Harvard Catalyst Profiles

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Iain Clark, Ph.D.


Cornell University, Ithaca, NYBS2003Bioengineering
UC Davis, Davis, CAMS2009Bioengineering
UC Berkeley, Berkeley, CAPhD2014Engineering
UC San Francisco, San Francisco, CAPostdoc, Abate lab

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 04 23; 372(6540). PMID: 33888612.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Clark IC, Mensa B, Ochs CJ, Schmidt NW, Mravic M, Quintana FJ, DeGrado WF, Abate AR. Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA. Proc Natl Acad Sci U S A. 2021 Mar 23; 118(12). PMID: 33723045.
    Citations:    Fields:    
  3. Clark IC, Delley CL, Sun C, Thakur R, Stott SL, Thaploo S, Li Z, Quintana FJ, Abate AR. Targeted Single-Cell RNA and DNA Sequencing With Fluorescence-Activated Droplet Merger. Anal Chem. 2020 11 03; 92(21):14616-14623. PMID: 33049138.
    Citations:    Fields:    Translation:HumansCells
  4. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020 02; 578(7796):593-599. PMID: 32051591.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  5. Clark IC, Abate AR. Microfluidic bead encapsulation above 20 kHz with triggered drop formation. Lab Chip. 2018 12 07; 18(23):3598-3605. PMID: 30362490.
    Citations: 3     Fields:    
  6. Clark IC, Thakur R, Abate AR. Concentric electrodes improve microfluidic droplet sorting. Lab Chip. 2018 02 27; 18(5):710-713. PMID: 29383336.
    Citations: 2     Fields:    Translation:Cells
  7. Kim SC, Clark IC, Shahi P, Abate AR. Single-Cell RT-PCR in Microfluidic Droplets with Integrated Chemical Lysis. Anal Chem. 2018 01 16; 90(2):1273-1279. PMID: 29256243.
    Citations: 20     Fields:    Translation:HumansCells
  8. Kim SC, Premasekharan G, Clark IC, Gemeda HB, Paris PL, Abate AR. Measurement of copy number variation in single cancer cells using rapid-emulsification digital droplet MDA. Microsyst Nanoeng. 2017; 3. PMID: 30147985.
    Citations: 2     
  9. Clark IC, Abate AR. Finding a helix in a haystack: nucleic acid cytometry with droplet microfluidics. Lab Chip. 2017 06 13; 17(12):2032-2045. PMID: 28540956.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  10. Haliburton JR, Kim SC, Clark IC, Sperling RA, Weitz DA, Abate AR. Efficient extraction of oil from droplet microfluidic emulsions. Biomicrofluidics. 2017 May; 11(3):034111. PMID: 28611871.
    Citations: 4     
  11. Z Yan*, IC Clark*, AR Abate. Rapid Encapsulation of Cell and Polymer Solutions with Bubble-Triggered Droplet Generation. Macromolecular Chemistry and Physics. 2017; 2(218):1600297.
  12. Youngblut MD, Tsai CL, Clark IC, Carlson HK, Maglaqui AP, Gau-Pan PS, Redford SA, Wong A, Tainer JA, Coates JD. Perchlorate Reductase Is Distinguished by Active Site Aromatic Gate Residues. J Biol Chem. 2016 Apr 22; 291(17):9190-202. PMID: 26940877.
    Citations: 12     Fields:    Translation:Cells
  13. Clark IC, Youngblut M, Jacobsen G, Wetmore KM, Deutschbauer A, Lucas L, Coates JD. Genetic dissection of chlorate respiration in Pseudomonas stutzeri PDA reveals syntrophic (per)chlorate reduction. Environ Microbiol. 2016 10; 18(10):3342-3354. PMID: 26411776.
    Citations: 6     Fields:    Translation:Cells
  14. Clark IC, Melnyk RA, Youngblut MD, Carlson HK, Iavarone AT, Coates JD. Synthetic and Evolutionary Construction of a Chlorate-Reducing Shewanella oneidensis MR-1. mBio. 2015 May 19; 6(3):e00282-15. PMID: 25991681.
    Citations: 4     Fields:    Translation:Cells
  15. Melnyk RA, Youngblut MD, Clark IC, Carlson HK, Wetmore KM, Price MN, Iavarone AT, Deutschbauer AM, Arkin AP, Coates JD. Novel mechanism for scavenging of hypochlorite involving a periplasmic methionine-rich Peptide and methionine sulfoxide reductase. mBio. 2015 May 12; 6(3):e00233-15. PMID: 25968643.
    Citations: 15     Fields:    Translation:Cells
  16. Carlström CI, Loutey D, Bauer S, Clark IC, Rohde RA, Iavarone AT, Lucas L, Coates JD. (Per)chlorate-reducing bacteria can utilize aerobic and anaerobic pathways of aromatic degradation with (per)chlorate as an electron acceptor. mBio. 2015 Mar 24; 6(2). PMID: 25805732.
    Citations: 4     Fields:    Translation:Cells
  17. Carlström CI, Loutey DE, Wang O, Engelbrektson A, Clark I, Lucas LN, Somasekhar PY, Coates JD. Phenotypic and genotypic description of Sedimenticola selenatireducens strain CUZ, a marine (per)chlorate-respiring gammaproteobacterium, and its close relative the chlorate-respiring Sedimenticola strain NSS. Appl Environ Microbiol. 2015 Apr; 81(8):2717-26. PMID: 25662971.
    Citations: 8     Fields:    Translation:Cells
  18. Clark IC, Melnyk RA, Iavarone AT, Novichkov PS, Coates JD. Chlorate reduction in Shewanella algae ACDC is a recently acquired metabolism characterized by gene loss, suboptimal regulation and oxidative stress. Mol Microbiol. 2014 Oct; 94(1):107-25. PMID: 25099177.
    Citations: 7     Fields:    Translation:Cells
  19. Melnyk RA, Clark IC, Liao A, Coates JD. Transposon and deletion mutagenesis of genes involved in perchlorate reduction in Azospira suillum PS. mBio. 2013 Dec 31; 5(1):e00769-13. PMID: 24381299.
    Citations: 11     Fields:    Translation:Cells
  20. Clark IC, Melnyk RA, Engelbrektson A, Coates JD. Structure and evolution of chlorate reduction composite transposons. mBio. 2013 Aug 06; 4(4). PMID: 23919996.
    Citations: 26     Fields:    Translation:Cells
  21. Carlson HK, Clark IC, Blazewicz SJ, Iavarone AT, Coates JD. Fe(II) oxidation is an innate capability of nitrate-reducing bacteria that involves abiotic and biotic reactions. J Bacteriol. 2013 Jul; 195(14):3260-8. PMID: 23687275.
    Citations: 18     Fields:    Translation:Cells
  22. Carlson HK, Clark IC, Melnyk RA, Coates JD. Toward a mechanistic understanding of anaerobic nitrate-dependent iron oxidation: balancing electron uptake and detoxification. Front Microbiol. 2012; 3:57. PMID: 22363331.
    Citations: 18     
  23. IC Clark, RH Zhang, SK Upadhyaya . The effect of low pressure and mixing on biological hydrogen production via anaerobic fermentation. International journal of hydrogen energy. 2012; 15(37):11504-11513.
  24. Clark IC, Carlson HK, Iavarone AT, and John D. Coates. Bioelectrical redox cycling of anthraquinone-2,6-disulfonate coupled to perchlorate reduction. Energy & Environmental Science. 2012; 79(5):7970-7978.
  25. Melnyk RA, Engelbrektson A, Clark IC, Carlson HK, Byrne-Bailey K, Coates JD. Identification of a perchlorate reduction genomic island with novel regulatory and metabolic genes. Appl Environ Microbiol. 2011 Oct; 77(20):7401-4. PMID: 21856823.
    Citations: 22     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.