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Fu Gui, Ph.D.

Title
Institution
Department
Address

Biography
Brigham and Women's Hospital, Boston, MAUrological Oncology
Mayo Clinic, FL, Jacksonville, FL10/2018Cancer Biology

Overview
My long-term research interests involve the mechanism of human tumorigenesis, targeted therapy of human cancers, the mechanisms of therapeutic response, and the mechanism of drug resistance to targeted therapies. My academic training and research experience have provided me with an excellent background in multiple biological disciplines including molecular biology, microbiology, and cell biology to successfully carry out the proposed research project. During my doctoral research, I was working on targeted therapeutics for human cancers using small-molecule inhibitors of various kinases. During my postdoctoral research in Dr. Ji's lab, my research focuses on developing novel therapeutic strategies and generating novel, inducible mouse models for pancreatitis and pancreatic cancer. I received the 2018 APA Young Investigator Award. Now during my second postdoctoral research in Dr. Jia's lab, my research focuses on the oncogenic WNT signaling and the resistant mechanism of BET bromodomain inhibitor JQ1 in prostate cancers and CDK12 degraders for prostate cancer therapy. The proposed research and training will further enhance my ability to be an independent investigator. And after years of efforts, I have successfully carried out and deeply involved in several projects.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lu Z, Sun Z, Li Y, Hao R, Chen Y, Chen B, Qin X, Tao X, Gui F. Effects of Elevated CO2 Concentration on Host Adaptability and Chlorantraniliprole Susceptibility in Spodoptera frugiperda. Insects. 2022 Nov 07; 13(11). PMID: 36354853.
    Citations:    
  2. Miao C, Tsujino T, Takai T, Gui F, Tsutsumi T, Sztupinszki Z, Wang Z, Azuma H, Szallasi Z, Mouw KW, Zou L, Kibel AS, Jia L. RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer. Sci Adv. 2022 02 18; 8(7):eabl9794. PMID: 35179959; PMCID: PMC8856618.
    Citations: 1     Fields:    Translation:HumansCells
  3. Sun Z, Wang R, Du Y, Gao B, Gui F, Lu K. Olfactory perception of herbicide butachlor by GOBP2 elicits ecdysone biosynthesis and detoxification enzyme responsible for chlorpyrifos tolerance in Spodoptera litura. Environ Pollut. 2021 Sep 15; 285:117409. PMID: 34049133.
    Citations:    Fields:    Translation:Animals
  4. Gui F, Lan T, Zhao Y, Guo W, Dong Y, Fang D, Liu H, Li H, Wang H, Hao R, Cheng X, Li Y, Yang P, Sahu SK, Chen Y, Cheng L, He S, Liu P, Fan G, Lu H, Hu G, Dong W, Chen B, Jiang Y, Zhang Y, Xu H, Lin F, Slippers B, Postma A, Jackson M, Abate BA, Tesfaye K, Demie AL, Bayeleygne MD, Degefu DT, Chen F, Kuria PK, Kinyua ZM, Liu TX, Yang H, Huang F, Liu X, Sheng J, Kang L. Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda. Protein Cell. 2022 07; 13(7):513-531. PMID: 33108584; PMCID: PMC9226219.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  5. Li W, Ni H, Wu S, Han S, Chen C, Li L, Li Y, Gui F, Han J, Deng X. Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis. FEBS Lett. 2020 07; 594(14):2294-2302. PMID: 32412649.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Gui F, Zhang Y, Wan J, Zhan X, Yao Y, Li Y, Haddock AN, Shi J, Guo J, Chen J, Zhu X, Edenfield BH, Zhuang L, Hu C, Wang Y, Mukhopadhyay D, Radisky ES, Zhang L, Lugea A, Pandol SJ, Bi Y, Ji B. Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H. J Clin Invest. 2020 01 02; 130(1):189-202. PMID: 31550238; PMCID: PMC6934224.
    Citations: 15     Fields:    Translation:HumansAnimals
  7. Gui F, Jiang J, He Z, Li L, Li Y, Deng Z, Lu Y, Wu X, Chen G, Su J, Song S, Zhang YM, Yun CH, Huang X, Weisberg E, Zhang J, Deng X. A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant BtkC481S mutation in B-cell malignancies. Br J Pharmacol. 2019 12; 176(23):4491-4509. PMID: 31364164; PMCID: PMC6932946.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  8. Gui B, Gui F, Takai T, Feng C, Bai X, Fazli L, Dong X, Liu S, Zhang X, Zhang W, Kibel AS, Jia L. Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function. Proc Natl Acad Sci U S A. 2019 07 16; 116(29):14573-14582. PMID: 31266892; PMCID: PMC6642419.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  9. Zhan X, Wan J, Zhang G, Song L, Gui F, Zhang Y, Li Y, Guo J, Dawra RK, Saluja AK, Haddock AN, Zhang L, Bi Y, Ji B. Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2019 06 01; 316(6):G816-G825. PMID: 30943050.
    Citations: 11     Fields:    Translation:AnimalsCells
  10. Jiang J, Gui F, He Z, Li L, Li Y, Li S, Wu X, Deng Z, Sun X, Huang X, Huang W, Han S, Zhang T, Wang Z, Jiao B, Song S, Wang H, Chen L, Zhou D, Liu Q, Ren R, Zhang J, Deng X. Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors. Cancer Res. 2017 01 01; 77(1):175-186. PMID: 27758886.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  11. Wang Y, Qi S, Zhan Y, Zhang N, Wu AA, Gui F, Guo K, Yang Y, Cao S, Hu Z, Zheng Z, Song S, Xu Q, Shen Y, Deng X. Aspertetranones A-D, Putative Meroterpenoids from the Marine Algal-Associated Fungus Aspergillus sp. ZL0-1b14. J Nat Prod. 2015 Oct 23; 78(10):2405-10. PMID: 26378981.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Zhang ZZ, Xing XL, Gu YS, Gui FK, Qi SH, Huang HF, Qu HF, Zhang L. [Distribution and enrichment characteristics of organochlorine pesticides in water and halobios from Qingbang Island in Zhoushan, China]. Huan Jing Ke Xue. 2015 Jan; 36(1):266-73. PMID: 25898674.
    Citations:    Fields:    Translation:PHPublic Health
  13. Chen B, Gui F, Xie B, Deng Y, Sun X, Lin M, Tao Y, Li S. Correction: Composition and Expression of Genes Encoding Carbohydrate-Active Enzymes in the Straw-Degrading Mushroom Volvariella volvacea. PLoS One. 2013; 8(9). PMID: 24116249.
    Citations: 1     Fields:    
  14. Chen B, Gui F, Xie B, Deng Y, Sun X, Lin M, Tao Y, Li S. Composition and expression of genes encoding carbohydrate-active enzymes in the straw-degrading mushroom Volvariella volvacea. PLoS One. 2013; 8(3):e58780. PMID: 23554925.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Chen BZ, Gui F, Xie BG, Zou F, Jiang YJ, Deng YJ. Sequence and comparative analysis of the MIP gene in Chinese straw mushroom, Volvariella volvacea. Genome. 2012 Sep; 55(9):667-72. PMID: 22937907.
    Citations: 1     Fields:    Translation:Animals
  16. Wan F, Liu W, Guo J, Qiang S, Li B, Wang J, Yang G, Niu H, Gui F, Huang W, Jiang Z, Wang W. Invasive mechanism and control strategy of Ageratina adenophora (Sprengel). Sci China Life Sci. 2010 Nov; 53(11):1291-8. PMID: 21046320.
    Citations: 14     Fields:    Translation:AnimalsPHPublic Health
  17. Wang XJ, Ai XF, Sun HY, Wang F, Xu SC, Gui FM, Shen H, Wang ZQ, Li QH, Liang XL, Zhu XF. [Relation of HLA-DRB1*15 with pathogenesis in 162 childhood cases of acute lymphoblastic leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Dec; 17(6):1507-10. PMID: 20030936.
    Citations: 4     Fields:    Translation:Humans
  18. Gui FR, Guo JY, Wan FH. [Application of ISSR molecular marker in invasive plant species study]. Ying Yong Sheng Tai Xue Bao. 2007 Apr; 18(4):919-27. PMID: 17615894.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Gui FR, Guo JY, Wan FH. [Genetic variations among populations of Ageratina adenophora from different areas, investigated by inter-simple sequence repeat markers]. Fen Zi Xi Bao Sheng Wu Xue Bao. 2007 Feb; 40(1):41-8. PMID: 17357448.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.