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I-Jen Chiu, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Perner C, Flayer CH, Zhu X, Aderhold PA, Dewan ZNA, Voisin T, Camire RB, Chow OA, Chiu IM, Sokol CL. Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity. 2020 Oct 21. PMID: 33098765.
  2. Wu M, Chen Y, Xia H, Wang C, Tan CY, Cai X, Liu Y, Ji F, Xiong P, Liu R, Guan Y, Duan Y, Kuang D, Xu S, Cai H, Xia Q, Yang D, Wang MW, Chiu IM, Cheng C, Ahern PP, Liu L, Wang G, Surana NK, Xia T, Kasper DL. Transcriptional and proteomic insights into the host response in fatal COVID-19 cases. Proc Natl Acad Sci U S A. 2020 Nov 10; 117(45):28336-28343. PMID: 33082228.
    Citations:    Fields:    
  3. Chiu I, Rolls A. Editorial overview: Brain, gut and immune system interactions. Curr Opin Neurobiol. 2020 06; 62:iii-v. PMID: 32507295.
    Citations:    Fields:    
  4. Chu C, Artis D, Chiu IM. Neuro-immune Interactions in the Tissues. Immunity. 2020 03 17; 52(3):464-474. PMID: 32187517.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Wang K, Yaghi OK, Spallanzani RG, Chen X, Zemmour D, Lai N, Chiu IM, Benoist C, Mathis D. Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5402-5408. PMID: 32102913.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 01; 577(7792):676-681. PMID: 31969699.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  7. Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020 01 09; 180(1):33-49.e22. PMID: 31813624.
    Citations: 9     Fields:    Translation:AnimalsCells
  8. Pinho-Ribeiro FA, Chiu IM. Nociceptor nerves set the stage for skin immunity. Cell Res. 2019 11; 29(11):877-878. PMID: 31619764.
    Citations: 1     Fields:    Translation:Cells
  9. Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):709-723.e6. PMID: 31604686.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Liu SW, Hsu CH, Chen MR, Chiu IM, Lin KM. A Tri-fusion Reporter Mouse Reveals Tissue-Specific FGF1B Promoter Activity in vivo. Sci Rep. 2019 07 31; 9(1):11143. PMID: 31367001.
  11. Baral P, Udit S, Chiu IM. Pain and immunity: implications for host defence. Nat Rev Immunol. 2019 07; 19(7):433-447. PMID: 30874629.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  12. Blake KJ, Jiang XR, Chiu IM. Neuronal Regulation of Immunity in the Skin and Lungs. Trends Neurosci. 2019 08; 42(8):537-551. PMID: 31213389.
    Citations: 2     Fields:    Translation:HumansAnimals
  13. Voisin T, Chiu IM. Mast Cells Get on Your Nerves in Itch. Immunity. 2019 05 21; 50(5):1117-1119. PMID: 31117004.
    Citations:    Fields:    Translation:HumansCells
  14. Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4. PMID: 31027995.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  15. Voisin T, Chiu IM. Molecular link between itch and atopic dermatitis. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12851-12853. PMID: 30538205.
    Citations:    Fields:    Translation:HumansCells
  16. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Author Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 Oct; 24(10):1625-1626. PMID: 30013196.
    Citations:    Fields:    
  17. Pinho-Ribeiro FA, Baddal B, Haarsma R, O'Seaghdha M, Yang NJ, Blake KJ, Portley M, Verri WA, Dale JB, Wessels MR, Chiu IM. Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. 2018 05 17; 173(5):1083-1097.e22. PMID: 29754819.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  18. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 05; 24(4):417-426. PMID: 29505031.
    Citations: 28     Fields:    Translation:AnimalsCells
  19. Blake KJ, Baral P, Voisin T, Lubkin A, Pinho-Ribeiro FA, Adams KL, Roberson DP, Ma YC, Otto M, Woolf CJ, Torres VJ, Chiu IM. Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nat Commun. 2018 01 02; 9(1):37. PMID: 29295977.
    Citations: 15     Fields:    Translation:AnimalsCells
  20. Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 11 30; 551(7682):658. PMID: 29143821.
    Citations:    Fields:    
  21. Chavan SS, Ma P, Chiu IM. Neuro-immune interactions in inflammation and host defense: Implications for transplantation. Am J Transplant. 2018 03; 18(3):556-563. PMID: 28941325.
    Citations: 5     Fields:    Translation:HumansAnimals
  22. Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 09 21; 549(7672):351-356. PMID: 28902842.
    Citations: 87     Fields:    Translation:AnimalsCells
  23. Voisin T, Bouvier A, Chiu IM. Neuro-immune interactions in allergic diseases: novel targets for therapeutics. Int Immunol. 2017 06 01; 29(6):247-261. PMID: 28814067.
    Citations: 12     Fields:    Translation:HumansAnimals
  24. Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. 2017 03 09; 168(6):1135-1148.e12. PMID: 28262351.
    Citations: 35     Fields:    Translation:AnimalsCells
  25. Chiu IM. Infection, Pain, and Itch. Neurosci Bull. 2018 Feb; 34(1):109-119. PMID: 28144843.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  26. Yang NJ, Chiu IM. Bacterial Signaling to the Nervous System through Toxins and Metabolites. J Mol Biol. 2017 03 10; 429(5):587-605. PMID: 28065740.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  27. Pinho-Ribeiro FA, Verri WA, Chiu IM. Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation. Trends Immunol. 2017 Jan; 38(1):5-19. PMID: 27793571.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  28. Baral P, Mills K, Pinho-Ribeiro FA, Chiu IM. Pain and Itch: Beneficial or Harmful to Antimicrobial Defense? . 2016 Jun 08; 19(6):755-9. PMID: 27281567.
    Citations: 10     Translation:HumansCells
  29. Chiu IM, Pinho-Ribeiro FA, Woolf CJ. Pain and infection: pathogen detection by nociceptors. Pain. 2016 06; 157(6):1192-3. PMID: 27183444.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  30. Hsu YC, Kao CY, Chung YF, Lee DC, Liu JW, Chiu IM. Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells. Exp Cell Res. 2016 06 10; 344(2):153-66. PMID: 27138904.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  31. Tarn WY, Kuo HC, Yu HI, Liu SW, Tseng CT, Dhananjaya D, Hung KY, Tu CC, Chang SH, Huang GJ, Chiu IM. RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression. Mol Biol Cell. 2016 05 15; 27(10):1676-83. PMID: 27009199.
    Citations: 9     Fields:    Translation:AnimalsCells
  32. Ghasemlou N, Chiu IM, Julien JP, Woolf CJ. CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6808-17. PMID: 26598697.
    Citations: 31     Fields:    Translation:AnimalsCells
  33. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54. PMID: 26119026.
    Citations: 66     Fields:    Translation:AnimalsCells
  34. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2014 Dec 19; 3. PMID: 25525749.
    Citations: 66     Fields:    Translation:AnimalsCells
  35. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. PMID: 25420066.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  36. Chen MS, Lin HK, Chiu H, Lee DC, Chung YF, Chiu IM. Human FGF1 promoter is active in ependymal cells and dopaminergic neurons in the brains of F1B-GFP transgenic mice. Dev Neurobiol. 2015 Mar; 75(3):232-48. PMID: 25104610.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  37. Hsu YC, Chen SL, Wang YJ, Chen YH, Wang DY, Chen L, Chen CH, Chen HH, Chiu IM. Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons. Stem Cells Transl Med. 2014 Jun; 3(6):713-22. PMID: 24736401.
    Citations: 1     Fields:    Translation:HumansCells
  38. Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 05; 501(7465):52-7. PMID: 23965627.
    Citations: 168     Fields:    Translation:AnimalsCells
  39. Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep. 2013 Jul 25; 4(2):385-401. PMID: 23850290.
    Citations: 191     Fields:    Translation:HumansAnimalsCells
  40. Liu JW, Hsu YC, Kao CY, Su HL, Chiu IM. Leukemia inhibitory factor-induced Stat3 signaling suppresses fibroblast growth factor 1-induced Erk1/2 activation to inhibit the downstream differentiation in mouse embryonic stem cells. Stem Cells Dev. 2013 Apr 15; 22(8):1190-7. PMID: 23205673.
    Citations: 5     Fields:    Translation:AnimalsCells
  41. Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci. 2012 Jul 26; 15(8):1063-7. PMID: 22837035.
    Citations: 121     Fields:    Translation:HumansCells
  42. Wang TC, Chiu H, Chang YJ, Hsu TY, Chiu IM, Chen L. The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons. PLoS One. 2011; 6(10):e26433. PMID: 22028877.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  43. Chen CW, Liu CS, Chiu IM, Shen SC, Pan HC, Lee KH, Lin SZ, Su HL. The signals of FGFs on the neurogenesis of embryonic stem cells. J Biomed Sci. 2010 Apr 29; 17:33. PMID: 20429889.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  44. Chen YC, Lee DC, Tsai TY, Hsiao CY, Liu JW, Kao CY, Lin HK, Chen HC, Palathinkal TJ, Pong WF, Tai NH, Lin IN, Chiu IM. Induction and regulation of differentiation in neural stem cells on ultra-nanocrystalline diamond films. Biomaterials. 2010 Jul; 31(21):5575-87. PMID: 20427083.
    Citations: 15     Fields:    Translation:AnimalsCells
  45. Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20960-5. PMID: 19933335.
    Citations: 63     Fields:    Translation:AnimalsCells
  46. Lee DC, Hsu YC, Chung YF, Hsiao CY, Chen SL, Chen MS, Lin HK, Chiu IM. Isolation of neural stem/progenitor cells by using EGF/FGF1 and FGF1B promoter-driven green fluorescence from embryonic and adult mouse brains. Mol Cell Neurosci. 2009 Jul; 41(3):348-63. PMID: 19409495.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  47. Chen YC, Lee DC, Hsiao CY, Chung YF, Chen HC, Thomas JP, Pong WF, Tai NH, Lin IN, Chiu IM. The effect of ultra-nanocrystalline diamond films on the proliferation and differentiation of neural stem cells. Biomaterials. 2009 Jul; 30(20):3428-35. PMID: 19406465.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  48. Hsu YC, Lee DC, Chen SL, Liao WC, Lin JW, Chiu WT, Chiu IM. Brain-specific 1B promoter of FGF1 gene facilitates the isolation of neural stem/progenitor cells with self-renewal and multipotent capacities. Dev Dyn. 2009 Feb; 238(2):302-14. PMID: 18855895.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  49. Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH, Carroll MC. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17913-8. PMID: 18997009.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  50. Yen ML, Chien CC, Chiu IM, Huang HI, Chen YC, Hu HI, Yen BL. Multilineage differentiation and characterization of the human fetal osteoblastic 1.19 cell line: a possible in vitro model of human mesenchymal progenitors. Stem Cells. 2007 Jan; 25(1):125-31. PMID: 17204605.
    Citations: 16     Fields:    Translation:HumansCells
  51. Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol. 2006 Oct 23; 175(2):209-15. PMID: 17060494.
    Citations: 99     Fields:    Translation:AnimalsCells
  52. Hu PY, Liu LT, Wu SJ, Chiu IS. Ventricular septal defect repair by the left-handed operator. J Card Surg. 2006 Mar-Apr; 21(2):170-1. PMID: 16492279.
    Citations:    Fields:    Translation:Humans
  53. Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC. Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006 Jan 23; 203(1):141-52. PMID: 16390934.
    Citations: 92     Fields:    Translation:Animals
  54. Deng LW, Chiu I, Strominger JL. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):757-62. PMID: 14718661.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.