Harvard Catalyst Profiles

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Clifford B. Saper, M.D.,Ph.D.

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Mentoring
Available: 09/24/18, Expires: 06/30/20

We use optogenetic and chemogenetic activation of genetically specified cell groups in the brain to test their role in regulating sleep and wakefulness. The student would assist with (and learn to perform) the experiments, and to do the subsequent immunohistochemistry.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS085477 (SAPER, CLIFFORD B) Jul 1, 2014 - Apr 30, 2019
    NIH/NINDS
    Hypothalamic arousal systems
    Role: Principal Investigator
  2. R01NS072337 (SAPER, CLIFFORD B) Sep 1, 2010 - Aug 31, 2014
    NIH/NINDS
    Circuitry for circadian rhythms
    Role: Principal Investigator
  3. R25NS070682 (POMEROY, SCOTT LOREN) Jul 1, 2010 - Jun 30, 2020
    NIH/NINDS
    CH/BIDMC/Harvard Medical School Neurology Resident Research Education Program Competing Renewal
    Role: Co-Principal Investigator
  4. P01HL095491 (SAPER, CLIFFORD B) Apr 1, 2009 - May 31, 2020
    NIH/NHLBI
    Mechanisms of Arousal in Sleep Apnea
    Role: Principal Investigator
  5. P50HL060292 (SAPER, CLIFFORD) Sep 1, 1998 - Aug 31, 2008
    NIH/NHLBI
    Harvard Center on Sleep Neurobiology and Sleep Apnea (SCOR)
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Saper CB. Passages 2019. Ann Neurol. 2019 Jan; 85(1):1-11. PMID: 30565284.
    Citations:    Fields:    
  2. Kroeger D, Absi G, Gagliardi C, Bandaru SS, Madara JC, Ferrari LL, Arrigoni E, M├╝nzberg H, Scammell TE, Saper CB, Vetrivelan R. Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice. Nat Commun. 2018 10 08; 9(1):4129. PMID: 30297727.
    Citations:    Fields:    Translation:AnimalsCells
  3. Saper CB. Is it time to reconsider the classic neurological examination? Ann Neurol. 2018 Oct; 84(4):483-484. PMID: 30225847.
    Citations:    Fields:    
  4. Boes AD, Fischer D, Geerling JC, Bruss J, Saper CB, Fox MD. Connectivity of sleep- and wake-promoting regions of the human hypothalamus observed during resting wakefulness. Sleep. 2018 Sep 01; 41(9). PMID: 29850898.
    Citations:    Fields:    
  5. Machado NLS, Abbott SBG, Resch JM, Zhu L, Arrigoni E, Lowell BB, Fuller PM, Fontes MAP, Saper CB. A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia. Curr Biol. 2018 Jul 23; 28(14):2291-2301.e5. PMID: 30017482.
    Citations: 2     Fields:    
  6. Todd WD, Fenselau H, Wang JL, Zhang R, Machado NL, Venner A, Broadhurst RY, Kaur S, Lynagh T, Olson DP, Lowell BB, Fuller PM, Saper CB. A hypothalamic circuit for the circadian control of aggression. Nat Neurosci. 2018 May; 21(5):717-724. PMID: 29632359.
    Citations: 1     Fields:    
  7. Abbott SBG, Saper CB. Role of the median preoptic nucleus in the autonomic response to heat-exposure. Temperature (Austin). 2018; 5(1):4-6. PMID: 29687039.
    Citations: 1     
  8. Holtzman DM, Saper CB. In memoriam: William M. Landau, MD. Ann Neurol. 2018 Feb; 83(2):205-207. PMID: 29315728.
    Citations:    
  9. Saper CB. Passages 2018. Ann Neurol. 2018 01; 83(1):1-9. PMID: 29315759.
    Citations:    Fields:    
  10. Saper CB. Reply to is there even such a thing as "idiopathic normal pressure hydrocephalus"? Ann Neurol. 2017 Dec; 82(6):1033. PMID: 29136294.
    Citations:    Fields:    
  11. Pedersen NP, Ferrari L, Venner A, Wang JL, Abbott SBG, Vujovic N, Arrigoni E, Saper CB, Fuller PM. Supramammillary glutamate neurons are a key node of the arousal system. Nat Commun. 2017 11 10; 8(1):1405. PMID: 29123082.
    Citations: 2     Fields:    Translation:AnimalsCells