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Justin Dean, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Morrison JL, Ayonrinde OT, Care AS, Clarke GD, Darby JRT, David AL, Dean JM, Hooper SB, Kitchen MJ, Macgowan CK, Melbourne A, McGillick EV, McKenzie CA, Michael N, Mohammed N, Sadananthan SA, Schrauben E, Regnault TRH, Velan SS. Seeing the fetus from a DOHaD perspective: discussion paper from the advanced imaging techniques of DOHaD applications workshop held at the 2019 DOHaD World Congress. J Dev Orig Health Dis. 2020 Sep 21; 1-15. PMID: 32955011.
    Citations:    
  2. Yang P, Davidson JO, Fowke TM, Galinsky R, Wassink G, Karunasinghe RN, Prasad JD, Ranasinghe S, Green CR, Bennet L, Gunn AJ, Dean JM. Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep. Int J Mol Sci. 2020 Sep 04; 21(18). PMID: 32899855.
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  3. Cho KH, Davidson JO, Dean JM, Bennet L, Gunn AJ. Cooling and immunomodulation for treating hypoxic-ischemic brain injury. Pediatr Int. 2020 Jul; 62(7):770-778. PMID: 32119180.
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  4. Galinsky R, Dean JM, Lingam I, Robertson NJ, Mallard C, Bennet L, Gunn AJ. A Systematic Review of Magnesium Sulfate for Perinatal Neuroprotection: What Have We Learnt From the Past Decade? Front Neurol. 2020; 11:449. PMID: 32536903.
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  5. Galinsky R, Dhillon SK, Dean JM, Davidson JO, Lear CA, Wassink G, Nott F, Kelly SB, Fraser M, Yuill C, Bennet L, Gunn AJ. Tumor necrosis factor inhibition attenuates white matter gliosis after systemic inflammation in preterm fetal sheep. J Neuroinflammation. 2020 Mar 23; 17(1):92. PMID: 32293473.
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  6. Murata K, Jadhav U, Madha S, van Es J, Dean J, Cavazza A, Wucherpfennig K, Michor F, Clevers H, Shivdasani RA. Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6. PMID: 32084390.
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  7. Cho KHT, Fraser M, Wassink G, Dhillon SJ, Davidson JO, Dean JM, Gunn AJ, Bennet L. TLR7 agonist modulation of postasphyxial neurophysiological and cardiovascular adaptations in preterm fetal sheep. . 2020 02 01; 318(2):R369-R378. PMID: 31913689.
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  8. Su W, Matsumoto S, Banine F, Srivastava T, Dean J, Foster S, Pham P, Hammond B, Peters A, Girish KS, Rangappa KS, Jose J, Hennebold JD, Murphy MJ, Bennett-Toomey J, Back SA, Sherman LS. A modified flavonoid accelerates oligodendrocyte maturation and functional remyelination. Glia. 2020 02; 68(2):263-279. PMID: 31490574.
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  9. Dean JM, Levison SW. Preface. Dev Neurosci. 2018; 40(5-6):381. PMID: 31256168.
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  10. Zhou KQ, Draghi V, Lear CA, Dean JM, Ashton JL, Hou Y, Bennet L, Gunn AJ, Davidson JO. Protection of axonal integrity with 48 or 72?h of cerebral hypothermia in near-term fetal sheep. Pediatr Res. 2020 07; 88(1):48-56. PMID: 31234193.
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  11. Reginald-Opara JN, Svirskis D, O'Carroll SJ, Sreebhavan S, Dean JM, Wu Z. Optimisation of glutathione conjugation to liposomes quantified with a validated HPLC assay. Int J Pharm. 2019 Aug 15; 567:118451. PMID: 31229530.
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  12. Fowke TM, Galinsky R, Davidson JO, Wassink G, Karunasinghe RN, Prasad JD, Bennet L, Gunn AJ, Dean JM. Loss of interneurons and disruption of perineuronal nets in the cerebral cortex following hypoxia-ischaemia in near-term fetal sheep. Sci Rep. 2018 12 06; 8(1):17686. PMID: 30523273.
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  13. Paton MCB, Allison BJ, Li J, Fahey MC, Sutherland AE, Nitsos I, Bischof RJ, Dean JM, Moss TJM, Polglase GR, Jenkin G, McDonald CA, Miller SL. Human Umbilical Cord Blood Therapy Protects Cerebral White Matter from Systemic LPS Exposure in Preterm Fetal Sheep. Dev Neurosci. 2018; 40(3):258-270. PMID: 30179864.
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  14. Karunasinghe RN, Dean JM, Lipski J. Acute sensitivity of astrocytes in the Substantia Nigra to oxygen and glucose deprivation (OGD) compared with hippocampal astrocytes in brain slices. Neurosci Lett. 2018 10 15; 685:137-143. PMID: 30153493.
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  15. Davidson JO, Dean JM, Fraser M, Wassink G, Andelius TC, Dhillon SK, Bennet L, Gunn AJ. Perinatal brain injury: mechanisms and therapeutic approaches. Front Biosci (Landmark Ed). 2018 06 01; 23:2204-2226. PMID: 29772556.
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  16. Dieriks BV, Dean JM, Aronica E, Waldvogel HJ, Faull RLM, Curtis MA. Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone. Dev Neurosci. 2018; 40(2):145-161. PMID: 29680832.
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  17. Srivastava T, Diba P, Dean JM, Banine F, Shaver D, Hagen M, Gong X, Su W, Emery B, Marks DL, Harris EN, Baggenstoss B, Weigel PH, Sherman LS, Back SA. A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors. J Clin Invest. 2018 05 01; 128(5):2025-2041. PMID: 29664021.
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  18. Galinsky R, Davidson JO, Dean JM, Green CR, Bennet L, Gunn AJ. Glia and hemichannels: key mediators of perinatal encephalopathy. Neural Regen Res. 2018 Feb; 13(2):181-189. PMID: 29557357.
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  19. Galinsky R, Lear CA, Dean JM, Wassink G, Dhillon SK, Fraser M, Davidson JO, Bennet L, Gunn AJ. Complex interactions between hypoxia-ischemia and inflammation in preterm brain injury. Dev Med Child Neurol. 2018 02; 60(2):126-133. PMID: 29194585.
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  20. Bennet L, Dhillon S, Lear CA, van den Heuij L, King V, Dean JM, Wassink G, Davidson JO, Gunn AJ. Chronic inflammation and impaired development of the preterm brain. J Reprod Immunol. 2018 02; 125:45-55. PMID: 29253793.
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  21. Fowke TM, Karunasinghe RN, Bai JZ, Jordan S, Gunn AJ, Dean JM. Hyaluronan synthesis by developing cortical neurons in vitro. Sci Rep. 2017 03 13; 7:44135. PMID: 28287145.
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  22. Galinsky R, Dean JM, Lear CA, Davidson JO, Dhillon S, Wassink G, Bennet L, Gunn AJ. In the Era of Therapeutic Hypothermia, How Well Do Studies of Perinatal Neuroprotection Control Temperature? Dev Neurosci. 2017; 39(1-4):7-22. PMID: 27988510.
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  23. van de Looij Y, Dean JM, Gunn AJ, Hüppi PS, Sizonenko SV. Advanced magnetic resonance spectroscopy and imaging techniques applied to brain development and animal models of perinatal injury. Int J Dev Neurosci. 2015 Oct; 45:29-38. PMID: 25818582.
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  24. Dean JM, Shi Z, Fleiss B, Gunn KC, Groenendaal F, van Bel F, Derrick M, Juul SE, Tan S, Gressens P, Mallard C, Bennet L, Gunn AJ. A Critical Review of Models of Perinatal Infection. Dev Neurosci. 2015; 37(4-5):289-304. PMID: 25720344.
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  25. Hagen MW, Riddle A, McClendon E, Gong X, Shaver D, Srivastava T, Dean JM, Bai JZ, Fowke TM, Gunn AJ, Jones DF, Sherman LS, Grafe MR, Hohimer AR, Back SA. Role of recurrent hypoxia-ischemia in preterm white matter injury severity. PLoS One. 2014; 9(11):e112800. PMID: 25390897.
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  26. Wassink G, Lear CA, Gunn KC, Dean JM, Bennet L, Gunn AJ. Analgesics, sedatives, anticonvulsant drugs, and the cooled brain. Semin Fetal Neonatal Med. 2015 Apr; 20(2):109-14. PMID: 25457080.
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  27. McClendon E, Chen K, Gong X, Sharifnia E, Hagen M, Cai V, Shaver DC, Riddle A, Dean JM, Gunn AJ, Mohr C, Kaplan JS, Rossi DJ, Kroenke CD, Hohimer AR, Back SA. Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons. Ann Neurol. 2014 Apr; 75(4):508-24. PMID: 24395459.
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  28. Bennet L, Van Den Heuij L, Dean JM, Drury P, Wassink G, Gunn AJ. Neural plasticity and the Kennard principle: Does it work for the preterm brain? Clin Exp Pharmacol Physiol. 2013 Nov; 40(11):774-84. PMID: 23735123.
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  29. Dean JM, Bennet L, Back SA, McClendon E, Riddle A, Gunn AJ. What brakes the preterm brain? An arresting story. Pediatr Res. 2014 Jan; 75(1-2):227-33. PMID: 24336432.
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  30. Preston M, Gong X, Su W, Matsumoto SG, Banine F, Winkler C, Foster S, Xing R, Struve J, Dean J, Baggenstoss B, Weigel PH, Montine TJ, Back SA, Sherman LS. Digestion products of the PH20 hyaluronidase inhibit remyelination. Ann Neurol. 2013 Feb; 73(2):266-80. PMID: 23463525.
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  31. Dean JM, McClendon E, Hansen K, Azimi-Zonooz A, Chen K, Riddle A, Gong X, Sharifnia E, Hagen M, Ahmad T, Leigland LA, Hohimer AR, Kroenke CD, Back SA. Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure through disturbances in neuronal arborization. Sci Transl Med. 2013 Jan 16; 5(168):168ra7. PMID: 23325800.
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  32. Uchida N, Chen K, Dohse M, Hansen KD, Dean J, Buser JR, Riddle A, Beardsley DJ, Wan Y, Gong X, Nguyen T, Cummings BJ, Anderson AJ, Tamaki SJ, Tsukamoto A, Weissman IL, Matsumoto SG, Sherman LS, Kroenke CD, Back SA. Human neural stem cells induce functional myelination in mice with severe dysmyelination. Sci Transl Med. 2012 Oct 10; 4(155):155ra136. PMID: 23052293.
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  33. Barrett RD, Bennet L, Naylor A, George SA, Dean JM, Gunn AJ. Effect of cerebral hypothermia and asphyxia on the subventricular zone and white matter tracts in preterm fetal sheep. Brain Res. 2012 Aug 21; 1469:35-42. PMID: 22765912.
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  34. van de Looij Y, Lodygensky GA, Dean J, Lazeyras F, Hagberg H, Kjellmer I, Mallard C, Hüppi PS, Sizonenko SV. High-field diffusion tensor imaging characterization of cerebral white matter injury in lipopolysaccharide-exposed fetal sheep. Pediatr Res. 2012 Sep; 72(3):285-92. PMID: 22907562.
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  35. Back SA, Riddle A, Dean J, Hohimer AR. The instrumented fetal sheep as a model of cerebral white matter injury in the premature infant. Neurotherapeutics. 2012 Apr; 9(2):359-70. PMID: 22399133.
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  36. Keller M, Enot DP, Hodson MP, Igwe EI, Deigner HP, Dean J, Bolouri H, Hagberg H, Mallard C. Inflammatory-induced hibernation in the fetus: priming of fetal sheep metabolism correlates with developmental brain injury. PLoS One. 2011; 6(12):e29503. PMID: 22242129.
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  37. Dean JM, van de Looij Y, Sizonenko SV, Lodygensky GA, Lazeyras F, Bolouri H, Kjellmer I, Huppi PS, Hagberg H, Mallard C. Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep. Ann Neurol. 2011 Nov; 70(5):846-56. PMID: 22002627.
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  38. Dean JM, Moravec MD, Grafe M, Abend N, Ren J, Gong X, Volpe JJ, Jensen FE, Hohimer AR, Back SA. Strain-specific differences in perinatal rodent oligodendrocyte lineage progression and its correlation with human. Dev Neurosci. 2011; 33(3-4):251-60. PMID: 21865655.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  39. Riddle A, Dean J, Buser JR, Gong X, Maire J, Chen K, Ahmad T, Cai V, Nguyen T, Kroenke CD, Hohimer AR, Back SA. Histopathological correlates of magnetic resonance imaging-defined chronic perinatal white matter injury. Ann Neurol. 2011 Sep; 70(3):493-507. PMID: 21796666.
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  40. Dean JM, Riddle A, Maire J, Hansen KD, Preston M, Barnes AP, Sherman LS, Back SA. An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors. Mol Neurodegener. 2011 Jul 05; 6:46. PMID: 21729326.
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  41. Buser JR, Segovia KN, Dean JM, Nelson K, Beardsley D, Gong X, Luo NL, Ren J, Wan Y, Riddle A, McClure MM, Ji X, Derrick M, Hohimer AR, Back SA, Tan S. Timing of appearance of late oligodendrocyte progenitors coincides with enhanced susceptibility of preterm rabbit cerebral white matter to hypoxia-ischemia. J Cereb Blood Flow Metab. 2010 May; 30(5):1053-65. PMID: 20068573.
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  42. Wang X, Stridh L, Li W, Dean J, Elmgren A, Gan L, Eriksson K, Hagberg H, Mallard C. Lipopolysaccharide sensitizes neonatal hypoxic-ischemic brain injury in a MyD88-dependent manner. J Immunol. 2009 Dec 01; 183(11):7471-7. PMID: 19917690.
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  43. Dean JM, George S, Naylor AS, Mallard C, Gunn AJ, Bennet L. Partial neuroprotection with low-dose infusion of the alpha2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep. Neuropharmacology. 2008 Aug; 55(2):166-74. PMID: 18572205.
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  44. Barrett RD, Bennet L, Davidson J, Dean JM, George S, Emerald BS, Gunn AJ. Destruction and reconstruction: hypoxia and the developing brain. Birth Defects Res C Embryo Today. 2007 Sep; 81(3):163-76. PMID: 17963273.
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  45. Wassink G, Bennet L, Booth LC, Jensen EC, Wibbens B, Dean JM, Gunn AJ. The ontogeny of hemodynamic responses to prolonged umbilical cord occlusion in fetal sheep. J Appl Physiol (1985). 2007 Oct; 103(4):1311-7. PMID: 17656627.
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  46. Bennet L, Booth LC, Ahmed-Nasef N, Dean JM, Davidson J, Quaedackers JS, Gunn AJ. Male disadvantage? Fetal sex and cardiovascular responses to asphyxia in preterm fetal sheep. . 2007 Sep; 293(3):R1280-6. PMID: 17596324.
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  47. Bennet L, Roelfsema V, Dean JM, Wassink G, Power GG, Jensen EC, Gunn AJ. Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep. . 2007 Apr; 292(4):R1569-76. PMID: 17170231.
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  48. Dean JM, George SA, Wassink G, Gunn AJ, Bennet L. Suppression of post-hypoxic-ischemic EEG transients with dizocilpine is associated with partial striatal protection in the preterm fetal sheep. Neuropharmacology. 2006 Mar; 50(4):491-503. PMID: 16376952.
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  49. Dean JM, Gunn AJ, Wassink G, Bennet L. Transient NMDA receptor-mediated hypoperfusion following umbilical cord occlusion in preterm fetal sheep. Exp Physiol. 2006 Mar; 91(2):423-33. PMID: 16317084.
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  50. Dean JM, Fraser M, Shelling AN, Bennet L, George S, Shaikh S, Scheepens A, Gunn AJ. Ontogeny of AMPA and NMDA receptor gene expression in the developing sheep white matter and cerebral cortex. Brain Res Mol Brain Res. 2005 Oct 03; 139(2):242-50. PMID: 15963598.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.