Harvard Catalyst Profiles

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Sofia Coimbra De Sousa, Ph.D.


University of Lyon, Lyon, France12/2018Bone metastasis
University of Turku, Turku, Finland03/2016Bone metastasis
University of Eastern Finland, Kuopio, FinlandPhD11/2015Bone metastasis
Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal07/2011Intestinal metaplasia
Faculty of Pharmacy, University of Porto, Porto, PortugalMSc09/2009Pharmaceutical Sciences
Faculty of Pharmacy, University of Porto, Porto, PortugalBSc07/2007Pharmacy
Best Poster Award
Best Poster Award

My research experience in cancer biology started eight years ago as a research trainee at the Institute of Molecular Pathology and Immunology of University of Porto, in which we studied translational regulation of preneoplastic gastric intestinal metaplasia. I attained my doctorate in Pharmacy in November 2015 at the University of Eastern Finland, with the thesis : Mechanisms of action of bisphosphonates in cancer: tumor-associated macrophages targeting strategies, under the supervision of Professor Jukka Monkkonen and Adjunct Professor Jorma Maatta. My positions as a post doctoral fellow in Professor Philippe Clezardin laboratory (from which a manuscript has been submitted) and my doctorate training within a European Marie Curie ITN network (Bonenet) gave me a broad understanding of the field of bone metastasis. Additionally, my doctoral thesis work, awoke my interest to the importance of inter individual immunological differences in the pathogenesis of cancer and other pathologies. I believe the immune system is a source of disease response variability and is a key aspect that should be harnessed into biomarker and personalized therapy development. That interest and the will to expand my scientific expertise in immunology immunotherapy in different disease settings, brought me to my current postdoc at Dr. Eva Guinan lab at Dana Farber Cancer Institute. My research will focus on the use of ex vivo generation of T regulatory cells for adoptive transfer to patients in different transplant and immunological imbalance settings.
I am a versatile team worker, highly motivated and independent researcher with over 7 years of research experience and a Pharmaceutical background. My high mobility across countries, research groups and sometimes research areas demonstrates that I am eager to learn and implement new techniques concepts in different work environments, improving individual and group potential impact.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.