Harvard Catalyst Profiles

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Kathleen Alice Christie, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Christie KA, Guo JA, Silverstein RA, Doll RM, Mabuchi M, Stutzman HE, Lin J, Ma L, Walton RT, Pinello L, Robb GB, Kleinstiver BP. Precise DNA cleavage using CRISPR-SpRYgests. Nat Biotechnol. 2022 Oct 06. PMID: 36203014.
    Citations:    Fields:    
  2. Christie KA, Kleinstiver BP. Making the cut with PAMless CRISPR-Cas enzymes. Trends Genet. 2021 12; 37(12):1053-1055. PMID: 34563399; PMCID: PMC9108897.
    Citations:    Fields:    
  3. McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK. Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease. Nature. 2021 07; 595(7869):701-706. PMID: 34262178; PMCID: PMC8934148.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  4. Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Németh I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemény LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 08 05; 184(16):4268-4283.e20. PMID: 34233163; PMCID: PMC8349839.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  5. Lukassen MV, Poulsen ET, Donaghy J, Mogensen EH, Christie KA, Roshanravan H, DeDioniso L, Nesbit MA, Moore T, Enghild JJ. Protein Analysis of the TGFBIR124H Mouse Model Gives Insight into Phenotype Development of Granular Corneal Dystrophy. Proteomics Clin Appl. 2020 11; 14(6):e1900072. PMID: 32558206.
    Citations:    Fields:    Translation:HumansAnimals
  6. Mahendra C, Christie KA, Osuna BA, Pinilla-Redondo R, Kleinstiver BP, Bondy-Denomy J. Author Correction: Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer. Nat Microbiol. 2020 Jun; 5(6):872. PMID: 32327734.
    Citations: 1     Fields:    
  7. Christie KA, Robertson LJ, Conway C, Blighe K, DeDionisio LA, Chao-Shern C, Kowalczyk AM, Marshall J, Turnbull D, Nesbit MA, Moore CBT. Mutation-Independent Allele-Specific Editing by CRISPR-Cas9, a Novel Approach to Treat Autosomal Dominant Disease. Mol Ther. 2020 08 05; 28(8):1846-1857. PMID: 32416058.
    Citations: 3     Fields:    Translation:HumansCells
  8. Osuna BA, Karambelkar S, Mahendra C, Christie KA, Garcia B, Davidson AR, Kleinstiver BP, Kilcher S, Bondy-Denomy J. Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes. Cell Host Microbe. 2020 07 08; 28(1):31-40.e9. PMID: 32325050.
    Citations: 20     Fields:    Translation:Cells
  9. Walton RT, Christie KA, Whittaker MN, Kleinstiver BP. Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants. Science. 2020 04 17; 368(6488):290-296. PMID: 32217751.
    Citations: 192     Fields:    Translation:HumansCells
  10. Mahendra C, Christie KA, Osuna BA, Pinilla-Redondo R, Kleinstiver BP, Bondy-Denomy J. Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer. Nat Microbiol. 2020 04; 5(4):620-629. PMID: 32218510.
    Citations: 21     Fields:    Translation:HumansCells
  11. McCloskey AG, Miskelly MG, Moore CBT, Nesbit MA, Christie KA, Owolabi AI, Flatt PR, McKillop AM. CRISPR/Cas9 gene editing demonstrates metabolic importance of GPR55 in the modulation of GIP release and pancreatic beta cell function. Peptides. 2020 03; 125:170251. PMID: 31923454.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  12. Moore T, Chao-Shern C, DeDionisio L, Christie KA, Nesbit MA. Gene Editing for Corneal Stromal Regeneration. Methods Mol Biol. 2020; 2145:59-75. PMID: 32542601.
    Citations:    Fields:    Translation:Humans
  13. Zhang L, Rossi A, Lange L, Meumann N, Koitzsch U, Christie K, Nesbit MA, Moore CBT, Hacker UT, Morgan M, Hoffmann D, Zengel J, Carette JE, Schambach A, Salvetti A, Odenthal M, Büning H. Capsid Engineering Overcomes Barriers Toward Adeno-Associated Virus Vector-Mediated Transduction of Endothelial Cells. Hum Gene Ther. 2019 10; 30(10):1284-1296. PMID: 31407607.
    Citations: 5     Fields:    Translation:HumansCells
  14. Schiroli D, Gómara MJ, Maurizi E, Atkinson SD, Mairs L, Christie KA, Cobice DF, McCrudden CM, Nesbit MA, Haro I, Moore T. Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide. Mol Ther Nucleic Acids. 2019 Sep 06; 17:891-906. PMID: 31476668; PMCID: PMC6723413.
    Citations: 8     
  15. Chao-Shern C, DeDionisio LA, Jang JH, Chan CC, Thompson V, Christie K, Nesbit MA, McMullen CBT. Evaluation of TGFBI corneal dystrophy and molecular diagnostic testing. Eye (Lond). 2019 06; 33(6):874-881. PMID: 30760895.
    Citations: 7     Fields:    Translation:Humans
  16. Blighe K, DeDionisio L, Christie KA, Chawes B, Shareef S, Kakouli-Duarte T, Chao-Shern C, Harding V, Kelly RS, Castellano L, Stebbing J, Lasky-Su JA, Nesbit MA, Moore CBT. Gene editing in the context of an increasingly complex genome. BMC Genomics. 2018 Aug 08; 19(1):595. PMID: 30086710.
    Citations:    Fields:    Translation:Humans
  17. Moore CBT, Christie KA, Marshall J, Nesbit MA. Personalised genome editing - The future for corneal dystrophies. Prog Retin Eye Res. 2018 07; 65:147-165. PMID: 29378321.
    Citations: 11     Fields:    Translation:Humans
  18. Christie KA, Courtney DG, DeDionisio LA, Shern CC, De Majumdar S, Mairs LC, Nesbit MA, Moore CBT. Towards personalised allele-specific CRISPR gene editing to treat autosomal dominant disorders. Sci Rep. 2017 11 23; 7(1):16174. PMID: 29170458.
    Citations: 28     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.