Harvard Catalyst Profiles

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Daniel Lawrence Faden, M.D.

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Biography
education and training
UCSF, San Francisco, CA07/2016Otolaryngology-Head and Neck Surgery

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R21 (Daniel Faden) Jul 1, 2022 - Jul 1, 2024
    NIH/NCI
    Circulating HPV DNA as a Prediagnostic Marker of Oropharyngeal Cancer
    Role: PI
  2. R03 (Daniel Faden) Apr 1, 2022 - Apr 1, 2024
    NIH/NIDCR
    Cell free HPV DNA detection in the diagnostic and surgical settings
    Role: PI
  3. K23 (Daniel Faden) Apr 1, 2021 - Apr 1, 2026
    NIH/NIDCR
    Dissecting Spatial and Temporal Dynamics of Immunotherapy Resistance
    Role: PI
  4. KL2 (Daniel Faden) Sep 1, 2020 - Sep 1, 2022
    NIH/Harvard Catalyst
    Dissecting temporal and spatial dynamics of immunotherapy resistance
    Role: PI

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Naegele S, Efthymiou V, Das D, Sadow PM, Richmon JD, Iafrate AJ, Faden DL. Detection and Monitoring of Circulating Tumor HPV DNA in HPV-Associated Sinonasal and Nasopharyngeal Cancers. JAMA Otolaryngol Head Neck Surg. 2023 02 01; 149(2):179-181. PMID: 36520425; PMCID: PMC9857222.
    Citations:    Fields:    Translation:HumansCells
  2. Miller LE, Au VH, Sivarajah S, Lin DT, Deschler DG, Varvares MA, Faden DL, Feng AL, Sadow PM, Richmon JD. Rate of atypical nodal metastases in surgically treated HPV-associated oropharyngeal squamous cell carcinoma. Head Neck. 2023 02; 45(2):409-416. PMID: 36416254; PMCID: PMC9875888.
    Citations:    Fields:    Translation:Humans
  3. Lin M, Sade-Feldman M, Wirth L, Lawrence MS, Faden DL. Single-cell transcriptomic profiling for inferring tumor origin and mechanisms of therapeutic resistance. NPJ Precis Oncol. 2022 Oct 10; 6(1):71. PMID: 36210388; PMCID: PMC9548500.
    Citations:    
  4. Rettig EM, Faden DL, Sandhu S, Wong K, Faquin WC, Warinner C, Stephens P, Kumar S, Kuperwasser C, Richmon JD, Uppaluri R, Varvares M, Sethi R, Hanna GJ, Sroussi H. Detection of circulating tumor human papillomavirus DNA before diagnosis of HPV-positive head and neck cancer. Int J Cancer. 2022 10 01; 151(7):1081-1085. PMID: 35262203.
    Citations: 1     Fields:    
  5. Lang Kuhs KA, Faden DL, Chen L, Smith DK, Pinheiro M, Wood CB, Davis S, Yeager M, Boland JF, Cullen M, Steinberg M, Bass S, Wang X, Liu P, Mehrad M, Tucker T, Lewis JS, Ferris RL, Mirabello L. Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosis. Ann Oncol. 2022 06; 33(6):638-648. PMID: 35306154; PMCID: PMC9350957.
    Citations:    Fields:    Translation:HumansCells
  6. Miller LE, Au V, Mokhtari TE, Goss D, Faden DL, Varvares MA. A Contemporary Review of Molecular Therapeutic Targets for Adenoid Cystic Carcinoma. Cancers (Basel). 2022 Feb 16; 14(4). PMID: 35205740; PMCID: PMC8869877.
    Citations:    
  7. Siravegna G, O'Boyle CJ, Varmeh S, Queenan N, Michel A, Stein J, Thierauf J, Sadow PM, Faquin WC, Perry SK, Bard AZ, Wang W, Deschler DG, Emerick KS, Varvares MA, Park JC, Clark JR, Chan AW, Andreu Arasa VC, Sakai O, Lennerz J, Corcoran RB, Wirth LJ, Lin DT, Iafrate AJ, Richmon JD, Faden DL. Cell-Free HPV DNA Provides an Accurate and Rapid Diagnosis of HPV-Associated Head and Neck Cancer. Clin Cancer Res. 2022 02 15; 28(4):719-727. PMID: 34857594; PMCID: PMC8866203.
    Citations: 2     Fields:    Translation:HumansCells
  8. O'Boyle CJ, Siravegna G, Varmeh S, Queenan N, Michel A, Pang KCS, Stein J, Thierauf JC, Sadow PM, Faquin WC, Wang W, Deschler DG, Emerick KS, Varvares MA, Park JC, Clark JR, Chan AW, Busse PM, Corcoran RB, Wirth LJ, Lin DT, Iafrate AJ, Richmon JD, Faden DL. Cell-free human papillomavirus DNA kinetics after surgery for human papillomavirus-associated oropharyngeal cancer. Cancer. 2022 06 01; 128(11):2193-2204. PMID: 35139236.
    Citations: 2     Fields:    Translation:HumansCells
  9. Haas M, Hansen EE, Lewis JS, Faden DL. Is it Time for a Molecular-based Classification System for Sinonasal Squamous Cell Carcinoma? Am J Surg Pathol. 2022 07 01; 46(7):873-877. PMID: 35131987.
    Citations:    Fields:    Translation:Humans
  10. Wang JJ, Rubin SJ, Devaiah AK, Faden DL, Salama AR, Edwards HA. Long-Term Opioid Use in Post-Surgical Management of Patients With Head and Neck Cancer. Ann Otol Rhinol Laryngol. 2022 Aug; 131(8):844-850. PMID: 34521247.
    Citations: 1     Fields:    Translation:Humans
  11. Faden DL, Kuhs KAL, Lin M, Langenbucher A, Pinheiro M, Yeager M, Cullen M, Boland JF, Steinberg M, Bass S, Lewis JS, Lawrence MS, Ferris RL, Mirabello L. APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma. Viruses. 2021 08 23; 13(8). PMID: 34452530; PMCID: PMC8402723.
    Citations: 2     Fields:    Translation:HumansCells
  12. Vyas A, Harbison RA, Faden DL, Kubik M, Palmer D, Zhang Q, Osmanbeyoglu HU, Kiselyov K, Méndez E, Duvvuri U. Recurrent Human Papillomavirus-Related Head and Neck Cancer Undergoes Metabolic Reprogramming and Is Driven by Oxidative Phosphorylation. Clin Cancer Res. 2021 11 15; 27(22):6250-6264. PMID: 34407971; PMCID: PMC8611487.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Faden DL. Liquid biopsy for the diagnosis of HPV-associated head and neck cancer. Cancer Cytopathol. 2022 01; 130(1):12-15. PMID: 34375020.
    Citations: 1     Fields:    Translation:HumansCells
  14. Feng AL, Holcomb AJ, Abt NB, Mokhtari TE, Suresh K, McHugh CI, Parikh AS, Holman A, Kammer RE, Goldsmith TA, Faden DL, Deschler DG, Varvares MA, Lin DT, Richmon JD. Feeding Tube Placement Following Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2022 04; 166(4):696-703. PMID: 34154449.
    Citations: 1     Fields:    Translation:Humans
  15. Holcomb AJ, Herberg M, Strohl M, Ochoa E, Feng AL, Abt NB, Mokhtari TE, Suresh K, McHugh CI, Parikh AS, Sadow P, Faquin W, Faden D, Deschler DG, Varvares MA, Lin DT, Fakhry C, Ryan WR, Richmon JD. Impact of surgical margins on local control in patients undergoing single-modality transoral robotic surgery for HPV-related oropharyngeal squamous cell carcinoma. Head Neck. 2021 08; 43(8):2434-2444. PMID: 33856083; PMCID: PMC9361190.
    Citations: 1     Fields:    Translation:Humans
  16. Lewis JS, Mirabello L, Liu P, Wang X, Dupont WD, Plummer WD, Pinheiro M, Yeager M, Boland JF, Cullen M, Steinberg M, Bass S, Mehrad M, O'Boyle C, Lin M, Faden DL, Lang-Kuhs KA. Oropharyngeal Squamous Cell Carcinoma Morphology and Subtypes by Human Papillomavirus Type and by 16 Lineages and Sublineages. Head Neck Pathol. 2021 Dec; 15(4):1089-1098. PMID: 33797697; PMCID: PMC8633182.
    Citations: 1     Fields:    Translation:HumansCells
  17. Patel KR, Lehmann AE, Jafari A, Faden DL. Prolapsed Nasal Polyp Causing Acute Airway Obstruction: An Exceptional Presentation. ORL J Otorhinolaryngol Relat Spec. 2021; 83(3):203-205. PMID: 33657548.
    Citations:    Fields:    Translation:Humans
  18. Faden DL, O'Boyle CJ, Lin DT, Deschler DG, Emerick KS, Varvares MA, Faquin WC, Sadow PM, Richmon JD. Prospective assessment of multiple HPV-positive oropharyngeal squamous cell carcinomas. Oral Oncol. 2021 06; 117:105212. PMID: 33602576; PMCID: PMC9353616.
    Citations:    Fields:    Translation:HumansCells
  19. Faden DL, Langenbucher A, Kuhs K, Lewis JS, Mirabello L, Yeager M, Boland JF, Bass S, Steinberg M, Cullen M, Lawrence MS, Ferris RL. HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures. Carcinogenesis. 2021 02 11; 42(1):14-20. PMID: 33075810; PMCID: PMC8014522.
    Citations: 1     Fields:    Translation:HumansCells
  20. Park JJ, Qureshi MM, Lam CM, Faden DL, Truong MT. A national cancer database analysis on stereotactic body radiation therapy of head and neck cancers. Am J Otolaryngol. 2021 May-Jun; 42(3):102913. PMID: 33460976.
    Citations:    Fields:    Translation:Humans
  21. Chang Sing Pang KJW, Mur T, Collins L, Rao SR, Faden DL. Human Papillomavirus in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Cancers (Basel). 2020 Dec 25; 13(1). PMID: 33561073.
    Citations: 5     
  22. Abt NB, Holcomb AJ, Feng AL, Suresh K, Mokhtari TE, McHugh CI, Parikh AS, Faden DL, Deschler DG, Varvares MA, Lin DT, Richmon JD. Opioid Usage and Prescribing Predictors Following Transoral Robotic Surgery for Oropharyngeal Cancer. Laryngoscope. 2021 06; 131(6):E1888-E1894. PMID: 33210756.
    Citations:    Fields:    Translation:Humans
  23. Campbell BR, Chen Z, Faden DL, Agrawal N, Li RJ, Hanna GJ, Iyer NG, Boot A, Rozen SG, Vettore AL, Panda B, Krishnan NM, Pickering CR, Myers JN, Guo X, Lang Kuhs KA. The mutational landscape of early- and typical-onset oral tongue squamous cell carcinoma. Cancer. 2021 02 15; 127(4):544-553. PMID: 33146897; PMCID: PMC7891879.
    Citations: 9     Fields:    Translation:Humans
  24. Park JC, Durbeck J, Clark JR, Faden DL. Treatment sequence of cetuximab and immune checkpoint inhibitor in head and neck squamous cell carcinoma differentially affects outcomes. Oral Oncol. 2020 12; 111:105024. PMID: 33065374.
    Citations: 1     Fields:    Translation:HumansCells
  25. Bollig CA, Lee DS, Mazul AL, Stepan K, Puram SV, Massa ST, Zenga J, Faden DL, Doering MM, Jackson RS, Pipkorn P. Systematic Review of Second Primary Oropharyngeal Cancers in Patients With p16+ Oropharyngeal Cancer. Otolaryngol Head Neck Surg. 2021 04; 164(4):733-740. PMID: 32928026.
    Citations: 1     Fields:    Translation:Humans
  26. Hildrew DM, Pang KCS, Faden D. Otolaryngology in the time of COVID: An overview of common open-source telemedicine platforms. Laryngoscope Investig Otolaryngol. 2020 Oct; 5(5):839-845. PMID: 33134530.
    Citations:    
  27. Mur T, Sakai O, Tracy L, Suzuki K, Faden D. Endopharyngeal Ultrasound: description of a novel technique to overcome a common diagnostic dilemma in a patient with a deep neck space mass. Clin Otolaryngol. 2020 Nov; 45(6):923-925. PMID: 32578375.
    Citations:    Fields:    Translation:Humans
  28. Elgart K, Faden DL. Sinonasal Squamous Cell Carcinoma: Etiology, Pathogenesis, and the Role of Human Papilloma Virus. Curr Otorhinolaryngol Rep. 2020 Jun; 8(2):111-119. PMID: 32582473; PMCID: PMC7314379.
    Citations: 7     
  29. Kim KN, Dyer MA, Qureshi MM, Shah NK, Grillone GA, Faden DL, Jalisi SM, Truong MT. Hypofractionated radiotherapy and surgery compared to standard radiotherapy in early glottic cancer. Am J Otolaryngol. 2020 Sep - Oct; 41(5):102544. PMID: 32505989.
    Citations: 1     Fields:    Translation:Humans
  30. Park JC, Faquin WC, Durbeck J, Faden DL. Immune checkpoint inhibitors in sinonasal squamous cell carcinoma. Oral Oncol. 2020 10; 109:104776. PMID: 32414645.
    Citations: 1     Fields:    Translation:Humans
  31. Faden DL, Chang Sing Pang K, Hildrew DM. The age of telemedicine is upon us. Laryngoscope Investig Otolaryngol. 2020 Jun; 5(3):584-585. PMID: 32587890.
    Citations: 2     
  32. Strober W, Shishido S, Wood B, Lewis JS, Kuhs K, Ferris RL, Faden DL. Two for the price of one: Prevalence, demographics and treatment implications of multiple HPV mediated Head and Neck Cancers. Oral Oncol. 2020 01; 100:104475. PMID: 31765835; PMCID: PMC7017724.
    Citations: 5     Fields:    Translation:Humans
  33. Faden DL, Ding F, Lin Y, Zhai S, Kuo F, Chan TA, Morris LG, Ferris RL. APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma. Oral Oncol. 2019 09; 96:140-147. PMID: 31422205; PMCID: PMC7492081.
    Citations: 19     Fields:    Translation:Humans
  34. Faden DL, Gomez-Casal R, Alvarado D, Duvvuri U. Genomic Correlates of Exceptional Response to ErbB3 Inhibition in Head and Neck Squamous Cell Carcinoma. JCO Precis Oncol. 2019; 3. PMID: 31440738.
    Citations: 3     Fields:    
  35. Lavigne P, Faden D, Gardner PA, Fernandez-Miranda JC, Wang EW, Snyderman CH. Validation of training levels in endoscopic endonasal surgery of the skull base. Laryngoscope. 2019 10; 129(10):2253-2257. PMID: 30843604.
    Citations: 3     Fields:    Translation:Humans
  36. Faden DL, Concha-Benavente F, Chakka AB, McMichael EL, Chandran U, Ferris RL. Immunogenomic correlates of response to cetuximab monotherapy in head and neck squamous cell carcinoma. Head Neck. 2019 08; 41(8):2591-2601. PMID: 30828910.
    Citations: 8     Fields:    Translation:HumansCells
  37. Lavigne P, Faden DL, Wang EW, Snyderman CH. Complications of Nasoseptal Flap Reconstruction: A Systematic Review. J Neurol Surg B Skull Base. 2018 Oct; 79(Suppl 4):S291-S299. PMID: 30210981; PMCID: PMC6133677.
    Citations: 11     
  38. Faden DL, Hughes MA, Lavigne P, Jankowitz BT, Wang EW, Fernandez-Miranda JC, Gardner PA, Snyderman CH. Diagnosis and endoscopic endonasal management of nontraumatic pseudoaneurysms of the cranial base. Int Forum Allergy Rhinol. 2018 05; 8(5):641-647. PMID: 29485762.
    Citations:    Fields:    Translation:Humans
  39. Faden DL, Thomas S, Cantalupo PG, Agrawal N, Myers J, DeRisi J. Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma. Oral Oncol. 2017 11; 74:8-14. PMID: 29103756.
    Citations: 23     Fields:    Translation:HumansCells
  40. Markey JD, Alemi AS, Naunheim ML, Faden DL, Heaton CM, Seth R. Spontaneous Iliopsoas Hematoma following Microvascular Free Tissue Transfer. Case Rep Otolaryngol. 2017; 2017:7631673. PMID: 28536664; PMCID: PMC5425841.
    Citations:    
  41. Faden DL, Asthana S, Tihan T, DeRisi J, Kliot M. Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1. PLoS One. 2017; 12(1):e0170348. PMID: 28099461; PMCID: PMC5242532.
    Citations: 12     Fields:    Translation:HumansCells
  42. Faden DL, Algazi A. Durable treatment of ameloblastoma with single agent BRAFi Re: Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma. J Natl Cancer Inst. 2017 01; 109(1). PMID: 27671684.
    Citations: 15     Fields:    
  43. Faden DL, Arron ST, Heaton CM, DeRisi J, South AP, Wang SJ. Targeted next-generation sequencing of TP53 in oral tongue carcinoma from non-smokers. J Otolaryngol Head Neck Surg. 2016 Sep 17; 45(1):47. PMID: 27640185.
    Citations: 3     Fields:    Translation:Humans
  44. Alemi AS, Faden DL. Otolaryngologic Manifestations of Levamisole-Induced Vasculitis. JAMA Otolaryngol Head Neck Surg. 2016 Mar; 142(3):299-300. PMID: 26822711.
    Citations:    Fields:    Translation:Humans
  45. Faden DL, Orloff LA, Ayeni T, Fink DS, Yung K. Stimulation threshold greatly affects the predictive value of intraoperative nerve monitoring. Laryngoscope. 2015 May; 125(5):1265-70. PMID: 25302692.
    Citations:    Fields:    Translation:Humans
  46. Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, Richmon J, Wood LD, Hruban RH, Bishop J, Westra WH, Chung CH, Califano J, Gourin CG, Bettegowda C, Meyerson M, Papadopoulos N, Kinzler KW, Vogelstein B, DeRisi JL, Koch WM, Agrawal N. Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Head Neck. 2015 Nov; 37(11):1642-9. PMID: 24954188.
    Citations: 35     Fields:    Translation:Humans
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