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Sofia Coimbra De Sousa, Ph.D.

Title
Institution
Department
Address
Phone

Biography
University of Lyon, Lyon, France12/2018Bone metastasis
University of Turku, Turku, Finland03/2016Bone metastasis
University of Eastern Finland, Kuopio, FinlandPhD11/2015Bone metastasis
Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal07/2011Intestinal metaplasia
Faculty of Pharmacy, University of Porto, Porto, PortugalMSc09/2009Pharmaceutical Sciences
Faculty of Pharmacy, University of Porto, Porto, PortugalBSc07/2007Pharmacy
2017
Best Poster Award
2014
Best Poster Award

Overview
My research experience in cancer biology started eight years ago as a research trainee at the Institute of Molecular Pathology and Immunology of University of Porto, in which we studied translational regulation of preneoplastic gastric intestinal metaplasia. I attained my doctorate in Pharmacy in November 2015 at the University of Eastern Finland, with the thesis : Mechanisms of action of bisphosphonates in cancer: tumor-associated macrophages targeting strategies, under the supervision of Professor Jukka Monkkonen and Adjunct Professor Jorma Maatta. My positions as a post doctoral fellow in Professor Philippe Clezardin laboratory (from which a manuscript has been submitted) and my doctorate training within a European Marie Curie ITN network (Bonenet) gave me a broad understanding of the field of bone metastasis. Additionally, my doctoral thesis work, awoke my interest to the importance of inter individual immunological differences in the pathogenesis of cancer and other pathologies. I believe the immune system is a source of disease response variability and is a key aspect that should be harnessed into biomarker and personalized therapy development. That interest and the will to expand my scientific expertise in immunology immunotherapy in different disease settings, brought me to my current postdoc at Dr. Eva Guinan lab at Dana Farber Cancer Institute. My research will focus on the use of ex vivo generation of T regulatory cells for adoptive transfer to patients in different transplant and immunological imbalance settings.
I am a versatile team worker, highly motivated and independent researcher with over 7 years of research experience and a Pharmaceutical background. My high mobility across countries, research groups and sometimes research areas demonstrates that I am eager to learn and implement new techniques concepts in different work environments, improving individual and group potential impact.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Polari L, Wiklund A, Sousa S, Kangas L, Linnanen T, Härkönen P, Määttä J. SERMs Promote Anti-Inflammatory Signaling and Phenotype of CD14+ Cells. Inflammation. 2018 Aug; 41(4):1157-1171. PMID: 29574654.
    Citations:    
  2. Sousa S, Clézardin P. Bone-Targeted Therapies in Cancer-Induced Bone Disease. Calcif Tissue Int. 2018 02; 102(2):227-250. PMID: 29079995.
    Citations:    
  3. Nerdal PT, Peters C, Oberg HH, Zlatev H, Lettau M, Quabius ES, Sousa S, Gonnermann D, Auriola S, Olive D, Määttä J, Janssen O, Kabelitz D. Butyrophilin 3A/CD277-Dependent Activation of Human ?d T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations. J Immunol. 2016 10 15; 197(8):3059-3068. PMID: 27619996.
    Citations:    
  4. Sousa S, Määttä J. The role of tumour-associated macrophages in bone metastasis. J Bone Oncol. 2016 Sep; 5(3):135-138. PMID: 27761375.
    Citations:    
  5. Sousa S, Brion R, Lintunen M, Kronqvist P, Sandholm J, Mönkkönen J, Kellokumpu-Lehtinen PL, Lauttia S, Tynninen O, Joensuu H, Heymann D, Määttä JA. Human breast cancer cells educate macrophages toward the M2 activation status. Breast Cancer Res. 2015 Aug 05; 17:101. PMID: 26243145.
    Citations:    
  6. Sousa S, Auriola S, Mönkkönen J, Määttä J. Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells. BMC Cancer. 2015 Jan 15; 15:4. PMID: 25588705.
    Citations:    
  7. Sousa S., Määttä JA. Bone Cancer. Chapter 9 - Macrophages and pathophysiology of bone cancers. 2015; 135-138.
  8. Sousa S. Dissertations in Health Sciences. Mechanisms of Action of Bisphosphonates in Cancer: Tumour Associated Macrophage Targeting Strategies. 2015.
  9. Ebert R, Meissner-Weigl J, Zeck S, Määttä J, Auriola S, Coimbra de Sousa S, Mentrup B, Graser S, Rachner TD, Hofbauer LC, Jakob F. Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells. Mol Cancer. 2014 Dec 11; 13:265. PMID: 25496233.
    Citations:    
  10. Pereira B, Sousa S, Barros R, Carreto L, Oliveira P, Oliveira C, Chartier NT, Plateroti M, Rouault JP, Freund JN, Billaud M, Almeida R. CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness. Nucleic Acids Res. 2013 Apr; 41(7):3986-99. PMID: 23408853.
    Citations:    
  11. Camilo V, Barros R, Sousa S, Magalhães AM, Lopes T, Mário Santos A, Pereira T, Figueiredo C, David L, Almeida R. Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells. Carcinogenesis. 2012 Oct; 33(10):1985-92. PMID: 22791809.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.