Harvard Catalyst Profiles

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Clifford B. Saper, M.D.,Ph.D.

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Mentoring
Available: 09/24/18, Expires: 06/30/20

We use optogenetic and chemogenetic activation of genetically specified cell groups in the brain to test their role in regulating sleep and wakefulness. The student would assist with (and learn to perform) the experiments, and to do the subsequent immunohistochemistry.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS085477 (SAPER, CLIFFORD B) Jul 1, 2014 - Apr 30, 2019
    NIH/NINDS
    Hypothalamic arousal systems
    Role: Principal Investigator
  2. R01NS072337 (SAPER, CLIFFORD B) Sep 1, 2010 - Mar 31, 2024
    NIH/NINDS
    Circuitry for circadian rhythms
    Role: Principal Investigator
  3. R25NS070682 (POMEROY, SCOTT LOREN) Jul 1, 2010 - Jun 30, 2020
    NIH/NINDS
    CH/BIDMC/Harvard Medical School Neurology Resident Research Education Program Competing Renewal
    Role: Co-Principal Investigator
  4. P01HL095491 (SAPER, CLIFFORD B) Apr 1, 2009 - May 31, 2020
    NIH/NHLBI
    Mechanisms of Arousal in Sleep Apnea
    Role: Principal Investigator
  5. P50HL060292 (SAPER, CLIFFORD) Sep 1, 1998 - Aug 31, 2008
    NIH/NHLBI
    Harvard Center on Sleep Neurobiology and Sleep Apnea (SCOR)
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Passages 2020. Ann Neurol. 2020 Feb; 87(2):159-169. PMID: 31909488.
    Citations:    
  2. Saper CB. Reply to "Medicare for All?" Ann Neurol. 2020 Jan; 87(1):156. PMID: 31658391.
    Citations:    
  3. Lombardi F, Gómez-Extremera M, Bernaola-Galván P, Vetrivelan R, Saper CB, Scammell TE, Ivanov PC. Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep and Wake. J Neurosci. 2020 Jan 02; 40(1):171-190. PMID: 31694962.
    Citations:    
  4. Saper CB. Why "Medicare for All" would be a disaster. Ann Neurol. 2019 Oct; 86(4):475-476. PMID: 31415099.
    Citations:    
  5. Venner A, Mochizuki T, De Luca R, Anaclet C, Scammell TE, Saper CB, Arrigoni E, Fuller PM. Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control. J Neurosci. 2019 Nov 06; 39(45):8929-8939. PMID: 31548232.
    Citations:    
  6. Gisabella B, Scammell T, Bandaru SS, Saper CB. Regulation of hippocampal dendritic spines following sleep deprivation. J Comp Neurol. 2020 Feb 15; 528(3):380-388. PMID: 31454077.
    Citations:    
  7. Kaur S, Saper CB. Neural Circuitry Underlying Waking Up to Hypercapnia. Front Neurosci. 2019; 13:401. PMID: 31080401.
    Citations:    
  8. Saper CB, Kaur S. Brain Circuitry for Arousal from Apnea. Cold Spring Harb Symp Quant Biol. 2018; 83:63-69. PMID: 31015281.
    Citations:    
  9. Garcia-Rill E, Saper CB, Rye DB, Kofler M, Nonnekes J, Lozano A, Valls-Solé J, Hallett M. Focus on the pedunculopontine nucleus. Consensus review from the May 2018 brainstem society meeting in Washington, DC, USA. Clin Neurophysiol. 2019 Jun; 130(6):925-940. PMID: 30981899.
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