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Manish Satish Hudlikar, Ph.D.

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Biography
The University of Georgia, Athens, GAPh.D.12/2017Chemistry
The University of Pune, IndiaM.Sc.6/2010Biochemistry
The University of Pune, IndiaB.Sc.6/2008Chemistry
2015 - 2017
Travel Award
2012
Innovative Technology Award
2011
Visiting Research Scholar
2010
Best Research Poster Award
2005 - 2008
KVPY Fellowship award

Overview
Being a chemical biologist with research experience in the multidisciplinary fields such as synthetic organic, analytical, polymer, bioconjugation chemistry, and cell/ molecular biology. I have applied this knowledge towards the development of targeted drug-delivery devices using nanoparticles and antibody-drug conjugates (ADCs) to improve the therapeutic index of many anticancer agents through structure-activity relationship (SAR) studies. I am highly motivated, productive and independent researcher with critical thinking, complex problem-solving abilities. I have been proficiently working in a team environment with an ability to work on multiple projects leading to increased productivity. With more than 7 years of experience in chemical biology, I have acquired expertise in drug discovery, site-specific conjugations for the preparation of homogeneous ADCs, multistep organic synthesis, total synthesis, bio-analytical techniques, and biological assays.

In addition to above assets, I have been efficiently managing lab waste as per EPA regulations and bulk order of common and special chemicals leading to cost reductions. I have added significant value in academic research by writing/reviewing grants/articles that have fostered industry collaborations to effectively translate therapeutic agents into the clinic. Recently, I have started my new adventure as a research fellow at MGH/Harvard Medical School with special focus on designing small molecules that can selectively target epigenetic gene regulatory complexes against multiple myeloma and acute myeloid leukemia.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hudlikar MS, Li X, Gagarinov IA, Kolishetti N, Wolfert MA, Boons GJ. Controlled Multi-functionalization Facilitates Targeted Delivery of Nanoparticles to Cancer Cells. Chemistry. 2016 Jan 22; 22(4):1415-23. PMID: 26683093.
    Citations:    Fields:    Translation:HumansCells
  2. Ledin PA, Kolishetti N, Hudlikar MS, Boons GJ. Exploring strain-promoted 1,3-dipolar cycloadditions of end functionalized polymers. Chemistry. 2014 Jul 07; 20(28):8753-60. PMID: 24906200.
    Citations: 2     Fields:    Translation:Cells
  3. Manish Hudlikar,Shreeram Joglekar, Mayur Dhaygude,Kisan Kodam. Latex-mediated synthesis of ZnS nanoparticles: green synthesis approach. Latex-mediated synthesis of ZnS nanoparticles: green synthesis approach. 2012; 865(14):1-6. View Publication.
  4. Harne S, Sharma A, Dhaygude M, Joglekar S, Kodam K, Hudlikar M. Novel route for rapid biosynthesis of copper nanoparticles using aqueous extract of Calotropis procera L. latex and their cytotoxicity on tumor cells. Colloids Surf B Biointerfaces. 2012 Jun 15; 95:284-8. PMID: 22483347.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Manish Hudlikar, Shreeram Joglekar, Mayur Dhaygude, KisanKodam. Green synthesis of TiO2 nanoparticles by using aqueous extract of Jatropha curcas L. latex. Green synthesis of TiO2 nanoparticles by using aqueous extract of Jatropha curcas L. latex. 2012; 75:196-199. View Publication.
  6. Shriram Joglekar, Kisan Kodam, Mayur Dhaygude, Manish Hudlikar. Novel route for rapid biosynthesis of lead nanoparticles using aqueous extract of Jatropha curcas L. latex. Novel route for rapid biosynthesis of lead nanoparticles using aqueous extract of Jatropha curcas L. latex. 2011; 65(19-20):3170-3172. View Publication.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.