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Ajit Johnson Nirmal, Ph.D.

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Biography
University of Edinburgh, UKPhD2018Immuno-Oncology
University College London, UKMS2011Molecular Medicine
Karunya University, IndiaB.Tech2010Biotechnology

Overview
Ajit Johnson Nirmal is a Research Fellow at DFCI and HMS, working under the mentorship of Prof. David Weinstock and Prof. Peter Sorger. He works on multi dimensional characterization of minimal residual disease (MRDs) in lymphoma to delineate their genetic, transcriptional, spatial and biophysical attributes at a single-cell level to identify MRD-specific vulnerabilities, thereby to shift the paradigm of lymphoma treatment from maximum tumor debulking to cure. The study also catalyzes advances across other cancer types by providing the necessary platform technologies, resources and computational tools. The ultimate impact is a paradigm shift toward biomarker-based approaches for converting deep remissions of lymphomas into cures.

Ajit received a PhD in cancer genetics and genomics from the University of Edinburgh. He used large cancer datasets to identify, characterize and model the immune system across different tumour types. He developed ImSig, a network-based computational framework that facilitates the characterization of immune cells within the tumor microenvironment.

Affiliations
Department of Medical Oncology, Dana-Farber Cancer Institute
Laboratory of Systems Pharmacology, Harvard Medical School
The Broad Institute

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99CA256497 (NIRMAL , AJIT JOHNSON) Mar 1, 2021 - Feb 28, 2023
    NIH
    Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sandercock DA, Barnett MW, Coe JE, Downing AC, Nirmal AJ, Di Giminiani P, Edwards SA, Freeman TC. Transcriptomics Analysis of Porcine Caudal Dorsal Root Ganglia in Tail Amputated Pigs Shows Long-Term Effects on Many Pain-Associated Genes. Front Vet Sci. 2019; 6:314. PMID: 31620455.
    Citations: 5     
  2. Nirmal AJ, Regan T, Shih BB, Hume DA, Sims AH, Freeman TC. Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors. Cancer Immunol Res. 2018 11; 6(11):1388-1400. PMID: 30266715.
    Citations: 31     Fields:    Translation:HumansCells
  3. Lee SS, Sivalingam J, Nirmal AJ, Ng WH, Kee I, Song IC, Kiong CY, Gales KA, Chua F, Pena EM, Ogden BE, Kon OL. Durable engraftment of genetically modified FVIII-secreting autologous bone marrow stromal cells in the intramedullary microenvironment. J Cell Mol Med. 2018 07; 22(7):3698-3702. PMID: 29682884.
    Citations: 3     Fields:    Translation:AnimalsCells
  4. Pridans C, Sauter KA, Irvine KM, Davis GM, Lefevre L, Raper A, Rojo R, Nirmal AJ, Beard P, Cheeseman M, Hume DA. Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. Am J Physiol Gastrointest Liver Physiol. 2018 03 01; 314(3):G388-G398. PMID: 29351395.
    Citations: 6     Fields:    Translation:AnimalsCells
  5. Shih BB, Nirmal AJ, Headon DJ, Akbar AN, Mabbott NA, Freeman TC. Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders. J Pathol. 2017 04; 241(5):600-613. PMID: 28008606.
    Citations: 5     Fields:    Translation:HumansCells
  6. Sivalingam J, Kenanov D, Han H, Nirmal AJ, Ng WH, Lee SS, Masilamani J, Phan TT, Maurer-Stroh S, Kon OL. Multidimensional Genome-wide Analyses Show Accurate FVIII Integration by ZFN in Primary Human Cells. Mol Ther. 2016 Mar; 24(3):607-19. PMID: 26689265.
    Citations: 6     Fields:    Translation:HumansCells
  7. Bartnik A, Nirmal AJ, Yang SY. Peptide Vaccine Therapy in Colorectal Cancer. Vaccines (Basel). 2012 Aug 24; 1(1):1-16. PMID: 26343847.
    Citations: 5     
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.