohse AW, McGovern B, Chung RT, Kwok WW, Kim AY, Lauer GM. Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. J Exp Med. 2012 Jan 16; 209(1):61-75. PMID: 22213804; PMCID: PMC3260872.
  23. Ciuffreda D, Kim AY. Update on hepatitis C virus-specific immunity. Curr Opin HIV AIDS. 2011 Nov; 6(6):559-65. PMID: 22001897; PMCID: PMC3307585.
  24. Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Schmidt J, Nitschke K, Sidney J, Caillet-Saguy C, Binder M, Kersting N, Kemper MW, Power KA, Ingber S, Reyor LL, Hills-Evans K, Kim AY, Lauer GM, Lohmann V, Sette A, Henn MR, Bressanelli S, Thimme R, Allen TM. Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology. 2011 Oct; 54(4):1157-66. PMID: 22006856; PMCID: PMC3201753.
  25. Oniangue-Ndza C, Kuntzen T, Kemper M, Berical A, Wang YE, Neumann-Haefelin C, Foote PK, Hills-Evans K, Reyor LL, Kane K, Gladden AD, Bloom AK, Power KA, Thimme R, Lauer GM, Henn MR, Kim AY, Allen TM. Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase. J Virol. 2011 Nov; 85(22):11883-90. PMID: 21880756; PMCID: PMC3209273.
  26. Strasak AM, Kim AY, Lauer GM, de Sousa PS, Ginuino CF, Fernandes CA, Velloso CE, de Almeida AJ, de Oliveira JM, Yoshida CF, Schulze zur Wiesch J, Paranhos-Baccalá G, Lang S, Brant LJ, Ulmer H, Strohmaier S, Kaltenbach L, Lampe E, Lewis-Ximenez LL. Antibody dynamics and spontaneous viral clearance in patients with acute hepatitis C infection in Rio de Janeiro, Brazil. BMC Infect Dis. 2011 Jan 12; 11:15. PMID: 21226945; PMCID: PMC3032695.
  27. Nagami EH, Kim AY, Birch CE, Bowen MJ, McGovern BH. A "one-two punch" leading to hepatitis C seroconversion. Clin Infect Dis. 2011 Feb 01; 52(3):361-3. PMID: 21189425; PMCID: PMC3060887.
  28. Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, Plenge RM, Deeks SG, Gianniny L, Crawford G, Sullivan J, Gonzalez E, Davies L, Camargo A, Moore JM, Beattie N, Gupta S, Crenshaw A, Burtt NP, Guiducci C, Gupta N, Gao X, Qi Y, Yuki Y, Piechocka-Trocha A, Cutrell E, Rosenberg R, Moss KL, Lemay P, O'Leary J, Schaefer T, Verma P, Toth I, Block B, Baker B, Rothchild A, Lian J, Proudfoot J, Alvino DM, Vine S, Addo MM, Allen TM, Altfeld M, Henn MR, Le Gall S, Streeck H, Haas DW, Kuritzkes DR, Robbins GK, Shafer RW, Gulick RM, Shikuma CM, Haubrich R, Riddler S, Sax PE, Daar ES, Ribaudo HJ, Agan B, Agarwal S, Ahern RL, Allen BL, Altidor S, Altschuler EL, Ambardar S, Anastos K, Anderson B, Anderson V, Andrady U, Antoniskis D, Bangsberg D, Barbaro D, Barrie W, Bartczak J, Barton S, Basden P, Basgoz N, Bazner S, Bellos NC, Benson AM, Berger J, Bernard NF, Bernard AM, Birch C, Bodner SJ, Bolan RK, Boudreaux ET, Bradley M, Braun JF, Brndjar JE, Brown SJ, Brown K, Brown ST, Burack J, Bush LM, Cafaro V, Campbell O, Campbell J, Carlson RH, Carmichael JK, Casey KK, Cavacuiti C, Celestin G, Chambers ST, Chez N, Chirch LM, Cimoch PJ, Cohen D, Cohn LE, Conway B, Cooper DA, Cornelson B, Cox DT, Cristofano MV, Cuchural G, Czartoski JL, Dahman JM, Daly JS, Davis BT, Davis K, Davod SM, DeJesus E, Dietz CA, Dunham E, Dunn ME, Ellerin TB, Eron JJ, Fangman JJ, Farel CE, Ferlazzo H, Fidler S, Fleenor-Ford A, Frankel R, Freedberg KA, French NK, Fuchs JD, Fuller JD, Gaberman J, Gallant JE, Gandhi RT, Garcia E, Garmon D, Gathe JC, Gaultier CR, Gebre W, Gilman FD, Gilson I, Goepfert PA, Gottlieb MS, Goulston C, Groger RK, Gurley TD, Haber S, Hardwicke R, Hardy WD, Harrigan PR, Hawkins TN, Heath S, Hecht FM, Henry WK, Hladek M, Hoffman RP, Horton JM, Hsu RK, Huhn GD, Hunt P, Hupert MJ, Illeman ML, Jaeger H, Jellinger RM, John M, Johnson JA, Johnson KL, Johnson H, Johnson K, Joly J, Jordan WC, Kauffman CA, Khanlou H, Killian RK, Kim AY, Kim DD, Kinder CA, Kirchner JT, Kogelman L, Kojic EM, Korthuis PT, Kurisu W, Kwon DS, LaMar M, Lampiris H, Lanzafame M, Lederman MM, Lee DM, Lee JM, Lee MJ, Lee ET, Lemoine J, Levy JA, Llibre JM, Liguori MA, Little SJ, Liu AY, Lopez AJ, Loutfy MR, Loy D, Mohammed DY, Man A, Mansour MK, Marconi VC, Markowitz M, Marques R, Martin JN, Martin HL, Mayer KH, McElrath MJ, McGhee TA, McGovern BH, McGowan K, McIntyre D, Mcleod GX, Menezes P, Mesa G, Metroka CE, Meyer-Olson D, Miller AO, Montgomery K, Mounzer KC, Nagami EH, Nagin I, Nahass RG, Nelson MO, Nielsen C, Norene DL, O'Connor DH, Ojikutu BO, Okulicz J, Oladehin OO, Oldfield EC, Olender SA, Ostrowski M, Owen WF, Pae E, Parsonnet J, Pavlatos AM, Perlmutter AM, Pierce MN, Pincus JM, Pisani L, Price LJ, Proia L, Prokesch RC, Pujet HC, Ramgopal M, Rathod A, Rausch M, Ravishankar J, Rhame FS, Richards CS, Richman DD, Rodes B, Rodriguez M, Rose RC, Rosenberg ES, Rosenthal D, Ross PE, Rubin DS, Rumbaugh E, Saenz L, Salvaggio MR, Sanchez WC, Sanjana VM, Santiago S, Schmidt W, Schuitemaker H, Sestak PM, Shalit P, Shay W, Shirvani VN, Silebi VI, Sizemore JM, Skolnik PR, Sokol-Anderson M, Sosman JM, Stabile P, Stapleton JT, Starrett S, Stein F, Stellbrink HJ, Sterman FL, Stone VE, Stone DR, Tambussi G, Taplitz RA, Tedaldi EM, Telenti A, Theisen W, Torres R, Tosiello L, Tremblay C, Tribble MA, Trinh PD, Tsao A, Ueda P, Vaccaro A, Valadas E, Vanig TJ, Vecino I, Vega VM, Veikley W, Wade BH, Walworth C, Wanidworanun C, Ward DJ, Warner DA, Weber RD, Webster D, Weis S, Wheeler DA, White DJ, Wilkins E, Winston A, Wlodaver CG, van't Wout A, Wright DP, Yang OO, Yurdin DL, Zabukovic BW, Zachary KC, Zeeman B, Zhao M. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science. 2010 Dec 10; 330(6010):1551-7. PMID: 21051598; PMCID: PMC3235490.
  29. Kim AY, Kuntzen T, Timm J, Nolan BE, Baca MA, Reyor LL, Berical AC, Feller AJ, Johnson KL, Schulze zur Wiesch J, Robbins GK, Chung RT, Walker BD, Carrington M, Allen TM, Lauer GM. Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes. Gastroenterology. 2011 Feb; 140(2):686-696.e1. PMID: 20875418; PMCID: PMC3021586.
  30. Salloum S, Kluge SF, Kim AY, Roggendorf M, Timm J. The resistance mutation R155K in the NS3/4A protease of hepatitis C virus also leads the virus to escape from HLA-A*68-restricted CD8 T cells. Antiviral Res. 2010 Aug; 87(2):272-5. PMID: 20488208.
    View in: PubMed
  31. Lewis-Ximenez LL, Lauer GM, Schulze Zur Wiesch J, de Sousa PS, Ginuino CF, Paranhos-Baccalá G, Ulmer H, Pfeiffer KP, Goebel G, Pereira JL, Mendes de Oliveira J, Yoshida CF, Lampe E, Velloso CE, Alves Pinto M, Coelho HS, Almeida AJ, Fernandes CA, Kim AY, Strasak AM. Prospective follow-up of patients with acute hepatitis C virus infection in Brazil. Clin Infect Dis. 2010 May 01; 50(9):1222-30. PMID: 20235831; PMCID: PMC3860186.
  32. Silverman BC, Kim AY, Freudenreich O. Interferon-induced psychosis as a "psychiatric contraindication" to hepatitis C treatment: a review and case-based discussion. Psychosomatics. 2010 Jan-Feb; 51(1):1-7. PMID: 20118434.
    View in: PubMed
  33. Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope. Hepatology. 2010 Jan; 51(1):54-62. PMID: 20034048; PMCID: PMC4396188.
  34. Chen TY, Ding EL, Seage Iii GR, Kim AY. Meta-analysis: increased mortality associated with hepatitis C in HIV-infected persons is unrelated to HIV disease progression. Clin Infect Dis. 2009 Nov 15; 49(10):1605-15. PMID: 19842982; PMCID: PMC2805261.
  35. Kasprowicz V, Kang YH, Lucas M, Schulze zur Wiesch J, Kuntzen T, Fleming V, Nolan BE, Longworth S, Berical A, Bengsch B, Thimme R, Lewis-Ximenez L, Allen TM, Kim AY, Klenerman P, Lauer GM. Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution. J Virol. 2010 Feb; 84(3):1656-63. PMID: 19906915; PMCID: PMC2812309.
  36. Corey KE, Servoss JC, Casson DR, Kim AY, Robbins GK, Franzini J, Twitchell K, Loomis SC, Abraczinskas DR, Terella AM, Dienstag JL, Chung RT. Pilot study of postexposure prophylaxis for hepatitis C virus in healthcare workers. Infect Control Hosp Epidemiol. 2009 Oct; 30(10):1000-5. PMID: 19743901; PMCID: PMC4331129.
  37. McGovern BH, Birch CE, Bowen MJ, Reyor LL, Nagami EH, Chung RT, Kim AY. Improving the diagnosis of acute hepatitis C virus infection with expanded viral load criteria. Clin Infect Dis. 2009 Oct 01; 49(7):1051-60. PMID: 19725787; PMCID: PMC2741541.
  38. McGovern BH, Nagami EH, Birch CE, Bowen MJ, Reyor LL, Chung RT, Kim AY. Rate of sustained virologic response in relation to baseline hepatitis C virus (HCV) RNA level and rapid virologic clearance in persons with acute HCV infection. J Infect Dis. 2009 Sep 15; 200(6):877-81. PMID: 19673649; PMCID: PMC2762747.
  39. Kim AY, Chung RT. Coinfection with HIV-1 and HCV--a one-two punch. Gastroenterology. 2009 Sep; 137(3):795-814. PMID: 19549523; PMCID: PMC3146750.
  40. McGovern B, Kim A, Lauer G. Acute hepatitis C infection in correctional settings. Gastroenterology. 2009 Jun; 136(7):2410-1. PMID: 19409289.
    View in: PubMed
  41. Kim AY, Timm J, Nolan BE, Reyor LL, Kane K, Berical AC, Zachary KC, Lauer GM, Kuntzen T, Allen TM. Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual. J Infect Dis. 2009 Mar 01; 199(5):737-41. PMID: 19199553; PMCID: PMC2653266.
  42. Silverman BC, Kim AY, Freudenreich O. . Inteferon-induced psychosis as a "psychiatric contraindication" to hepatitis C treatment: a review and case-based discussion. Psychosomatics (in press). 2009.
  43. Cox AL, Page K, Bruneau J, Shoukry NH, Lauer GM, Kim AY, Rosen HR, Radziewicz H, Grakoui A, Fierer DS, Branch AD, Kaplan DE, Chang KM. Rare birds in North America: acute hepatitis C cohorts. Gastroenterology. 2009 Jan; 136(1):26-31. PMID: 19059257; PMCID: PMC4143376.
  44. Kuntzen T, Timm J, Berical A, Lennon N, Berlin AM, Young SK, Lee B, Heckerman D, Carlson J, Reyor LL, Kleyman M, McMahon CM, Birch C, Schulze Zur Wiesch J, Ledlie T, Koehrsen M, Kodira C, Roberts AD, Lauer GM, Rosen HR, Bihl F, Cerny A, Spengler U, Liu Z, Kim AY, Xing Y, Schneidewind A, Madey MA, Fleckenstein JF, Park VM, Galagan JE, Nusbaum C, Walker BD, Lake-Bakaar GV, Daar ES, Jacobson IM, Gomperts ED, Edlin BR, Donfield SM, Chung RT, Talal AH, Marion T, Birren BW, Henn MR, Allen TM. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients. Hepatology. 2008 Dec; 48(6):1769-78. PMID: 19026009; PMCID: PMC2645896.
  45. Kim AY, Timm J. Resistance mechanisms in HCV: from evolution to intervention. Expert Rev Anti Infect Ther. 2008 Aug; 6(4):463-78. PMID: 18662114.
    View in: PubMed
  46. Northfield JW, Kasprowicz V, Lucas M, Kersting N, Bengsch B, Bengsh B, Kim A, Phillips RE, Walker BD, Thimme R, Lauer G, Klenerman P. CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation. Hepatology. 2008 Feb; 47(2):396-406. PMID: 18219672.
    View in: PubMed
  47. Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan BE, Longworth S, Berical A, Blum J, McMahon C, Reyor LL, Elias N, Kwok WW, McGovern BG, Freeman G, Chung RT, Klenerman P, Lewis-Ximenez L, Walker BD, Allen TM, Kim AY, Lauer GM. High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol. 2008 Mar; 82(6):3154-60. PMID: 18160439; PMCID: PMC2258997.
  48. Samuels MA, Gonzalez RG, Kim AY, Stemmer-Rachamimov A. Case records of the Massachusetts General Hospital. Case 34-2007. A 77-year-old man with ear pain, difficulty speaking, and altered mental status. N Engl J Med. 2007 Nov 08; 357(19):1957-65. PMID: 17989389.
    View in: PubMed
  49. Kim AY, Chung RT. Sex, drugs, and hepatitis C virus in men who have sex with men: evidence for permucosal transmission. Gastroenterology. 2007 Nov; 133(5):1734-6; discussion 1736-7. PMID: 17983821.
    View in: PubMed
  50. Klenerman P, Kim A. HCV-HIV coinfection: simple messages from a complex disease. PLoS Med. 2007 Oct 09; 4(10):e240. PMID: 17927445; PMCID: PMC2001208.
  51. Kuntzen T, Timm J, Berical A, Lewis-Ximenez LL, Jones A, Nolan B, Schulze zur Wiesch J, Li B, Schneidewind A, Kim AY, Chung RT, Lauer GM, Allen TM. Viral sequence evolution in acute hepatitis C virus infection. J Virol. 2007 Nov; 81(21):11658-68. PMID: 17699568; PMCID: PMC2168804.
  52. Timm J, Li B, Daniels MG, Bhattacharya T, Reyor LL, Allgaier R, Kuntzen T, Fischer W, Nolan BE, Duncan J, Schulze zur Wiesch J, Kim AY, Frahm N, Brander C, Chung RT, Lauer GM, Korber BT, Allen TM. Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution. Hepatology. 2007 Aug; 46(2):339-49. PMID: 17559151.
    View in: PubMed
  53. Kim AY, Lauer GM. Pathogenesis of HIV-HCV Coinfection. Curr Infect Dis Rep. 2007 Jul; 9(4):331-7. PMID: 17618554.
    View in: PubMed
  54. Kim, AY. Earlier antiretroviral therapy to combat HCV in HIV-1/HCV coinfection. Future Virology. 2007; 2(4):319-323.
  55. Schulze Zur Wiesch J, Lauer GM, Timm J, Kuntzen T, Neukamm M, Berical A, Jones AM, Nolan BE, Longworth SA, Kasprowicz V, McMahon C, Wurcel A, Lohse AW, Lewis-Ximenez LL, Chung RT, Kim AY, Allen TM, Walker BD. Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection. Blood. 2007 Sep 01; 110(5):1559-69. PMID: 17475911; PMCID: PMC1975840.
  56. Timm J, Neukamm M, Kuntzen T, Kim AY, Chung RT, Brander C, Lauer GM, Walker BD, Allen TM. Characterization of full-length hepatitis C virus genotype 4 sequences. J Viral Hepat. 2007 May; 14(5):330-7. PMID: 17439522.
    View in: PubMed
  57. Kim AY, Schulze zur Wiesch J, Kuntzen T, Timm J, Kaufmann DE, Duncan JE, Jones AM, Wurcel AG, Davis BT, Gandhi RT, Robbins GK, Allen TM, Chung RT, Lauer GM, Walker BD. Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection. PLoS Med. 2006 Dec; 3(12):e492. PMID: 17194190; PMCID: PMC1705826.
  58. Corey KE, Ross AS, Wurcel A, Schulze Zur Wiesch J, Kim AY, Lauer GM, Chung RT. Outcomes and treatment of acute hepatitis C virus infection in a United States population. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1278-82. PMID: 16931171; PMCID: PMC1828916.
  59. Lichterfeld M, Williams KL, Mui SK, Shah SS, Mothe BR, Sette A, Kim A, Johnston MN, Burgett N, Frahm N, Cohen D, Brander C, Rosenberg ES, Walker BD, Altfeld M, Yu XG. T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily. Int Immunol. 2006 Jul; 18(7):1179-88. PMID: 16772368.
    View in: PubMed
  60. McGovern BH, Wurcel A, Kim AY, Schulze zur Wiesch J, Bica I, Zaman MT, Timm J, Walker BD, Lauer GM. Acute hepatitis C virus infection in incarcerated injection drug users. Clin Infect Dis. 2006 Jun 15; 42(12):1663-70. PMID: 16705568.
    View in: PubMed
  61. Lauer GM, Kim AY. Spontaneous resolution of chronic hepatitis C virus infection: are we missing something? Clin Infect Dis. 2006 Apr 01; 42(7):953-4. PMID: 16511758.
    View in: PubMed
  62. Lauer GM, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Schulze Zur Wiesch J, Paranhos-Baccala G, Sheridan I, Casson DR, Reiser M, Gandhi RT, Li B, Allen TM, Chung RT, Klenerman P, Walker BD. Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy. J Virol. 2005 Oct; 79(20):12979-88. PMID: 16189000; PMCID: PMC1235828.
  63. Schulze zur Wiesch J, Lauer GM, Day CL, Kim AY, Ouchi K, Duncan JE, Wurcel AG, Timm J, Jones AM, Mothe B, Allen TM, McGovern B, Lewis-Ximenez L, Sidney J, Sette A, Chung RT, Walker BD. Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. J Immunol. 2005 Sep 15; 175(6):3603-13. PMID: 16148104.
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  64. Schulze Zur Wiesch J, Lauer GM, Day CL, Kim AY, Ouchi K, Duncan JE, Wurcel AG, Timm J, Jones AM, Mothe B, Allen TM, McGovern B, Lewis-Ximenez L, Sidney J, Sette A, Chung RT, Walker BD. Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. Journal of Immunology. 2005; 175(6):3603-13.
  65. Timm J, Lauer GM, Kavanagh DG, Sheridan I, Kim AY, Lucas M, Pillay T, Ouchi K, Reyor LL, Schulze zur Wiesch J, Gandhi RT, Chung RT, Bhardwaj N, Klenerman P, Walker BD, Allen TM. CD8 epitope escape and reversion in acute HCV infection. J Exp Med. 2004 Dec 20; 200(12):1593-604. PMID: 15611288; PMCID: PMC2212005.
  66. Kim AY, Lauer GM, Ouchi K, Addo MM, Lucas M, Schulze Zur Wiesch J, Timm J, Boczanowski M, Duncan JE, Wurcel AG, Casson D, Chung RT, Draenert R, Klenerman P, Walker BD. The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. Blood. 2005 Feb 01; 105(3):1170-8. PMID: 15459014.
    View in: PubMed
  67. Lauer GM, Barnes E, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Robbins GK, Casson DR, Reiser M, Dusheiko G, Allen TM, Chung RT, Walker BD, Klenerman P. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology. 2004 Sep; 127(3):924-36. PMID: 15362047.
    View in: PubMed
  68. Kim AY and Chung RT. HIV and Hepatitis C Virus Coinfection Update. Current Hepatitis Reports. 2004; 3(3):83-90.
  69. Ivers LC, Kim AY, Sax PE. Predictive value of polymerase chain reaction of cerebrospinal fluid for detection of Epstein-Barr virus to establish the diagnosis of HIV-related primary central nervous system lymphoma. Clin Infect Dis. 2004 Jun 01; 38(11):1629-32. PMID: 15156453.
    View in: PubMed
  70. Draenert R, Verrill CL, Tang Y, Allen TM, Wurcel AG, Boczanowski M, Lechner A, Kim AY, Suscovich T, Brown NV, Addo MM, Walker BD. Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection. J Virol. 2004 Jan; 78(2):630-41. PMID: 14694094; PMCID: PMC368768.
  71. Kim AY, Rubin RH, Goldberg MB. Salmonella: pathogenesis and vaccines. In: Gorbach SL, Bartlett JG, Blacklow NR, editors. Infectious diseases in medicine and surgery. 2003.
  72. Kim AY, Goldberg MB, Rubin RH. Salmonella infections. In: Gorbach SL, Bartlett JG, Blacklow NR, editors. Infectious diseases in medicine and surgery. 2003.
  73. Lauer GM, Ouchi K, Chung RT, Nguyen TN, Day CL, Purkis DR, Reiser M, Kim AY, Lucas M, Klenerman P, Walker BD. Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol. 2002 Jun; 76(12):6104-13. PMID: 12021343; PMCID: PMC136241.
  74. Kim AY, Chung RT, Polsky B. Human immunodeficiency virus and hepatitis B and C co-infection: pathogenic interactions, natural history and therapy. AIDS Clinical Review 2000/2001 ed. Volberding and Jacobsen. 2001; 263-306..
  75. Anderson KS, Kim AY, Quillen JM, Sayers E, Yang XJ, Miles EW. Kinetic characterization of channel impaired mutants of tryptophan synthase. J Biol Chem. 1995 Dec 15; 270(50):29936-44. PMID: 8530393.
    View in: PubMed
  76. Schlichting I, Yang XJ, Miles EW, Kim AY, Anderson KS. Structural and kinetic analysis of a channel-impaired mutant of tryptophan synthase. J Biol Chem. 1994 Oct 28; 269(43):26591-3. PMID: 7929385.
    View in: PubMed
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