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Prakash Kharel, Ph.D.


Kent State University, OH, USAPh.D.10/2018Biochemistry
Tribhuvan University, Kathmandu, NepalM.Sc.2010Chemistry
Tribhuvan University, Kathmandu, NepalB.Sc.2006Chemistry and Biology

RNA biology, G-quadruplexes, Nucleic acids therapeutics, Neurological and neuromuscular disorders.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kharel P, Fay M, Manasova EV, Anderson PJ, Kurkin AV, Guo JU, Ivanov P. Stress promotes RNA G-quadruplex folding in human cells. Nat Commun. 2023 Jan 13; 14(1):205. PMID: 36639366; PMCID: PMC9839774.
    Citations:    Fields:    
  2. Beals N, Farhath MM, Kharel P, Croos B, Mahendran T, Johnson J, Basu S. Rationally designed DNA therapeutics can modulate human TH expression by controlling specific GQ formation in its promoter. Mol Ther. 2022 02 02; 30(2):831-844. PMID: 33992806; PMCID: PMC8822133.
    Citations: 1     Fields:    Translation:HumansCells
  3. Gyawali P, Saha R, Smith GP, Salamonczyk M, Kharel P, Basu S, Li R, Fukuto M, Gleeson JT, Clark NA, Jákli A, Balci H, Sprunt S. Mono- and bilayer smectic liquid crystal ordering in dense solutions of "gapped" DNA duplexes. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). PMID: 33731478; PMCID: PMC8000353.
    Citations:    Fields:    Translation:Cells
  4. Kharel P, Becker G, Tsvetkov V, Ivanov P. Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back. Nucleic Acids Res. 2020 12 16; 48(22):12534-12555. PMID: 33264409.
    Citations: 21     Fields:    Translation:HumansCells
  5. Lyons SM, Kharel P, Akiyama Y, Ojha S, Dave D, Tsvetkov V, Merrick W, Ivanov P, Anderson P. eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function. Nucleic Acids Res. 2020 06 19; 48(11):6223-6233. PMID: 32374873.
    Citations: 15     Fields:    Translation:HumansCells
  6. Mineo M, Lyons SM, Zdioruk M, von Spreckelsen N, Ferrer-Luna R, Ito H, Alayo QA, Kharel P, Giantini Larsen A, Fan WY, Auduong S, Grauwet K, Passaro C, Khalsa JK, Shah K, Reardon DA, Ligon KL, Beroukhim R, Nakashima H, Ivanov P, Anderson PJ, Lawler SE, Chiocca EA. Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mol Cell. 2020 06 18; 78(6):1207-1223.e8. PMID: 32504554.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  7. Akiyama Y, Kharel P, Abe T, Anderson P, Ivanov P. Isolation and initial structure-functional characterization of endogenous tRNA-derived stress-induced RNAs. RNA Biol. 2020 08; 17(8):1116-1124. PMID: 32116132.
    Citations: 20     Fields:    Translation:HumansCells
  8. Kharel P, Balaratnam S, Beals N, Basu S. The role of RNA G-quadruplexes in human diseases and therapeutic strategies. Wiley Interdiscip Rev RNA. 2020 01; 11(1):e1568. PMID: 31514263.
    Citations: 26     Fields:    Translation:HumansCells
  9. Mirihana Arachchilage G, Kharel P, Reid J, Basu S. Targeting of G-Quadruplex Harboring Pre-miRNA 92b by LNA Rescues PTEN Expression in NSCL Cancer Cells. ACS Chem Biol. 2018 04 20; 13(4):909-914. PMID: 29529863.
    Citations: 14     Fields:    Translation:HumansCells
  10. Bhattacharyya D, Morris MJ, Kharel P, Mirihana Arachchilage G, Fedeli KM, Basu S. Engineered domain swapping indicates context dependent functional role of RNA G-quadruplexes. Biochimie. 2017 Jun; 137:147-150. PMID: 28322930.
    Citations: 5     Fields:    Translation:HumansCells
  11. Gibbons BA, Kharel P, Robinson LC, Synowicki RA, Model MA. Volume measurements and fluorescent staining indicate an increase in permeability for organic cation transporter substrates during apoptosis. Exp Cell Res. 2016 05 15; 344(1):112-119. PMID: 26997529.
    Citations: 1     Fields:    Translation:HumansCells
  12. Kharel P, McDonough J, Basu S. Evidence of extensive RNA oxidation in normal appearing cortex of multiple sclerosis brain. Neurochem Int. 2016 Jan; 92:43-8. PMID: 26706235.
    Citations: 3     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.