Harvard Catalyst Profiles

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Naoki Akanuma, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Akanuma N, Liu J, Liou GY, Yin X, Bejar KR, Liu C, Sun LZ, Storz P, Wang P. Paracrine Secretion of Transforming Growth Factor ß by Ductal Cells Promotes Acinar-to-Ductal Metaplasia in Cultured Human Exocrine Pancreas Tissues. Pancreas. 2017 10; 46(9):1202-1207. PMID: 28902792.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  2. Toyozumi T, Hoshino I, Takahashi M, Usui A, Akutsu Y, Hanari N, Murakami K, Kano M, Akanuma N, Suitoh H, Matsumoto Y, Sekino N, Komatsu A, Matsubara H. Fra-1 Regulates the Expression of HMGA1, Which is Associated with a Poor Prognosis in Human Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 2017 Oct; 24(11):3446-3455. PMID: 27882471.
    Citations: 4     Fields:    Translation:HumansCells
  3. Liu J, Akanuma N, Liu C, Naji A, Halff GA, Washburn WK, Sun L, Wang P. TGF-ß1 promotes acinar to ductal metaplasia of human pancreatic acinar cells. Sci Rep. 2016 08 03; 6:30904. PMID: 27485764.
    Citations: 11     Fields:    Translation:HumansCells
  4. Maruyama T, Akutsu Y, Suganami A, Tamura Y, Fujito H, Ouchi T, Akanuma N, Isozaki Y, Takeshita N, Hoshino I, Uesato M, Toyota T, Hayashi H, Matsubara H. Treatment of near-infrared photodynamic therapy using a liposomally formulated indocyanine green derivative for squamous cell carcinoma. PLoS One. 2015; 10(4):e0122849. PMID: 25850029.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Hoshino I, Akutsu Y, Murakami K, Akanuma N, Isozaki Y, Maruyama T, Toyozumi T, Matsumoto Y, Suito H, Takahashi M, Sekino N, Komatsu A, Suzuki T, Matsubara H. Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells. Ann Surg Oncol. 2016 Jan; 23(1):312-20. PMID: 25791791.
    Citations: 7     Fields:    Translation:HumansCells
  6. Hoshino I, Maruyama T, Fujito H, Tamura Y, Suganami A, Hayashi H, Toyota T, Akutsu Y, Murakami K, Isozaki Y, Akanuma N, Takeshita N, Toyozumi T, Komatsu A, Matsubara H. Detection of peritoneal dissemination with near-infrared fluorescence laparoscopic imaging using a liposomal formulation of a synthesized indocyanine green liposomal derivative. Anticancer Res. 2015 Mar; 35(3):1353-9. PMID: 25750285.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Isozaki Y, Hoshino I, Akutsu Y, Hanari N, Mori M, Nishimori T, Murakami K, Akanuma N, Takeshita N, Maruyama T, Toyozumi T, Takahashi M, Suito H, Matsubara H. Usefulness of microRNA-375 as a prognostic and therapeutic tool in esophageal squamous cell carcinoma. Int J Oncol. 2015 Mar; 46(3):1059-66. PMID: 25501018.
    Citations: 6     Fields:    Translation:HumansAnimals
  8. Akutsu Y, Hanari N, Kono T, Uesato M, Hoshino I, Murakami K, Natsume T, Isozaki Y, Akanuma N, Toyozumi T, Suito H, Matsubara H. The outcome of laparoscopic surgery with and without short gastric vessel division for achalasia. Int Surg. 2014 Nov-Dec; 99(6):846-50. PMID: 25437598.
    Citations:    Fields:    Translation:Humans
  9. Qin W, Akutsu Y, Andocs G, Suganami A, Hu X, Yusup G, Komatsu-Akimoto A, Hoshino I, Hanari N, Mori M, Isozaki Y, Akanuma N, Tamura Y, Matsubara H. Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice. Oncol Rep. 2014 Dec; 32(6):2373-9. PMID: 25242303.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  10. Isozaki Y, Hoshino I, Akutsu Y, Hanari N, Mori M, Nishimori T, Murakami K, Akanuma N, Toyozumi T, Takahashi M, Suito H, Takeshita N, Maruyama T, Suzuki A, Nakayama T, Matsubara H. Screening of alternative drugs to the tumor suppressor miR-375 in esophageal squamous cell carcinoma using the connectivity map. Oncology. 2014; 87(6):351-63. PMID: 25195536.
    Citations: 3     Fields:    Translation:HumansCells
  11. Nakano A, Akutsu Y, Shuto K, Uesato M, Kono T, Hoshino I, Akanuma N, Maruyama T, Isozaki Y, Matsubara H. Giant esophageal gastrointestinal stromal tumor: report of a case. Surg Today. 2015 Feb; 45(2):247-52. PMID: 24890800.
    Citations: 2     Fields:    Translation:Humans
  12. Yusup G, Akutsu Y, Mutallip M, Qin W, Hu X, Komatsu-Akimoto A, Hoshino I, Hanari N, Mori M, Akanuma N, Isozaki Y, Matsubara H. A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma. Int J Oncol. 2014 Apr; 44(4):1146-52. PMID: 24535229.
    Citations: 9     Fields:    Translation:HumansCells
  13. Sakaida E, Sekine I, Iwasawa S, Kurimoto R, Uehara T, Ooka Y, Akanuma N, Tada Y, Imai C, Oku T, Takiguchi Y. Incidence, risk factors and treatment outcomes of extravasation of cytotoxic agents in an outpatient chemotherapy clinic. Jpn J Clin Oncol. 2014 Feb; 44(2):168-71. PMID: 24302758.
    Citations: 1     Fields:    Translation:Humans
  14. Akutsu Y, Uesato M, Shuto K, Kono T, Hoshino I, Horibe D, Sazuka T, Takeshita N, Maruyama T, Isozaki Y, Akanuma N, Matsubara H. The overall prevalence of metastasis in T1 esophageal squamous cell carcinoma: a retrospective analysis of 295 patients. Ann Surg. 2013 Jun; 257(6):1032-8. PMID: 23108117.
    Citations: 44     Fields:    Translation:Humans
  15. Akutsu Y, Shuto K, Kono T, Uesato M, Hoshino I, Shiratori T, Miyazawa Y, Isozaki Y, Akanuma N, Matsubara H. A phase 1/11 study of second-line chemotherapy with fractionated docetaxel and nedaplatin for 5-FU/cisplatin-resistant esophageal squamous cell carcinoma. Hepatogastroenterology. 2012 Oct; 59(119):2095-8. PMID: 22328303.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  16. Takeshita N, Mori M, Kano M, Hoshino I, Akutsu Y, Hanari N, Yoneyama Y, Ikeda N, Isozaki Y, Maruyama T, Akanuma N, Miyazawa Y, Matsubara H. miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1. Int J Oncol. 2012 Nov; 41(5):1653-61. PMID: 22940702.
    Citations: 29     Fields:    Translation:HumansCells
  17. Isozaki Y, Hoshino I, Nohata N, Kinoshita T, Akutsu Y, Hanari N, Mori M, Yoneyama Y, Akanuma N, Takeshita N, Maruyama T, Seki N, Nishino N, Yoshida M, Matsubara H. Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma. Int J Oncol. 2012 Sep; 41(3):985-94. PMID: 22752059.
    Citations: 21     Fields:    Translation:HumansCells
  18. Akanuma N, Hoshino I, Akutsu Y, Shuto K, Shiratori T, Kono T, Uesato M, Sato A, Isozaki Y, Maruyama T, Takeshita N, Matsubara H. Primary esophageal adenocarcinoma arising from heterotopic gastric mucosa: report of a case. Surg Today. 2013 Apr; 43(4):446-51. PMID: 22706784.
    Citations: 5     Fields:    Translation:Humans
  19. Akutsu Y, Shuto K, Kono T, Uesato M, Hoshino I, Shiratori T, Isozaki Y, Akanuma N, Uno T, Matsubara H. The number of pathologic lymph nodes involved is still a significant prognostic factor even after neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma. J Surg Oncol. 2012 Jun 15; 105(8):756-60. PMID: 22162007.
    Citations: 10     Fields:    Translation:Humans
  20. Imai K, Shirotani N, Hirai E, Akanuma N, Nishino T, Sato J, Kimura K, Egawa T, Shimono S. [The present state and task of the Palliative Care Team at Tokyo Women's Medical University Yachiyo Medical Center]. Gan To Kagaku Ryoho. 2007 Dec; 34 Suppl 2:201-2. PMID: 20443260.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.