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Jane Elizabeth Brock, M.B.,B.Ch., Ph.D.

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Biography
education and training
Oxford University, UKBA(Hons)1993Physiological Sciences
University College London, UKPhD1997Anatomy and Developmental Biology
University College London, UKMBBS1999Medicine and Surgery
Brigham & Women's Hospital, Boston, USA2007Anatomic Pathology Residency

Overview
overview
Dr. Brock joined the Brigham and Women's Hospital faculty in 2008 and was promoted to Assistant Professor in 2012 based on academic and clinical work in her subspecialty field of breast pathology. She has served as Medical Director of the Surgical Pathology Grossing Room since 2012, focusing on resident education, and overseeing laboratory quality control and safety programs. In 2016, she took over departmental responsibility for the Partners in Health (PIH) activities that comprise cases received from Haiti and Rwanda for expert consultation. She has worked voluntarily in low-income countries, including Myanmar, Haiti and Rwanda, focusing on education in breast pathology, and laboratory management. In 2016, she was appointed Breast Fellowship Program Director, and since 2017, has served as Breast Pathology Division Chief overseeing more than 6,700 cases annually, with responsibility for quality control, turn-around time, and personnel competency.

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Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mugabe M, Ho KE, Ruhangaza D, Milner D, Rugwizangoga B, Chu VC, Wu NC, Rizo A, Weidler JM, Wong W, Bates M, Brock JE. Use of the Xpert Breast Cancer STRAT4 for Biomarker Evaluation in Tissue Processed in a Developing Country. Am J Clin Pathol. 2021 Oct 13; 156(5):766-776. PMID: 34050358; PMCID: PMC8512210.
    Citations:    Fields:    Translation:Humans
  2. Tolaney SM, Ziehr DR, Guo H, Ng MR, Barry WT, Higgins MJ, Isakoff SJ, Brock JE, Ivanova EV, Paweletz CP, Demeo MK, Ramaiya NH, Overmoyer BA, Jain RK, Winer EP, Duda DG. Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients. Oncologist. 2021 Aug; 26(8):e1483. PMID: 33978307.
    Citations:    Fields:    
  3. LeJeune A, Brock JE, Morgan EA, Kasten JL, Martei YM, Fadelu T, Rinder HM, Goulart R, Shulman LN, Milner DA. Harmonization of the Essentials: Matching Diagnostics to Treatments for Global Oncology. JCO Glob Oncol. 2020 08; 6:1352-1356. PMID: 32886559.
    Citations:    Fields:    
  4. DeSimone MS, DeSimone AK, Sun EX, Laur O, Miskin NP, Brock JE, Matalon SA. Cross-Residency Radiologic/Pathologic Correlation Curriculum: Teaching Correlation of Surgical Specimens With Imaging. Acad Pathol. 2020 Jan-Dec; 7:2374289520939258. PMID: 32733994; PMCID: PMC7370337.
    Citations:    
  5. Anglade F, Milner DA, Brock JE. Can pathology diagnostic services for cancer be stratified and serve global health? Cancer. 2020 05 15; 126 Suppl 10:2431-2438. PMID: 32348564.
    Citations: 8     Fields:    Translation:Humans
  6. Warren LEG, Chen YH, Halasz LM, Brock JE, Capuco A, Punglia RS, Wong JS, Golshan M, Bellon JR. Long-term outcomes of breast-conserving therapy for women with ductal carcinoma in situ. Breast Cancer Res Treat. 2019 Dec; 178(3):607-615. PMID: 31493031.
    Citations: 4     Fields:    Translation:Humans
  7. Iorgulescu JB, Freedman RA, Lester SC, Mittendorf EA, Brock JE. 21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort. JCO Precis Oncol. 2019; 3. PMID: 32457931; PMCID: PMC7250459.
    Citations: 1     Fields:    
  8. Jencks SF, Schuster A, Dougherty GB, Gerovich S, Brock JE, Kind AJH. Safety-Net Hospitals, Neighborhood Disadvantage, and Readmissions Under Maryland's All-Payer Program: An Observational Study. Ann Intern Med. 2019 07 16; 171(2):91-98. PMID: 31261378; PMCID: PMC6736732.
    Citations: 20     Fields:    Translation:Humans
  9. Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, Martincorena I, Alexandrov LB, Martin S, Wedge DC, Van Loo P, Ju YS, Smid M, Brinkman AB, Morganella S, Aure MR, Lingjærde OC, Langerød A, Ringnér M, Ahn SM, Boyault S, Brock JE, Broeks A, Butler A, Desmedt C, Dirix L, Dronov S, Fatima A, Foekens JA, Gerstung M, Hooijer GKJ, Jang SJ, Jones DR, Kim HY, King TA, Krishnamurthy S, Lee HJ, Lee JY, Li Y, McLaren S, Menzies A, Mustonen V, O'Meara S, Pauporté I, Pivot X, Purdie CA, Raine K, Ramakrishnan K, Rodríguez-González FG, Romieu G, Sieuwerts AM, Simpson PT, Shepherd R, Stebbings L, Stefansson OA, Teague J, Tommasi S, Treilleux I, Van den Eynden GG, Vermeulen P, Vincent-Salomon A, Yates L, Caldas C, Van't Veer L, Tutt A, Knappskog S, Tan BKT, Jonkers J, Borg Å, Ueno NT, Sotiriou C, Viari A, Futreal PA, Campbell PJ, Span PN, Van Laere S, Lakhani SR, Eyfjord JE, Thompson AM, Birney E, Stunnenberg HG, van de Vijver MJ, Martens JWM, Børresen-Dale AL, Richardson AL, Kong G, Thomas G, Stratton MR. Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. 2019 02; 566(7742):E1. PMID: 30659290.
    Citations: 6     Fields:    
  10. Metzger-Filho O, Ferreira AR, Jeselsohn R, Barry WT, Dillon DA, Brock JE, Vaz-Luis I, Hughes ME, Winer EP, Lin NU. Mixed Invasive Ductal and Lobular Carcinoma of the Breast: Prognosis and the Importance of Histologic Grade. Oncologist. 2019 07; 24(7):e441-e449. PMID: 30518616.
    Citations: 11     Fields:    Translation:Humans
  11. Natsuhara KH, Losk K, King TA, Lin NU, Camuso K, Golshan M, Pochebit S, Brock JE, Bunnell CA, Freedman RA. Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria. Oncologist. 2019 05; 24(5):595-602. PMID: 30076279.
    Citations: 6     Fields:    Translation:Humans
  12. Silveira LJ, Fleck SB, Sonnenfeld N, Manna J, Zhang L, Irby KB, Brock JE. Estimated Cost Savings: Everyone With Diabetes Counts (EDC) Program. Fam Community Health. 2018 Jul/Sep; 41(3):185-193. PMID: 29489464.
    Citations: 1     Fields:    Translation:Humans
  13. Harrison BT, Brock JE. Contemporary Evaluation of Breast Lymph Nodes in Anatomic Pathology. Am J Clin Pathol. 2018 May 31; 150(1):4-17. PMID: 29746624.
    Citations:    Fields:    Translation:Humans
  14. Guilbert MC, Frost EP, Brock JE, Lester SC. Distinguishing papillary endothelial hyperplasia and angiosarcoma on core needle biopsy of the breast: The importance of clinical and radiologic correlation. Breast J. 2018 07; 24(4):487-492. PMID: 29476585.
    Citations: 2     Fields:    Translation:Humans
  15. Sanders MA, Brock JE, Harrison BT, Wieczorek TJ, Hong X, Guidi AJ, Dillon DA, Max L, Lester SC. Nipple-Invasive Primary Carcinomas: Clinical, Imaging, and Pathologic Features of Breast Carcinomas Originating in the Nipple. Arch Pathol Lab Med. 2018 May; 142(5):598-605. PMID: 29431468.
    Citations: 6     Fields:    Translation:Humans
  16. Martei YM, Pace LE, Brock JE, Shulman LN. Breast Cancer in Low- and Middle-Income Countries: Why We Need Pathology Capability to Solve This Challenge. Clin Lab Med. 2018 03; 38(1):161-173. PMID: 29412880; PMCID: PMC6277976.
    Citations: 16     Fields:    Translation:Humans
  17. Kuba MG, Lester SC, Giess CS, Bertagnolli MM, Wieczorek TJ, Brock JE. Fibromatosis of the Breast: Diagnostic Accuracy of Core Needle Biopsy. Am J Clin Pathol. 2017 Sep 01; 148(3):243-250. PMID: 28821190.
    Citations: 4     Fields:    Translation:Humans
  18. Harrison BT, Dillon DA, Richardson AL, Brock JE, Guidi AJ, Lester SC. Quality Assurance in Breast Pathology: Lessons Learned From a Review of Amended Reports. Arch Pathol Lab Med. 2017 Feb; 141(2):260-266. PMID: 27959581.
    Citations: 1     Fields:    Translation:Humans
  19. Tolaney SM, Ziehr DR, Guo H, Ng MR, Barry WT, Higgins MJ, Isakoff SJ, Brock JE, Ivanova EV, Paweletz CP, Demeo MK, Ramaiya NH, Overmoyer BA, Jain RK, Winer EP, Duda DG. Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients. Oncologist. 2017 01; 22(1):25-32. PMID: 27789775; PMCID: PMC5313267.
    Citations: 33     Fields:    Translation:HumansCTClinical Trials
  20. Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, Martincorena I, Alexandrov LB, Martin S, Wedge DC, Van Loo P, Ju YS, Smid M, Brinkman AB, Morganella S, Aure MR, Lingjærde OC, Langerød A, Ringnér M, Ahn SM, Boyault S, Brock JE, Broeks A, Butler A, Desmedt C, Dirix L, Dronov S, Fatima A, Foekens JA, Gerstung M, Hooijer GK, Jang SJ, Jones DR, Kim HY, King TA, Krishnamurthy S, Lee HJ, Lee JY, Li Y, McLaren S, Menzies A, Mustonen V, O'Meara S, Pauporté I, Pivot X, Purdie CA, Raine K, Ramakrishnan K, Rodríguez-González FG, Romieu G, Sieuwerts AM, Simpson PT, Shepherd R, Stebbings L, Stefansson OA, Teague J, Tommasi S, Treilleux I, Van den Eynden GG, Vermeulen P, Vincent-Salomon A, Yates L, Caldas C, van't Veer L, Tutt A, Knappskog S, Tan BK, Jonkers J, Borg Å, Ueno NT, Sotiriou C, Viari A, Futreal PA, Campbell PJ, Span PN, Van Laere S, Lakhani SR, Eyfjord JE, Thompson AM, Birney E, Stunnenberg HG, van de Vijver MJ, Martens JW, Børresen-Dale AL, Richardson AL, Kong G, Thomas G, Stratton MR. Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. 2016 06 02; 534(7605):47-54. PMID: 27135926; PMCID: PMC4910866.
    Citations: 823     Fields:    Translation:HumansCells
  21. Pace LE, Dusengimana JM, Hategekimana V, Habineza H, Bigirimana JB, Tapela N, Mutumbira C, Mpanumusingo E, Brock JE, Meserve E, Uwumugambi A, Dillon D, Keating NL, Shulman LN, Mpunga T. Benign and Malignant Breast Disease at Rwanda's First Public Cancer Referral Center. Oncologist. 2016 05; 21(5):571-5. PMID: 27009935.
    Citations: 19     Fields:    Translation:Humans
  22. Wong SM, Freedman RA, Stamell E, Sagara Y, Brock JE, Desantis SD, Golshan M. Modern Trends in the Surgical Management of Paget's Disease. Ann Surg Oncol. 2015 Oct; 22(10):3308-16. PMID: 26202552.
    Citations: 6     Fields:    Translation:Humans
  23. Sagara Y, Barry WT, Mallory MA, Vaz-Luis I, Aydogan F, Brock JE, Winer EP, Golshan M, Metzger-Filho O. Surgical Options and Locoregional Recurrence in Patients Diagnosed with Invasive Lobular Carcinoma of the Breast. Ann Surg Oncol. 2015 Dec; 22(13):4280-6. PMID: 25893416; PMCID: PMC4801503.
    Citations: 4     Fields:    Translation:Humans
  24. Braunstein LZ, Brock JE, Chen YH, Truong L, Russo AL, Arvold ND, Harris JR. Invasive lobular carcinoma of the breast: local recurrence after breast-conserving therapy by subtype approximation and surgical margin. Breast Cancer Res Treat. 2015 Jan; 149(2):555-64. PMID: 25604797.
    Citations: 11     Fields:    Translation:Humans
  25. Manion E, Brock JE, Raza S, Reisenbichler ES. MRI-guided breast needle core biopsies: pathologic features of newly diagnosed malignancies. Breast J. 2014 Sep-Oct; 20(5):453-60. PMID: 25040910.
    Citations: 1     Fields:    Translation:Humans
  26. Jencks SF, Brock JE. Hospital accountability and population health: lessons from measuring readmission rates. Ann Intern Med. 2013 Nov 05; 159(9):629-30. PMID: 24189596.
    Citations: 3     Fields:    Translation:Humans
  27. Reisenbichler ES, Lester SC, Richardson AL, Dillon DA, Ly A, Brock JE. Interobserver concordance in implementing the 2010 ASCO/CAP recommendations for reporting ER in breast carcinomas: a demonstration of the difficulties of consistently reporting low levels of ER expression by manual quantification. Am J Clin Pathol. 2013 Oct; 140(4):487-94. PMID: 24045544.
    Citations: 19     Fields:    Translation:Humans
  28. Kansal KJ, Dominici LS, Tolaney SM, Isakoff SJ, Smith BL, Jiang W, Brock JE, Winer EP, Krop IE, Golshan M. Neoadjuvant bevacizumab: surgical complications of mastectomy with and without reconstruction. Breast Cancer Res Treat. 2013 Sep; 141(2):255-9. PMID: 24026859.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  29. Russo AL, Arvold ND, Niemierko A, Wong N, Wong JS, Bellon JR, Punglia RS, Golshan M, Troyan SL, Brock JE, Harris JR. Margin status and the risk of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy. Breast Cancer Res Treat. 2013 Jul; 140(2):353-61. PMID: 23836011.
    Citations: 13     Fields:    Translation:Humans
  30. Kluk MJ, Ashworth T, Wang H, Knoechel B, Mason EF, Morgan EA, Dorfman D, Pinkus G, Weigert O, Hornick JL, Chirieac LR, Hirsch M, Oh DJ, South AP, Leigh IM, Pourreyron C, Cassidy AJ, Deangelo DJ, Weinstock DM, Krop IE, Dillon D, Brock JE, Lazar AJ, Peto M, Cho RJ, Stoeck A, Haines BB, Sathayanrayanan S, Rodig S, Aster JC. Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS One. 2013; 8(6):e67306. PMID: 23825651.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  31. Margalit DN, Sreedhara M, Chen YH, Catalano PJ, Nguyen PL, Golshan M, Overmoyer BA, Harris JR, Brock JE. Microinvasive breast cancer: ER, PR, and HER-2/neu status and clinical outcomes after breast-conserving therapy or mastectomy. Ann Surg Oncol. 2013 Mar; 20(3):811-8. PMID: 22956068.
    Citations: 13     Fields:    Translation:Humans
  32. Halasz LM, Sreedhara M, Chen YH, Bellon JR, Punglia RS, Wong JS, Harris JR, Brock JE. Improved outcomes of breast-conserving therapy for patients with ductal carcinoma in situ. Int J Radiat Oncol Biol Phys. 2012 Mar 15; 82(4):e581-6. PMID: 22208975.
    Citations: 9     Fields:    Translation:Humans
  33. Manion E, Hornick JL, Lester SC, Brock JE. A comparison of equivocal immunohistochemical results with anti-HER2/neu antibodies A0485 and SP3 with corresponding FISH results in routine clinical practice. Am J Clin Pathol. 2011 Jun; 135(6):845-51. PMID: 21571957.
    Citations: 6     Fields:    Translation:HumansAnimals
  34. Phillips KA, Marshall DA, Haas JS, Elkin EB, Liang SY, Hassett MJ, Ferrusi I, Brock JE, Van Bebber SL. Clinical practice patterns and cost effectiveness of human epidermal growth receptor 2 testing strategies in breast cancer patients. Cancer. 2009 Nov 15; 115(22):5166-74. PMID: 19753618; PMCID: PMC2783254.
    Citations: 23     Fields:    Translation:Humans
  35. Brock JE, Hornick JL, Richardson AL, Dillon DA, Lester SC. A comparison of estrogen receptor SP1 and 1D5 monoclonal antibodies in routine clinical use reveals similar staining results. Am J Clin Pathol. 2009 Sep; 132(3):396-401. PMID: 19687316.
    Citations: 6     Fields:    Translation:Humans
  36. Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szász AM, Wang ZC, Brock JE, Richardson AL, Weinberg RA. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell. 2009 Jun 12; 137(6):1032-46. PMID: 19524507.
    Citations: 430     Fields:    Translation:HumansAnimalsCells
  37. Brock JE, Perez-Atayde AR, Kozakewich HP, Richkind KE, Fletcher JA, Vargas SO. Cytogenetic aberrations in perineurioma: variation with subtype. Am J Surg Pathol. 2005 Sep; 29(9):1164-9. PMID: 16096405.
    Citations: 8     Fields:    Translation:Humans
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