Harvard Catalyst Profiles

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Bing Chen, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI147884 (CHEN, BING) Jan 16, 2020 - Dec 31, 2024
    Structure of HIV-1 envelope spike in the context of membrane
    Role: Principal Investigator
  2. R01AI141002 (CHEN, BING) May 15, 2018 - Apr 30, 2023
    Structural Basis of Coreceptor Recognition by HIV-1 Envelope Spike
    Role: Principal Investigator
  3. R56AI129721 (CHEN, BING) Jul 19, 2017 - Jun 30, 2019
    Novel therapeutics targeting the membrane proximal external region of HIV-1 Env
    Role: Principal Investigator
  4. R01AI127193 (CHEN, BING) May 20, 2016 - Jun 30, 2026
    Structure-function studies of the membrane-interacting domains of HIV-1 Env spike
    Role: Principal Investigator
  5. R56AI112489 (CHEN, BING) Aug 15, 2014 - Jul 31, 2016
    Small-Molecule Fusion Inhibitors Targeting a Fusion Intermediate State of HIV-1 g
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang J, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Rits-Volloch S, Wang S, Sliz P, Wesemann DR, Yang W, Seaman MS, Lu J, Xiao T, Chen B. Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Cell Rep. 2022 04 26; 39(4):110729. PMID: 35452593; PMCID: PMC8995406.
    Citations: 12     Fields:    Translation:HumansCells
  2. Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh RM, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B. Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science. 2021 Dec 10; 374(6573):1353-1360. PMID: 34698504.
    Citations: 69     Fields:    Translation:HumansCells
  3. Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A, Lu S, Sterling SM, Walsh RM, Rits-Volloch S, Lu J, Wesemann DR, Yang W, Seaman MS, Chen B. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. Science. 2021 08 06; 373(6555):642-648. PMID: 34168070; PMCID: PMC9245151.
    Citations: 70     Fields:    Translation:HumansCells
  4. Zhang J, Cai Y, Xiao T, Lu J, Peng H, Sterling SM, Walsh RM, Rits-Volloch S, Zhu H, Woosley AN, Yang W, Sliz P, Chen B. Structural impact on SARS-CoV-2 spike protein by D614G substitution. Science. 2021 04 30; 372(6541):525-530. PMID: 33727252.
    Citations: 116     Fields:    Translation:HumansCells
  5. Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B. A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. Nat Struct Mol Biol. 2021 02; 28(2):202-209. PMID: 33432247; PMCID: PMC7895301.
    Citations: 32     Fields:    Translation:HumansCells
  6. Cai Y, Zhang J, Xiao T, Peng H, Sterling SM, Walsh RM, Rawson S, Rits-Volloch S, Chen B. Distinct conformational states of SARS-CoV-2 spike protein. Science. 2020 09 25; 369(6511):1586-1592. PMID: 32694201.
    Citations: 365     Fields:    Translation:HumansCells
  7. Piai A, Fu Q, Cai Y, Ghantous F, Xiao T, Shaik MM, Peng H, Rits-Volloch S, Chen W, Seaman MS, Chen B, Chou JJ. Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein. Nat Commun. 2020 05 08; 11(1):2317. PMID: 32385256; PMCID: PMC7210310.
    Citations: 11     Fields:    Translation:HumansCells
  8. Xiao T, Frey G, Fu Q, Lavine CL, Scott DA, Seaman MS, Chou JJ, Chen B. HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes. Nat Chem Biol. 2020 05; 16(5):529-537. PMID: 32152540.
    Citations: 9     Fields:    Translation:HumansCells
  9. Chen B. Molecular Mechanism of HIV-1 Entry. Trends Microbiol. 2019 10; 27(10):878-891. PMID: 31262533; PMCID: PMC6744290.
    Citations: 69     Fields:    Translation:Cells
  10. Shaik MM, Peng H, Lu J, Rits-Volloch S, Xu C, Liao M, Chen B. Structural basis of coreceptor recognition by HIV-1 envelope spike. Nature. 2019 01; 565(7739):318-323. PMID: 30542158.
    Citations: 73     Fields:    Translation:HumansCells
  11. Fu Q, Shaik MM, Cai Y, Ghantous F, Piai A, Peng H, Rits-Volloch S, Liu Z, Harrison SC, Seaman MS, Chen B, Chou JJ. Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):E8892-E8899. PMID: 30185554; PMCID: PMC6156635.
    Citations: 36     Fields:    Translation:Cells
  12. Liu Y, Pan J, Cai Y, Grigorieff N, Harrison SC, Chen B. Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol. 2017 05 15; 91(10). PMID: 28250125; PMCID: PMC5411591.
    Citations: 10     Fields:    Translation:Cells
  13. Cai Y, Karaca-Griffin S, Chen J, Tian S, Fredette N, Linton CE, Rits-Volloch S, Lu J, Wagh K, Theiler J, Korber B, Seaman MS, Harrison SC, Carfi A, Chen B. Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4477-4482. PMID: 28396421; PMCID: PMC5410843.
    Citations: 9     Fields:    Translation:HumansCells
  14. Dev J, Park D, Fu Q, Chen J, Ha HJ, Ghantous F, Herrmann T, Chang W, Liu Z, Frey G, Seaman MS, Chen B, Chou JJ. Structural basis for membrane anchoring of HIV-1 envelope spike. Science. 2016 Jul 08; 353(6295):172-175. PMID: 27338706.
    Citations: 77     Fields:    Translation:Cells
  15. Chen J, Kovacs JM, Peng H, Rits-Volloch S, Lu J, Park D, Zablowsky E, Seaman MS, Chen B. HIV-1 ENVELOPE. Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein. Science. 2015 Jul 10; 349(6244):191-5. PMID: 26113642.
    Citations: 70     Fields:    Translation:HumansCells
  16. Kovacs JM, Noeldeke E, Ha HJ, Peng H, Rits-Volloch S, Harrison SC, Chen B. Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18542-7. PMID: 25512514; PMCID: PMC4284565.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  17. Chen J, Frey G, Peng H, Rits-Volloch S, Garrity J, Seaman MS, Chen B. Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41. J Virol. 2014 Jan; 88(2):1249-58. PMID: 24227838.
    Citations: 66     Fields:    Translation:HumansCells
  18. Kovacs JM, Nkolola JP, Peng H, Cheung A, Perry J, Miller CA, Seaman MS, Barouch DH, Chen B. HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12111-6. PMID: 22773820.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  19. Freeman MM, Seaman MS, Rits-Volloch S, Hong X, Kao CY, Ho DD, Chen B. Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody. Structure. 2010 Dec 08; 18(12):1632-41. PMID: 21134642.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  20. Frey G, Chen J, Rits-Volloch S, Freeman MM, Zolla-Pazner S, Chen B. Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies. Nat Struct Mol Biol. 2010 Dec; 17(12):1486-91. PMID: 21076402.
    Citations: 59     Fields:    Translation:HumansCells
  21. Alam SM, Morelli M, Dennison SM, Liao HX, Zhang R, Xia SM, Rits-Volloch S, Sun L, Harrison SC, Haynes BF, Chen B. Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20234-9. PMID: 19906992.
    Citations: 166     Fields:    Translation:HumansCells
  22. Frey G, Peng H, Rits-Volloch S, Morelli M, Cheng Y, Chen B. A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3739-44. PMID: 18322015.
    Citations: 156     Fields:    Translation:Cells
  23. Rits-Volloch S, Frey G, Harrison SC, Chen B. Restraining the conformation of HIV-1 gp120 by removing a flexible loop. EMBO J. 2006 Oct 18; 25(20):5026-35. PMID: 17006538; PMCID: PMC1618118.
    Citations: 14     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.