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Jingjing Chen, Ph.D.

Title
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Biography
Institute of Oncology Research (IOR), Faculty of Biology and Medicine, University of Lausanne, Bellinzona, SwitzerlandPh.D.3/2018Life Sciences
Second Military Medical University, Shanghai, ChinaMasters07/2008Oncology
East China University of Science and Technology, Shanghai, ChinaBachelor07/2003Biotechnology
2019
Pfizer Research Award in Oncology, Pfizer Research Prize Foundation
2019
Prix de la Faculté de biologie et de médecine, University of Lausanne
2019 - 2020
Early Postdoc.Mobility Fellowship, Swiss National Science Foundation
2018
Award of the Best Publication, the 8th Giornata della Ricerca della Svizzera Italiana
2013
IBSA Foundation Fellowship Award for Scientific Research, IBSA Foundation

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P2LAP3_184040 (Jingjing Chen) Feb 1, 2019 - Aug 31, 2020
    Swiss National Science Foundation
    Tumour Derived Vaccine Adjuvants for Advanced Cancers
    Role Description: The overall goal of the project is to develop a novel approach of tumour derived vaccine adjuvants for cancer immunotherapy. The proposal leverages on the key findings on the involvement of the nucleic acids including noncoding RNA in innate immunity and the facts that chemical synthesized, or bacterial nucleic acid vaccine adjuvants elicited striking tumor suppression. These discoveries shed the light that aberrantly expressed non-coding RNA initiated upon chromosome damage due to the replicative stress during the cancer progression or genotoxic agent treatment could potentially trigger cancer cell-autonomous innate immunity for anti-cancer therapy. This proposal will take advantage of CRISPR activation screen platform, etc to investigate whether boosting the expression of tumour derived non-coding RNAs striving in genomic integrity maintenance in advanced cancers will make cancer cells self-exposed to or ‘visualized’ by innate immune surveillance and this novel noncoding RNA adjuvant may represent a breakthrough for the therapeutic vaccination against cancer.
    Role: Research Fellow

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sgrignani J, Chen J, Alimonti A, Cavalli A. How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study. Sci Rep. 2018 10 02; 8(1):14683. PMID: 30279533.
    Citations:    
  2. Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, Pasquini E, Alajati A, Pinton S, Losa M, Civenni G, Catapano CV, Sgrignani J, Cavalli A, D'Antuono R, Asara JM, Morandi A, Chiarugi P, Crotti S, Agostini M, Montopoli M, Masgras I, Rasola A, Garcia-Escudero R, Delaleu N, Rinaldi A, Bertoni F, de Bono J, Carracedo A, Alimonti A. Publisher Correction: Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet. 2018 09; 50(9):1343. PMID: 30089860.
    Citations:    Fields:    
  3. Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, Pasquini E, Alajati A, Pinton S, Losa M, Civenni G, Catapano CV, Sgrignani J, Cavalli A, D'Antuono R, Asara JM, Morandi A, Chiarugi P, Crotti S, Agostini M, Montopoli M, Masgras I, Rasola A, Garcia-Escudero R, Delaleu N, Rinaldi A, Bertoni F, Bono J, Carracedo A, Alimonti A. Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet. 2018 02; 50(2):219-228. PMID: 29335542.
    Citations: 3     Fields:    
  4. Revandkar A, Perciato ML, Toso A, Alajati A, Chen J, Gerber H, Dimitrov M, Rinaldi A, Delaleu N, Pasquini E, D'Antuono R, Pinton S, Losa M, Gnetti L, Arribas A, Fraering P, Bertoni F, Nepveu A, Alimonti A. Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence. Nat Commun. 2016 12 12; 7:13719. PMID: 27941799.
    Citations:    
  5. Matic I, Revandkar A, Chen J, Bisio A, Dall'Acqua S, Cocetta V, Brun P, Mancino G, Milanese M, Mattei M, Montopoli M, Alimonti A. Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assay. Aging (Albany NY). 2016 12 01; 8(12):3223-3240. PMID: 27922821.
    Citations:    
  6. Kalathur M, Toso A, Chen J, Revandkar A, Danzer-Baltzer C, Guccini I, Alajati A, Sarti M, Pinton S, Brambilla L, Di Mitri D, Carbone G, Garcia-Escudero R, Padova A, Magnoni L, Tarditi A, Maccari L, Malusa F, Kalathur RK, A Pinna L, Cozza G, Ruzzene M, Delaleu N, Catapano CV, Frew IJ, Alimonti A. A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours. Nat Commun. 2015 Jun 18; 6:7227. PMID: 26085373.
    Citations:    
  7. Di Mitri D, Toso A, Chen JJ, Sarti M, Pinton S, Jost TR, D'Antuono R, Montani E, Garcia-Escudero R, Guccini I, Da Silva-Alvarez S, Collado M, Eisenberger M, Zhang Z, Catapano C, Grassi F, Alimonti A. Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer. Nature. 2014 Nov 06; 515(7525):134-7. PMID: 25156255.
    Citations:    
  8. Zhao J, Chen J, Lu B, Dong L, Wang H, Bi C, Wu G, Guo H, Wu M, Guo Y. TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma. Cancer Res. 2008 Jun 01; 68(11):4133-41. PMID: 18519672.
    Citations:    
  9. Zhao J, Dong L, Lu B, Wu G, Xu D, Chen J, Li K, Tong X, Dai J, Yao S, Wu M, Guo Y. Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis. Gastroenterology. 2008 Sep; 135(3):956-68. PMID: 18555021.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.