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Tracy Young-Pearse, Ph.D.


Young-Pearse lab website:

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1NS117446 (YOUNG-PEARSE, TRACY L) Sep 15, 2020 - Aug 31, 2024
    Cell and Molecular Consequences of Alzheimer's Disease Genetic Variants on BBB Integrity and Function
    Role: Principal Investigator
  2. R21MH118576 (YOUNG-PEARSE, TRACY L) Apr 1, 2019 - Feb 28, 2021
    Establishing a human cellular model of sex differences in the brain
    Role: Principal Investigator
  3. R01AG055909 (YOUNG-PEARSE, TRACY L) Jul 15, 2018 - Apr 30, 2023
    Probing Heterogeneity of Alzheimer's disease using iPSCs
    Role: Principal Investigator
  4. RF1AG057457 (CHANG, RUI) Sep 15, 2017 - Aug 31, 2021
    Building Novel Predictive Networks for high-throughput, in-silico Key Driver Prioritization to Enhance Drug Target Discovery in AMP-AD and M2OVE-AD
    Role: Co-Principal Investigator
  5. R21AG056011 (YOUNG-PEARSE, TRACY L) Apr 1, 2017 - Mar 31, 2019
    Feasibility of studying vulnerability versus protection to high amyloid load using iPSCs
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lagomarsino VN, Pearse RV, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, Fancher SB, He A, Merchant JP, Duong DM, Martinez H, Zhou M, Bah F, Vicent MA, Stricker JMS, Xu J, Dammer EB, Levey AI, Chibnik LB, Menon V, Seyfried NT, De Jager PL, Noggle S, Selkoe DJ, Bennett DA, Young-Pearse TL. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Neuron. 2021 Nov 03; 109(21):3402-3420.e9. PMID: 34473944.
    Citations:    Fields:    
  2. Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, Selkoe DJ, Bartels T. Analysis of a-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies. Brain Commun. 2020; 2(1):fcaa010. PMID: 32280944.
    Citations: 5     
  3. Negri J, Menon V, Young-Pearse TL. Assessment of Spontaneous Neuronal Activity In Vitro Using Multi-Well Multi-Electrode Arrays: Implications for Assay Development. eNeuro. 2020 Jan/Feb; 7(1). PMID: 31896559.
    Citations: 5     Fields:    Translation:AnimalsCells
  4. Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-ß plaque pathology in an APP knock-in mouse model. Mol Neurodegener. 2020 01 08; 15(1):3. PMID: 31915042.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  5. Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, Young-Pearse TL, Billinton A, Walsh DM. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta Neuropathol. 2020 03; 139(3):503-526. PMID: 31853635.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  6. Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Cell models of lipid-rich a-synuclein aggregation validate known modifiers of a-synuclein biology and identify stearoyl-CoA desaturase. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20760-20769. PMID: 31548371.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  7. Babiloni C, Blinowska K, Bonanni L, Cichocki A, De Haan W, Del Percio C, Dubois B, Escudero J, Fernández A, Frisoni G, Guntekin B, Hajos M, Hampel H, Ifeachor E, Kilborn K, Kumar S, Johnsen K, Johannsson M, Jeong J, LeBeau F, Lizio R, Lopes da Silva F, Maestú F, McGeown WJ, McKeith I, Moretti DV, Nobili F, Olichney J, Onofrj M, Palop JJ, Rowan M, Stocchi F, Struzik ZM, Tanila H, Teipel S, Taylor JP, Weiergräber M, Yener G, Young-Pearse T, Drinkenburg WH, Randall F. What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons. Neurobiol Aging. 2020 01; 85:58-73. PMID: 31739167.
    Citations: 18     Fields:    Translation:HumansAnimals
  8. Pearse RV, Young-Pearse TL. Lost in translational biology: Understanding sex differences to inform studies of diseases of the nervous system. Brain Res. 2019 11 01; 1722:146352. PMID: 31351977.
    Citations: 5     Fields:    Translation:HumansAnimals
  9. Graham EJ, Vermeulen M, Vardarajan B, Bennett D, De Jager P, Pearse RV, Young-Pearse TL, Mostafavi S. Somatic mosaicism of sex chromosomes in the blood and brain. Brain Res. 2019 10 15; 1721:146345. PMID: 31348909.
    Citations: 5     Fields:    Translation:HumansCells
  10. Pescosolido MF, Kavanaugh BC, Pochet N, Schmidt M, Jerskey BA, Rogg JM, De Jager PL, Young-Pearse TL, Liu JS, Morrow EM. Complex Neurological Phenotype in Female Carriers of NHE6 Mutations. Mol Neuropsychiatry. 2019 Apr; 5(2):98-108. PMID: 31192222.
    Citations: 1     
  11. Sullivan SE, Liao M, Smith RV, White C, Lagomarsino VN, Xu J, Taga M, Bennett DA, De Jager PL, Young-Pearse TL. Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aß and TAU proteostasis. Hum Mol Genet. 2019 03 01; 28(5):718-735. PMID: 30371777.
    Citations: 9     Fields:    Translation:HumansCells
  12. Klein HU, McCabe C, Gjoneska E, Sullivan SE, Kaskow BJ, Tang A, Smith RV, Xu J, Pfenning AR, Bernstein BE, Meissner A, Schneider JA, Mostafavi S, Tsai LH, Young-Pearse TL, Bennett DA, De Jager PL. Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains. Nat Neurosci. 2019 01; 22(1):37-46. PMID: 30559478.
    Citations: 49     Fields:    Translation:HumansCells
  13. Srikanth P, Lagomarsino VN, Pearse RV, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL. Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Transl Psychiatry. 2018 11 08; 8(1):245. PMID: 30410030.
    Citations: 5     Fields:    Translation:HumansCells
  14. Raj T, Li YI, Wong G, Humphrey J, Wang M, Ramdhani S, Wang YC, Ng B, Gupta I, Haroutunian V, Schadt EE, Young-Pearse T, Mostafavi S, Zhang B, Sklar P, Bennett DA, De Jager PL. Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. Nat Genet. 2018 11; 50(11):1584-1592. PMID: 30297968.
    Citations: 90     Fields:    Translation:HumansCells
  15. Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aß antibodies for Alzheimer's disease. Nat Commun. 2018 07 11; 9(1):2676. PMID: 29992960.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  16. Yu L, Petyuk VA, Gaiteri C, Mostafavi S, Young-Pearse T, Shah RC, Buchman AS, Schneider JA, Piehowski PD, Sontag RL, Fillmore TL, Shi T, Smith RD, De Jager PL, Bennett DA. Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia. Ann Neurol. 2018 07; 84(1):78-88. PMID: 29908079.
    Citations: 31     Fields:    Translation:Humans
  17. Mostafavi S, Gaiteri C, Sullivan SE, White CC, Tasaki S, Xu J, Taga M, Klein HU, Patrick E, Komashko V, McCabe C, Smith R, Bradshaw EM, Root DE, Regev A, Yu L, Chibnik LB, Schneider JA, Young-Pearse TL, Bennett DA, De Jager PL. A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease. Nat Neurosci. 2018 06; 21(6):811-819. PMID: 29802388.
    Citations: 113     Fields:    Translation:HumansCells
  18. Srikanth P, Lagomarsino VN, Muratore CR, Ryu SC, He A, Taylor WM, Zhou C, Arellano M, Young-Pearse TL. Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids. Transl Psychiatry. 2018 04 12; 8(1):77. PMID: 29643329.
    Citations: 21     Fields:    Translation:HumansCells
  19. Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. Int J Mol Sci. 2018 Feb 27; 19(3). PMID: 29495441.
    Citations: 48     Fields:    Translation:HumansCells
  20. Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Stem Cell Reports. 2017 12 12; 9(6):1868-1884. PMID: 29153990.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  21. Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse TL, Spires-Jones TL, Walsh DM. Human Brain-Derived Aß Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP. J Neurosci. 2017 12 06; 37(49):11947-11966. PMID: 29101243.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  22. Sato Y, Uchida Y, Hu J, Young-Pearse TL, Niikura T, Mukouyama YS. Soluble APP functions as a vascular niche signal that controls adult neural stem cell number. Development. 2017 08 01; 144(15):2730-2736. PMID: 28694255.
    Citations: 6     Fields:    Translation:AnimalsCells
  23. Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL. Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Dev Biol. 2017 04 15; 424(2):138-146. PMID: 28284905.
    Citations: 5     Fields:    Translation:AnimalsCells
  24. Liao MC, Muratore CR, Gierahn TM, Sullivan SE, Srikanth P, De Jager PL, Love JC, Young-Pearse TL. Single-Cell Detection of Secreted Aß and sAPPa from Human IPSC-Derived Neurons and Astrocytes. J Neurosci. 2016 Feb 03; 36(5):1730-46. PMID: 26843653.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  25. Young-Pearse TL, Morrow EM. Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities. Curr Opin Neurobiol. 2016 Feb; 36:66-73. PMID: 26517284.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  26. Sullivan SE, Young-Pearse TL. Induced pluripotent stem cells as a discovery tool for Alzheimer?s disease. Brain Res. 2017 02 01; 1656:98-106. PMID: 26459988.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  27. Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. Cell Rep. 2015 Sep 01; 12(9):1414-29. PMID: 26299970.
    Citations: 49     Fields:    Translation:HumansCells
  28. Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. J Neurosci. 2015 Jul 29; 35(30):10851-65. PMID: 26224867.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  29. Muratore CR, Srikanth P, Callahan DG, Young-Pearse TL. Comparison and optimization of hiPSC forebrain cortical differentiation protocols. PLoS One. 2014; 9(8):e105807. PMID: 25165848.
    Citations: 34     Fields:    Translation:HumansCells
  30. Preitner N, Quan J, Nowakowski DW, Hancock ML, Shi J, Tcherkezian J, Young-Pearse TL, Flanagan JG. APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly. Cell. 2014 Jul 17; 158(2):368-382. PMID: 25036633.
    Citations: 65     Fields:    Translation:AnimalsCells
  31. Srikanth P, Young-Pearse TL. Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells. J Neurogenet. 2014 Mar-Jun; 28(1-2):5-29. PMID: 24628482.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  32. Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet. 2014 Jul 01; 23(13):3523-36. PMID: 24524897.
    Citations: 122     Fields:    Translation:HumansCells
  33. Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 2013 May 14; 52(19):3264-77. PMID: 23597280.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  34. Rice HC, Townsend M, Bai J, Suth S, Cavanaugh W, Selkoe DJ, Young-Pearse TL. Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Development. 2012 Nov; 139(21):3986-96. PMID: 22992957.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  35. Taniguchi Y, Young-Pearse T, Sawa A, Kamiya A. In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors. Neuroscientist. 2012 Apr; 18(2):169-79. PMID: 21551077.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  36. Rice H, Suth S, Cavanaugh W, Bai J, Young-Pearse TL. In utero electroporation followed by primary neuronal culture for studying gene function in subset of cortical neurons. J Vis Exp. 2010 Oct 08; (44). PMID: 20972409.
    Citations: 12     Fields:    Translation:AnimalsCells
  37. Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. J Neurosci. 2010 Aug 04; 30(31):10431-40. PMID: 20685985.
    Citations: 48     Fields:    Translation:AnimalsCells
  38. Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev. 2008 Jun 23; 3:15. PMID: 18573216.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  39. Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci. 2007 Dec 26; 27(52):14459-69. PMID: 18160654.
    Citations: 168     Fields:    Translation:AnimalsCells
  40. Young-Pearse TL, Ivic L, Kriegstein AR, Cepko CL. Characterization of mice with targeted deletion of glycine receptor alpha 2. Mol Cell Biol. 2006 Aug; 26(15):5728-34. PMID: 16847326.
    Citations: 32     Fields:    Translation:Animals
  41. Young TL, Matsuda T, Cepko CL. The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina. Curr Biol. 2005 Mar 29; 15(6):501-12. PMID: 15797018.
    Citations: 200     Fields:    Translation:AnimalsCells
  42. Rowan S, Chen CM, Young TL, Fisher DE, Cepko CL. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development. 2004 Oct; 131(20):5139-52. PMID: 15459106.
    Citations: 62     Fields:    Translation:Animals
  43. Young TL, Cepko CL. A role for ligand-gated ion channels in rod photoreceptor development. Neuron. 2004 Mar 25; 41(6):867-79. PMID: 15046720.
    Citations: 46     Fields:    Translation:AnimalsCells
  44. Livesey FJ, Young TL, Cepko CL. An analysis of the gene expression program of mammalian neural progenitor cells. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1374-9. PMID: 14734810.
    Citations: 30     Fields:    Translation:AnimalsCells
  45. Belliveau MJ, Young TL, Cepko CL. Late retinal progenitor cells show intrinsic limitations in the production of cell types and the kinetics of opsin synthesis. J Neurosci. 2000 Mar 15; 20(6):2247-54. PMID: 10704500.
    Citations: 35     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.