Tae Ho Lee, Ph.D.
|Title||Assistant Professor of Medicine|
|Institution||Beth Israel Deaconess Medical Center|
|Address||Beth Israel Deaconess Medical Center|
Gerontology, DA 519A
330 Brookline Ave
Boston MA 02215
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Our laboratory focuses on understanding the role that post-translational modifications in proteins including phosphorylation play in aging and age-related disease. Significantly, many of these aging modulators in other biological processes are regulated by protein phosphorylation, whose deregulation contributes to age-related disease, notably Alzheimer’s disease (AD). However, the significance and regulation of this signaling pathway in aging is largely unknown
We have recently shown that DAPK1 (death-associated protein kinase 1) is the inhibitory kinase responsible for phosphorylation of Pin1. This is especially exciting because Pin1 is a pivotal role in aging processes and Pin1 knockout mice display widespread premature aging and AD-like phenotypes. Our lab is interested in understanding how DAPK1 mediate the interplay between Pin1 activity and aging.
The main goals of our research are: 1) to determine the molecular mechanisms by which DAPK1 regulates in aging, 2) to understand pathogenic mechanisms in age-related diseases, and 3) to identify novel DAPK1 substrates and determine their function in normal aging and age-related disease. To accomplish these goals, our research integrates molecular biology, biochemistry, proteomics, cell biology and mouse genetics. This study will have a significant impact upon our basic understanding of aging and age-related disease, and might eventually facilitate the development of novel treatments of human diseases.
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