Harvard Catalyst Profiles

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Danesh Moazed, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM079535 (MOAZED, DANESH) Mar 1, 2007 - Feb 28, 2012
    Regulation of rRNA Genes by Silencing Mechanisms
    Role: Principal Investigator
  2. R01GM072805 (MOAZED, DANESH) Feb 1, 2005 - Jun 30, 2021
    Epigenetic Inheritance of Heterochromatin
    Role: Principal Investigator
  3. R01GM061641 (MOAZED, DANESH) Jul 1, 2000 - Jun 30, 2016
    Mechanism of Action of Yeast Silencing Complexes
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, Zhang J, Luo Z, Gygi SP, Adelman K, Moazed D. Rixosomal RNA degradation contributes to silencing of Polycomb target genes. Nature. 2022 04; 604(7904):167-174. PMID: 35355014; PMCID: PMC8986528.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Tatarakis A, Moazed D. Real-Time Quantitative PCR and Fluorescence In Situ Hybridization for Subcellular Localization of miRNAs in Neurons. Methods Mol Biol. 2022; 2417:1-17. PMID: 35099787.
    Citations:    Fields:    Translation:Cells
  3. Wang X, Paulo JA, Li X, Zhou H, Yu J, Gygi SP, Moazed D. A composite DNA element that functions as a maintainer required for epigenetic inheritance of heterochromatin. Mol Cell. 2021 10 07; 81(19):3979-3991.e4. PMID: 34375584; PMCID: PMC8500937.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D. A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin. Elife. 2020 06 03; 9. PMID: 32491985.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  5. Iglesias N, Paulo JA, Tatarakis A, Wang X, Edwards AL, Bhanu NV, Garcia BA, Haas W, Gygi SP, Moazed D. Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance. Mol Cell. 2020 01 02; 77(1):51-66.e8. PMID: 31784357.
    Citations: 25     Fields:    Translation:AnimalsCells
  6. Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D. Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability. Nature. 2018 08; 560(7719):504-508. PMID: 30051891; PMCID: PMC6287498.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  7. Yu R, Wang X, Moazed D. Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation. Nature. 2018 06; 558(7711):615-619. PMID: 29925950; PMCID: PMC6312107.
    Citations: 43     Fields:    Translation:AnimalsCells
  8. Tatarakis A, Behrouzi R, Moazed D. Evolving Models of Heterochromatin: From Foci to Liquid Droplets. Mol Cell. 2017 Sep 07; 67(5):725-727. PMID: 28886332.
    Citations: 11     Fields:    Translation:Cells
  9. Iglesias N, Moazed D. Silencing repetitive DNA. Elife. 2017 08 01; 6. PMID: 28760198.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Jih G, Iglesias N, Currie MA, Bhanu NV, Paulo JA, Gygi SP, Garcia BA, Moazed D. Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription. Nature. 2017 07 27; 547(7664):463-467. PMID: 28682306; PMCID: PMC5576860.
    Citations: 47     Fields:    Translation:AnimalsCells
  11. Wang X, Moazed D. DNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation. Science. 2017 04 07; 356(6333):88-91. PMID: 28302794; PMCID: PMC5718040.
    Citations: 48     Fields:    Translation:AnimalsCells
  12. Kusevic D, Kudithipudi S, Iglesias N, Moazed D, Jeltsch A. Clr4 specificity and catalytic activity beyond H3K9 methylation. Biochimie. 2017 Apr; 135:83-88. PMID: 28143796.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Huang J, Iglesias N, Moazed D. Evaluation of the Nucleolar Localization of the RENT Complex to Ribosomal DNA by Chromatin Immunoprecipitation Assays. Methods Mol Biol. 2017; 1505:195-213. PMID: 27826866.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Mathew RS, Tatarakis A, Rudenko A, Johnson-Venkatesh EM, Yang YJ, Murphy EA, Todd TP, Schepers ST, Siuti N, Martorell AJ, Falls WA, Hammack SE, Walsh CA, Tsai LH, Umemori H, Bouton ME, Moazed D. A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory. Elife. 2016 12 21; 5. PMID: 28001126.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Behrouzi R, Lu C, Currie MA, Jih G, Iglesias N, Moazed D. Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes. Elife. 2016 11 11; 5. PMID: 27835568; PMCID: PMC5106214.
    Citations: 14     Fields:    Translation:AnimalsCells
  16. Jain R, Iglesias N, Moazed D. Distinct Functions of Argonaute Slicer in siRNA Maturation and Heterochromatin Formation. Mol Cell. 2016 07 21; 63(2):191-205. PMID: 27397687; PMCID: PMC5576859.
    Citations: 8     Fields:    Translation:AnimalsCells
  17. Yu R, Moazed D. CSR-1 Slices a Balance. Cell. 2016 Apr 07; 165(2):267-9. PMID: 27058659.
    Citations:    Fields:    Translation:AnimalsCells
  18. Martienssen R, Moazed D. RNAi and heterochromatin assembly. Cold Spring Harb Perspect Biol. 2015 Aug 03; 7(8):a019323. PMID: 26238358.
    Citations: 114     Fields:    Translation:AnimalsCells
  19. Gerace E, Moazed D. Affinity Pull-Down of Proteins Using Anti-FLAG M2 Agarose Beads. Methods Enzymol. 2015; 559:99-110. PMID: 26096505; PMCID: PMC4794115.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  20. Gerace E, Moazed D. Affinity Purification of Protein Complexes Using TAP Tags. Methods Enzymol. 2015; 559:37-52. PMID: 26096502; PMCID: PMC4794980.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  21. Holoch D, Moazed D. Small-RNA loading licenses Argonaute for assembly into a transcriptional silencing complex. Nat Struct Mol Biol. 2015 Apr; 22(4):328-35. PMID: 25730778; PMCID: PMC4385408.
    Citations: 23     Fields:    Translation:Animals
  22. Holoch D, Moazed D. RNA-mediated epigenetic regulation of gene expression. Nat Rev Genet. 2015 Feb; 16(2):71-84. PMID: 25554358; PMCID: PMC4376354.
    Citations: 376     Fields:    Translation:AnimalsCells
  23. Ragunathan K, Jih G, Moazed D. Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment. Science. 2015 Apr 03; 348(6230):1258699. PMID: 25831549; PMCID: PMC4385470.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  24. Egan ED, Braun CR, Gygi SP, Moazed D. Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex. RNA. 2014 Jun; 20(6):867-81. PMID: 24713849.
    Citations: 55     Fields:    Translation:Cells
  25. Gerace E, Moazed D. Coimmunoprecipitation of proteins from yeast. Methods Enzymol. 2014; 541:13-26. PMID: 24674059; PMCID: PMC4370295.
    Citations: 8     Fields:    
  26. Yu R, Jih G, Iglesias N, Moazed D. Determinants of heterochromatic siRNA biogenesis and function. Mol Cell. 2014 Jan 23; 53(2):262-76. PMID: 24374313; PMCID: PMC4357591.
    Citations: 40     Fields:    Translation:AnimalsCells
  27. Johnson A, Wu R, Peetz M, Gygi SP, Moazed D. Heterochromatic gene silencing by activator interference and a transcription elongation barrier. J Biol Chem. 2013 Oct 04; 288(40):28771-82. PMID: 23940036.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  28. Heard E, Moazed D. Cell nucleus. Curr Opin Cell Biol. 2013 Jun; 25(3):279-80. PMID: 23746906.
    Citations:    Fields:    Translation:HumansAnimalsCells
  29. Moazed D. Chromatin: a tail of repression. Curr Biol. 2013 May 20; 23(10):R456-9. PMID: 23701691.
    Citations:    Fields:    Translation:Animals
  30. Wang F, Li G, Altaf M, Lu C, Currie MA, Johnson A, Moazed D. Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8495-500. PMID: 23650358.
    Citations: 42     Fields:    Translation:AnimalsCells
  31. Moazed D. A piRNA to remember. Cell. 2012 Apr 27; 149(3):512-4. PMID: 22541425.
    Citations:    Fields:    
  32. Holoch D, Moazed D. RNAi in fission yeast finds new targets and new ways of targeting at the nuclear periphery. Genes Dev. 2012 Apr 15; 26(8):741-5. PMID: 22508721.
    Citations: 4     Fields:    Translation:AnimalsCells
  33. Moazed D. Mechanisms for the inheritance of chromatin states. Cell. 2011 Aug 19; 146(4):510-8. PMID: 21854979; PMCID: PMC3244757.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  34. Tung SY, Hong JY, Walz T, Moazed D, Liou GG. Chromatin affinity-precipitation using a small metabolic molecule: its application to analysis of O-acetyl-ADP-ribose. Cell Mol Life Sci. 2012 Feb; 69(4):641-50. PMID: 21796450; PMCID: PMC3266462.
    Citations: 6     Fields:    Translation:AnimalsCells
  35. Gullerova M, Moazed D, Proudfoot NJ. Autoregulation of convergent RNAi genes in fission yeast. Genes Dev. 2011 Mar 15; 25(6):556-68. PMID: 21357674.
    Citations: 19     Fields:    Translation:AnimalsCells
  36. Gerace EL, Moazed D. Histone demethylation and timely DNA replication. Mol Cell. 2010 Dec 10; 40(5):683-4. PMID: 21145476; PMCID: PMC3016942.
    Citations: 2     Fields:    
  37. Gerace EL, Halic M, Moazed D. The methyltransferase activity of Clr4Suv39h triggers RNAi independently of histone H3K9 methylation. Mol Cell. 2010 Aug 13; 39(3):360-72. PMID: 20705239; PMCID: PMC2941148.
    Citations: 46     Fields:    Translation:AnimalsCells
  38. Mekhail K, Moazed D. The nuclear envelope in genome organization, expression and stability. Nat Rev Mol Cell Biol. 2010 May; 11(5):317-28. PMID: 20414256; PMCID: PMC3246372.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  39. Halic M, Moazed D. Dicer-independent primal RNAs trigger RNAi and heterochromatin formation. Cell. 2010 Feb 19; 140(4):504-16. PMID: 20178743; PMCID: PMC3020400.
    Citations: 104     Fields:    Translation:AnimalsCells
  40. Halic M, Moazed D. 22G-RNAs in transposon silencing and centromere function. Mol Cell. 2009 Oct 23; 36(2):170-1. PMID: 19854125; PMCID: PMC3244753.
    Citations: 6     Fields:    Translation:AnimalsCells
  41. Moazed D. Molecular biology. Rejoice--RNAi for yeast. Science. 2009 Oct 23; 326(5952):533-4. PMID: 19900888; PMCID: PMC3245747.
    Citations: 5     Fields:    Translation:AnimalsCells
  42. Johnson A, Li G, Sikorski TW, Buratowski S, Woodcock CL, Moazed D. Reconstitution of heterochromatin-dependent transcriptional gene silencing. Mol Cell. 2009 Sep 24; 35(6):769-81. PMID: 19782027; PMCID: PMC2842978.
    Citations: 52     Fields:    Translation:AnimalsCells
  43. Sinha M, Watanabe S, Johnson A, Moazed D, Peterson CL. Recombinational repair within heterochromatin requires ATP-dependent chromatin remodeling. Cell. 2009 Sep 18; 138(6):1109-21. PMID: 19766565.
    Citations: 44     Fields:    Translation:AnimalsCells
  44. Halic M, Moazed D. Transposon silencing by piRNAs. Cell. 2009 Sep 18; 138(6):1058-60. PMID: 19766558; PMCID: PMC3244755.
    Citations: 30     Fields:    Translation:AnimalsCells
  45. Li H, Motamedi MR, Yip CK, Wang Z, Walz T, Patel DJ, Moazed D. An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Mol Cell. 2009 Apr 24; 34(2):155-67. PMID: 19394293.
    Citations: 23     Fields:    Translation:AnimalsCells
  46. Tomson BN, Rahal R, Reiser V, Monje-Casas F, Mekhail K, Moazed D, Amon A. Regulation of Spo12 phosphorylation and its essential role in the FEAR network. Curr Biol. 2009 Mar 24; 19(6):449-60. PMID: 19268588.
    Citations: 28     Fields:    Translation:AnimalsCells
  47. Moazed D. Small RNAs in transcriptional gene silencing and genome defence. Nature. 2009 Jan 22; 457(7228):413-20. PMID: 19158787; PMCID: PMC3246369.
    Citations: 333     Fields:    Translation:AnimalsCells
  48. Motamedi MR, Hong EJ, Li X, Gerber S, Denison C, Gygi S, Moazed D. HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol Cell. 2008 Dec 26; 32(6):778-90. PMID: 19111658; PMCID: PMC2735125.
    Citations: 126     Fields:    Translation:AnimalsCells
  49. Mekhail K, Seebacher J, Gygi SP, Moazed D. Role for perinuclear chromosome tethering in maintenance of genome stability. Nature. 2008 Dec 04; 456(7222):667-70. PMID: 18997772; PMCID: PMC2596277.
    Citations: 131     Fields:    Translation:AnimalsCells
  50. Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K. Epigenomics: a roadmap, but to where? Science. 2008 Oct 03; 322(5898):43-4. PMID: 18832628.
    Citations: 14     Fields:    Translation:Cells
  51. Buchberger JR, Onishi M, Li G, Seebacher J, Rudner AD, Gygi SP, Moazed D. Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae. Mol Cell Biol. 2008 Nov; 28(22):6903-18. PMID: 18794362.
    Citations: 34     Fields:    Translation:AnimalsCells
  52. Bühler M, Spies N, Bartel DP, Moazed D. TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway. Nat Struct Mol Biol. 2008 Oct; 15(10):1015-23. PMID: 18776903; PMCID: PMC3240669.
    Citations: 110     Fields:    Translation:AnimalsCells
  53. Iida T, Nakayama J, Moazed D. siRNA-mediated heterochromatin establishment requires HP1 and is associated with antisense transcription. Mol Cell. 2008 Jul 25; 31(2):178-89. PMID: 18657501; PMCID: PMC2575423.
    Citations: 63     Fields:    Translation:AnimalsCells
  54. Kanfi Y, Shalman R, Peshti V, Pilosof SN, Gozlan YM, Pearson KJ, Lerrer B, Moazed D, Marine JC, de Cabo R, Cohen HY. Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett. 2008 Mar 05; 582(5):543-8. PMID: 18242175; PMCID: PMC3263697.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  55. Onishi M, Liou GG, Buchberger JR, Walz T, Moazed D. Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly. Mol Cell. 2007 Dec 28; 28(6):1015-28. PMID: 18158899.
    Citations: 96     Fields:    Translation:Cells
  56. Bühler M, Moazed D. Transcription and RNAi in heterochromatic gene silencing. Nat Struct Mol Biol. 2007 Nov; 14(11):1041-8. PMID: 17984966.
    Citations: 130     Fields:    Translation:AnimalsCells
  57. Colmenares SU, Buker SM, Buhler M, Dlakic M, Moazed D. Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi. Mol Cell. 2007 Aug 03; 27(3):449-61. PMID: 17658285.
    Citations: 82     Fields:    Translation:AnimalsCells
  58. Skiniotis G, Moazed D, Walz T. Acetylated histone tail peptides induce structural rearrangements in the RSC chromatin remodeling complex. J Biol Chem. 2007 Jul 20; 282(29):20804-8. PMID: 17535815.
    Citations: 16     Fields:    Translation:AnimalsCells
  59. Niu H, Li X, Job E, Park C, Moazed D, Gygi SP, Hollingsworth NM. Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis. Mol Cell Biol. 2007 Aug; 27(15):5456-67. PMID: 17526735; PMCID: PMC1952091.
    Citations: 65     Fields:    Translation:AnimalsCells
  60. Bühler M, Haas W, Gygi SP, Moazed D. RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing. Cell. 2007 May 18; 129(4):707-21. PMID: 17512405.
    Citations: 133     Fields:    Translation:AnimalsCells
  61. Lan F, Zaratiegui M, Villén J, Vaughn MW, Verdel A, Huarte M, Shi Y, Gygi SP, Moazed D, Martienssen RA, Shi Y. S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Mol Cell. 2007 Apr 13; 26(1):89-101. PMID: 17434129.
    Citations: 51     Fields:    Translation:AnimalsCells
  62. Buker SM, Iida T, Bühler M, Villén J, Gygi SP, Nakayama J, Moazed D. Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast. Nat Struct Mol Biol. 2007 Mar; 14(3):200-7. PMID: 17310250.
    Citations: 62     Fields:    Translation:AnimalsCells
  63. Morris CA, Moazed D. Centromere assembly and propagation. Cell. 2007 Feb 23; 128(4):647-50. PMID: 17320502.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  64. Huang J, Brito IL, Villén J, Gygi SP, Amon A, Moazed D. Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev. 2006 Oct 15; 20(20):2887-901. PMID: 17043313; PMCID: PMC1619942.
    Citations: 103     Fields:    Translation:Cells
  65. Matecic M, Martins-Taylor K, Hickman M, Tanny J, Moazed D, Holmes SG. New alleles of SIR2 define cell-cycle-specific silencing functions. Genetics. 2006 Aug; 173(4):1939-50. PMID: 16783021.
    Citations: 11     Fields:    Translation:Animals
  66. Bühler M, Verdel A, Moazed D. Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing. Cell. 2006 Jun 02; 125(5):873-86. PMID: 16751098.
    Citations: 196     Fields:    Translation:AnimalsCells
  67. Huang J, Moazed D. Sister chromatid cohesion in silent chromatin: each sister to her own ring. Genes Dev. 2006 Jan 15; 20(2):132-7. PMID: 16418479.
    Citations: 7     Fields:    Translation:AnimalsCells
  68. Moazed D, Bühler M, Buker SM, Colmenares SU, Gerace EL, Gerber SA, Hong EJ, Motamedi MR, Verdel A, Villén J, Gygi SP. Studies on the mechanism of RNAi-dependent heterochromatin assembly. Cold Spring Harb Symp Quant Biol. 2006; 71:461-71. PMID: 17381328.
    Citations: 21     Fields:    Translation:AnimalsCells
  69. Verdel A, Moazed D. RNAi-directed assembly of heterochromatin in fission yeast. FEBS Lett. 2005 Oct 31; 579(26):5872-8. PMID: 16223485.
    Citations: 61     Fields:    Translation:AnimalsCells
  70. Hong EJ, Villén J, Gerace EL, Gygi SP, Moazed D. A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation. RNA Biol. 2005 Jul-Sep; 2(3):106-11. PMID: 17114925.
    Citations: 97     Fields:    Translation:AnimalsCells
  71. Buratowski S, Moazed D. Gene regulation: expression and silencing coupled. Nature. 2005 Jun 30; 435(7046):1174-5. PMID: 15988510.
    Citations: 3     Fields:    Translation:AnimalsCells
  72. Rudner AD, Hall BE, Ellenberger T, Moazed D. A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin. Mol Cell Biol. 2005 Jun; 25(11):4514-28. PMID: 15899856; PMCID: PMC1140625.
    Citations: 57     Fields:    Translation:AnimalsCells
  73. Liou GG, Tanny JC, Kruger RG, Walz T, Moazed D. Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation. Cell. 2005 May 20; 121(4):515-527. PMID: 15907466.
    Citations: 128     Fields:    Translation:AnimalsCells
  74. Verdel A, Moazed D. Labeling and characterization of small RNAs associated with the RNA interference effector complex RITS. Methods Enzymol. 2005; 392:297-307. PMID: 15644188.
    Citations: 2     Fields:    Translation:AnimalsCells
  75. Sugiyama T, Cam H, Verdel A, Moazed D, Grewal SI. RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):152-7. PMID: 15615848; PMCID: PMC544066.
    Citations: 133     Fields:    Translation:AnimalsCells
  76. Motamedi MR, Verdel A, Colmenares SU, Gerber SA, Gygi SP, Moazed D. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell. 2004 Dec 17; 119(6):789-802. PMID: 15607976.
    Citations: 251     Fields:    Translation:AnimalsCells
  77. Denison C, Rudner AD, Gerber SA, Bakalarski CE, Moazed D, Gygi SP. A proteomic strategy for gaining insights into protein sumoylation in yeast. Mol Cell Proteomics. 2005 Mar; 4(3):246-54. PMID: 15542864.
    Citations: 119     Fields:    Translation:AnimalsCells
  78. Noma K, Sugiyama T, Cam H, Verdel A, Zofall M, Jia S, Moazed D, Grewal SI. RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat Genet. 2004 Nov; 36(11):1174-80. PMID: 15475954.
    Citations: 178     Fields:    Translation:AnimalsCells
  79. Tanny JC, Kirkpatrick DS, Gerber SA, Gygi SP, Moazed D. Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions. Mol Cell Biol. 2004 Aug; 24(16):6931-46. PMID: 15282295; PMCID: PMC479720.
    Citations: 45     Fields:    Translation:AnimalsCells
  80. Stegmeier F, Huang J, Rahal R, Zmolik J, Moazed D, Amon A. The replication fork block protein Fob1 functions as a negative regulator of the FEAR network. Curr Biol. 2004 Mar 23; 14(6):467-80. PMID: 15043811.
    Citations: 31     Fields:    Translation:AnimalsCells
  81. Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, Moazed D. RNAi-mediated targeting of heterochromatin by the RITS complex. Science. 2004 Jan 30; 303(5658):672-6. PMID: 14704433; PMCID: PMC3244756.
    Citations: 499     Fields:    Translation:AnimalsCells
  82. Moazed D, Rudner AD, Huang J, Hoppe GJ, Tanny JC. A model for step-wise assembly of heterochromatin in yeast. Novartis Found Symp. 2004; 259:48-56; discussion 56-62, 163-9. PMID: 15171246.
    Citations: 25     Fields:    Translation:AnimalsCells
  83. Huang J, Moazed D. Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev. 2003 Sep 01; 17(17):2162-76. PMID: 12923057; PMCID: PMC196457.
    Citations: 134     Fields:    Translation:Animals
  84. Grewal SI, Moazed D. Heterochromatin and epigenetic control of gene expression. Science. 2003 Aug 08; 301(5634):798-802. PMID: 12907790.
    Citations: 361     Fields:    Translation:HumansAnimalsCells
  85. Shankaranarayana GD, Motamedi MR, Moazed D, Grewal SI. Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast. Curr Biol. 2003 Jul 15; 13(14):1240-6. PMID: 12867036.
    Citations: 92     Fields:    Translation:AnimalsCells
  86. Chang JF, Hall BE, Tanny JC, Moazed D, Filman D, Ellenberger T. Structure of the coiled-coil dimerization motif of Sir4 and its interaction with Sir3. Structure. 2003 Jun; 11(6):637-49. PMID: 12791253.
    Citations: 32     Fields:    Translation:AnimalsCells
  87. Li J, Moazed D, Gygi SP. Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation. J Biol Chem. 2002 Dec 20; 277(51):49383-8. PMID: 12381723.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  88. Tanny JC, Moazed D. Recognition of acetylated proteins: lessons from an ancient family of enzymes. Structure. 2002 Oct; 10(10):1290-2. PMID: 12377115.
    Citations: 1     Fields:    Translation:Cells
  89. Hoppe GJ, Tanny JC, Rudner AD, Gerber SA, Danaie S, Gygi SP, Moazed D. Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol. 2002 Jun; 22(12):4167-80. PMID: 12024030.
    Citations: 155     Fields:    Translation:AnimalsCells
  90. Kellogg DR, Moazed D. Protein- and immunoaffinity purification of multiprotein complexes. Methods Enzymol. 2002; 351:172-83. PMID: 12073344.
    Citations: 3     Fields:    
  91. Moazed D. Common themes in mechanisms of gene silencing. Mol Cell. 2001 Sep; 8(3):489-98. PMID: 11583612.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  92. Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem. 2001 Oct 19; 276(42):38837-43. PMID: 11483616.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  93. Shou W, Sakamoto KM, Keener J, Morimoto KW, Traverso EE, Azzam R, Hoppe GJ, Feldman RM, DeModena J, Moazed D, Charbonneau H, Nomura M, Deshaies RJ. Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Mol Cell. 2001 Jul; 8(1):45-55. PMID: 11511359.
    Citations: 63     Fields:    Translation:AnimalsCells
  94. Moazed D. Enzymatic activities of Sir2 and chromatin silencing. Curr Opin Cell Biol. 2001 Apr; 13(2):232-8. PMID: 11248558.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  95. Tanny JC, Moazed D. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product. Proc Natl Acad Sci U S A. 2001 Jan 16; 98(2):415-20. PMID: 11134535; PMCID: PMC14600.
    Citations: 98     Fields:    Translation:AnimalsCells
  96. Tanny JC, Dowd GJ, Huang J, Hilz H, Moazed D. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell. 1999 Dec 23; 99(7):735-45. PMID: 10619427.
    Citations: 176     Fields:    Translation:AnimalsCells
  97. Straight AF, Shou W, Dowd GJ, Turck CW, Deshaies RJ, Johnson AD, Moazed D. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell. 1999 Apr 16; 97(2):245-56. PMID: 10219245.
    Citations: 177     Fields:    Translation:AnimalsCells
  98. Shou W, Seol JH, Shevchenko A, Baskerville C, Moazed D, Chen ZW, Jang J, Shevchenko A, Charbonneau H, Deshaies RJ. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell. 1999 Apr 16; 97(2):233-44. PMID: 10219244.
    Citations: 311     Fields:    Translation:AnimalsCells
  99. Merryman C, Moazed D, Daubresse G, Noller HF. Nucleotides in 23S rRNA protected by the association of 30S and 50S ribosomal subunits. J Mol Biol. 1999 Jan 08; 285(1):107-13. PMID: 9878392.
    Citations: 23     Fields:    Translation:Cells
  100. Merryman C, Moazed D, McWhirter J, Noller HF. Nucleotides in 16S rRNA protected by the association of 30S and 50S ribosomal subunits. J Mol Biol. 1999 Jan 08; 285(1):97-105. PMID: 9878391.
    Citations: 26     Fields:    Translation:Cells
  101. Moazed D, Kistler A, Axelrod A, Rine J, Johnson AD. Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2186-91. PMID: 9122169; PMCID: PMC20062.
    Citations: 106     Fields:    Translation:AnimalsCells
  102. Moazed D, Johnson D. A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae. Cell. 1996 Aug 23; 86(4):667-77. PMID: 8752220.
    Citations: 82     Fields:    Translation:AnimalsCells
  103. Moazed D, Samaha RR, Gualerzi C, Noller HF. Specific protection of 16 S rRNA by translational initiation factors. J Mol Biol. 1995 Apr 28; 248(2):207-10. PMID: 7739034.
    Citations: 52     Fields:    Translation:Cells
  104. Moazed D, O'Farrell PH. Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development. 1992 Nov; 116(3):805-10. PMID: 1363229; PMCID: PMC2755082.
    Citations: 50     Fields:    Translation:Animals
  105. Woodcock J, Moazed D, Cannon M, Davies J, Noller HF. Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA. EMBO J. 1991 Oct; 10(10):3099-103. PMID: 1915283; PMCID: PMC453027.
    Citations: 50     Fields:    Translation:Cells
  106. Moazed D, Noller HF. Sites of interaction of the CCA end of peptidyl-tRNA with 23S rRNA. Proc Natl Acad Sci U S A. 1991 May 01; 88(9):3725-8. PMID: 2023922; PMCID: PMC51525.
    Citations: 62     Fields:    Translation:Cells
  107. Moazed D, Noller HF. Binding of tRNA to the ribosomal A and P sites protects two distinct sets of nucleotides in 16 S rRNA. J Mol Biol. 1990 Jan 05; 211(1):135-45. PMID: 2405162.
    Citations: 92     Fields:    Translation:Cells
  108. Moazed D, Noller HF. Intermediate states in the movement of transfer RNA in the ribosome. Nature. 1989 Nov 09; 342(6246):142-8. PMID: 2682263.
    Citations: 285     Fields:    Translation:Cells
  109. Moazed D, Noller HF. Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites. Cell. 1989 May 19; 57(4):585-97. PMID: 2470511.
    Citations: 172     Fields:    Translation:Cells
  110. De Stasio EA, Moazed D, Noller HF, Dahlberg AE. Mutations in 16S ribosomal RNA disrupt antibiotic--RNA interactions. EMBO J. 1989 Apr; 8(4):1213-6. PMID: 2472961; PMCID: PMC400937.
    Citations: 58     Fields:    Translation:Cells
  111. Moazed D, Robertson JM, Noller HF. Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA. Nature. 1988 Jul 28; 334(6180):362-4. PMID: 2455872.
    Citations: 172     Fields:    Translation:Cells
  112. Stern S, Moazed D, Noller HF. Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension. Methods Enzymol. 1988; 164:481-9. PMID: 2468070.
    Citations: 212     Fields:    Translation:Cells
  113. Moazed D, Noller HF. Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA. Biochimie. 1987 Aug; 69(8):879-84. PMID: 3122849.
    Citations: 119     Fields:    Translation:Cells
  114. Moazed D, Noller HF. Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature. 1987 Jun 4-10; 327(6121):389-94. PMID: 2953976.
    Citations: 351     Fields:    Translation:Cells
  115. Noller HF, Stern S, Moazed D, Powers T, Svensson P, Changchien LM. Studies on the architecture and function of 16S rRNA. Cold Spring Harb Symp Quant Biol. 1987; 52:695-708. PMID: 3454283.
    Citations: 6     Fields:    Translation:Cells
  116. Moazed D, Noller HF. Transfer RNA shields specific nucleotides in 16S ribosomal RNA from attack by chemical probes. Cell. 1986 Dec 26; 47(6):985-94. PMID: 2430725.
    Citations: 150     Fields:    Translation:AnimalsCells
  117. Moazed D, Van Stolk BJ, Douthwaite S, Noller HF. Interconversion of active and inactive 30 S ribosomal subunits is accompanied by a conformational change in the decoding region of 16 S rRNA. J Mol Biol. 1986 Oct 05; 191(3):483-93. PMID: 2434656.
    Citations: 41     Fields:    Translation:Cells
  118. Moazed D, Stern S, Noller HF. Rapid chemical probing of conformation in 16 S ribosomal RNA and 30 S ribosomal subunits using primer extension. J Mol Biol. 1986 Feb 05; 187(3):399-416. PMID: 2422386.
    Citations: 224     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.