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Hanne Demant Hansen, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Raval NR, Madsen CA, Shalgunov V, Nasser A, Battisti UM, Beaman EE, Juhl M, Jørgensen LM, Herth MM, Hansen HD, Plavén-Sigray P, Knudsen GM. Evaluation of the a-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs. Nucl Med Biol. 2022 Nov-Dec; 114-115:42-48. PMID: 36095921.
    Citations:    Fields:    Translation:HumansAnimals
  2. Norgaard M, Matheson GJ, Hansen HD, Thomas A, Searle G, Rizzo G, Veronese M, Giacomel A, Yaqub M, Tonietto M, Funck T, Gillman A, Boniface H, Routier A, Dalenberg JR, Betthauser T, Feingold F, Markiewicz CJ, Gorgolewski KJ, Blair RW, Appelhoff S, Gau R, Salo T, Niso G, Pernet C, Phillips C, Oostenveld R, Gallezot JD, Carson RE, Knudsen GM, Innis RB, Ganz M. PET-BIDS, an extension to the brain imaging data structure for positron emission tomography. Sci Data. 2022 03 02; 9(1):65. PMID: 35236846; PMCID: PMC8891322.
    Citations: 9     Fields:    
  3. Jørgensen LM, Henriksen T, Mardosiene S, Keller SH, Stenbæk DS, Hansen HD, Jespersen B, Thomsen C, Weikop P, Svarer C, Knudsen GM. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study. J Cereb Blood Flow Metab. 2021 08; 41(8):1954-1963. PMID: 33461410; PMCID: PMC8327106.
    Citations: 6     Fields:    Translation:HumansCells
  4. Raval NR, Johansen A, Donovan LL, Ros NF, Ozenne B, Hansen HD, Knudsen GM. A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain. Int J Mol Sci. 2021 Jan 15; 22(2). PMID: 33467676.
    Citations: 28     Fields:    Translation:AnimalsCells
  5. Donovan LL, Johansen JV, Ros NF, Jaberi E, Linnet K, Johansen SS, Ozenne B, Issazadeh-Navikas S, Hansen HD, Knudsen GM. Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig. Eur Neuropsychopharmacol. 2021 01; 42:1-11. PMID: 33288378.
    Citations: 6     Fields:    Translation:Animals
  6. Shalgunov V, Xiong M, L'Estrade ET, Raval NR, Andersen IV, Edgar FG, Speth NR, Baerentzen SL, Hansen HD, Donovan LL, Nasser A, Peitersen ST, Kjaer A, Knudsen GM, Syvänen S, Palner M, Herth MM. Blocking of efflux transporters in rats improves translational validation of brain radioligands. EJNMMI Res. 2020 Oct 19; 10(1):124. PMID: 33074370.
    Citations: 6     
  7. Hansen HD, Lindberg U, Ozenne B, Fisher PM, Johansen A, Svarer C, Keller SH, Hansen AE, Knudsen GM. Visual stimuli induce serotonin release in occipital cortex: A simultaneous positron emission tomography/magnetic resonance imaging study. Hum Brain Mapp. 2020 11; 41(16):4753-4763. PMID: 32813903.
    Citations: 2     Fields:    Translation:Humans
  8. Donovan LL, Magnussen JH, Dyssegaard A, Lehel S, Hooker JM, Knudsen GM, Hansen HD. Imaging HDACs In Vivo: Cross-Validation of the [11C]Martinostat Radioligand in the Pig Brain. Mol Imaging Biol. 2020 06; 22(3):569-577. PMID: 31290052.
    Citations: 3     Fields:    Translation:HumansAnimals
  9. Donat CK, Hansen HH, Hansen HD, Mease RC, Horti AG, Pomper MG, L'Estrade ET, Herth MM, Peters D, Knudsen GM, Mikkelsen JD. In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [125I]Iodo-ASEM and [18F]ASEM as Radiotracers of Homo- and Heteromeric a7 Nicotinic Acetylcholine Receptors. Molecules. 2020 Mar 20; 25(6). PMID: 32245032.
    Citations: 4     Fields:    Translation:AnimalsCells
  10. Sander CY, Hansen HD, Wey HY. Advances in simultaneous PET/MR for imaging neuroreceptor function. J Cereb Blood Flow Metab. 2020 06; 40(6):1148-1166. PMID: 32169011.
    Citations: 9     Fields:    Translation:HumansCells
  11. L 'Estrade ET, Shalgunov V, Edgar FG, Strebl-Bantillo MG, Xiong M, Crestey F, Neelamegam R, Dyssegaard A, Lehel S, Erlandsson M, Ohlsson T, Hooker JM, Knudsen GM, Herth MM, Hansen HD. Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors. J Labelled Comp Radiopharm. 2020 02; 63(2):46-55. PMID: 31674045.
    Citations: 2     Fields:    Translation:Animals
  12. Johansen A, Holm S, Dall B, Keller S, Kristensen JL, Knudsen GM, Hansen HD. Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions. EJNMMI Res. 2019 Jul 31; 9(1):71. PMID: 31367837; PMCID: PMC6669221.
    Citations: 4     
  13. Deen M, Hougaard A, Hansen HD, Schain M, Dyssegaard A, Knudsen GM, Ashina M. Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding. JAMA Neurol. 2019 07 01; 76(7):834-840. PMID: 31135819; PMCID: PMC6547094.
    Citations: 8     Fields:    Translation:HumansCells
  14. L'Estrade ET, Hansen HD, Falk-Petersen C, Haugaard A, Griem-Krey N, Jung S, Lüddens H, Schirmeister T, Erlandsson M, Ohlsson T, Knudsen GM, Herth MM, Wellendorph P, Frølund B. Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the d-Subunit-Containing ?-Aminobutyric Acid Type A Receptors. ACS Omega. 2019 May 31; 4(5):8846-8851. PMID: 31459972; PMCID: PMC6648289.
    Citations: 2     
  15. Stéen EJL, Jørgensen JT, Petersen IN, Nørregaard K, Lehel S, Shalgunov V, Birke A, Edem PE, L'Estrade ET, Hansen HD, Villadsen J, Erlandsson M, Ohlsson T, Yazdani A, Valliant JF, Kristensen JL, Barz M, Knudsen GM, Kjær A, Herth MM. Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging. Bioorg Med Chem Lett. 2019 04 15; 29(8):986-990. PMID: 30795854.
    Citations: 9     Fields:    Translation:Animals
  16. Hansen HD, Constantinescu CC, Barret O, Herth MM, Magnussen JH, Lehel S, Dyssegaard A, Colomb J, Billard T, Zimmer L, Tamagnan G, Knudsen GM. Evaluation of [18 F]2FP3 in pigs and non-human primates. J Labelled Comp Radiopharm. 2019 01; 62(1):34-42. PMID: 30414212.
    Citations: 2     Fields:    Translation:Animals
  17. Deen M, Hougaard A, Hansen HD, Svarer C, Eiberg H, Lehel S, Knudsen GM, Ashina M. Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding. Cephalalgia. 2019 04; 39(4):526-532. PMID: 30089402.
    Citations: 7     Fields:    Translation:HumansCells
  18. T L'Estrade E, Hansen HD, Erlandsson M, Ohlsson TG, Knudsen GM, Herth MM. Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging. ACS Chem Neurosci. 2018 06 20; 9(6):1226-1229. PMID: 29763291.
    Citations: 4     Fields:    Translation:HumansAnimals
  19. Deen M, Hansen HD, Hougaard A, Nørgaard M, Eiberg H, Lehel S, Ashina M, Knudsen GM. High brain serotonin levels in migraine between attacks: A 5-HT4 receptor binding PET study. Neuroimage Clin. 2018; 18:97-102. PMID: 29387527.
    Citations: 14     Fields:    Translation:Humans
  20. Johansen A, Hansen HD, Svarer C, Lehel S, Leth-Petersen S, Kristensen JL, Gillings N, Knudsen GM. The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions. J Cereb Blood Flow Metab. 2018 04; 38(4):659-668. PMID: 29215308; PMCID: PMC5888860.
    Citations: 13     Fields:    Translation:Humans
  21. Villadsen J, Hansen HD, Jørgensen LM, Keller SH, Andersen FL, Petersen IN, Knudsen GM, Svarer C. Automatic delineation of brain regions on MRI and PET images from the pig. J Neurosci Methods. 2018 01 15; 294:51-58. PMID: 29146191.
    Citations: 9     Fields:    Translation:Animals
  22. Hansen HD, Mandeville JB, Sander CY, Hooker JM, Catana C, Rosen BR, Knudsen GM. Functional Characterization of 5-HT1B Receptor Drugs in Nonhuman Primates Using Simultaneous PET-MR. J Neurosci. 2017 11 01; 37(44):10671-10678. PMID: 28972127; PMCID: PMC5666586.
    Citations: 3     Fields:    Translation:Animals
  23. Edgar FG, Hansen HD, Leth-Petersen S, Ettrup A, Kristensen JL, Knudsen GM, Herth MM. Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT2A receptor agonists [18 F]Cimbi-92 and [18 F]Cimbi-150. J Labelled Comp Radiopharm. 2017 10; 60(12):586-591. PMID: 28856700.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Petersen IN, Villadsen J, Hansen HD, Madsen J, Jensen AA, Gillings N, Lehel S, Herth MM, Knudsen GM, Kristensen JL. 18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands. Org Biomol Chem. 2017 May 23; 15(20):4351-4358. PMID: 28474719.
    Citations: 2     Fields:    Translation:AnimalsCells
  25. Deen M, Hansen HD, Hougaard A, da Cunha-Bang S, Nørgaard M, Svarer C, Keller SH, Thomsen C, Ashina M, Knudsen GM. Low 5-HT1B receptor binding in the migraine brain: A PET study. Cephalalgia. 2018 03; 38(3):519-527. PMID: 28730894.
    Citations: 10     Fields:    Translation:Humans
  26. Ganz M, Feng L, Hansen HD, Beliveau V, Svarer C, Knudsen GM, Greve DN. Cerebellar heterogeneity and its impact on PET data quantification of 5-HT receptor radioligands. J Cereb Blood Flow Metab. 2017 Sep; 37(9):3243-3252. PMID: 28075185.
    Citations: 8     Fields:    Translation:HumansCells
  27. Jensen CH, Hansen HD, Bay T, Vogensen SB, Lehel S, Thiesen L, Bundgaard C, Clausen RP, Knudsen GM, Herth MM, Wellendorph P, Frølund B. Radiosynthesis and Evaluation of [11C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity ?-Hydroxybutyric Acid Binding Sites. ACS Chem Neurosci. 2017 01 18; 8(1):22-27. PMID: 28095676.
    Citations: 2     Fields:    Translation:AnimalsCells
  28. Klein AB, Bay T, Villumsen IS, Falk-Petersen CB, Marek A, Frølund B, Clausen RP, Hansen HD, Knudsen GM, Wellendorph P. Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using 3H-HOCPCA. Neurochem Int. 2016 11; 100:138-145. PMID: 27615059.
    Citations: 3     Fields:    Translation:AnimalsCells
  29. Petersen IN, Villadsen J, Hansen HD, Jensen AA, Lehel S, Gillings N, Herth MM, Knudsen GM, Kristensen JL. Convergent 18F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands. Bioorg Med Chem. 2016 11 01; 24(21):5353-5356. PMID: 27624522.
    Citations: 2     Fields:    Translation:HumansCells
  30. Jørgensen LM, Weikop P, Villadsen J, Visnapuu T, Ettrup A, Hansen HD, Baandrup AO, Andersen FL, Bjarkam CR, Thomsen C, Jespersen B, Knudsen GM. Cerebral 5-HT release correlates with [11C]Cimbi36 PET measures of 5-HT2A receptor occupancy in the pig brain. J Cereb Blood Flow Metab. 2017 Feb; 37(2):425-434. PMID: 26825776; PMCID: PMC5381441.
    Citations: 19     Fields:    Translation:Animals
  31. Deen M, Christensen CE, Hougaard A, Hansen HD, Knudsen GM, Ashina M. Serotonergic mechanisms in the migraine brain - a systematic review. Cephalalgia. 2017 Mar; 37(3):251-264. PMID: 27013238.
    Citations: 27     Fields:    Translation:Humans
  32. Mandeville JB, Sander CYM, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR. A regularized full reference tissue model for PET neuroreceptor mapping. Neuroimage. 2016 Oct 01; 139:405-414. PMID: 27364474.
    Citations: 6     Fields:    Translation:HumansAnimals
  33. Herth MM, Petersen IN, Hansen HD, Hansen M, Ettrup A, Jensen AA, Lehel S, Dyssegaard A, Gillings N, Knudsen GM, Kristensen JL. Synthesis and evaluation of (18)F-labeled 5-HT2A receptor agonists as PET ligands. Nucl Med Biol. 2016 08; 43(8):455-62. PMID: 27209485.
    Citations: 6     Fields:    Translation:Animals
  34. Feng L, Svarer C, Madsen K, Ziebell M, Dyssegaard A, Ettrup A, Hansen HD, Lehel S, Yndgaard S, Paulson OB, Knudsen GM, Pinborg LH. Design of Infusion Schemes for Neuroreceptor Imaging: Application to [(11)C]Flumazenil-PET Steady-State Study. Biomed Res Int. 2016; 2016:9132840. PMID: 27123457.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  35. Leth-Petersen S, Gabel-Jensen C, Gillings N, Lehel S, Hansen HD, Knudsen GM, Kristensen JL. Metabolic Fate of Hallucinogenic NBOMes. Chem Res Toxicol. 2016 Jan 19; 29(1):96-100. PMID: 26669514.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  36. Knudsen GM, Jensen PS, Erritzoe D, Baaré WFC, Ettrup A, Fisher PM, Gillings N, Hansen HD, Hansen LK, Hasselbalch SG, Henningsson S, Herth MM, Holst KK, Iversen P, Kessing LV, Macoveanu J, Madsen KS, Mortensen EL, Nielsen FÅ, Paulson OB, Siebner HR, Stenbæk DS, Svarer C, Jernigan TL, Strother SC, Frokjaer VG. The Center for Integrated Molecular Brain Imaging (Cimbi) database. Neuroimage. 2016 Jan 01; 124(Pt B):1213-1219. PMID: 25891375.
    Citations: 38     Fields:    Translation:Humans
  37. Herth MM, Andersen VL, Hansen HD, Stroth N, Volk B, Lehel S, Dyssegaard A, Ettrup A, Svenningsson P, Knudsen GM, Kristensen JL. Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs. J Med Chem. 2015 Apr 23; 58(8):3631-6. PMID: 25825999.
    Citations:    Fields:    Translation:Animals
  38. Hansen HD, Andersen VL, Lehel S, Magnussen JH, Dyssegaard A, Stroth N, Kristensen JL, Knudsen GM, Herth MM. Labeling and preliminary in vivo evaluation of the 5-HT(7) receptor selective agonist [(11)C]E-55888. Bioorg Med Chem Lett. 2015 May 01; 25(9):1901-4. PMID: 25857944.
    Citations:    Fields:    Translation:AnimalsCells
  39. Andersen VL, Hansen HD, Herth MM, Dyssegaard A, Knudsen GM, Kristensen JL. (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand. Bioorg Med Chem Lett. 2015 Mar 01; 25(5):1053-6. PMID: 25655720.
    Citations: 6     Fields:    Translation:AnimalsCells
  40. Andersen VL, Hansen HD, Herth MM, Knudsen GM, Kristensen JL. (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand. Bioorg Med Chem Lett. 2014 Jun 01; 24(11):2408-11. PMID: 24786133.
    Citations: 3     Fields:    Translation:Animals
  41. Hansen HD, Lacivita E, Di Pilato P, Herth MM, Lehel S, Ettrup A, Andersen VL, Dyssegaard A, De Giorgio P, Perrone R, Berardi F, Colabufo NA, Niso M, Knudsen GM, Leopoldo M. Synthesis, radiolabeling and in vivo evaluation of [(11)C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT(7) receptor. Eur J Med Chem. 2014 May 22; 79:152-63. PMID: 24732791.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  42. Hansen HD, Herth MM, Ettrup A, Andersen VL, Lehel S, Dyssegaard A, Kristensen JL, Knudsen GM. Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors. J Nucl Med. 2014 Apr; 55(4):640-6. PMID: 24566002.
    Citations: 6     Fields:    Translation:Animals
  43. Lacivita E, Niso M, Hansen HD, Di Pilato P, Herth MM, Lehel S, Ettrup A, Montenegro L, Perrone R, Berardi F, Colabufo NA, Leopoldo M, Knudsen GM. Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor. Bioorg Med Chem. 2014 Mar 01; 22(5):1736-50. PMID: 24508140.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Hansen HD, Ettrup A, Herth MM, Dyssegaard A, Ratner C, Gillings N, Knudsen GM. Direct comparison of [(18) F]MH.MZ and [(18) F] altanserin for 5-HT2A receptor imaging with PET. Synapse. 2013 Jun; 67(6):328-37. PMID: 23390031.
    Citations: 10     Fields:    Translation:Animals
  45. Kragh CL, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH. FAS-dependent cell death in a-synuclein transgenic oligodendrocyte models of multiple system atrophy. PLoS One. 2013; 8(1):e55243. PMID: 23372841.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  46. Risgaard R, Ettrup A, Balle T, Dyssegaard A, Hansen HD, Lehel S, Madsen J, Pedersen H, Püschl A, Badolo L, Bang-Andersen B, Knudsen GM, Kristensen JL. Radiolabelling and PET brain imaging of the a1-adrenoceptor antagonist Lu AE43936. Nucl Med Biol. 2013 Jan; 40(1):135-40. PMID: 23165140.
    Citations: 6     Fields:    Translation:AnimalsCells
  47. Pinborg LH, Feng L, Haahr ME, Gillings N, Dyssegaard A, Madsen J, Svarer C, Yndgaard S, Kjaer TW, Parsey RV, Hansen HD, Ettrup A, Paulson OB, Knudsen GM. No change in [¹¹C]CUMI-101 binding to 5-HT(1A) receptors after intravenous citalopram in human. Synapse. 2012 Oct; 66(10):880-4. PMID: 22730164.
    Citations: 19     Fields:    Translation:Humans
  48. Herth MM, Hansen HD, Ettrup A, Dyssegaard A, Lehel S, Kristensen J, Knudsen GM. Synthesis and evaluation of [¹¹C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging. Bioorg Med Chem. 2012 Jul 15; 20(14):4574-81. PMID: 22682922.
    Citations: 2     Fields:    Translation:Animals
  49. Kragh CL, Lund LB, Febbraro F, Hansen HD, Gai WP, El-Agnaf O, Richter-Landsberg C, Jensen PH. Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells. J Biol Chem. 2009 Apr 10; 284(15):10211-22. PMID: 19203998.
    Citations: 65     Fields:    Translation:AnimalsCells
  50. Andersen LM, Wind T, Hansen HD, Andreasen PA. A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue. Biochem J. 2008 Jun 15; 412(3):447-57. PMID: 18318660.
    Citations: 6     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.