Harvard Catalyst Profiles

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Frederic Schaper, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bongartz H, Gille K, Hessenkemper W, Mandel K, Lewitzky M, Feller SM, Schaper F. The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner. Cell Commun Signal. 2019 10 24; 17(1):135. PMID: 31651330.
  2. Klepsch O, Namer LS, Köhler N, Kaempfer R, Dittrich A, Schaper F. Intragenic regulation of SOCS3 isoforms. Cell Commun Signal. 2019 06 25; 17(1):70. PMID: 31238931.
  3. Reeh H, Rudolph N, Billing U, Christen H, Streif S, Bullinger E, Schliemann-Bullinger M, Findeisen R, Schaper F, Huber HJ, Dittrich A. Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor a to gp130 expression: fusing experimental insights and dynamic modelling. Cell Commun Signal. 2019 05 17; 17(1):46. PMID: 31101051.
  4. Billing U, Jetka T, Nortmann L, Wundrack N, Komorowski M, Waldherr S, Schaper F, Dittrich A. Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling. Commun Biol. 2019; 2:27. PMID: 30675525.
  5. Thiele S, Heise S, Hessenkemper W, Bongartz H, Fensky M, Schaper F, Klamt S. Designing optimal experiments to discriminate interaction graph models. IEEE/ACM Trans Comput Biol Bioinform. 2018 Mar 15. PMID: 29993657.
    Citations:    Fields:    
  6. Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM. Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nat Commun. 2018 01 12; 9(1):168. PMID: 29330478.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Bongartz H, Hessenkemper W, Müller C, Fensky M, Fritsch J, Mandel K, Behrmann I, Haan C, Fischer T, Feller SM, Schaper F. The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells. Cell Signal. 2017 07; 35:37-47. PMID: 28365441.
    Citations:    Fields:    Translation:HumansCells
  8. Pinno J, Bongartz H, Klepsch O, Wundrack N, Poli V, Schaper F, Dittrich A. Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner. Cell Signal. 2016 08; 28(8):907-16. PMID: 27094713.
    Citations:    Fields:    Translation:HumansCells
  9. Rose-John S, Scheller J, Schaper F. "Family reunion"--A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines. Cytokine Growth Factor Rev. 2015 Oct; 26(5):471-4. PMID: 26235233.
    Citations: 3     Fields:    Translation:HumansAnimals
  10. Schaper F, Rose-John S. Interleukin-6: Biology, signaling and strategies of blockade. Cytokine Growth Factor Rev. 2015 Oct; 26(5):475-87. PMID: 26189695.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  11. Dittrich A, Hessenkemper W, Schaper F. Systems biology of IL-6, IL-12 family cytokines. Cytokine Growth Factor Rev. 2015 Oct; 26(5):595-602. PMID: 26187858.
    Citations: 8     Fields:    Translation:HumansAnimals
  12. Wolf A, Eulenfeld R, Bongartz H, Hessenkemper W, Simister PC, Lievens S, Tavernier J, Feller SM, Schaper F. MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch. Cell Signal. 2015 Feb; 27(2):340-52. PMID: 25460044.
    Citations: 2     Fields:    Translation:HumansCells
  13. Müller PJ, Rigbolt KT, Paterok D, Piehler J, Vanselow J, Lasonder E, Andersen JS, Schaper F, Sobota RM. Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia. J Proteomics. 2013 Jun 12; 84:132-47. PMID: 23584145.
    Citations: 4     Fields:    Translation:HumansCells
  14. Wolf A, Eulenfeld R, Gäbler K, Rolvering C, Haan S, Behrmann I, Denecke B, Haan C, Schaper F. JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells. JAKSTAT. 2013 Jul 01; 2(3):e24574. PMID: 24069558.
    Citations: 4     
  15. Blätke MA, Dittrich A, Rohr C, Heiner M, Schaper F, Marwan W. JAK/STAT signalling--an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology. Mol Biosyst. 2013 Jun; 9(6):1290-307. PMID: 23443149.
    Citations: 2     Fields:    Translation:HumansCells
  16. Thiem S, Pierce TP, Palmieri M, Putoczki TL, Buchert M, Preaudet A, Farid RO, Love C, Catimel B, Lei Z, Rozen S, Gopalakrishnan V, Schaper F, Hallek M, Boussioutas A, Tan P, Jarnicki A, Ernst M. mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. J Clin Invest. 2013 Feb; 123(2):767-81. PMID: 23321674.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  17. Dittrich A, Siewert E, Schaper F. Determination of protein turnover rates in the JAK/STAT pathway using a radioactive pulse-chase approach. Methods Mol Biol. 2013; 967:69-80. PMID: 23296722.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  18. Vlamings R, Zeef DH, Janssen ML, Oosterloo M, Schaper F, Jahanshahi A, Temel Y. Lessons learned from the transgenic Huntington's disease rats. Neural Plast. 2012; 2012:682712. PMID: 22852099.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  19. Dittrich A, Quaiser T, Khouri C, Görtz D, Mönnigmann M, Schaper F. Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling. Mol Biosyst. 2012 Aug; 8(8):2119-34. PMID: 22711165.
    Citations: 4     Fields:    Translation:HumansCells
  20. Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J. Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine Growth Factor Rev. 2012 Jun; 23(3):85-97. PMID: 22595692.
    Citations: 51     Fields:    Translation:HumansCells
  21. Dittrich A, Khouri C, Sackett SD, Ehlting C, Böhmer O, Albrecht U, Bode JG, Trautwein C, Schaper F. Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor. Hepatology. 2012 Jan; 55(1):256-66. PMID: 21898505.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  22. Eulenfeld R, Dittrich A, Khouri C, Müller PJ, Mütze B, Wolf A, Schaper F. Interleukin-6 signalling: more than Jaks and STATs. Eur J Cell Biol. 2012 Jun-Jul; 91(6-7):486-95. PMID: 22138086.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  23. Khouri C, Dittrich A, Sackett SD, Denecke B, Trautwein C, Schaper F. Glucagon counteracts interleukin-6-dependent gene expression by redundant action of Epac and PKA. Biol Chem. 2011 Dec; 392(12):1123-34. PMID: 22050227.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Bode JG, Albrecht U, Häussinger D, Heinrich PC, Schaper F. Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-?B-dependent signaling. Eur J Cell Biol. 2012 Jun-Jul; 91(6-7):496-505. PMID: 22093287.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  25. Ryll A, Samaga R, Schaper F, Alexopoulos LG, Klamt S. Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification. Mol Biosyst. 2011 Dec; 7(12):3253-70. PMID: 21968890.
    Citations: 9     Fields:    Translation:HumansCells
  26. Quaiser T, Dittrich A, Schaper F, Mönnigmann M. A simple work flow for biologically inspired model reduction--application to early JAK-STAT signaling. BMC Syst Biol. 2011 Feb 21; 5:30. PMID: 21338487.
    Citations: 6     Fields:    Translation:Cells
  27. Simister PC, Schaper F, O'Reilly N, McGowan S, Feller SM. Self-organization and regulation of intrinsically disordered proteins with folded N-termini. PLoS Biol. 2011 Feb 15; 9(2):e1000591. PMID: 21347241.
    Citations: 8     Fields:    Translation:HumansCells
  28. Radtke S, Wüller S, Yang XP, Lippok BE, Mütze B, Mais C, de Leur HS, Bode JG, Gaestel M, Heinrich PC, Behrmann I, Schaper F, Hermanns HM. Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation. J Cell Sci. 2010 Mar 15; 123(Pt 6):947-59. PMID: 20200229.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  29. Entschladen F, Lindquist JA, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R, Friedrich K. Signal transduction--receptors, mediators, and genes. Sci Signal. 2009 Mar 24; 2(63):mr3. PMID: 19318619.
    Citations: 1     Fields:    Translation:Cells
  30. Friedrich K, Lindquist JA, Entschladen F, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R. Signal transduction in the footsteps of goethe and schiller. Cell Commun Signal. 2009 Feb 04; 7:2. PMID: 19193215.
    Citations:    Fields:    
  31. Eulenfeld R, Schaper F. A new mechanism for the regulation of Gab1 recruitment to the plasma membrane. J Cell Sci. 2009 Jan 01; 122(Pt 1):55-64. PMID: 19050043.
    Citations: 19     Fields:    Translation:HumansCells
  32. Clahsen T, Schaper F. Interleukin-6 acts in the fashion of a classical chemokine on monocytic cells by inducing integrin activation, cell adhesion, actin polymerization, chemotaxis, and transmigration. J Leukoc Biol. 2008 Dec; 84(6):1521-9. PMID: 18765478.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  33. Sobota RM, Müller PJ, Heinrich PC, Schaper F. Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation. Biochem J. 2008 May 15; 412(1):65-72. PMID: 18271757.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  34. Sobota RM, Müller PJ, Khouri C, Ullrich A, Poli V, Noguchi T, Heinrich PC, Schaper F. SHPS-1/SIRP1alpha contributes to interleukin-6 signalling. Cell Signal. 2008 Jul; 20(7):1385-91. PMID: 18450421.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  35. Albrecht U, Yang X, Asselta R, Keitel V, Tenchini ML, Ludwig S, Heinrich PC, Häussinger D, Schaper F, Bode JG. Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene. Cell Signal. 2007 Sep; 19(9):1866-78. PMID: 17543500.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  36. Ehlting C, Lai WS, Schaper F, Brenndörfer ED, Matthes RJ, Heinrich PC, Ludwig S, Blackshear PJ, Gaestel M, Häussinger D, Bode JG. Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade. J Immunol. 2007 Mar 01; 178(5):2813-26. PMID: 17312125.
    Citations: 31     Fields:    Translation:AnimalsCells
  37. Tron K, Samoylenko A, Musikowski G, Kobe F, Immenschuh S, Schaper F, Ramadori G, Kietzmann T. Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes. J Hepatol. 2006 Jul; 45(1):72-80. PMID: 16510205.
    Citations: 13     Fields:    Translation:AnimalsCells
  38. Stross C, Radtke S, Clahsen T, Gerlach C, Volkmer-Engert R, Schaper F, Heinrich PC, Hermanns HM. Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. J Biol Chem. 2006 Mar 31; 281(13):8458-68. PMID: 16459330.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  39. Yang XP, Schaper F, Teubner A, Lammert F, Heinrich PC, Matern S, Siewert E. Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo. J Hepatol. 2005 Oct; 43(4):704-10. PMID: 16040151.
    Citations: 16     Fields:    Translation:AnimalsCells
  40. Sommer U, Schmid C, Sobota RM, Lehmann U, Stevenson NJ, Johnston JA, Schaper F, Heinrich PC, Haan S. Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases. J Biol Chem. 2005 Sep 09; 280(36):31478-88. PMID: 16000307.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  41. Lehmann U, Sommer U, Smyczek T, Hörtner M, Frisch W, Volkmer-Engert R, Heinrich PC, Schaper F, Haan S. Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130. Cell Signal. 2006 Jan; 18(1):40-9. PMID: 15927449.
    Citations: 2     Fields:    Translation:AnimalsCells
  42. Clahsen T, Lehmann U, Stross C, Hermanns HM, Volkmer-Engert R, Schneider-Mergener J, Heinrich PC, Schaper F. The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling. Cell Signal. 2005 May; 17(5):559-69. PMID: 15683731.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  43. Weissenbach M, Clahsen T, Weber C, Spitzer D, Wirth D, Vestweber D, Heinrich PC, Schaper F. Interleukin-6 is a direct mediator of T cell migration. Eur J Immunol. 2004 Oct; 34(10):2895-906. PMID: 15368306.
    Citations: 25     Fields:    Translation:HumansCells
  44. Yang XP, Albrecht U, Zakowski V, Sobota RM, Häussinger D, Heinrich PC, Ludwig S, Bode JG, Schaper F. Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression. J Biol Chem. 2004 Oct 22; 279(43):45279-89. PMID: 15308667.
    Citations: 8     Fields:    Translation:HumansCells
  45. Zhao L, Hart S, Cheng J, Melenhorst JJ, Bierie B, Ernst M, Stewart C, Schaper F, Heinrich PC, Ullrich A, Robinson GW, Hennighausen L. Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK. J Biol Chem. 2004 Oct 15; 279(42):44093-100. PMID: 15292206.
    Citations: 20     Fields:    Translation:AnimalsCells
  46. Fischer P, Lehmann U, Sobota RM, Schmitz J, Niemand C, Linnemann S, Haan S, Behrmann I, Yoshimura A, Johnston JA, Müller-Newen G, Heinrich PC, Schaper F. The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling. Biochem J. 2004 Mar 01; 378(Pt 2):449-60. PMID: 14611646.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  47. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003 Aug 15; 374(Pt 1):1-20. PMID: 12773095.
    Citations: 692     Fields:    Translation:HumansAnimalsCells
  48. Bode JG, Schweigart J, Kehrmann J, Ehlting C, Schaper F, Heinrich PC, Häussinger D. TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex. J Immunol. 2003 Jul 01; 171(1):257-66. PMID: 12817006.
    Citations: 9     Fields:    Translation:AnimalsCells
  49. Niemand C, Nimmesgern A, Haan S, Fischer P, Schaper F, Rossaint R, Heinrich PC, Müller-Newen G. Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3. J Immunol. 2003 Mar 15; 170(6):3263-72. PMID: 12626585.
    Citations: 89     Fields:    Translation:HumansCells
  50. Bode JG, Ludwig S, Ehrhardt C, Albrecht U, Erhardt A, Schaper F, Heinrich PC, Häussinger D. IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3. FASEB J. 2003 Mar; 17(3):488-90. PMID: 12551851.
    Citations: 88     Fields:    Translation:HumansCells
  51. Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol Chem. 2003 Jan 03; 278(1):661-71. PMID: 12403768.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.